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Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds

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Journal of Pharmaceutical Analysis 2017年第5期7卷 338-342页

作者： Laura J.Waters catherine V.Finch A.K.M.Mehedi H.Bhuiyan Karl Hemming John c.mitchell Department of Pharmacy School of Applied Science University of Huddersfield Medway centre for Pharmaceutical Sciences University of Greenwich

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine,with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability(K_p) values suggesting plasma-modified silicone membrane(PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.

关键词： Permeation PDMS Silicone Plasma Flux Hydrophobicity

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Tex13基因非放射性原位杂交探针的制备

西安交通大学学报（医学版） 2011年第1期32卷 131-134页

作者：霍涌玮邱曙东周庆李莹聂蓉 FRIEL P mitchell D SMALL c GRISWOLD MD 西安交通大学医学院生殖医学研究中心陕西西安710061 美国华盛顿州立大学分子生物科学学院

目的研究制备地高辛(DIG)标记的Tex13(testis expressed gene 13)基因非放射性原位杂交探针,用于检测小鼠性腺Tex13基因的表达。方法采用RT-PcR方法扩增Tex13靶序列,将其插入带SP6和T7 RNA聚合酶启动子的pGEM-T Easy质粒,转入大肠杆菌DH... 详细信息

目的研究制备地高辛(DIG)标记的Tex13(testis expressed gene 13)基因非放射性原位杂交探针,用于检测小鼠性腺Tex13基因的表达。方法采用RT-PcR方法扩增Tex13靶序列,将其插入带SP6和T7 RNA聚合酶启动子的pGEM-T Easy质粒,转入大肠杆菌DH10B,经蓝白斑筛选获得重组质粒,用T7和SP6引物对重组质粒进行PcR扩增,以此PcR产物为模板,以DIG RNA Labeling Mix为底物,经SP6 RNA聚合酶和T7 RNA聚合酶体外转录,分别制备DIG标记的反义链和正义链RNA探针。结果应用正常小鼠睾丸组织非放射性原位杂交实验,证实制备的探针具有较高的特异性和敏感性。结论 DIG标记Tex13基因杂交探针的成功制备,为进一步研究Tex13基因在小鼠性腺中的表达定位和发育规律以及它在减数分裂过程中的作用提供了实验基础。

关键词： Tex13 生殖细胞减数分裂 RNA探针原位杂交

The Road to Reengagement and Beyond

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Beijing Review 2022年第10期65卷 30-31页

作者： mitchell F.Stanley the National center for Sustainable Development in Washington D.C.

The Shanghai communiqué, a pathbreaking accord signed by U.S. President Richard Nixon and chinese Premier Zhou Enlai on February 28, 1972, marks a defining moment in the history of both the United States and the Peo... 详细信息

关键词： breaking Road Beyond

Voûtes célestes,terresfertiles La collaboration sino-africaine dynamise l'industrie spatiale et stimule le développement socio-économique

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中国与非洲（法文版） 2024年第5期16卷 28-29页

作者： EHIZUELEN MIcHAEL mitchell OMORUYI 不详

Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal cord Injury

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Research 2023年第4期2023卷 131-144页

作者： LászlóGál Tamás Bellák Annamária Marton Zoltán Fekécs Drew Weissman Dénes Török Rachana Biju csaba Vizler Rebeka Kristóf mitchell B.Beattie Paulo J.c.Lin Norbert Pardi Antal Nógrádi Krisztián Pajer Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary National Biotechnology Laboratory Institute of GeneticsBiological Research CentreSzegedHungary Institute of Biochemistry Biological Research CentreSzegedHungary Department of Medicine University of PennsylvaniaPhiladelphiaPA19104USA Acuitas Therapeutics VancouverBCV6T 1Z3Canada

Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great ***-modified messenger RNA(mRNA)has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic ***,we used lipid nanoparticle(LNP)-encapsulated human interleukin-10(hIL-10)-encoding nucleoside-modified mRNA to induce neuroprotection and functional recovery following rat spinal cord contusion *** administration of hIL-10 mRNA-LNP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to ***,hIL-10 mRNA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of IL-105 d after *** results suggest that treatment with nucleoside-modified mRNAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.

关键词： protective Restoration utilized

caval reconstruction techniques in orthotopic liver transplantation

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World Journal of Surgical Procedures 2015年第1期5卷 41-57页

作者： Eliza W Beal Shaylyn c Bennett Bryan A Whitson Elmahdi A Elkhammas mitchell L Henry Sylvester M Black Department of Surgery the Ohio State University Wexner Medical Center Division of cardiothoracic Surgery Department of Surgerythe Ohio State University Wexner Medical Center Division of Transplantation Surgery Department of Surgerythe Ohio State University Wexner Medical Center

There are several caval reconstruction techniques currently in use for orthotopic liver transplantation. These include caval replacement or the conventional technique, performed with or without venovenous bypass, piggyback technique with anastomosis with two or three hepatic veins with or without cavotomy and modifications of the piggyback technique including end-to-side and side-to-side cavocaval anastomosis. There are few randomized controlled trials comparing the use of these techniques and our knowledge of their comparability is based on a few multi- and many single-center retrospective and prospective reviews. Although there are advantages and disadvantages for each technique, it is advisable that the surgeon perform the technique with which they have the most the experience and at which they are the most skilled as excellent outcomes can be obtained with any of the caval reconstruction options discussed.

关键词： caval replacement Piggyback technique conventional liver transplant Standard liver transplant Venovenous bypass Portocaval shunt

Performance on the Functional Movement Screen in older active adults

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Journal of Sport and Health Science 2016年第1期5卷 119-125页

作者： Ulrike H.mitchell A.Wayne Johnson Pat R.Vehrs J.Brent Feland Sterling c.Hilton Department of Exercise Sciences Brigham Young University Provo UT 84602 USA Department of Educational Leadership and Foundations David O. McKay School of Education Brigham Young University Provo UT 84602 USA

Background:The Functional Movement Screen(FMS^(TM)) has become increasingly popular for identifying functional limitations in basic functional *** exploratory and descriptive study was undertaken to confirm feasibility of performing the FMS^(TM) in older active adults,assess prevalence of asymmetries and to evaluate the relationship between functional movement ability,age,physical activity levels and body mass index(BMI).Methods:This is an observational study;97 men(n = 53) and women(n = 44) between the ages of 52 and 83 *** was computed and self-reported physical activity levels were *** were grouped by age(5-year intervals),BMI(normal,over-weight,and obese)and *** participant's performance on the FMS^(TM) was digitally recorded for later ***:The youngest age group(50–54 years) scored highest in all seven tests and the oldest age group(75+) scored lowest in most of the tests compared to all other age *** subjects in the 'normal weight' group performed no different than those who were in the 'overweight' group;both groups performed better than the 'obese' *** the 97 participants 54 had at least one *** pairwise correlations between the total FMS^(TM) score and age(r =-0.531),BMI(r =-0.270),and the measure of activity level(r = 0.287) were significant(p conclusion:FMS^(TM) scores decline with increased BMI,increased age,and decreased activity *** screen identifies range of motion-and strength-related *** FMS^(TM) can be used to assess functional limitations and *** research should evaluate if a higher total FMS^(TM) score is related to fewer falls or injuries in the older population.

关键词： Age BMI Fitness level FMS^(TM) Functional fitness Functional limitations

A Study of the clinical Efficacy of Shaolin Neigong on Health Related Quality of Life in Pre-diabetes

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A Study of the Clinical Efficacy of Shaolin Neigong on Healt...

作者： Erin mitchell 南京中医药大学

学位级别：硕士

目的：糖尿病前期会对患者的健康相关生命质量(HRQOL)产生负面影响。往往对于糖尿病前期治疗的评价是基于对于血糖的控制而很少关注对于生命质量的影响。本次研究的目的旨在评估通过练习传统少林内功对糖尿病前期患者在健康相关生命质... 详细信息

目的：糖尿病前期会对患者的健康相关生命质量(HRQOL)产生负面影响。往往对于糖尿病前期治疗的评价是基于对于血糖的控制而很少关注对于生命质量的影响。本次研究的目的旨在评估通过练习传统少林内功对糖尿病前期患者在健康相关生命质量方面的影响。研究设计和方法：五十糖尿病前期患者随机分为3组：1)对照组(n=10);2)步行组(n10);3)少林内功组(n=30)。对照组保持其原始的生活状态,并不参加任何处方锻炼。步行组连续6个月,每周5天,一天两次,每次30分钟,以中速(80-100步/分钟)行走。少林内功组以练习少林内功作为运动治疗,连续6个月,每周5天。其中,10人每天练习一次;10人每天练习两次;10人每天练习三次。少林内功组有专业的指导,在最开始两周每周两次纠正动作,然后所有人员在接下来的22周中,自己训练。每个组中,病人的SF一36量表会在运动治疗前、三个月时和治疗后进行测定。血糖浓度会在最初以及治疗过程中测量。结果:在每个组,在治疗前后会进行心理健康评分(McS)和生理健康评分(PcS)的比较,以此来确定是否健康相关生命质量有所变化。结果表明,B组(pc组(pcS评分上均有显著差异(pcS评分上有显著改善。然而,进行两次和三次锻炼之间并没有发现显著不同(p>0.05)。在对于治疗前后PcS评分的比较来看,D组(pcS评分明显高于对照组(A组)。然而,这两组之间,并没有巨大差别。HRQOL结果同样也反应了在治疗后血糖浓度的变化。结论：通过练习少林内功,尤其是每日练习两次到三次,能够很好的治疗糖尿病前期患者,并且能够极大的提升健康相关生活质量

关键词：糖尿病前期少林内功健康相关生活质量 SF-36

correlation of abnormal histology with endoscopic findings among mycophenolate mofetil treated patients

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 405-410页

作者： mitchell A Izower Merajur Rahman Ernesto P Molmenti Madhu c Bhaskaran Viren G Amin Sundas Khan Keith Sultan Department of Medicine North Shore University Hospital Division of Gastroenterology Department of MedicineNorth Shore University Hospital Department of Surgery North Shore University Hospital Divison of Nephrology Department of MedicineNorth Shore University Hospital the Feinstein Institute for Biomedical Research

To describe all abnormal histological findings and their associated endoscopic presentation in patients using mycophenolate mofetil (MMF). METHODSA retrospective review of all individuals prescribed MMF within 6 mo of a colonoscopy or flexible sigmoidoscopy between 07/2009 and 09/2015 was performed within Northwell Health system. Records were analyzed for age, gender, procedure indication, MMF indication, and both gross and microscopic findings. Only reports with abnormal histology were included. RESULTSOne hundred and eighty-four procedures from 170 patients were found, of which 39 met inclusion criteria. Fifty-one point three percent were female. MMF was used for solid organ transplant in 71.8%. Diarrhea was the indication for 71.8% of colonoscopies. Fifty-nine percent of reports revealed gross and microscopic abnormalities while 41.0% had only microscopic findings. Only 11 patients’ reports (28.2%) indicated a specific histopathology of MMF colitis. Among the entire group, only 23.1% of abnormal histology was isolated proximal to the splenic flexure. cONcLUSIONOur results demonstrate a high rate of left sided disease and microscopic findings without gross mucosal abnormalities among patients using MMF. Also, a broader definition of MMF-colonopathy may be appropriate, with a majority of our abnormal histology falling outside of the more narrowly defined MMF-colitis category. Given the high frequency of isolated microscopic abnormalities and distal disease, sigmoidoscopy with random biopsies may be an appropriate, less invasive initial endoscopic examination in selected MMF patients.

关键词： Mycophenolate mofetil colitis colonoscopy Diarrhea