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悉尼系统:新的胃炎分类法第九届世界胃肠病学悉尼会议资料之一

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国外医学（内科学分册） 1991年第7期18卷 289-292,318页

作者： misiewicz jj 胡品津

新的胃炎分类法——悉尼系统是一套高度灵活的分类系统,将以往不同分类法统一起来,具有广泛的应用价值。该系统包括组织学分类和内镜分类两大部分。组织学分类由病因、病变部位和病理形态三部分组成。按病理形态将胃炎分为急性、慢性和... 详细信息

新的胃炎分类法——悉尼系统是一套高度灵活的分类系统,将以往不同分类法统一起来,具有广泛的应用价值。该系统包括组织学分类和内镜分类两大部分。组织学分类由病因、病变部位和病理形态三部分组成。按病理形态将胃炎分为急性、慢性和特异性三大类。对炎症、活动性、萎缩、肠上皮化生和幽门螺旋菌五项主要病变程度分成无、轻、中及重四个级别。病变部位要注明胃窦、胃体或全胃。病因包括幽门螺旋菌、自身免疫、药物及特发性等。内镜分类是对胃粘膜炎症特征作分级描述并注明部位,据此将胃镜胃类归纳为红斑渗出性、平坦糜烂性、隆起糜烂性、萎缩性、出血性、返流性及肥厚性等类型。文章最后对微生物及免疫因素的重要性及胃炎的自然病程和预后作了简要介绍。

关键词：胃炎分类法悉尼系统

上消化道疾病基础知识(四) 幽门螺杆菌感染的治疗

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英国医学杂志中文版 2003年第2期6卷 104-108页

作者： Adam Harris.jj misiewicz 王玉珍 Central Middlesex Hospital London.

本文讨论针对内镜表现不同的消化不良患者幽门螺杆菌(HP)感染的治疗问题。我们所依据的是近期的研究结果以及适用于初级和中级医疗保健的国际性共识。十二指肠溃疡在未服用非甾体抗炎药的患者中,95％的十二指肠溃疡是由幽门螺杆菌感... 详细信息

本文讨论针对内镜表现不同的消化不良患者幽门螺杆菌(HP)感染的治疗问题。我们所依据的是近期的研究结果以及适用于初级和中级医疗保健的国际性共识。十二指肠溃疡在未服用非甾体抗炎药的患者中,95％的十二指肠溃疡是由幽门螺杆菌感染引起的。

关键词：上消化道疾病基础知识幽门螺杆菌感染十二指肠溃疡

Chemical Approaches to Emerging Advancements in Deformable Bioelectronics:Synthesis,Device Concepts,Performance,and Applications

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CCS Chemistry 2024年第1期6卷 11-26页

作者： jj Abu-Halimah Aman Majmudar Bozhi Tian Department of Chemistry University of ChicagoChicagoIllinois 60637 The James Franck Institute University of ChicagoChicagoIllinois 60637 The Institute for Biophysical Dynamics University of ChicagoChicagoIllinois 60637

This mini review examines the current advances and future prospects of chemical approaches in deformable bioelectronics,emphasizing their transformative potential in healthcare and other *** mini review outlines novel fabrication strategies that rely on chemical principles to create adaptable,comfortable,and durable bioelectronic devices that are capable of seamlessly integrating into the dynamic biological *** discussion also extends to the integration of innovative device concepts that enhance the outcomes in both sensing and modulation ***-enhancing strategies that use chemistry to refine the sensitivity and precision of these devices are also ***,the mini review explores the emerging applications of chemically enhanced bioelectronic devices in healthcare,reflecting the potential of this field to revolutionize patient care and improve health *** the outlook section,this mini review investigates the promising future of transient and living bioelectronics,emphasizing the pivotal role of chemical approaches in their *** additionally covers the potential of chemical techniques in powering bioelectronic devices using biological systems and discusses the prospective applications of chemically synthesized bioelectronic devices outside of *** the field has made substantial progress,this mini review also identifies challenges that must be addressed,thus underlining the necessity for continued research and chemical innovation in bioelectronics.

关键词： deformable bioelectronics hydrogels biointerfaces sensing modulation semiconductors cells and tissues

高特异性σ2R/TMEM97配体FEM-1689可减轻神经病理性疼痛并抑制整合应激反应

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中国疼痛医学杂志 2024年第3期30卷 161-165页

作者：龙沙沙(译) 韩清见(校) 复旦大学脑科学研究院

在药理学界,σ2受体(σ2R)早在30多年前就被描述过,但其分子特征仍模糊不清,直到最近才被确认为跨膜蛋白97 (TMEM97)。经研究证明σ_(2)R/TMEM97配体可减轻小鼠神经病理性疼痛模型的机械超敏反应,其最大抗痛作用的时间为给药后24 h。该... 详细信息

在药理学界,σ2受体(σ2R)早在30多年前就被描述过,但其分子特征仍模糊不清,直到最近才被确认为跨膜蛋白97 (TMEM97)。经研究证明σ_(2)R/TMEM97配体可减轻小鼠神经病理性疼痛模型的机械超敏反应,其最大抗痛作用的时间为给药后24 h。该研究试图通过解决2个关键问题来了解其抗神经病理性疼痛效应:σ_(2)R/TMEM97化合物是否通过受体选择性地发挥作用,以及它们对痛觉神经元的下游机制是什么?该研究使用了一种Tmem97全身基因敲除小鼠,发现σ_(2)R/TMEM97结合化合物FEM-1689,需要该基因才能在小鼠神经损伤模型中产生抗痛作用。利用小鼠背根神经节原代神经元证明,FEM-1689能抑制整合应激反应(ISR),并通过σ_(2)R/TMEM97特异性作用促进神经元生长。随后,该研究扩展了其临床转化价值,证明FEM-1689可降低人类感觉神经元中的整合应激反应(ISR)和p-eIF2α水平,并可减轻甲基乙二醛对ISR的致病作用。同时,研究还证明了σ_(2)R/TMEM97在人类痛觉感受器和卫星胶质细胞中均有表达。这些结果证实了σ_(2)R/TMEM97有希望成为治疗神经病理性疼痛的靶点。

关键词：抗痛作用特异性作用受体选择性痛觉感受器甲基乙二醛神经病理性疼痛痛觉神经高特异性

An Enzyme Electrode Based on the Covalently Binding of Horseradish Peroxidase to a Self-assembling Monolayer Modified Gold Electrode

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Chinese Chemical Letters 1998年第2期9卷 157-160页

作者： Sun, jj Xu, jj Fang, HQ Chen, HY Nanjing Univ State Key Lab Coordinat Chem Dept Chem Nanjing 210093 Peoples R China

A new procedure for developing high performance enzyme electrode is described. The procedure is based on the covalently binding of horseradish peroxidase to a self-assembling monolayer on a gold electrode. An enhanced catalytic current is observed with addition of hydrogen peroxide into phosphate buffer solution (PBS) in the presence of mediators. The electrode exhibits high sensitivity and a wide linear range to hydrogen peroxide.

关键词： high performance enzyme electrode high sensitivity wide linear range

Electrochemical reduction process of bilirubin in dimethylformamide

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Chinese Journal of Chemistry 1995年第4期13卷 289-298页

作者： NIU, jj DONG, SJ CHINESE ACAD SCI CHANGCHUN INST APPL CHEMELECTROANALYT CHEM LABCHANGCHUN 130022PEOPLES R CHINA

The electrochemical reduction behavior of bilirubin (BR) at platinum electrode in DMF was investigated by cyclic voltammetry, in situ electron spin resonance spectroscopy and in situ rapid scanning thin layer spectroelectrochemistry. Experimental results revealed that the reduction of BR firstly undergoes an ECE process: GRAPHICS The generated (BR)(2)(3-). can be re-oxidized to BR and then to purpurin (Pu) by a series of oxidation processes: GRAPHICS However, the re-reduction reactions of Pu are not the reverse processes. The different reduction mechanisms are discussed in detail.

关键词： BILIRUBIN BILIVERDIN PURPURIN SPECTROELECTROCHEMISTRY BIOELECTROCHEMISTRY

Persistent Currents in Toroidal Single-wall Carbon Nanotubes

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Journal of Materials Science & Technology 1999年第4期15卷 342-344页

作者： Liu, jj Zhang, G Gu, BL Tsing Hua Univ Dept Phys Beijing 100084 Peoples R China

In this paper the persistent currents of ideal toroidal single-wall carbon nanotubes (TSWNTs) are calculated from the tight-binding model and the periodic boundary conditions. The electronic structure and persistent current of a TSWNT strongly depend on its helicity and longitudinal circumference, making the TSWNTs a geometry-sensitive kind of materials. The interatomic carbonic interactions other than pp pi-type are also studied and are found to introduce more steps to the persistent current. The diamagnetic-paramagnetic transitions occur more frequently, and the persistent current depends on the interaction energy values, while the periodicity of magnetic flux preserves.

关键词： Nanotubes

Effects of Charge Inheritance on High Zn-Al Based Alloy

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Journal of Materials Science & Technology 1995年第2期11卷 153-156页

作者： GENG, H MA, jj YANG, SH Shandong Polytechnic Univ Jinan China

The effects of several kinds of charges on microstructure and mechanical properties of ZA27 zinc alloy have been studied. Experimental results show that a certain amount of the mechining charge, granular charge and remelting charge treated in suitable way can increase greatly the mechanical properties of ZA27 alloy. It is thought that the charges possess microstructure inheritance to ZA27 alloy, so cause the property changes according to the viewpoints of casting alloy inheritance.

关键词： Zinc alloys

Indications for 5-aminosalicylate in inflammatory bowel disease:Is the body of evidence complete?

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World Journal of Gastroenterology 2006年第38期12卷 6115-6123页

作者： Ad A van Bodegraven Chris jj Mulder Section of Inflammatory Bowel Diseases VU University medical centre Amsterdam The Netherlands Department of Gastroenterology VU University medical centre Amsterdam The Netherlands

Mesalazine is a safe drug, although adverse events may be seen in a minority of patients. This applies also to pregnant women and children. The role of mesalazine in combination therapy to improve efficacy and con- comitant drug pharmacokinetics, or in chemoprevention against inflammatory bowel disease (IBD)-related co- lonic carcinoma has not yet been completely elucidated. Therapeutic success of mesalazine may be optimized by a combination of high dose and low frequency of dos- age to improve compliance. Therefore, due to its supe- rior safety profile and pharmacokinetic characteristics, mesalazine is preferable to sulphasalazine. This paper reviews the literature concerning mechanisms of action, indications and off-label use, pharmacokinetic properties and formulations, therapeutic efficacy, compliance, pae- diatric indications, chemoprevention, and safety issues and adverse event profile of mesalazine treatment versus sulphasalazine. It also highlights these controversies in order to clarify the potential benefits of mesalazines in IBD therapy and evidence for its use.

关键词： Mesalazine Sulphasalazine Review Ulcerative colitis Crohn's disease Treatment Chemoprevention Pregnancy Adverse events