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A modified Johnson-Cook constitutive relationship for a rare-earth containing magnesium alloy

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Journal of Rare Earths 2013年第12期31卷 1202-1207页

作者： F.A.mirza 陈道伦李德江曾小勤 Department of Mechanical and Industrial Engineering Ryerson University The State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong University

Lightweight magnesium alloy has recently attracted a considerable interest in the automotive and aerospace industries to improve fuel efficiency and reduce CO2 emissions via the weight reduction of ***-earth（RE） element addition can remarkably improve the mechanical properties of magnesium alloys through weakening crystallographic textures associated with the strong mechanical anisotropy and tension-compression yield *** the addition of RE elements sheds some light on the alteration in the mechanical anisotropy,available information on the constitutive relationships used to describe the flow behavior of RE-containing magnesium alloys is *** establish such a constitutive relationship,uniaxial compressive deformation tests were first conducted on an extruded Mg-10Gd-3Y-0.5Zr（GW103K） magnesium alloy at the strain rates ranging from 1×10–1 to 1×10–4s–1 at room temperature.A modified Johnson-Cook constitutive equation based on a recent strain hardening equation was proposed to predict the flow stresses of GW103K *** between the predicted and experimental results showed that the modified Johnson-Cook constitutive equation was able to predict the flow stresses of the RE-containing magnesium alloy fairly accurately with a standard deviation of about 1.8%.

关键词： magnesium alloy rare-earth element compression constitutive equation

Gravitomagnetic Effects on Collective Plasma Oscillations in Compact Stars

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Communications in Theoretical Physics 2006年第3期45卷 568-572页

作者： Babur M. mirza Hamid Saleem Depaxtment of Mathematics Quaid-i-Azam University Islamabaci 45320 Pakistan PINSTECH Nilore Islamabad Pakistan COMSATS Institute of Information Technology Islamabad Pakistan

血浆摆动上的 gravitomagnetic 力量的效果用同类的电子上中立的血浆的运动理论被调查当不在时外部电或磁场。随机的阶段假设被采用关于一个固定离子背景忽视电子的热运动。gravitomagnetic forcer 引出，这被发现因此提高媒介的折射索... 详细信息

血浆摆动上的 gravitomagnetic 力量的效果用同类的电子上中立的血浆的运动理论被调查当不在时外部电或磁场。随机的阶段假设被采用关于一个固定离子背景忽视电子的热运动。gravitomagnetic forcer 引出，这被发现因此提高媒介的折射索引的血浆的典型频率。为预言的效果的估计为一个典型白矮子，脉冲星，和中子星被给。

关键词：地磁效应等离子振荡动力理论电力中性等离子体脉冲星

Cosmological Expansion and Its Effect on Small Systems

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Communications in Theoretical Physics 2006年第6X期46卷 987-990页

作者： B. mirza M. Zamani-Nasab Department of Physics Isfahan University of Technology (IUT) Isfahan (84156) Iran

In order to study the effect of large scale cosmological expansion on small systems, we assume a Friedmann–Robertson–Walker type coordinate system in presence of a nonzero cosmological constant and derive a non-static Reissner–Nrdström metric. It is an analytic function of r for all values except at r = 0, which is singular. By determining the equation of motion in this metric we can estimate how expansion of the universe may affect Pioneer's motion. Because the metric does not have any event horizon and so high potential regions are accessible, this may help us in better understanding AGN phenomenon.

关键词：宇宙膨胀小系统影响广义相对论精确解

Diversifying on the Ark:multiple new endemic lineages of dwarf geckos from the Western Ghats provide insights into the systematics and biogeography of South Asian Cnemaspis(Reptilia:Squamata)

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Zoological Research 2021年第6期42卷 675-691页

作者： Saunak Pal Zeeshan A.mirza Princia Dsouza Kartik Shanker Bombay Natural History Society MumbaiMaharashtra 400001India Centre for Ecological Sciences Indian Institute of ScienceBengaluruKarnataka 560012India National Centre for Biological Sciences Tata Institute of Fundamental ResearchBengaluruKarnataka 560065India

The highly speciose gekkonid genus Cnemaspis Strauch,1887 is polyphyletic,with three distantly related and geographically isolated clades from Africa,South Asia(SA),and Southeast *** present,there are 85 known species within SA Cnemaspis,although the number continues to increase rapidly with focused surveys and rigorous taxonomic *** studies have provided valuable insights into the diversity and evolutionary history of SA Cnemaspis;however,most of these studies lack sufficient sampling in the Western Ghats(WG),where the genus has its greatest *** addressed this research gap by conducting extensive sampling across the WG and re-examining museum specimens,thus providing a systematic account of various extant Cnemaspis species along with their distribution and natural *** described 12 new species and a southern WG endemic clade of SA *** of the newly described species are endemic to the forests of the southern *** also identified 10 well-supported subclades that can be separated across morphological,geographic,and phylogenetic axes.A time-calibrated phylogeny and ancestral area reconstructions confirmed the Paleocene origin of SA Cnemaspis in the WG and provide insights into its evolutionary history and *** discovery of multiple endemic and deeply divergent lineages further highlights the evolutionary significance of the WG for lizards.

关键词： Biogeography Cnemaspis Dwarf geckos Molecular phylogeny New species Osteology South Asia Systematics Western Ghats

Advanced glycation end product signaling and metabolic complications:Dietary approach

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World Journal of Diabetes 2023年第7期14卷 995-1012页

作者： Mohammad Idreesh Khan Fauzia Ashfaq Abdulrahman A Alsayegh Alshaimaa Hamouda Fahmida Khatoon Tahani Nasser Altamimi Fahad Saad Alhodieb mirza Masroor Ali Beg Department of Clinical Nutrition College of Applied Health Sciences in Ar RassQassim UniversityAr Rass 51921Saudi Arabia Clinical Nutrition Department Applied Medical Sciences CollegeJazan UniversityJazan 82817Saudi Arabia Department of Biochemistry College of MedicineUniversity of HailHail 2240Saudi Arabia Department of Family and Community Medicine College of MedicineUniversity of HailHail 2240Saudi Arabia Faculty of Medicine Alatoo International UniversityBishkek 720048Kyrgyzstan

Advanced glycation end products(AGEs)are a heterogeneous collection of compounds formed during industrial processing and home cooking through a sequence of nonenzymatic glycation *** modern western diet is full of heat-treated foods that contribute to AGE *** high in AGEs in the contemporary diet include processed cereal *** to industrialization and marketing strategies,restaurant meals are modified rather than being traditionally or conventionally ***,grilled,baked,and boiled foods have the greatest AGE *** AGE-content foods include dry nuts,roasted walnuts,sunflower seeds,fried chicken,bacon,and *** proteins and processed plant foods contain furosine,acrylamide,heterocyclic amines,and ***(2-furoil-methyl-lysine)is an amino acid found in cooked meat products and other processed *** concentrations of carboxymethyl-lysine,carboxyethyl-lysine,and methylglyoxal-O are found in heat-treated nonvegetarian foods,peanut butter,and cereal *** plasma levels of AGEs,which are harmful chemicals that lead to age-related diseases and physiological aging,diabetes,and autoimmune/inflammatory rheumatic diseases such as systemic lupus erythematosus and rheumatoid *** in the pathophysiology of metabolic diseases have been linked to individuals with diabetes mellitus who have peripheral nerves with high amounts of AGEs and diabetes has been linked to increased myelin *** resistance and hyperglycemia can impact numerous human tissues and organs,leading to long-term difficulties in a number of systems and organs,including the cardiovascular *** AGE levels are linked to all-cause mortality in individuals with diabetes who have fatal or nonfatal coronary artery disease,such as ventricular *** levels of tissue AGEs are independently associated with cardiac systolic dysfunction in diabetic patients with heart failure compared with diabetic pat

关键词： Advanced glycation end products Receptor for advanced glycation end products Heat-treated diets Food safety Maillard reaction products Metabolic disorder Diabetes Cardiac complication

Influence of thyroid volume reduction on absorbed dose in ^(131)I therapy studied by using Geant4 Monte Carlo simulation

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Chinese Physics C 2014年第5期38卷 62-68页

作者： Ziaur Rahman Sikander M mirza Waheed Arshed Nasir M mirza Waheed Ahmed Health Physics Division Pakistan Institute of Nuclear Science and Technology Department of Physics and Applied Mathematics Pakistan Institute of Engineering and Applied Sciences

A simulation study has been performed to quantify the effect of volume reduction on the thyroid absorbed dose per decay and to investigate the variation of energy deposition per decay due to β- and γ-activity of 131I with volume/mass of thyroid, for water, ICRP- and ICRU-soft tissue taken as thyroid material. A Monte Carlo model of the thyroid, in the Geant4 radiation transport simulation toolkit was constructed to compute the β- and γ-absorbed dose in the simulated thyroid phantom for various values of its volume. The effect of the size and shape of the thyroid on energy deposition per decay has also been studied by using spherical, ellipsoidal and cylindrical models for the thyroid and varying its volume in 1-25 cm3 range. The relative differences of Geant4 results for different models with each other and MCNP results lie well below 1.870%. The maximum relative difference among the Geant4 estimated results for water with ICRP and ICRU soft tissues is not more than 0.225%. S-values for ellipsoidal, spherical and cylindrical thyroid models were estimated and the relative difference with published results lies within 3.095%. The absorbed fraction values for beta particles show a good agreement with published values within 2.105% deviation. The Geant4 based simulation results of absorbed fractions for gammas again show a good agreement with the corresponding MCNP and EGS4 results （±6.667%） but have 29.032% higher values than that of MIRD calculated values. Consistent with previous studies, the reduction of the thyroid volume is found to have a substantial effect on the absorbed dose. Geant4 simulations confirm dose dependence on the volume/mass of thyroid in agreement with MCNP and EGS4 computed values but are substantially different from MIRD8 data. Therefore, inclusion of size/mass dependence is indicated for 131I radiotherapy of the thyroid.

关键词： mean absorbed dose rate Geant4 Monte Carlo simulation and 131I therapy

Linear and non-linear approaches to predict the Darcy-Weisbach friction factor of overland flow using the extreme learning machine approach

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International Journal of Sediment Research 2018年第4期33卷 415-432页

作者： Kiyoumars Roushangar Saba mirza Alipour Dominique Mouaze Division of Hydraulics Department of Civil Engineering University of Tabriz Morphodynamic Laboratory University of Caen

In modeling of overland flow and erosion, the overland flow friction factor(f), is a crucial factor. Due to the importance of a good understanding of f and its variability, the current study aimed to investigate the capability of non-linear approaches to estimate the Darcy-Weisbach friction factor of overland flow and its components(sediment transport, wave, form, and grain friction factors) through the Extreme Learning Machine(ELM) approach. Four datasets were used herein which were obtained from flume experiments done by different researchers. In order to investigate the effects of different parameters on the friction factor, numerous models consisting of various parameters were utilized to predict the friction factor using the ELM approach. The modeling procedure was established in two stages; the first stage aimed to model the overland flow friction factor and investigate the effect of the different parameters on the friction factor using non-linear separation via the ELM approach. In the second stage, the friction factor was linearly separated into different types of friction factors and then the separate components were estimated. Sensitivity analysis results confirmed the key role of Froude number(Fr) values for most of the models. On the other hand, the results obtained for estimated values of the friction factor were acceptable and outperformed available empirical approaches.

关键词： Overland flow Extreme Learning Machine(ELM) Friction factor Sediment transport friction factor Wave friction factor Grain friction factor Form friction factor

Antimicrobial stewardship program in pediatric medicine

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Pediatric Investigation 2021年第3期5卷 229-238页

作者： Varvara Probst Florinda Islamovic Ayesha mirza University of Florida College of MedicineJacksonvilleFLUSA

The rising threats from antimicrobial resistance due to inappropriate utilization of antimicrobial agents in health care including the pediatric population has been a topic of concern at the global level for the last several *** antimicrobial stewardship program(ASP)is a multidisciplinary institutional initiative focusing primarily on the improvement of antimicrobial prescribing practices and limiting inappropriate *** play an important role in the implementation of healthcare strategies in pediatrics worldwide to reduce antimicrobial *** published reports demonstrate how adapted ASPs in pediatrics result in improvement of unnecessary antimicrobial utilization,decreasing drug resistance and treatment failure,minimization of adverse clinical outcomes,decreasing healthcare costs and hospital length of stay,and optimization of diagnostic ***,some barriers in pediatric ASP still *** narrative review describes core elements of ASP,the impact of implemented ASPs on pediatric healthcare,and challenges of pediatric ASP as seen by the authors.

关键词： Antimicrobial stewardship Pediatrics Antimicrobial resistance Infection control

Ab-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Ab Secretion in Neural Cells

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Neuroscience Bulletin 2016年第3期32卷 227-238页

作者： Dema Najem Michelle Bamji-mirza Ze Yang Wandong Zhang Faculty of Medicine University of Ottawa Human Health Therapeutics National Research Council of Canada Beijing Hospital Institute of Geriatrics-Chinese Health Ministry

Alzheimer＇s disease（AD） is characterized by amyloid-b（Ab） toxicity,tau pathology,insulin resistance,neuroinflammation,and dysregulation of cholesterol homeostasis,all of which play roles in *** has polytrophic effects on neurons and may be at the center of these pathophysiological *** this study,we investigated possible relationships among insulin signaling and cholesterol biosynthesis,along with the effects of Ab42 on these pathways in *** found that neuroblastoma 2a（N2a） cells transfected with the human gene encoding amyloid-b protein precursor（Ab PP）（N2aAb PP） produced Ab and exhibited insulin resistance by reduced p-Akt and a suppressed cholesterol-synthesis pathway following insulin treatment,and by increased phosphorylation of insulin receptor subunit-1 at serine 612（p-IRS-S612） as compared to parental N2 a *** of human neuroblastoma SH-SY5 Y cells with Ab42 also increased p-IRS-S612,suggesting that Ab42 is responsible for insulin *** insulin resistance was alleviated when N2a-Ab PP cells were treated with higher insulin *** increased Ab release from N2 aAb PP cells,by which it may promote Ab *** increased cholesterol-synthesis gene expression in SHSY5 Y and N2 a cells,including 24-dehydrocholesterol reductase（DHCR24） and 3-hydroxy-3-methyl-glutaryl-Co A reductase（HMGCR） through sterol-regulatory element-binding protein-2（SREBP2）.While Ab42-treated SH-SY5 Y cells exhibited increased HMGCR expression and c-Jun phosphorylation as pro-inflammatory responses,they also showed down-regulation of neuro-protective/antiinflammatory *** results suggest that Ab42 may cause insulin resistance,activate JNK for c-Jun phosphorylation,and lead to dysregulation of cholesterol homeostasis,and that enhancing insulin signaling may relieve the insulin-resistant phenotype and the dysregulated cholesterol-synthesis pathway to promote Ab release for clearance from neural cells.

关键词： Alzheimer's disease Insulin resistance Ab peptides Insulin signaling Cholesterol synthesis pathway Pro-inflammatory response