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Expanding active-learning opportunities in a pathophysiology course

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中国病理生理杂志 2009年第11期25卷 2278-2278页

作者： miroslav Sarac Xavier University of Louisiana College of PharmacyDivision of Basic Pharmaceutical Sciences

Pathophysiology is an important course in the pre-clinical education of pharmacists pursuing a doctoral degree as it represents a foundation for building pharmaceutical knowledge. In recent years pharmacy students hav... 详细信息

关键词：病理生理学课程学习机博士学位知识基础动物实验

Clinical Efficacy and Safety of Oxaliplatin-tegafur,Gimeracil and Oteracil Potassium and Vinorelbine-Pt in the Treatment of Advanced Triple Negative Breast Cancer

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Advances in Modern Oncology Research 2019年第5期5卷 21-24页

作者： miroslav Samaržija Lela Bitar US Food and Drug Administration Center for Biologics Evaluation and ResearchOffice of Biostatistics and EpidemiologySilver SpringMD Memorial Sloan Kettering Cancer Center New YorkNY

The purpose of this study was to investigate the efficacy and safety of oxaliplatin combined with tegafur,gimeracil and oteracil potassium(SOX regimen)and vinorelbine combined with Pt(NP regimen)in the treatment of advanced triple negative breast cancer(TNBC).First of all,88 patients with advanced breast cancer were selected and divided into observation group and control group with 44 cases each by random number *** groups received conventional supportive *** this basis,SOX regimen was adopted in the observation group and NP regimen in the control group,and the efficacy,occurrence of toxic and side effects in the two groups were *** results showed that the objective effective rates and clinical benefit rates of the two groups were statistically significant(P<0.05).In addition,both groups had hand foot syndrome,diarrhea,liver function damage,decreased platelet(PLT)and other toxic side effects,but the incidence of rash,oral ulcer and pigmentation in the observation group was significantly lower than that in the control group(P<0.05).Therefore,both SOX regimen and NP regimen can effectively treat advanced TNBC adverse reactions,but SOX regimen was more effective.

关键词： Oxaliplatin Tegafur,gimeracil and oteracil potassium Vinorelbine Pt

Molecular biology of pancreatic cancer

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World Journal of Gastroenterology 2011年第24期17卷 2897-2908页

作者： miroslav Zavoral Petra Minarikova Filip Zavada Cyril Salek Marek Minarik Charles University 1st Medical FacultyInternal Clinic Institute of hematology and blood transfusion Center for Applied Genomics of Solid Tumors(CEGES) Genomac International

In spite of continuous research efforts directed at early detection and treatment of pancreatic cancer, the outlook for patients affected by the disease remains dismal. With most cases still being diagnosed at advanced stages, no improvement in survival prognosis is achieved with current diagnostic imaging approaches. In the absence of a dominant precancerous condition, several risk factors have been identified including family history, chronic pancreatitis, smoking, diabetes mellitus, as well as certain genetic disorders such as hereditary pancreatitis, cystic fibrosis, familial atypical multiple mole melanoma, and Peutz-Jeghers and Lynch syn- dromes. Most pancreatic carcinomas, however, remain sporadic. Current progress in experimental molecular techniques has enabled detailed understanding of the molecular processes of pancreatic cancer development. According to the latest information, malignant pancre- atic transformation involves multiple oncogenes and tumor-suppressor genes that are involved in a variety of signaling pathways. The most characteristic aberrations （somatic point mutations and allelic losses） affect onco- genes and tumor-suppressor genes within RAS, AK-I- and Wnt signaling, and have a key role in transcription and proliferation, as well as systems that regulate the cell cycle （SMAD/DPC, CDKN2A/p16） and apoptosis （TP53）. Understanding of the underlying molecular mechanisms should promote development of new methodology for early diagnosis and facilitate improvement in current approaches for pancreatic cancer treatment.

关键词： Pancreatic cancer Risk factors Molecularbiology Pancreatitis Diabetes

Case of rectal angioleiomyoma in a female patient

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World Journal of Gastroenterology 2013年第13期19卷 2114-2117页

作者： Goran Z Stanojevi Dragan S Mihailovi Milica D Nestorovi Milan D Radojkovi Milan M Jovanovi miroslav P Stojanovi Branko B Brankovi General Surgery Clinic Ni Clinical CentreFaculty of MedicineUniversity of Ni18000 NiSerbia Institute of Pathology NiClinical CentreFaculty of MedicineUniversity of Ni18000 NiSerbia

Angioleiomyoma represents a benign stromal tumor, which usually occurs in the subcutaneous tissue of the extremities, although its occurrence in the gastrointestinal tract is very rare. A case of rectal angioleiomyoma in a 40 year-old female patient is described here. Six months earlier, the patient suffered from periodical prolapse of an oval tumor from the anus, along with difficulties in bowel movement. A transanal extirpation of the tumor was performed. This is the first reported case in the English literature of a patient presenting with prolapsed angioleiomyoma of the rectum. During the immediate postoperative period, as well as 6 mo later, the patient had an unremarkable postoperative recovery.

关键词： Prolapsed tumor Angioleiomyoma Rectum Leiomyoma

Primary colorectal lymphoma:An overview

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World Journal of Gastrointestinal Oncology 2011年第1期3卷 14-18页

作者： Goran Z Stanojevic Milica D Nestorovic Branko R Brankovic miroslav P Stojanovic Milan M Jovanovic Milan D Radojkovic Clinic for General Surgery Clinical Center NisBul Zorana Djindjica 4818000 NisSerbia

Lymphomas represent common hematological malignancies with increasing incidence in recent *** major site of extranodal non-Hodgkin lymphoma is the gastrointestinal *** of the large intestine is rare in comparison to the stomach or small *** disease appears later in life,predominantly in the male *** are nonspecific,requiring a high index of suspicion in order to establish the *** treatment varies from chemotherapy alone to multimodal therapies combining surgery,chemotherapy and *** small number of patients with various histological subtypes and different stage at presentation results in unclear protocol for the treatment of primary colorectal *** purpose of this paper is to review current data on primary lymphoma of the colon and rectum while analyzing reported case series and published material on the subject.

关键词： Lymphoma non-Hodgkin Extranodal lympho-ma Large intestine Colorectal surgery Chemotherapy

How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?

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World Journal of Gastroenterology 2016年第36期22卷 8103-8111页

作者： Stepan Suchanek Tomas Grega Ondrej Ngo Gabriela Vojtechova Ondrej Majek Petra Minarikova Nagyija Brogyuk Bohus Bunganic Bohumil Seifert Ladislav Dusek miroslav Zavoral Department of Internal Medicine 1st Faculty of Medicine Charles University Military University Hospital Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Institute of General Medicine 1st Faculty of Medicine Charles University

The incidence and prevalence of metabolic syndrome(MS) and colorectal cancer(CRC) has been rising in developed countries. The association between these two diseases has been widely studied and reported. Less evidence is available about the relationship between MS and CRC precancerous lesions(adenomatous polyps, adenomas). The aim of this paper is to present an overview of our scientific understanding of that topic and its implication in clinical practice. One of the principal goals of current CRC secondary prevention efforts is to detect and remove the precancerous lesions in individuals with an average CRC risk to prevent the development of invasive cancer. MS is not currently considered a high-risk CRC factor and is therefore not included in the guidelines of organized screening programs. However, in light of growing scientific evidence, the approach to patients with MS should be changed. Metabolic risk factors for the development of adenomas and cancers are the same- obesity, impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus type 2. Therefore, the key issue in the near future is the development of a simple scoring system, easy to use in clinical practice, which would identify individuals with high metabolic risk of colorectal neoplasia and would be used for individual CRC secondary prevention strategies. Currently, such scoring systems have been published based on Asian(Asia-Pacific Colorectal Screening Score; APCS) and Polish populations.

关键词： Metabolic syndrome Diabetes mellitus type 2 Heart ischemic disease Colorectal neoplasia

The Influence of Selected Somatometric Indicators on Students＇ Aerobic Performance at the Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava

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Journal of Sports Science 2015年第5期3卷 234-238页

作者： Pelucha Robin Jaroslav Hancak Bobrlk miroslav Department of Physical education and Sport Slovak University of Technology in Bratislava Bratislava Slovak Republic 812 3 7Slovak Republic

The aim of our work is to identify the differences in selected somatometric indicators between men and women and their impact on aerobic performance. The research sample consisted of students of first year of Faculty of Chemical and Food Technology in Bratislava in the number of 596 （187 men and 409 women）. Aerobic performance （VO2max） was calculated on the basis of performance in Beep test. Within somatometrie indicators, we measured BMI （body mass index） and body fat using digital scales with body analysis OMRON BF-511. In the first chapter we were looking for differences in the values of body mass index between men and women. We found out statistically significant differences in the categories of underweight, overweight and obesity. In the second chapter, we focused on mutual comparison of maximal aerobic capacity with selected somatometric indicators. As a first somatometric indicator, we used BMI index. Our assumption that VO2max values are significantly lower among students with underweight and normal weight as students with overweight, resp. obesity was not confirmed. As a second somatometric indicator, we used body fat levels. In the mutual comparison we observed statistically significant differences in the category of very poor （P 〈 0.01） and above average （P 〈 0.05） where students with low-normal body fat achieved better values than students with high-very high body fat.

关键词： Obesity motor performance body fat BMI VO2max

Photometric and Spectroscopic Study of Ten Low Mass Ratio Contact Binary Systems:Orbital Stability,O'Connell Effect and Infrared Calcium Line Filling

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Research in Astronomy and Astrophysics 2024年第8期24卷 212-222页

作者： Surjit S.Wadhwa Adam Popowicz Raúl Michel Petar Kostić Oliver Vince Nick F.H.Tothill Ain Y.De Horta miroslav D.Filipović School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Department of Electronics Electrical Engineering and MicroelectronicsSilesian University of TechnologyAkademicka 1644120 GliwicePoland Instituto de Astronomía UNAM.A.P.87722800 EnsenadaBCMéxico Astronomical Observatory Volgina 711060 BelgradeSerbia

Low mass ratio contact binary systems are more likely to have unstable orbits and potentially *** addition,such systems exhibit characteristics such as starspots and high energy emissions(UV)suggestive of chromospheric and magnetic *** curve modeling of ten contact binary systems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and three were found to be potentially unstable and possible merger *** of the infrared calcium absorption lines is a marker of increased chromospheric *** use the available Large Sky Area Multi-Object Fiber Spectroscopic Telescope spectra along with matched standard spectra(broadened for rotation)to measure the excess filling of the central core depression flux of the two main infrared calcium absorption linesλ8542 andλ*** find that all reported contact binaries have excess filling of the core flux in the infrared calcium *** of the systems reported were also observed by the Galaxy Evolution Explorer mission and we find that all three have features of excess ultraviolet emissions further adding evidence for increased chromospheric activity in low mass ratio contact *** of both orbital stability and absorption line filling is dependent on the determination of geometric and absolute parameters from light curve *** an insignificant number of contact binary light curves exhibit the O’Connell effect,usually attributed to *** discuss the inclusion of starspots in light curve solutions and how they influence the geometric and absolute parameters.

关键词： (stars)binaries eclipsing-techniques photometric-stars chromospheres

Modeling Digital Evidence Management and Dynamics Using Petri Nets

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Computer Technology and Application 2011年第7期2卷 545-549页

作者： Jasmin Cosic Zoran Cosic miroslav Baca IT Section of Police Administration Ministry of the Interior Bihac 77000 Bosnia and Herzegovina Statheros Kastel Stari Split Croatia Faculty of Organization and Informatics University of Zagreb Varazdin 42000 Croatia

In all phases of forensic investigation, digital evidence is exposed to external influences and coming into contact with many factors. Legal admissibility of digital evidence is the ability of that evidence being accepted as evidence in a court of law. Life cycle of digital evidence is very complex. In each stage there is more impact that can violate a chain of custody and its integrity. Contact with different variables occurs through a life cycle of digital evidence and can disrupt its integrity. In order for the evidence to be accepted by the court as valid, chain of custody for digital evidence must be kept, or it must be known who exactly came into contact with evidence in each stage of the investigation. This paper presents a dynamics and life cycle of digital evidence. The Petri nets will be proposed and used for modeling and simulation of this process.

关键词： Digital evidence digital forensic chain of custody digital evidence integrity digital evidence manipulating Petri nets