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Gastric duplication cyst communicating to accessory pancreatic lobe: A case report and review of the literature

World Journal of Clinical Cases 2018年第16期6卷 1182-1188页

作者： Michael Rousek David Kachlik Andrej Nikov Jirina Pintova miroslav ryska Department of Surgery 2~(nd) Faculty of Medicine Charles University and Central Military Hospital Department of Anatomy 2~(nd) Faculty of Medicine Charles University Department of gastroenterology Jablonec nad Nisou Hospital

Background The combination of a gastric duplication cyst and duplicated part of the pancreas is an extremely rare developmental defect. The incidence in the population, or the clinical impact thereof, has not been uncovered. Symptoms are unspecific. Surgery is the treatment of choice. Timely diagnostics are of utmost importance, albeit they might be challenging at times. Being so rare, case reports are currently the only relevant source of information about the condition. Therefore each published finding is of a clinical *** summary Our work describes the case of a 22 year-old patient, who developed idiopathic acute pancreatitis. A computed tomography scan discovered liquid collection between the antrum of the stomach and the head of the pancreas. Initially, the collection was thought to be a pancreatic pseudocyst. Endoscopic ultrasoundguided transgastric drainage showed to have only a temporary therapeutic effect. Magnetic resonance cholangiopancreatography showed an accessory pancreatic lobe with a separate duct system. The accessory pancreatic lobe exited the body of the pancreas andwas in contact with the cystic collection. The patient was indicated for surgical resection. Within the surgery, an en bloc resection of the accessory pancreatic lobe was performed with the antrum of the stomach containing the gastric duplication cyst. No complications were observed in the surgery or thereafter. In the five months follow-up period, the patient was completely symptom free. Histopathological findings confirmed the gastric duplication cyst communicating to accessory pancreatic *** This developmental defect is extremely rare. It can cause recurrent acute pancreatitis. Diagnostics are challenging. Surgery is treatment of choice.

关键词： Pancreatic resection Accessory pancreatic lobe Acute pancreatitis Developmental defect Gastric duplication cyst Case report

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Natural orifice transluminal endoscopic surgeryvs laparoscopic ovariectomy:Complications and inflammatory response

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World Journal of Gastroenterology 2012年第27期18卷 3558-3564页

作者： Jan Martínek Ondej ryska Tereza Filípková Radek Dolezel Stefan Juhas Jan Motlík Monika Holubová Vladimír Nosek Barbora Rotnáglová miroslav Zavoral miroslav ryska Department of Internal Medicine 1st Faculty of MedicineUniversity Military Hospital16000 PragueCharles UniversityCzech Republic Department of Surgery 2nd Faculty of MedicineUniversity Military HospitalCharles University16000 PragueCzech Republic Department of Surgery Domazlice Hospital34401 DomazliceCzech Republic Institute of Animal Physiology and Genetics Academy of Sciences27721 LibechovCzech Republic Department of Gastroenterology Jablonec Hospital46601 Jablonec nad NisouCzech Republic

AIM:To compare natural orifice transluminal endoscopic surgery (NOTES) vs standard laparoscopic ovariectomy in mini pigs with respect to technical aspects,complications and parameters of systemic inflammatory ***:This was a randomized,experimental,survival *** female mini pigs underwent NOTES transgastric ovariectomy (NOTES group) and ten female mini pigs underwent laparoscopic ovariectomy (LAP group).A "percutaneous endoscopic gastrostomy" approach with guidewire and sphincterotome was used for gastrotomy *** ovary was resected using standard biopsy forceps and a *** access site was closed using a "KING" closure with a single endoloop and several *** the laparoscopic group,a three-port laparoscopy and an ovariectomy were performed with the use of standard laparoscopic devices.C-reactive protein (CRP),white blood count and interleukin (IL)-6 plasma levels were used as indicators of systemic inflammatory *** animals were euthanized 28 d after ***:All animals survived without *** mean procedure time was 41.3 min ± 17.6 min (NOTES group) and 25.7 min ± 5.25 min (LAP group,P < 0.02).Postmortem examinations demonstrated that 50% and 70% of animals were free of any complications in the NOTES and LAP groups,*** remaining animals developed minor complications (adhesions) in a comparable frequency between the two *** the NOTES group,one animal developed a small intramural gastric abscess close to the gastrotomy site.A minor serous exudate that was present in 50% and 40% of the animals in the NOTES and laparoscopy groups,respectively,was not considered a *** both groups CRP levels increased significantly on the 2nd and 7th postoperative days (POD) and returned to normal after 28 *** POD 2,an increase of CRP level was significantly higher in the NOTES group compared to the LAP *** of IL-6 did not differ from baseline values in either of the groups postoperatively.

关键词： Natural orifice transluminal endoscopic sur-gery Laparoscopy Ovariectomy Systemic inflammatoryresponse

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Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA

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World Journal of Gastroenterology 2019年第48期25卷 6939-6948页

作者： Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil miroslav ryska miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik Centre for Applied Genomics of Solid Tumors Genomac Research InstitutePrague CZ 16100Czech Republic Surgery Department 2nd Faculty of Medicine of Charles University Prague and Military University HospitalPrague CZ 16902Czech Republic Surgery Department 1st Faculty of MedicineCharles University Prague and Thomayer HospitalPrague CZ 14059Czech Republic Surgery Department 2nd Faculty of Medicine of Charles University Prague and Motol University HospitalPrague CZ 15006Czech Republic Institute of Biostatistics and Analyses of the Masaryk University Brno CZ 62500Czech Republic Elphogene Prague CZ 16100Czech Republic

BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative *** referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be *** is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or *** To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal *** total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical *** postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA *** addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month *** presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the *** Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 *** 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive dur

关键词： Circulating tumor DNA Metastatic colorectal cancer Postoperative Radicality of resection Follow-up Recurrence

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