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Small intestinal bacterial overgrowth syndrome

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World Journal of Gastroenterology 2010年第24期16卷 2978-2990页

作者： Jan Bures Jiri Cyrany Darina Kohoutova miroslav Frstl Stanislav Rejchrt Jaroslav Kvetina Viktor Vorisek Marcela Kopacova 2nd Department of Medicine Charles University in Praha Faculty of Medicine at Hradec Kralove University Teaching Hospital Institute of Clinical Microbiology Charles University in Praha Faculty of Medicine at Hradec Kralove University Teaching Hospital Institute of Experimental Biopharmaceutics Joint Research Centre of Czech Academy of Sciences and PRO.MED.CS Praha a.s. Institute of Clinical Biochemistry and Diagnostics Charles University in Praha Faculty of Medicine at Hradec Kralove University Teaching Hospital

Human intestinal microbiota create a complex polymi-crobial ecology. This is characterised by its high population density, wide diversity and complexity of interaction. Any dysbalance of this complex intestinal microbiome, both qualitative and quantitative, might have serious health consequence for a macro-organism, including small intestinal bacterial overgrowth syndrome (SIBO).SIBO is defined as an increase in the number and/or alteration in the type of bacteria in the upper gastro-intestinal tract. There are several endogenous defence mechanisms for preventing bacterial overgrowth: gastric acid secretion, intestinal motility, intact ileo-caecal valve, immunoglobulins within intestinal secretion and bacte-riostatic properties of pancreatic and biliary secretion. Aetiology of SIBO is usually complex, associated with disorders of protective antibacterial mechanisms (e.g. achlorhydria, pancreatic exocrine insuff iciency, immuno-deficiency syndromes), anatomical abnormalities (e.g. small intestinal obstruction, diverticula, f istulae, surgical blind loop, previous ileo-caecal resections) and/or motility disorders (e.g. scleroderma, autonomic neuropathy in diabetes mellitus, post-radiation enteropathy, small intestinal pseudo-obstruction). In some patients more than one factor may be involved. Symptoms related to SIBO are bloating, diarrhoea, malabsorption, weight loss and malnutrition. The gold standard for diagnosing SIBO is still microbial investigation of jejunal aspirates. Noninvasive hydrogen and methane breath tests are most commonly used for the diagnosis of SIBO using glucose or lactulose. Therapy for SIBO must be com-plex, addressing all causes, symptoms and complica-tions, and fully individualised. It should include treatment of the underlying disease, nutritional support and cyclical gastro-intestinal selective antibiotics. Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO.

关键词： Bacterial overgrowth Breath test Hydrogen Methane Small intestine

Modalities of testing Helicobacter pylori in patients with nonmalignant bile duct diseases

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World Journal of Gastroenterology 2002年第2期8卷 301-304页

作者： Milutin Bulajic Bojan Stimec miroslav Milicevic Matthias Loehr Petra Mueller Ivan Boricic Nada Kovacevic Mirko Bulajic Department of Internal Medicine Clinical Center"Dr Dragisa Misovic"-DedinjeBelgradeYugoslavia Institute for Anatomy School of MedicineBelgrade Yugoslavia First Surgical Clinic Institute for digestive DiseasesUniversity Clinical CenterBelgradeYugoslavia Department of Medicine Ⅱ Medical Faculty MannheimUniversity of HeidelbergGermany Department of Medicine University of RostockGermany Institute for Pathology School of Medicine BelgradeYugoslavia Clinic for Gastroenterology and Hepatology Institute for Digestive DiseasesUniversity Clinical CenterBelgradeYugoslavia

AIM:This paper describes the procedure of detection of Helicobacter pylori(***)in bile specimens in patients suffering from benign diseases of biliary ducts(lithiasis with/without nonspecific cholangitis). METHODS:The group of 72 patients entering the study consisted of 32 male and 40 female(45 % and 55 %, respectively).Bile was obtained during ERCP in 68 patients, and during cholecystectomy in 4 patients.A fast urease test (FUT)to determine the existence of *** in gastric mucosa was carried out for all the patients during the endoscopic *** existence of genetic material of *** was determined by detection of ure A gene by the method of nested *** results of this reaction were shown by electrophoresis on 10 g·L^(-1)agarose gel in a band of 256 bp. RESULTS:The majority of the patients included in our study had biliary lithiasis without signs of cholangitis(48 patients, 67 %),whereas other patients were complicated by cholangitis(17 patients,24 %).Seven patients(9 %)had normal ERCP,forming thus the control *** the group of patients with lithiasis 26 patients(24.2 %)had positive PCR of *** in bile and among the patients with associated cholangitis positive PCR was detected in 9 patients(52.9 %).Among the seven patients with normal ERCP only one(14 %)had positive PCR of ***.A high percentage of *** infection of gastric mucosa was observed(57 patients,79 %).It was also observed that its slightly higher positivity was in the patients with distinct bile pathology:81% FLIT positive patients in the group with choledocholithiasis alone and 76 % in the group with choledocholithiasis associated with ***-one percent of the patients with regular findings had positive ***: The prevalence of H. pylori infection both in bile and in gastric mucosa in patients with benign diseases of biliary ducts does not show a statistically significant difference in relation to the prevalence of the same with the patients

关键词： Adolescent Adult Aged Aged, 80 and over Bile Bile Ducts Child Cholangiopancreatography, Endoscopic Retrograde Cholangitis Cholelithiasis Female Gastric Mucosa Helicobacter Infections Helicobacter pylori purification Humans Male Middle Aged Research Support, Non-U.S. Gov't Urease

Repeated penile girth enhancement with biodegradable scaffolds： microscopic ultrastructural analysis and surgical benefits

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Asian Journal of Andrology 2018年第5期20卷 488-492页

作者： miroslav L Djordjevic Uros Bumbasirevic Borko Stojanovic Tamara Kravic Stevovic Tamara Martinovic Marta Bizic Vladimir Kojovic School of Medicine University of Belgrade Belgrade 11000 Serbia University Children's Hospital Belgrade 11000 Serbia Institute for Urology Clinical Center ofSerbia Belgrade 11000 Serbia

Autologous tissue engineering using biodegradable scaffolds as a carrier is a well-known procedure for penile girth enhancement. We evaluated a group of previously treated patients with the aim to analyze histomorphometric changes after tissue remodeling and to estimate the benefits of repeated procedure. Between February 2012 and December 2016, a group of 21 patients, aged 22-37 （mean 28.0） years, underwent a repeated penile girth enhancement procedure with biodegradable scaffolds. Procedure included insertion of two poly-lactic-co-glycolic acid scaffolds seeded with laboratory-prepared fibroblasts from scrotal tissue specimens. During this procedure, biopsy specimens of tissue formed after the first surgery were taken for microscopic analysis. The mean follow-up was 38 months. Connective tissue with an abundance of connective tissue fibers, small blood vessels, and inflammatory cells were observed in all analyzed surgically removed tissue. Ultrastructural analysis of these tissue samples discovered the presence of large quantities of collagen fibrils running parallel to each other, forming bundles, with a few widely spread fibroblasts. In total, the mean values of flaccid and erect gain in girth after the second surgery were 1.1 ± 0.4 （range： 0.6- 1.7） cm and 1.0±0.3 （range： 0.6-1.5） cm, respectively. Microscopic evaluation of newly formed tissue, induced by autologous tissue engineering using biodegradable scaffolds, showed the presence of vascularized loose connective tissue with an abundance of collagen fibers, fibroblasts, and inflammatory cells, indicating active neovascularization and fibrinogenesis. The benefit of the repeated enhancement procedure was statistically significant.

关键词： biodegradable scaffolds microscopy penile enhancement tissue engineering

Cyberbullying Sexism Harassment Identification by Metaheurustics-Tuned eXtreme Gradient Boosting

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Computers, Materials & Continua 2024年第9期80卷 4997-5027页

作者： Milos Dobrojevic Luka Jovanovic Lepa Babic miroslav Cajic Tamara Zivkovic Miodrag Zivkovic Suresh Muthusamy Milos Antonijevic Nebojsa Bacanin Technical Faculty Singidunum UniversityBelgrade11000Serbia Informatics and Computing Singidunum UniversityBelgrade11000Serbia Business Economics Singidunum UniversityBelgrade11000Serbia Computing and Informatics Sinergija UniversityBijeljina76300Bosnia and Herzegovina Department for Information Systems and Technologies University“Union Nikola Tesla”Cara DusanaBelgrade11080Serbia Department for Computer Science and Informatics School of Electrical EngineeringUniversity of BelgradeBelgrade11000Serbia Department of Electrical and Electronics Engineering Kongu Engineering College(Autonomous)PerunduraiErode638060India Department of Mathematics Saveetha School of Engineering(Deemed to be University)SIMATS ThandalamChennai602105India MEU Research Unit Middle East UniversityAmman11831Jordan

Cyberbullying is a form of harassment or bullying that takes place online or through digital devices like smartphones,computers,or *** can occur through various channels,such as social media,text messages,online forums,or gaming *** involves using technology to intentionally harm,harass,or intimidate others and may take different forms,including exclusion,doxing,impersonation,harassment,and ***,due to the rapid growth of malicious internet users,this social phenomenon is becoming more frequent,and there is a huge need to address this ***,the main goal of the research proposed in this manuscript is to tackle this emerging challenge.A dataset of sexist harassment on Twitter,containing tweets about the harassment of people on a sexual basis,for natural language processing(NLP),is used for this *** algorithms are used to transform the text into a meaningful representation of numbers for machine learning(ML)input:Term frequency inverse document frequency(TF-IDF)and Bidirectional encoder representations from transformers(BERT).The well-known eXtreme gradient boosting(XGBoost)ML model is employed to classify whether certain tweets fall into the category of sexual-based harassment or ***,with the goal of reaching better performance,several XGBoost models were devised conducting hyperparameter tuning by *** this purpose,the recently emerging Coyote optimization algorithm(COA)was modified and adjusted to optimize the XGBoost ***,other cutting-edge metaheuristics approach for this challenge were also implemented,and rigid comparative analysis of the captured classification metrics(accuracy,Cohen kappa score,precision,recall,and F1-score)was ***,the best-generated model was interpreted by Shapley additive explanations(SHAP),and useful insights were gained about the behavioral patterns of people who perform social harassment.

关键词： Coyote optimization algorithm NLP TF-IDF BERT XGBoost online harassment and cyberbullying metaheuristics

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OJAPr Editorial

Open Journal of Antennas and Propagation 2013年第1期1卷 1-3页

作者： miroslav Joler Faculty of Engineering University of Rijeka Rijeka Croatia

Open Journal?of?Antennas and Propagation?

关键词： Editorial

铂基双金属催化剂上二苯胺脱氢环化生成咔唑(英文)

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催化学报 2010年第12期31卷 1439-1444页

作者： miroslav VLKO Zuzana CVENGROOV Zuzana CIBULKOV Milan HRONEC Institute of Organic Chemistry Catalysis and PetrochemistryFaculty of Chemical and Food TechnologySlovak University of Technology Institute of Physical Chemistry and Chemical Physics Faculty of Chemical and Food Technology Slovak University of Technology

Gas phase dehydrocyclization of diphenylamine (DPA) to carbazole over monometallic and bimetallic 0.4 wt% Pt-based catalysts in a fixed bed reactor was studied in the presence of hydrogen at a temperature of 550 oC. Alumina and carbon supported Pt catalysts showed very high initial activity (> 95%). The selectivity for carbazole over carbon supported Pt catalysts was slightly lower. Doping of the catalyst with potassium led to an increase in the selectivity for carbazole by 15%. Bimetallic Pt-Sn catalysts prepared by co-impregnation were less selective than catalysts prepared by successive impregnation. The selectivity for carbazole over bimetallic Pt-Sn catalysts prepared by successive impregnation was 75%,but their activity decreased with increased Sn loading. Highly active and reasonably selective catalysts were Ir-doped bimetallic Pt-based catalysts. The conversion of diphenylamine over Pt-Ir catalysts was above 98% and the selectivity for carbazole was nearly 55%,while the lifetime was much longer.

关键词： diphenylamine carbazole dehydrocyclization platinum tin iridium bimetallic catalyst

Colorectal cancer screening:20 years of development and recent progress

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World Journal of Gastroenterology 2014年第14期20卷 3825-3834页

作者： miroslav Zavoral Stepan Suchanek Ondrej Majek Premysl Fric Petra Minarikova Marek Minarik Bohumil Seifert Ladislav Dusek Department of Medicine 1st Faculty of MedicineMilitary University HospitalCharles University Institute of Biostatistics and Analyses Masaryk University Genomac Research Institute Centre for Applied Genomics of Solid Tumors Institute of General Medicine 1st Faculty of MedicineCharles University

Colorectal cancer(CRC)is the second most common cancer in Europe and its incidence is steadily *** trend could be reversed through timely secondary prevention(screening).In the last twenty years,CRC screening programs across Europe have experienced considerable improvements(fecal occult blood testing;transition from opportunistic to population based program settings).The Czech Republic is a typical example of a country with a long history of nationwide CRC screening programs in the face of very high CRC incidence and mortality *** year,approximately 8000 people are diagnosed with CRC and some 4000 die from this *** years ago,the first pilot studies on CRC screening led to the introduction of the opportunistic Czech National Colorectal Cancer Screening Program in ***,this program was based on the guaiac fecal occult blood test(FOBT)offered by general practitioners,followed by colonoscopy in cases of FOBT *** program has continuously evolved,namely with the implementation of immunochemical FOBTs and screening colonoscopy,as well as the involvement of *** the establishment of the Czech CRC Screening Registry in 2006,2405850 FOBTs have been performed and 104565 preventive colonoscopies recorded within the screening *** overall program expanded to cover 25.0%of the target population by ***,stagnation in the annual number of performed FOBTs lately has led to switching to the option of a population-based program with personal invitation,which is currently being prepared.

关键词： Colorectal cancer Population-based screening program Colonoscopy Fecal occult blood test

Finite dimensional factor algebras of F_(2)[X_(1),…,X_(n)]and their fixed point subalgebras

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Open Journal of Applied Sciences 2012年第4期2卷 212-214页

作者： miroslav Kures Institute of Mathematics Brno University of Technology Brno Czech Republic

Fixed point subalgebras of finite dimensional factor algebras of algebras of polynomials in n indeterminates over the finite field F2 (with respect to all F2-algebra automorphisms) are fully described.

关键词： polynomial finite field group of automorphisms fixed point

On the applicability of PID control to nonlinear second-order systems

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National Science Review 2017年第5期4卷 668-668页

作者： miroslav Krstic Department of Mechanical and Aerospace Engineering University of California

Proportional-integral-derivative(PID)controllers,which react to the regulated signal’s present,past and predicted future behavior,are popular,for two ***,they are model-free and require minimal background and prelimi... 详细信息

关键词： PID On the applicability of PID control to nonlinear second-order systems