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GOECP/SEOR radiotherapy guidelines for thymic epithelial tumours

World Journal of Clinical Oncology 2021年第4期12卷 195-216页

作者： Mikel Rico Sonia Flamarique Cristina Casares Tamara García miriam López Maribel Martínez Javier Serrano Manuel Blanco Raúl Hernanz Lourdes de Ingunza-Barón Francisco JoséMarcos Felipe Couñago Department of Radiation Oncology Complejo Hospitalario de NavarraPamplona 31008NavarraSpain Health Research Institute of Navarre(IdiSNA) Navarra BiomedPamplona 31008NavarraSpain Department of Radiation Oncology University Hospital Miguel ServetZaragoza 50009AragónSpain Department of Radiation Oncology University Hospital of CaceresCáceres 10004ExtremaduraSpain Department of Radiation Oncology Hospital Universitario de FuenlabradaFuenlabrada 28942MadridSpain Department of Radiation Oncology Hospital Clínico Universitario Lozano BlesaZaragoza 50009AragónSpain Department of Radiation Oncology Clínica Universidad de NavarraMadrid 28027Spain Department of Radiation Oncology Hospital Universitario TorrecárdenasAlmería 04009AndalucíaSpain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario Puerta del MarCádiz 11009AndalucíaSpain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223Spain

Thymic epithelial tumours(TET)are rare,heterogeneous neoplasms that range from resectable indolent tumours to aggressive thymic carcinomas with a strong tendency to *** pathological diagnosis is complex,in part due to the management of TETs is scant and mainly based on non-randomised studies and retrospective ***,the clinical management of TETs tends to be highly heterogenous,which makes it difficult to improve the evidence *** role of technological advances in the field of radiotherapy and new systemic therapies in the treatment of TETs has received little attention to *** the present clinical guidelines,developed by the GOECP/SEOR,we review recent developments in the diagnosis and classification of *** also present a consensus-based therapeutic strategy for each disease stage that takes into consideration the best available *** guidelines focus primarily on the role of radiotherapy,including recent advances,in the management of *** main aim of this document is to promote the standardisation of clinical practice and lay the foundations for future studies to clarify the main unresolved questions related to the optimal management of TET.

关键词： Targeted therapies Thymic epithelial tumors Radiotherapy Reirradiation Guidelines Chemotherapy

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稳定同位素标记辅助的脂质组学用于脂质代谢网络的动态解析

稳定同位素标记辅助的脂质组学用于脂质代谢网络的动态解析

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中国化学会首届全国质谱分析学术研讨会

作者：李佳赵欣捷 miriam Hoene Rainer Lehmann 许国旺中国科学院大连化学物理研究所中科院分离分析化学重点实验室

脂质是一类重要的代谢物,参与能量动态平衡,构筑细胞膜,信号转导等诸多生命过程。脂质组学(Lipidomics)是基于质谱技术的研究脂质代谢的有力手段。然而大部分的脂质组学只能获取"快照式(snapshot)"的静态脂质代谢指纹,无法对脂质代谢的... 详细信息

脂质是一类重要的代谢物,参与能量动态平衡,构筑细胞膜,信号转导等诸多生命过程。脂质组学(Lipidomics)是基于质谱技术的研究脂质代谢的有力手段。然而大部分的脂质组学只能获取"快照式(snapshot)"的静态脂质代谢指纹,无法对脂质代谢的动态过程(如合成、转化、降解等)进行深入研究。将稳定同位素标记的前体分子引入实验体系中,可帮助捕获脂质动态代谢信息。经典方法有气相色谱-同位素比例质谱(gas-chromatography-isotope ratio mass spectrometry,GC-IRMS)、基于气相色谱-质谱联用(gas-chromatography mass spectrometry,GC-MS)的质量同位素异构体分布分析(mass isotopomer distribution analysis。MIDA)。上述方法样品预处理复杂,且无法实现分子水平上的MID分析。相反,基于液相色谱-质谱联用(LC-MS)结合二级质谱(MS/MS)可提高分子特异性。目前有报道,通过LC-MS测定胆固醇酯、磷脂、三酰甘油、鞘脂或酯酰辅酶A等脂质库对稳定同位素前体的吸收,来研究干预下的脂质代谢应答。然而,这些研究只关注少数脂质。鉴于此,我们发展并评价了一种基于稳定同位素标记辅助的脂质组学,并结合非靶向的同位素异构体(isotopomer)筛选的新型策略,以实现对脂质代谢网络的动态过程研究。该策略首先通过细胞培养等方式引入稳定同位素标记的脂质合成前体分子;脂质提取物用超高效液相色谱-高分辨质谱联用以全扫描形式进行脂质组学数据采集;随后对采集的质谱信息以非靶向模式进行同位素异构体的筛选和匹配,检测尽可能多的标记脂质,并获取该标记脂质的相关同位素异构体组成信息。通过计算[C+C]和[C/(C+C)],同时得到脂质代谢指纹(等同于常规的脂质组学)和与动态过程相关联的标记信息。我们发展了相应的自动化程序以辅助该质谱数据的解析过程。在用C全标记棕榈酸([U-C]-palmitate)培养的人类骨骼肌细胞中,我们在>7000离子中检测到692个脂质同位素异构体离子,归属于203个脂质分子,覆盖磷脂酰胆碱(PC),溶血磷脂酰胆碱(LPC),磷脂酰乙醇胺(PE),溶血磷脂酰乙醇胺(LPE),磷脂酰丝氨酸(PS),磷脂酰肌醇(PI),神经酰胺(Cer),二氢神经酰胺(dHCer),已糖苷神经酰胺(HexCer),鞘磷脂(SM),二酰甘油(DG),三酰甘油(TG)共12类脂质。基于稳定同位素标记的MS/MS,有助于确定标记位置,研究合成来源,辅助验证结构鉴定和同位素异构体的匹配。对QC(quality contro1)样本的考察表明该方法稳健可靠重复性好,变异系数(CV)中值在所有脂质的水平([C+C]),和标记脂质的标记比例(C/[C+C])中分别为6.91%和3.74%.该策略成功应用于人类骨骼肌细胞在脂毒性环境下的脂质代谢研究。通过构建包含动态过程的脂质代谢网络,揭示了不同脂质对于过量[U-C]-pahnitate造成的脂毒性下的动态代谢应答过程。综上,我们发展了一种基于稳定同位素标记辅助的脂质组学,并结合非靶向的同位素异构体(isotopomer)筛选的新型策略,在获得静态脂质代谢指纹的同时,可以捕获包含其中的动态代谢过程。该方法具有高度的分子特异性和广泛的网络覆盖能力,方法重复、稳健、可靠,为深入研究脂质代谢开辟了新思路,以期对生物体系的病理生理过程、代谢扰动获得更深刻全面的理解。

关键词：脂质组学稳定同位素标记脂质代谢液相色谱-质谱联用

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Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2013年第18期19卷 2772-2780页

作者： Dessy Chan miriam Yuen-Tung Tsoi Christina Di Liu SauHing Chan Simon Ying-Kit Law Kwok-Wah Chan Yuen-Piu Chan Vinod Gopalan Alfred King-Yin Lam Johnny Cheuk-On Tang State Key Laboratory of Chirosciences Lo Ka Chung Centre for Natural Anti-cancer Drug Development Department of Applied Biology and Chemical Technology the Hong Kong Polytechnic University Department of Surgery Li Ka Shing Faculty of Medicine the University of Hong Kong Department of Pathology Li Ka Shing Faculty of Medicine the University of Hong Kong Department of Pathology Griffith Medical School and Griffith Health Institute Griffith University

AIM: To identify the downstream regulated genes of GAEC1 oncogene in esophageal squamous cell carcinoma and their clinicopathological significance. METHODS: The anti-proliferative effect of knocking down the expression of GAEC1 oncogene was stud-ied by using the RNA interference (RNAi) approach through transfecting the GAEC1 -overexpressed esophageal carcinoma cell line KYSE150 with the pSilencer vector cloned with a GAEC1 -targeted sequence, followed by MTS cell proliferation assay and cell cycle analysis using flow cytometry. RNA was then extracted from the parental, pSilencer-GAEC1 -targeted sequence transfected and pSilencer negative control vector transfected KYSE150 cells for further analysis of different patterns in gene expression. Genes differentially expressed with suppressed GAEC1 expression were then determined using Human Genome U133 Plus 2.0 cDNA microarray analysis by comparing with the parental cells and normalized with the pSilencer negative control vector transfected cells. The most prominently regulated genes were then studied by immunohistochemical staining using tissue microarrays to determine their clinicopathological correlations in esophageal squamous cell carcinoma by statistical analyses. RESULTS: The RNAi approach of knocking down gene expression showed the effective suppression of GAEC1 expression in esophageal squamous cell carcinoma cell line KYSE150 that resulted in the inhibition of cell proliferation and increase of apoptotic population. cDNA microarray analysis for identifying differentially expressed genes detected the greatest levels of downregulation of calpain 10 (CAPN10 ) and upregulation of trinucleotide repeat containing 6C (TNRC6C ) transcripts when GAEC1 expression was suppressed. At the tissue level, the high level expression of calpain 10 protein was significantly associated with longer patient survival (month) of esophageal squamous cell carcinoma compared to the patients with low level of calpain 10 expression (37.73 ±

关键词： Esophageal squamous cell carcinoma Oncogene RNA interference Calpain 10 Tissue microarray

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Current treatment landscape for oligometastatic non-small cell lung cancer

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World Journal of Clinical Oncology 2022年第6期13卷 485-495页

作者： Javier Garde-Noguera Margarita Martín-Martín Andres Obeso miriam López-Mata Inigo Royo Crespo Lira Pelari-Mici O Juan Vidal Xabier Mielgo-Rubio Juan Carlos Trujillo-Reyes Felipe Couñago Department of Medical Oncology Hospital Arnau de VilanovaValencia 46015Spain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Thoracic Surgery Hospital Clínico Universitario de Santiago de CompostelaVigo 15706Spain Department of Radiation Oncology Hospital Clínico Universitario Lozano BlesaZaragoza 50009Spain Department of Thoracic Surgery Hospital Universitari Vall d’HebronBarcelona 08035Spain Department of Medical Oncology Hospital Universitario y Politécnico La FeValencia 46026Spain Department of Medical Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029Spain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

The management of patients with advanced non-small cell lung carcinoma(NSCLC)has undergone major changes in recent *** the one hand,improved sensitivity of diagnostic tests,both radiological and endoscopic,has altered the way patients are *** the other hand,the arrival of new drugs with antitumoral activity,such as targeted therapies or immunotherapy,has changed the prognosis of patients,improving disease control and prolonging ***,the development of radiotherapy and surgical and interventional radiology techniques means that radical ablative treatments can be performed on metastases in any location in the *** of these advances have impacted the treatment of patients with advanced lung cancer,especially in a subgroup of these patients in which all of these treatment modalities *** poses a challenge for physicians who must decide upon the best treatment strategy for each patient,without solid evidence for one optimal mode of treatment in this patient *** aim of this article is to review,from a practical and multidisciplinary perspective,published evidence on the management of oligometastatic NSCLC *** evaluate the different alternatives for radical ablative treatments,the role of primary tumor resection or radiation,the impact of systemic treatments,and the therapeutic *** short,the present document aims to provide clinicians with a practical guide for the treatment of oligometastatic patients in routine clinical practice.

关键词： Oligometastatic Non-small cell lung carcinoma Non-small cell lung cancer Oligometastasis

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Homocysteine as a Biomarker for Predicting Disease-Free Survival in Breast Cancer

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Advances in Breast Cancer Research 2013年第2期2卷 24-31页

作者： Daniela Filippini Ierardi Luis Gustavo Raimundo Gimena Aguiar Patrícia Bandeira Rueda Germano Luiz Henrique Gebrim Nelson Carvas Bruno Frederico Aguilar Calegare Vania D’Almeida Catarina Segreti Porto miriam Galvonas Jasiulionis Mariangela Correa Departamento de Farmacologia Universidade Federal de Sao Paulo Sao Paulo Brazil Instituto do Cancer do Estado de Sao Paulo Sao Paulo Brazil Disciplina de Imunologia Universidade Federal de Sao Paulo Sao Paulo Brazil Centro de Referência da Saúde da Mulher Hospital Pérola Byington Sao Paulo Brazil Disciplina de Mastologia Universidade Federal de Sao Paulo Sao Paulo Brazil Departamento de Psicobiologia Universidade Federal de Sao Paulo Sao Paulo Brazil Instituto de Educacao e Ciência Hospital Alemao Oswaldo Cruz Sao Paulo Brazil

Introduction: Breast cancer is the leading cause of cancer mortality among women. Some biomarkers and clinical features are used for the diagnosis and prognosis of this tumor, but no prognostic or predictive marker is routinely available specifically for hormone receptor positive tumors. Homocysteine is well known as a risk factor in atherosclerotic vascular diseases, but its participation in cancer biology is still unclear. The aim of this study was to evaluate serum Homocysteine and Cysteine as biomarkers of disease progression in breast tumor. As a secondary objective, the effect of a short course (one month) of hormonal treatment on Homocysteine, Cysteine and DNA methylation levels was also evaluated. Methods: Blood samples, tumor samples and normal adjacent tissue were collected during the initial biopsy (pre-treatment) and after one month of hormonal therapy (post-treatment). Serum Homocysteine and Cysteine were analyzed by HPLC and tissue global DNA methylation was determined by the Methylation-Sensitive Restriction Enzyme (MSRE) technique. Results: Variations in Homocysteine levels were significantly correlated with Disease-Free Survival. Cox proportional risk model demonstrated that nodal status and Homocysteine levels were independent prognostic factors for disease-free survival (DFS). A significant difference was observed between pre-and post-treatment levels of Homocysteine and Cysteine in advanced tumors, suggesting a prognostic role in patients with poor clinical characteristics. Conclusion: Although more studies are needed to confirm these results, our research suggests that Hcy might be used as a prognostic biomarker for breast cancer.

关键词： Homocysteine Cysteine Breast Cancer Estrogen Receptor Prognostic and Predictive Biomarker Tamoxifen Anastrozol

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Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes

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World Journal of Gastroenterology 2015年第15期21卷 4499-4508页

作者： Elke Kaemmerer Paula Kuhn Ursula Schneider Min Kyung Jeon Christina Klaus miriam Schiffer Danika Weisner Christian Liedtke J?rg J?kel Lieven Nils Kennes Ralf-Dieter Hilgers Norbert Wagner Nikolaus Gassler Institute of Pathology RWTH Aachen University Department of Pediatrics RWTH Aachen University Department of Medicine Ⅲ RWTH Aachen University Department of Medical Statistics RWTH Aachen University

AIM: To verify the hypothesis that caspase-8(Casp8), which regulates cellular apoptosis and necroptosis, is critically involved in enterocyte ***: Casp8-silenced Caco2 cells were used in migration assays. In addition, enterocyte-specific Casp8 heterozygous(Casp8+/?int) or homozygous knockout mice(Casp8?int) were generated by crossing genetically modified mice carrying lox P recombination sites in intron 2 and 4 of the murine Casp8 gene with transgenic animals expressing a cre-transgene under control of the villin promoter in a pure C57/BL6 genetic background. The nucleoside analog Brd U was injected i.p. in male Casp8+/?int and Casp8?int animals 4 h, 20 h, or 40 h before performing morphometric studies. Locations of anti-Brd U-immunostained cells(cellmax) in at least 50 hemi-crypts of 6 histoanatomically distinct intestinal mucosal regions were numbered and extracted for statistical procedures. For the mice cohort(n = 28), the walking distance of enterocytes was evaluated from cellmax within crypt(n = 57), plateau(n = 19), and villus(n = 172) positions, resulting in a total of 6838 observations. Data analysis was performed by fitting a three-level mixed effects modelto the ***: In cell culture experiments with Caco2 cells, Casp8 knockdown efficiency mediated by RNA interference on Casp8 transcripts was 80% controlled as determined by Western blotting. In the scratch assay, migration of Casp8-deleted Caco2 cells was significantly diminished when compared with controls(Casp8?scramble and Caco2). In Brd U-labeled Casp8?int mice, cellmax locations were found along the hemi-crypts in a lower position than it was for Casp8+/?int or control(cre-negative) animals. Statistical data analysis with a three-level mixed effects model revealed that in the six different intestinal locations(distinct segments of the small and large intestine), cell movement between the three mice groups differed widely. Especially in duodenal hemi-crypts, enterocyte movement w

关键词： Barrier function Caspase 8 Cell migration Inflammatory bowel disease Intestinal morphogenesis

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Watch and wait in locally advance rectal cancer:Past,present and future

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World Journal of Meta-Analysis 2021年第4期9卷 327-332页

作者： miriam Alvarez-Aguilera Rosa M Jimenez-Rodriguez Departamento de Cirugía Hospital Universitario Virgen del RocioSevilla 41013Spain

In rectal cancer,a complete pathological response after neoadjuvant therapy means better rates survival and better rates of local ***,these patients suffer from complications following surgery such as low anterior resection syndrome,sexual dysfunction or colostomy for the rest of their *** to this,several groups are working in an organ preservation strategy when a clinical response is *** strategy is known as watch and *** this editorial,we review the past,present and future perspectives for this conservative management.

关键词： Rectal cancer Watch and wait Neoadjuvant treatment Organ preservation Complete response

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后殖民时代阿拉伯世界女性的“越界”现象

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北大中东研究 2015年第1期 131-146页

作者：米丽娅姆·库克林哲杜克大学杜克大学中东研究中心北京大学阿拉伯语系

在过去的25年间，阿拉伯妇女获得了后殖民主义带给她们的自由，取得了巨大的进步。然而不幸的是，战争和争夺允许并促使她们开始“越界”进入男性的领域。阿尔及利亚妇女因战争时期的沉默而被边缘化，有鉴于此，其他阿拉伯国家的妇女开... 详细信息

在过去的25年间，阿拉伯妇女获得了后殖民主义带给她们的自由，取得了巨大的进步。然而不幸的是，战争和争夺允许并促使她们开始“越界”进入男性的领域。阿尔及利亚妇女因战争时期的沉默而被边缘化，有鉴于此，其他阿拉伯国家的妇女开始记录她们自己的战争体验。今日，阿拉伯妇女更是“越界”进入了分析和重新解读宗教经典的领域。而在过去，古兰经只可由男性进行解读和诠释。在重新解读经典和历史的过程中，这些妇女运用的乃是一种“多重批评”的体系。

关键词：后殖民时代阿拉伯女性 “越界” 多重批评

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“作用于皮肤和头发”:克拉考尔的《电影理论》和1940年的“马赛笔记”

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贵州大学学报（艺术版） 2020年第4期34卷 34-49页

作者：米利亚姆·汉森安爽(译) 芝加哥大学人文学院美国芝加哥60601 中国人民大学文学院北京100872

作者以“历史化”的方式重新解读克拉考尔的《电影理论》这一经典文本,以打开它超越本体论的丰富向度。《电影理论》一书的意义需要在早期草稿和最终版本之间的张力中去理解,从而这本书的最初的草稿“马赛笔记”就在文章中占据了重要位... 详细信息

作者以“历史化”的方式重新解读克拉考尔的《电影理论》这一经典文本,以打开它超越本体论的丰富向度。《电影理论》一书的意义需要在早期草稿和最终版本之间的张力中去理解,从而这本书的最初的草稿“马赛笔记”就在文章中占据了重要位置。“马赛笔记”中“物质维度”的概念不仅包括了“物质现实”,也把主体包含在内,这也就为打开这一文本的社会政治潜能提供了切入点。

关键词：《电影理论》马赛笔记克拉考尔物质维度

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被动采样法评估石油类化学物质的生物有效性

被动采样法评估石油类化学物质的生物有效性

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中国毒理学会环境与生态毒理学专业委员会第七届学术研讨会

作者：陈慧婷 Aaron D.Redman Louise Camenzuli miriam Leon Paumen 埃克森美孚(中国)投资有限公司 ExxonMobil Biomedical Science Inc.

石油类化学物质是一类UVCB物质,即化学结构未知、组分可变、复杂的反应产物或生物材料物质。由于其组分的复杂性,以及异构的多样性,详细分析每一种组分具有非常大的困难,因此基于每种成分来进行危害评估是不切实际的。评估石油类物质的... 详细信息

石油类化学物质是一类UVCB物质,即化学结构未知、组分可变、复杂的反应产物或生物材料物质。由于其组分的复杂性,以及异构的多样性,详细分析每一种组分具有非常大的困难,因此基于每种成分来进行危害评估是不切实际的。评估石油类物质的毒性时,通常采用总多环芳烃（TPAH）或总石油烃（TPH）等指标描绘剂量效应关系。然而,这些方法在不同石油类物质之间无法比较,无法为确认效应关系提供一致的基础。因此,有必要开发一种方便的分析技术来量化对石油物质的整体毒性有贡献的所有成分的生物利用度。本报告将介绍固相微萃取（SPME）（一种便捷的被动采样工具）在石油物质生物利用度评估中的应用,以支持危害和风险评估。采用聚二甲基硅氧烷（PDMS）模拟碳氢化合物在生物系统（即生物体细胞膜）与环境系统间的分配。进行固相微萃取时,低PDMS/水比率可以确保在暴露过程中,环境暴露浓度不会显著降低,以模拟生物在环境中的同等效应,即所谓的仿生提取（BE）。PDMS上碳氢化合物的总摩尔数作为可被生物利用的碳氢化合物的总和的替代测量值,用GC-FID进行检测。结合检测所得的BE值作为暴露指标,与毒性数据相结合,可绘制基于BE测量值的剂量效应曲线。综合不同营养级生物的急性、慢性毒性数据,结果表明BE测量值可以很好的描述石油类化学物质的毒性,因此而得出基于BE测量值的毒性终点。BE测量是对总生物可利用物质的综合测量,它可以为表征石油物质的水生暴露提供合理的替代指标,从而帮助描述观察到的毒性,以应用于石油物质的环境危害和风险评估。

关键词：石油类化学物质被动采样法 BE-SPME 生物有效性危害评估

来源： cnki会议评论

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