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The Iberian roma Population Variant Server(IrPVS)

Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.ortuño Amador Valladares miren L.Álvarez-Villegas Gema roldán rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en red Enfermedades Neurodegenerativas(CIBErNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiEr) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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Double balloon device compared to oxytocin for induction of labour after previous caesarean section

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open Journal of obstetrics and Gynecology 2013年第1期3卷 212-216页

作者： Estefanía rodríguez Ferradas Izaskun Lasa Alvarado miren Arrue Gabilondo Irene Diez-Itza José García-Adanez Departament of obstetrics and Gynecology Asturias Central Hospital Oviedo Spain Departament of obstetrics and Gynecology Donostia Hospital San Sebastián Spain

objective: To assess cervical changes, duration of oxytocin infusion, mode of delivery and complications after cervical ripening using a double balloon device in women with a previous caesarean section. Methods: Longitudinal study including 80 women with a previous caesarean section, no previous vaginal delivery and an unfavourable cervix (Bishop

关键词： Double Balloon Device Induction Labor Vaginal Birth after Caesarean Cervical ripening

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Environmental levels and toxicological potencies of a novel mixed halogenated carbazole

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Emerging Contaminants 2016年第3期2卷 166-172页

作者： miren Pena-Abaurrea Matthew robson Sri Chaudhuri Nicole riddell robert McCrindle Brock Chittim robert Parette Un-Ho Jin Stephen Safe David Poirier ralph ruffolo richard Dyer rachael Fletcher Paul A..Helm Eric J.reiner Department of Analysis CEPSA Research CenterAlcala de Henares28805Spain Department of Chemistry University of TorontoTorontoONM5S 3H6Canada ontario Ministry of the Environment and Climate Change TorontoONM9P 3V6Canada Conservation ontario NewmarketONL3Y 2P5Canada Department of Chemistry Brock UniversitySt.CatharinesONL2S 3A1Canada Wellington Laboratories Inc. GuelphONN1G 3M5Canada Department of Chemistry University of GuelphGuelphONN1G 2W1Canada Matson&Associates Inc.State CollegePA16801USA Veterinary Medicine&Biomedical Sciences Texas A&M UniversityTexasTX77843e4461USA Ministry of Northern Development and Mines SudburyONP3E 6B5Canada School of the Environment University of TorontoONM5S 3EBCanada

The present work involves an extensive analytical and toxicological description of a recently identified mixed halogenated carbazole found in sediment samples,1,8-dibromo-3,6-dichloro-9H-carbazole(BCCZ).Concentrations and the relative effect potency(rEP)were calculated for the target BCCZ in a set of stream sediments collected in 2008 in ontario,*** levels calculated for BCCZ as compared to those previously assessed for legacy persistent organic pollutants(PoPs)in the same samples revealed a significant contribution of BCCZ to the total organic chemical contamination(rage 37%).The corresponding dioxin toxic equivalencies(TEQs)of BCCZ in the sediment extracts were estimated from experimental rEP *** experimental data presented supports the classification of this emerging halogenated chemical as a contaminant of emerging environmental *** potential emission sources could not be identified,this study highlights the importance of on-going research for complete characterization of halogenated carbazoles and related compounds.

关键词： Halogenated carbazoles Levels GC×GC rEP TEQ Dioxin-like risk assessment regulation

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Technical aspects of uniportal VATS lung major resections with bronchovascular reconstruction

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中华胸部外科电子杂志 2021年第4期8卷 209-217页

作者： Julio Sesma Sergio Bolufer Carlos Galvez Francisco Lirio Juan JoséMafé Jone miren del Campo Sergio Maroto Leyre Sebastian Marta ortega Luis Jorge Cerezal Department of Thoracic Surgery Hospital General Universitario AlicanteAlicanteSpain

Lung major resections involving bronchovascular reconstruction pose a surgical challenge due to their technical complexity and *** traditional techniques to perform vascular or bronchial reconstructions through multiportal video-assisted thoracoscopic surgery(VATS)approach can be applied also by uniportal VATS ***,specific tools have already been developed in order to facilitate these procedures through uniportal VATS approach increasing comfort and workspace through the single port *** procedures must be performed just in very highly uniportal VATS trained teams and it is recommended that teams who perform these techniques previously have completed the advanced learning curve for lung major resections through uniportal VATS *** aim of this paper is to describe the major key points for performing most frequent bronchovascular reconstructions through uniportal VATS approach in a safe and feasible *** technique is step by step described in order to safely perform most common uniportal VATS left/right side lung major bronchovascular resections and *** tip and tricks are detailed in order to facilitate vascular control,bronchovascular reconstructions and unexpected bleeding control through uniportal VATS approach.

关键词： Video-assisted thoracoscopic surgery(VATS) uniportal angioplasty bronchoplasty lung cancer sleeve bronchovascular reconstruction

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Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes released by CrC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer

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Engineering 2021年第10期7卷 1393-1412页

作者： Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros rodrigo Sanz Jana Dziaková Javier rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella rebeca Magnolia Torrente-rodríguez miren Alonso-Navarro Vivian de los ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano rodrigo Barderas Chronic Disease Program(UFIEC) Carlos III Health InstituteMadrid E-28220Spain Department of Biochemistry and Molecular Biology Faculty of Optics and OptometryComplutense University of MadridMadrid E-28040Spain Gastroenterology Unit San Carlos Clinical HospitalMadrid E-28040Spain Surgical Pathology Department San Carlos Clinical HospitalMadrid E-28040Spain Translational oncology Division OncoHealth InstituteJimenez Diaz Foundation University HospitalMadrid E-28040Spain Department of Biochemistry Faculty of MedicineAlberto Sols Institute of Biomedical ResearchCSIC-UAMMadrid E-28029Spain Department of Analytical Chemistry Faculty of Chemical SciencesComplutense University of MadridMadrid E-28040Spain Center for Biological research Spanish National Research Council(CSIC)MadridE-28040Spain Molecular Pathology and Therapeutic Targets Group La Paz University Hospital(IdiPAZ)Madrid E-28046Spain

Colorectal cancer(CrC)is the second leading cause of cancer-related death *** five-year survival rate of CrC patients depends on the stage at diagnosis,being higher than 80%when CrC is diagnosed in the early stages but lower than 10%when CrC is diagnosed in advanced *** against specific CrC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early ***,we herein aim to identify autoantigens target of autoantibodies specific to CrC that possess a significant ability to discriminate between CrC patients and healthy individuals by means of liquid *** that end,we examined the protein content of the exosomes released by five CrC cell lines and tissue samples from CrC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to *** bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CrC autoantigens in order to evaluate their role in CrC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CrC *** validation,all but one showed a statistically significant high diagnostic ability to distinguish CrC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CrC *** together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here

关键词： Autoantibodies Diagnosis Colorectal cancer Exosomes Tumor microenviroment Humoral immune response Point of care Biosensors

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Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

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Translational Neurodegeneration 2021年第4期10卷 666-677页

作者： Nuole Zhu Miguel Santos-Santos Ignacio lllán-Gala Victor Montal Teresa Estellés Isabel Barroeta miren Altuna Javier Arranz Laia Muñoz olivia Belbin Isabel Sala Maria Belén Sánchez-Saudinós Andrea Subirana Laura Videla Jordi Pegueroles rafael Blesa Jordi Clarimón Maria Carmona-Iragui Juan Fortea Alberto Lleó Daniel Alcolea Sant Pau Memory Unit Department of NeurologyInstitut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant PauUniversitat Autònoma de Barcelona08041 BarcelonaSpain Centro de Investigación Biomédica en red en Enfermedades Neurodegenerativas(CIBErNED) 28031 MadridSpain Autonomous University of Barcelona 08913 BarcelonaSpain Fundación Catalana Sindrome de Down Centre Mèdic Down08029 BarcelonaSpain

Background:Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative *** of glial fibrillary acidic protein(GFAP),an astrocytic damage marker,may help advance our understanding of different neurodegenerative *** this study,we investigated the diagnostic performance of plasma GFAP(pGFAP),plasma neurofilament light chain(pNfL)and their combination for frontotemporal dementia(FTD)and Alzheimer's disease(AD)and their clinical utility in predicting disease ***:pGFAP and pNfL concentrations were measured in 72 FTD,56 AD and 83 cognitively normal(CN)participants using the Single Molecule Array *** the 211 participants,199 underwent cerebrospinal(CSF)analysis and 122 had magnetic resonance *** compared cross-sectional biomarker levels between groups,studied their diagnostic performance and assessed correlation between CSF biomarkers,cognitive performance and cortical *** prognostic performance was investigated,analyzing cognitive decline through group comparisons by ***:Unlike pNfL,which was increased similarly in both clinical groups,pGFAP was increased in FTD but lower than in AD(all Pombination of both plasma markers improved the diagnostic performance to discriminate FTD from AD(area under the curve[AUC]:combination 0.78;pGFAP 0.7;pNfL 0.61,all Porrelated with cognition,CSF and plasma NfL,and cortical thickness(all Pr tertile of pGFAP was associated with greater change in MMSE score and poor cognitive outcome during follow-up both in FTD(1.40 points annually,hazard ratio[Hr]3.82,Points annually,Hr 2.26,Ponclusions:pGFAP and pNfL levels differ in FTD and AD;and their combination is useful for distinguishing between the two *** could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.

关键词： Glial fibrillary acidic protein Neurofilament Frontotemporal dementia Plasma biomarkers

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确保正确放置种蛋以最大化孵化产出

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国外畜牧学（猪与禽） 2019年第11期39卷 50-51页

作者：蔡霞(译) 刘珅(译) 张配配(校) 唐彩琰(图) miren Arbe 不详法国诗华大药厂

入孵时种蛋存放方向影响出雏率和雏鸡质量,孵化场内多种人为因素会影响到种蛋存放的方向,从而影响效益。

关键词：孵化种蛋存放

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应变速率对注浆体力学特性影响规律

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哈尔滨工业大学学报 2020年第9期52卷 176-184,192页

作者：王海龙戎密仁戎虎仁董浩曹海云赵二朋范昊嘉石家庄铁道大学交通运输学院石家庄050043 河北建筑工程学院土木工程学院河北张家口075000 山西大学土木工程系太原030013 河北建筑工程学院建筑与艺术学院河北张家口075000 石家庄铁道大学土木学院石家庄050043

为研究微震荷载作用下注浆加固体力学特性,以裂隙倾角30°、宽度4 mm的红砂岩裂隙注浆体为研究对象,借助岩石三轴伺服压力机进行变应变速率(10^-5~5×10^-3 s^-1)单轴压缩试验;然后从能量耗散、裂纹扩展及破坏形态等3个方面,分析变应变... 详细信息

为研究微震荷载作用下注浆加固体力学特性,以裂隙倾角30°、宽度4 mm的红砂岩裂隙注浆体为研究对象,借助岩石三轴伺服压力机进行变应变速率(10^-5~5×10^-3 s^-1)单轴压缩试验;然后从能量耗散、裂纹扩展及破坏形态等3个方面,分析变应变速率对注浆体力学特性的影响规律及机理.研究表明:随着应变速率的增加,注浆体的峰值强度、弹性模量均随之而增大;且峰值强度与应变速率呈指数函数关系变化;注浆体受应变速率影响的响应分为敏感应变速率阶段和滞缓应变速率阶段,主要差异在于峰值强度变化率和弹性模量变化率;随着应变速率的增大,注浆体的总能量在增大;压密阶段是影响不同应变速率下注浆体力学特性的主要阶段;敏感应变速率阶段和滞缓应变率阶段中的压密阶段主要区别在于积散比大小,积散比进一步决定产生裂纹的多少和分布区域与规律;耗散能密度对注浆体破坏脱落面积以及粒径分布影响较大,耗散能密度越大,碎块越以大块为主(粒径大的比率逐渐增加),滞缓应变率阶段耗散能密度较敏感应变率阶段大,其破碎块体较敏感应变率阶段大.研究在裂隙注浆加固体的变应变速率影响下力学特性,从能理原理、分形理论角度得到了其影响机理.

关键词：注浆体应变速率力学性能能量演化破坏形态

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铁路隧道结构构造重要度权重计算分析研究

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自然灾害学报 2017年第6期26卷 69-76页

作者：戎密仁王海龙戎虎仁霍晓燕曹海云石家庄铁道大学交通运输学院河北石家庄050043 河北建筑工程学院土木工程学院河北张家口075000 河北地质大学管理科学与工程学院河北石家庄050031 河北建筑工程学院建筑与艺术学院河北张家口075000

在地震灾害发生后,铁路隧道会受到不同程度的破坏,如何对震后损失情况进行定性定量评估成为一项非常重要的工作。本文从铁路隧道结构构造角度出发,采用分层加权综合评估法对铁路隧道的不同构造及常见震害形式权重值进行了计算、分析,研... 详细信息

在地震灾害发生后,铁路隧道会受到不同程度的破坏,如何对震后损失情况进行定性定量评估成为一项非常重要的工作。本文从铁路隧道结构构造角度出发,采用分层加权综合评估法对铁路隧道的不同构造及常见震害形式权重值进行了计算、分析,研究表明:在铁路隧道震后灾害损失定量评估时,准确合理的权重值,可以实现震后单座隧道以及整个震区所有隧道的震害损失评估,也可以为震害修缮或重建决策提供依据。

关键词：铁路隧道结构构造常见震害形式权重计算研究

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管道压浆浆液外加剂类型及掺量影响研究

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地质与勘探 2023年第2期59卷 398-407页

作者：戎密仁薛志坤李向国刘喜坤李帅河北地质大学城市地质与工程学院河北石家庄050031 河北省地下人工环境智慧开发与管控技术创新中心河北石家庄050031 石家庄铁道大学土木工程学院河北石家庄050043 河北省建筑科学研究院有限公司河北石家庄050227

预应力管道压浆浆液外加剂种类及配合比的选取是管道压浆工艺的重要部分。为研究减水剂和矿物掺和料对管道压浆浆液的影响及作用机理,进而研制一种流动性、保水性及力学性能优异的管道压浆浆液,本研究采用单组分掺和试验的方法,对掺有... 详细信息

预应力管道压浆浆液外加剂种类及配合比的选取是管道压浆工艺的重要部分。为研究减水剂和矿物掺和料对管道压浆浆液的影响及作用机理,进而研制一种流动性、保水性及力学性能优异的管道压浆浆液,本研究采用单组分掺和试验的方法,对掺有减水剂与矿物掺合料两种不同压浆浆料进行流动性、压力泌水率、沉积密度比、抗压及抗折性能试验研究,并得到不同掺量外加剂对压浆浆液和易性与力学性能的影响和作用机理,以及合适的外加剂掺量配比。研究表明:聚羧酸减水剂30 min与60 min流动度最佳,且压力泌水率表现也较为良好,综合考虑聚羧酸减水剂为压浆浆液的优良减水剂;聚羧酸减水剂掺量在0.4%~0.5%时,浆液的流动性与保水性表现良好,随掺量的继续增加,流动性提升较小;微珠由于其物理性质以及化学性质,对提高压浆浆液和易性与力学性能的效果较为明显;微珠掺量在10%~15%时,压浆浆液的和易性达到临界状态。

关键词：压浆浆液单组分掺和试验外加剂和易性力学性能

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