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Chronic Ankle Instability: Therapeutic Exercise and Data Analysis

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Alternative therapeutic strategies in diabetes management

Open Journal of Orthopedics（矫形学期刊） 2024年第5期 201页

作者： Rosa Grazia Bellomo Giulia Barletta mirco brunetti Claudia Barbato

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World Journal of Diabetes 2024年第6期15卷 1142-1161页

作者： Alessia Annicchiarico Barbara Barile Cinzia Buccoliero Grazia Paola Nicchia Giacomina brunetti Department of Biosciences Biotechnologies and EnvironmentUniversity of Bari Aldo MoroBari 70125Italy

Diabetes is a heterogeneous metabolic disease characterized by elevated blood glucose levels resulting from the destruction or malfunction of pancreaticβcells,insulin resistance in peripheral tissues,or both,and results in a non-sufficient production of *** adjust blood glucose levels,diabetic patients need exogenous insulin administration together with medical nutrition therapy and physical *** the aim of improving insulin availability in diabetic patients as well as ameliorating diabetes comorbidities,different strategies have been *** first approaches included enhancing endogenousβcell activity or transplanting new *** protocol for this kind of intervention has recently been optimized,leading to standardized *** is indicated for diabetic patients with severe hypoglycemia,complicated by impaired hypoglycemia awareness or exacerbated glycemic *** has been associated with improvement in all comorbidities associated with diabetes,quality of life,and ***,different trials are ongoing to further improve the beneficial effects of ***,to overcome some limitations associated with the availability of islets/pancreas,alternative therapeutic strategies are under evaluation,such as the use of mesenchymal stem cells(MSCs)or induced pluripotent stem cells for *** cotransplantation of MSCs with islets has been successful,thus providing protection against proinflammatory cytokines and hypoxia through different mechanisms,including exosome *** use of induced pluripotent stem cells is recent and requires further *** advantages of MSC implantation have also included the improvement of diabetes-related comorbidities,such as wound *** the number of advantages of the direct injection of MSCs,new strategies involving biomaterials and scaffolds have been developed to improve the efficacy of mesenchymal cell delivery with promising resul

关键词： Diabetes Pancreas/islet transplantation Mesenchymal stem cells Induced pluripotent stem cells Exosomes Scaffolds

Inertia and Spectral Symmetry for the Eccentricity Matrices of Clique Trees

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Acta Mathematicae Applicatae Sinica 2024年

作者： Xiao-hong LI Jian-feng WANG Maurizio brunetti School of Mathematics and Statistics Shandong University of Technology Basic Education Department Weifang Engineering Vocational College Department of Mathematics and Applications University Federico II'

The eccentricity matrix E(G) of a connected graph G is obtained from the distance matrix of G by leaving unchanged the largest nonzero entries in each row and each column,and replacing the remaining ones with *** this paper,we consider the set CT of clique trees whose blocks contain at most two cut-vertices of the clique *** with studying the structural properties of a clique tree in CT,we prove its eccentricity matrix to be irreducible,and then determine its inertia showing that every graph in CT with more than four vertices and odd diameter has two positive and two negative *** E-eigenvalues and negative E-eigenvalues turn out to be equal in number even for graphs in CT with even diameter;that shared cardinality also counts the‘diametrally distinguished’***,we prove that the spectrum of the eccentricity matrix of a clique tree G in CT is symmetric with respect to the origin if and only if G has an odd diameter and exactly two adjacent central *** results generalize those achieved on trees by *** and *** in 2022.

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

Metabolic characterization of selected probiotic consortia during gluten and wheat bread simulated digestion

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Food Science and Human Wellness 2024年

作者： mirco Vacca Giuseppe Celano Olga Nikoloudaki Bodo Speckmann Francesco Maria Calabrese Marco Gobbetti Maria de Angelis Faculty of Science and Technology， Free University of Bozen Evonik Operations GmbH Department of Soil Plant and Food Sciences， University of Bari Aldo Moro

While exerting their metabolic activities in the gastrointestinal milieu， probiotics impact the host well-being by boosting immunity， treating metabolic disorders， and modulating microbiota and metabolome. Due to the high incidence of gluten-based disorders， the present work aims to deeply explore the metabolism of two selected microbial consortia (MCs) during gluten digestion under simulated gastrointestinal conditions. Featured by high protease and peptidase activity， both MCs accounted for different lactic acid bacteria and Bacillus strains that were combined with two commercial protease enzymes. Gluten substrates were used as purified extracts， white and whole wheat breads. Control samples， instead， relied onto the microbial enzyme lack. Twenty-four hours of simulated digestion were sufficient to completely hydrolyze gluten in one of the two MC-containing experimental sets， and the relative 48 h-digested extract did not alter the cytokine expression in duodenal biopsies from celiac disease (CeD) patients. When digested samples were assayed for antioxidant and phytase activities， microbial enzymes demonstrated to significantly improve both ABTS and DPPH values and to decrease the phytic acid concentration. The inspection of the free amino acid profiles allowed for distinguishing the two MCs， whereas the detection of a heterogeneous panel of volatile organic compounds supported the presence/activity of microbial enzymes without statistically significant differences between MCs. As functional contribution， digested extracts with MCs also proved to reduce the inflammatory cytokine concentrations in cell lines exposed to lipopolysaccharide trigger. Therefore， in line with studies exploring novel adjuvant therapies， the present innovative probiotic consortium featured by high gluten-hydrolyzing metabolism also showed the capability to improve various parameters usually found to be altered in patients affected by gluten-based disorders or CeD.

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Utilization of irradiance ratios for calculating the effect of reflections from obstructions in building energy simulation

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Building Simulation 2021年第4期14卷 945-967页

作者： Gian Luca brunetti Politecnico di Milano Department of Architecture and Urban Studies(DAStU)via Bonardi 320133MilanoItaly

The ability to take into account reflections from obstructions is of fundamental importance in building energy simulation (BES), because reflections can have a substantial influence on solar gains. In BES tools, this ability is often implemented duplicating functionalities that have already been solved efficiently in lighting simulation tools. This happens because importing those functionalities from a lighting simulation tool (source) into a BES tool (target) is usually a complex operation producing non-portable results. This article demonstrates that this ability can be imported modularly and portably without intervening in the internals of the two tools. This can be obtained by: (1) creating, in the source tool, pairs of models which are analogue-on the one hand-to the original model in the target tool, and-on the other hand-to the model in the target tool hypothetically enriched with some predictive ability only available in the source tool;(2) measuring, at each time step, the ratio between the performances predicted by the source tool as regards the two analogue models;(3) re-scaling, at each time-step, the performance predicted by the target tool on the basis of that ratio. When appropriate analogue models are utilized, this strategy enables distinct simulation tools to work like an integrated computing unit.

关键词： irradiance ratios shading factors analogue models solar reflections insolation factors

Major liver resections,perioperative issues and posthepatectomy liver failure:A comprehensive update for the anesthesiologist

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World Journal of Critical Care Medicine 2024年第2期13卷 49-71页

作者： Andrea De Gasperi Laura Petrò Ombretta Amici Ilenia Scaffidi Pietro Molinari Caterina Barbaglio Eva Cibelli Beatrice Penzo Elena Roselli Andrea brunetti Maxim Neganov Alessandro Giacomoni Paolo Aseni Elena Guffanti Former Head Anesthesia and Critical Care Service 2Grande Ospedale Metropolitano Niguarda ASST GOM NiguardaMilan 20163Italy AR1 Ospedale Papa Giovanni 23Bergamo 24100Italy Anesthesia and Critical Care Service 2 Grande Ospedale Metropolitano Niguarda AR2ASST GOM NiguardaMilan 20163Italy Anestesia e Terapia Intensiva Generale Istituto Clinico HumanitasRozzano 20089Italy Chirurgia Oncologica Miniinvasiva Grande Ospedale Metropolitano Niguarda ASST GOM NiguardaMilan 20163Italy Dipartimento di Medicina d’Urgenza ed Emergenza Grande Ospedale Metropolitano Niguarda ASST GOM NiguardaMilano 20163MIItaly

Significant advances in surgical techniques and relevant medium-and long-term outcomes over the past two decades have led to a substantial expansion in the indications for major liver *** support these outstanding results and to reduce perioperative complications,anesthesiologists must address and master key perioperative issues(preoperative assessment,proactive intraoperative anesthesia strategies,and implementation of the Enhanced Recovery After Surgery approach).Intensive care unit monitoring immediately following liver surgery remains a subject of active and often unresolved *** postoperative complications,posthepatectomy liver failure(PHLF)occurs in different grades of severity(A-C)and frequency(9%-30%),and it is the main cause of 90-d postoperative ***,recently redefined with pragmatic clinical criteria and perioperative scores,can be predicted,prevented,or *** review highlights:(1)The systemic consequences of surgical manipulations anesthesiologistsmust respond to or prevent,to positively impact PHLF(a proactive approach);and(2)the maximal intensivetreatment of PHLF,including artificial options,mainly based,so far,on Acute Liver Failure treatment(s),to buytime waiting for the recovery of the native liver or,when appropriate and in very selected cases,toward *** a clinical context requires a strong commitment to surgeons,anesthesiologists,and intensivists towork together,for a fruitful collaboration in a mandatory clinical continuum.

关键词： Liver resection Chronic liver disease Preoperative assessment Vascular clamping Intraoperative hemodynamic monitoring Postoperative intensive care unit Posthepatectomy liver failure Artificial liver support

REALISTIC AND CORRECT MODELS OF IMPRESSED SOURCES FOR TIME-HARMONIC ELECTROMAGNETIC BOUNDARY VALUE PROBLEMS INVOLVING METAMATERIALS

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第3期4卷 97-148页

作者： PAOLO FERNANDES mirco RAFFETTO Istituto di Matematica Applicata e Tecnologie Informatiche del Consiglio Nazionale delle Ricerche Via De Marini 6 I-16149 GenoaItaly Department of Biophysical and Electronic Engineering University of Genoa Via Opera Pia 11a I-16145GenoaItaly

The aim of this work is to analyze the role of the impressed sources in determining the well or ill-posedness of time harmonic electromagnetic boundary value problems involving isotropic effective *** is shown,in particular,that,even if all interfaces are regular,the class of ill-posed problems can be very large in the presence of general square-integrable impressed ***,when a simple and realistic constraint is enforced on these sources,requiring that the support of the sources does not include any interface between a traditional medium and a metamaterial,among the problems here considered just those involving an interface between complementary materials remain *** considerations have a very significant impact also on the approximability of the solution of well-posed problems since the numerical noise can introduce small fictitious sources even where the sources to be simulated are not *** effects on finite element simulators are fully ***,we propose an algorithm that allows to obtain much better approximations of the solutions of the most critical wellposed problems.

关键词： Time-harmonic electromagnetic boundary value problems electromagnetic modeling of composite media waveguide discontinuity problems ill-posedness metamaterials electromagnetic simulators finite element methods.

＇Hot stuff＇： inflammatory lymphocyte populations in acute coronary syndrome

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Cellular & Molecular Immunology 2015年第4期12卷 513-514页

作者： Natale Daniele brunetti FESC Departement of Medical & SurgicalSciences University of Foggia Foggia Italy

Acute myocardial infarction and co- ronary unstable plaque： definitely＇hot stuff to address. However, it is not just a pun. Atherosderosis and acute coronary syndrome are both characterized by active inflammation） Increased levels of C-react- ive protein and inflammatory cytokines have been found during the very early phases of acute myocardial infarction2 and are associated with a worse prognosis.

关键词： ANGIOGRAPHIC FINDINGS UNSTABLE ANGINA ATHEROSCLEROSIS PLAQUE