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Metabolic characterization of selected probiotic consortia during gluten and wheat bread simulated digestion

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Food Science and Human Wellness 2024年

作者： mirco Vacca Giuseppe Celano Olga Nikoloudaki Bodo Speckmann Francesco Maria Calabrese Marco Gobbetti Maria de Angelis Faculty of Science and Technology， Free University of Bozen Evonik Operations GmbH Department of Soil Plant and Food Sciences， University of Bari Aldo Moro

While exerting their metabolic activities in the gastrointestinal milieu， probiotics impact the host well-being by boosting immunity， treating metabolic disorders， and modulating microbiota and metabolome. Due to the high incidence of gluten-based disorders， the present work aims to deeply explore the metabolism of two selected microbial consortia (MCs) during gluten digestion under simulated gastrointestinal conditions. Featured by high protease and peptidase activity， both MCs accounted for different lactic acid bacteria and Bacillus strains that were combined with two commercial protease enzymes. Gluten substrates were used as purified extracts， white and whole wheat breads. Control samples， instead， relied onto the microbial enzyme lack. Twenty-four hours of simulated digestion were sufficient to completely hydrolyze gluten in one of the two MC-containing experimental sets， and the relative 48 h-digested extract did not alter the cytokine expression in duodenal biopsies from celiac disease (CeD) patients. When digested samples were assayed for antioxidant and phytase activities， microbial enzymes demonstrated to significantly improve both ABTS and DPPH values and to decrease the phytic acid concentration. The inspection of the free amino acid profiles allowed for distinguishing the two MCs， whereas the detection of a heterogeneous panel of volatile organic compounds supported the presence/activity of microbial enzymes without statistically significant differences between MCs. As functional contribution， digested extracts with MCs also proved to reduce the inflammatory cytokine concentrations in cell lines exposed to lipopolysaccharide trigger. Therefore， in line with studies exploring novel adjuvant therapies， the present innovative probiotic consortium featured by high gluten-hydrolyzing metabolism also showed the capability to improve various parameters usually found to be altered in patients affected by gluten-based disorders or CeD.

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Chronic Ankle Instability: Therapeutic Exercise and Data Analysis

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Open Journal of Orthopedics 2024年第5期14卷 201-217页

作者： Rosa Grazia Bellomo Giulia Barletta mirco Brunetti Claudia Barbato Department of Biomolecular Sciences University of Study of Urbino Carlo Bo Urbino Italy

Background and Objectives: Ankle injuries are the most common type of injury in healthy active individuals. If not treated properly, recurrent sprains can lead to a condition of chronic ankle instability (CAI). The present paper examines some subjects with a previous history of acute inversion ankle sprain who have developed a subsequent condition of instability, grouping them according to inclusion criteria and analyzing them through four field tests considered objective by the scientific literature: SEBT test, BEES test, TIBT test, SHT test. The data obtained were stored in order to compare them following a re-education protocol aimed at improving proprioception, balance, walking and strengthening the extrinsic and intrinsic muscles of the foot. per year. The subjects were then divided into two categories: subjects with CAI > 1 year and subjects with CAI ≤ 1 year. A protocol lasting 6 weeks was administered to both groups, trying to work on improving balance in single stance, improving static and dynamic stability, strengthening the gluteus medius and maximus (pelvis stabilizers) and strengthening of the intrinsic muscles of the foot. At the end of the protocol the subjects were all re-evaluated with the same field tests used previously and the data obtained were compared both with the pre-protocol data and with the data measured by the control subjects.

关键词： Ankle Instability Ankle Sprain Ankle Injuries Exercise

REALISTIC AND CORRECT MODELS OF IMPRESSED SOURCES FOR TIME-HARMONIC ELECTROMAGNETIC BOUNDARY VALUE PROBLEMS INVOLVING METAMATERIALS

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第3期4卷 97-148页

作者： PAOLO FERNANDES mirco RAFFETTO Istituto di Matematica Applicata e Tecnologie Informatiche del Consiglio Nazionale delle Ricerche Via De Marini 6 I-16149 GenoaItaly Department of Biophysical and Electronic Engineering University of Genoa Via Opera Pia 11a I-16145GenoaItaly

The aim of this work is to analyze the role of the impressed sources in determining the well or ill-posedness of time harmonic electromagnetic boundary value problems involving isotropic effective *** is shown,in particular,that,even if all interfaces are regular,the class of ill-posed problems can be very large in the presence of general square-integrable impressed ***,when a simple and realistic constraint is enforced on these sources,requiring that the support of the sources does not include any interface between a traditional medium and a metamaterial,among the problems here considered just those involving an interface between complementary materials remain *** considerations have a very significant impact also on the approximability of the solution of well-posed problems since the numerical noise can introduce small fictitious sources even where the sources to be simulated are not *** effects on finite element simulators are fully ***,we propose an algorithm that allows to obtain much better approximations of the solutions of the most critical wellposed problems.

关键词： Time-harmonic electromagnetic boundary value problems electromagnetic modeling of composite media waveguide discontinuity problems ill-posedness metamaterials electromagnetic simulators finite element methods.

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地拉那金字塔

世界建筑导报 2024年第4期39卷 121-125页

作者： Ronald Hoogeveen Stavros Gargaretas Guido Boeters Angel Sanchez Navarro Boris Tikvarski Jasper van der Ven mirco Facchinelli Manuel Magnaguagno Leo Stuckardt MVRDV

地拉那金字塔是一个新型的文化中心,位于阿尔巴尼亚首都的中心地带。地拉那金字塔最初是作为纪念共产主义者恩维尔·霍查(EnverHoxha)而建的博物馆,MVRDV对其进行了巨大的改造,现在的地拉那金字塔重新使用了混凝土结构,已经成为了一个... 详细信息

地拉那金字塔是一个新型的文化中心,位于阿尔巴尼亚首都的中心地带。地拉那金字塔最初是作为纪念共产主义者恩维尔·霍查(EnverHoxha)而建的博物馆,MVRDV对其进行了巨大的改造,现在的地拉那金字塔重新使用了混凝土结构,已经成为了一个新公园中的开放式雕塑。公园和雕塑中散布着一个个五颜六色的盒子,这些盒子散落在原来的建筑中及其周围,里面有咖啡馆、工作室、工作坊、创业办公室、孵化器、节庆活动,还有供阿尔巴尼亚青年免费学习各种技术和知识的教室。建筑倾斜的外墙还增加了台阶,让阿尔巴尼亚人民可以在这位前共产主义者的杰作上漫步。

关键词：工作坊金字塔节庆活动孵化器阿尔巴尼亚咖啡馆工作室混凝土结构

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High-contrast,high-resolution photochromic silicone polymer based on photoswitchable[Ru(bpy)_(2)OSO]PF_(6)building blocks

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Photonics Research 2013年第4期1卷 197-201页

作者： Kristin Springfeld Volker Dieckmann mirco Imlau Department of Physics Osnabrück UniversityBarbarastraße 749076 OsnabrückGermany

The implementation of photoinduced linkage isomerism in molecular-based optical materials represents a promising approach for the synthesis of high-contrast,high-resolution photosensitive materials that are necessary for high-density(holographic)data storage and/or real-three-dimensional(holographic)*** unsolved task of embedding a photofunctional coordination complex into a matrix like polymer polydimethylsiloxane(PDMS)with photoinduced isomerism of a SO-bond in the sulfoxide compoundRubpy2OSOPF6 is *** approach allows to preserve the spectral properties within the solid dielectric environment,with an impact of PDMS on population and relaxation *** data are discussed in the framework of photofunctionality,storage,and display applications.

关键词： dynamics. holographic polymer

Spatial and temporal intercomparison of four global burned area products

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International Journal of Digital Earth 2019年第4期12卷 460-484页

作者： Michael L.Humber Luigi boschetti Louis Giglio Christopher O.Justice Department of Geographical Sciences University of MarylandCollege ParkMDUSA Department of Natural Resources and Society University of IdahoMoscowIDUSA

We characterize the agreement and disagreement of four publically available burned products(Fire CCI,Copernicus Burnt Area,MODIS MCD45A1,and MODIS MCD64A1)at a finer spatial and temporal scale than previous assessments using a grid of three-dimensional cells defined both in space and in *** analysis,conducted using seven years of data(2005–2011),shows that estimates of burned area vary greatly between products in terms of total area burned,the location of burning,and the timing of the *** use regional and monthly units for analysis to provide insight into the variation between products that can be lost when considering products yearly and/or *** with independent,contemporaneous MODIS active fire observations provides one indication of which products most reasonably capture the burning *** results have implications for the use of global burned area products in fire ecology,management and emissions applications.

关键词： Global burned area product intercomparison burning patterns voxel

Chirp control of femtosecond-pulse scattering from drag-reducing surface-relief gratings

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Photonics Research 2018年第6期6卷 542-548页

作者： JULIANE EGGERT BJOERN BOURDON STEFAN NOLTE JOERG RISCHMUELLER mirco IMLAU School of Physics Osnabrück University

The role of chirp on the light-matter interaction of femto- and pico-second laser pulses with functional structured surfaces is studied using drag-reducing riblets as an example. The three-dimensional, periodic microstructure naturally gives rise to a mutual interplay of （i） reflection, （ii） scattering, and （iii） diffraction phenomena of incident coherent light. Furthermore, for femtosecond pulses, the structure induces （iv） an optical delay equivalent to a consecutive temporal delay of 230 fs in places of the pulse. These features enable studying experimentally and numerically the effect of tuning both pulse duration τ and spectral bandwidth Δω on the features of the wideangle scattering pattern from the riblet structure. As a result, we discovered a significant breakdown of fringes in the scattering pattern with decreasing pulse duration and/or increasing spectral bandwidth. This unique type of chirp control is straightforward/y explained and verified by numerical modeling considering the spectral and temporal interaction between different segments within the scattered, linearly chirped pulse and the particular geometric features of the riblet structure. The visibility of the fringe pattern can be precisely adjusted, and the offstate is achieved using τ 〈 230 fs or Δω〉 2.85 × 10^13 rad/s.

关键词： Optical inspection Surface measurements figure Linear and nonlinear lightscattering from surfaces Optical sensing and sensors Chirping Femtosecond phenomena

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Multi-stage rodingitization of ophiolitic bodies from Northern Apennines(Italy): Constraints from petrography, geochemistry and thermodynamic modelling

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Geoscience Frontiers 2020年第6期11卷 2103-2125页

作者： Emma Salvioli-Mariani Tiziano boschetti Lorenzo Toscani Alessandra Montanini Jasmine Rita Petriglieri Danilo Bersani Department of Chemistry Life Sciences and Environmental SustainabilityUniversity of ParmaParco Area delle Scienze 157/A43124ParmaItaly Department of Chemistry University of TorinoVia Pietro Giuria10125TorinoItaly Institute of Exact and Applied Sciences Universitéde la Nouvelle CalédonieCampus de NouvilleBP R4-98851 Nouméa CedexNew CaledoniaFrance Department of Mathematical Physical and Computer SciencesUniversity of ParmaParco Area delle Scienze 7/A43124ParmaItaly

The investigated mantle bodies from the External Ligurians(Groppo di Gorro and ***)show evidences of a complex evolution determined by an early high temperature metasomatism,due to percolating melts of asthenospheric origin,and a later metasomatism at relatively high temperature by hydrothermal fluids,with formation of *** Groppo di Gorro,the serpentinization and chloritization processes obliterated totally the pyroxenite protolith,whereas at *** relics of peridotite and pyroxenite protoliths were preserved from *** rodingite parageneses consist of diopside+vesuvianite+garnet+calcite+chlorite at Groppo di Gorro and garnet+diopside+serpentine±vesuvianite±prehnite±chlorite±pumpellyite at *** inclusion measurements show that rodingitization occurred at relatively high temperatures(264-334℃ at 500 bar and 300-380℃ at 1 kbar).Garnet,the first phase of rodingite to form,consists of abundant hydrogarnet component at Groppo di Gorro,whereas it is mainly composed of grossular and andradite at *** last stage of rodingitization is characterized by the vesuvianite *** nucleation requires high Ca and low silica fluids,whereas the formation of vesuvianite does not need CO2-poor *** formation of calcite at Groppo di Gorro points to mildly oxidizing conditions compatible with hydrothermal fluids;the presence of andradite associated with serpentine and magnetite at *** suggests Fe^3+-bearing fluids with fO2 slightly higher than iron-magnetite *** propose that the formation of the studied rodingite could be related to different pulses of hydrothermal fluids mainly occurring in an oceancontinent transitional setting and,locally,in an accretionary prism associated with intra-oceanic subduction.

关键词： Rodingite Hydrothermal alteration Raman spectroscopy Thermodynamic modelling Ligurian ophiolite Northern Apennines

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Biomechanics of the anterior cruciate ligament:Physiology,rupture and reconstruction techniques

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World Journal of Orthopedics 2016年第2期7卷 82-93页

作者： Christoph Domnick Michael J Raschke mirco Herbort Department of Trauma Hand and Reconstructive SurgeryWestphalian Wilhelms University Muenster

The influences and mechanisms of the physiology,rupture and reconstruction of the anterior cruciate ligament(ACL)on kinematics and clinical outcomes have been investigated in many biomechanical and clinical studies over the last several *** knee is a complex joint with shifting contact points,pressures and axes that are affected when a ligament is *** ACL,as one of the intra-articular ligaments,has a strong influence on the resulting ***,other meniscal or ligamentous injuries accompany ACL ruptures and further deteriorate the resulting kinematics and clinical *** the surgical options,anatomic relations and current evidence to restore ACL function and considering the influence of concomitant injuries on resulting kinematics to restore full function can together help to achieve an optimal outcome.

关键词： Biomechanics anterior cruciate ligament joint pressure anterior cruciate ligament rupture graft fixation anterior cruciate ligament reconstruction