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Genetic polymorphisms of GSTM1,GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population

Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 982-989页

作者： mir muhammad nasir uddin Maizbha uddin Ahmed Mohammad Safiqul Islam Mohammad Siddiqul Islam muhammad Shahdaat Bin Sayeed Yearul Kabir Abul Hasnat Department of Clinical Pharmacy and Pharmacology Faculty of PharmacyUniversity of Dhaka Department of Pharmacy Noakhali Science and Technology University Department of Biochemistry and Molecular Biology University of Dhaka

Objective:To verify possible associations between polymorphisms of glutathione S-transferase Mu(GSTM1),glutathione S-transferase θ(GSTT1) and glutathione S-transferase Pi(GSTP1)genes and susceptibility to lung ***:A total of 106 lung cancer patients and 116 controls were enrolled in a case-control *** GSTM1 and GSTT1 were analyzed using PCR while GSTP1 was analyzed using PCR-restriction fragment length *** of lung cancer was estimated as odds ratio at 95%confidence interval using unconditional logistic regression models adjusting for age,sex,and tobacco ***:GSTM1 null and GSTT1 null genotypes did not show a significant risk for developing lung cancer.A significandy elevated lung cancer risk was associated with GSTP1 heterozygous,mutant and combined heterozygous+mutant variants of *** classified by tobacco consumption status,no association with risk of lung cancer was found in case of tobacco smokers and nonsmokers carrying null and present genotypes of GSTM1 and GSTTL There is a three-fold(approximately) increase in the risk of lung cancer in case of both heterozygous(AG) and heterozygous+mutant homozygous(AG+GG) genotypes whereas there is an eightfold increase in risk of lung cancer in cases of GG with respect to AA genotype in ***:Carrying the GSTM1 and GSTT1 null genotype is not a risk factor for lung cancer and GSTP1Ile105 Val is associated with elevated risk of lung cancer.

关键词： Lung cancer Glutathione S-transferase Genetic polymorphism Smoking

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Cytotoxic,antibacterial and analgesic activities of Rhaphidophora glauca(Wall.)Schott leaves

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Journal of Coastal Life Medicine 2016年第9期4卷 750-756页

作者： mir muhammad nasir uddin Raju Dash Mohammad Shah Hafez Kabir MdMominur Rahman Mohammad Nazmul Islam Arkajyoti Paul Department of Pharmacy University of ChittagongChittagong-4331Bangladesh Department of Pharmacy BGC Trust University BangladeshChittagong-4000Bangladesh Department of Pharmacy International Islamic University ChittagongChittagong-4203Bangladesh

Objective:To investigation of cytotoxic,antimicrobial and analgesic activities of different fractions of Rhaphidophora glauca(Wall.)***:Two partially purified aqueous methanolic fractions from ethyl acetate extract(AMF-1)and chloroform extract(AMF-2)obtained from the partitioning were used in *** cytotoxic effect was determined by brine shrimp lethality *** activity was investigated by disc diffusion and minimal inhibitory concentration *** plate method and acetic acid test was used for determining analgesic ***:The LC_(50)values of AMF-1 and AMF-2 were found to be 287.73 and 428.54μg/mL respectively,where colchicines showed LC_(50)of 11.16μg/*** zone of inhibition of the fractions AMF-1 and AMF-2 was found to be in the range of 8-26 mm in 2000μg/disc,as compared to reference antibiotics kanamycin(11-28 mm at 30μg/disc)and ciprofloxacin(20-25 mm at 30μg/disc)indicating the antibacterial *** hot plate test,the highest pain inhibitory activity was found at a dose of 250 mg/kg for AMF-1 which was statistically significant(P<0.05)compared to both positive and negative control at 30 min *** acid induced model,both AMF-1 and AMF-2 at a dose of 500 mg/kg showed significant activity compared to positive and negative ***:This study found that Rhaphidophora glauca possesses potential cytotoxic,antibacterial and analgesic *** study may be needed to isolate the bioactive compounds responsible for different activities with subsequent mechanistic study.

关键词： Rhaphidophora glauca Cytotoxicity Antimicrobial Analgesic Kanamycin

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Anti-hypercholesterolemic and anti-hyperglycaemic effects of conventional and supercritical extracts of black cumin(Nigella sativa)

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 1014-1022页

作者： muhammad Jawad Iqbal Masood Sadiq Butt mir muhammad nasir Qayyum Hafiz Ansar Rasul Suleria National Institute of Food Science and Technology Faculty of FoodNutrition and Home SciencesUniversity of AgricultureFaisalabadPakistan Department of Agriculture and Food Technology Karakoram International UniversityGilgit-BaltistanPakistan UQ Diamantina Institute Translational Research InstituteFaculty of MedicineThe University of Queensland37 Kent Street WoolloongabbaBrisbaneQLD 4102Australia Department of Food NutritionDietetics and HealthKansas State UniversityManhattanKS 66506USA

Objective: To explore the hypoglycaemic and hypocholesterolemic potential of conventional and supercritical extracts of black ***: Purposely, rat modelling was carried out for 2 months by designing three studies i.e. study Ⅰ(normal rats), study Ⅱ(hyperglycaemic rats) and study Ⅲ(hypercholesterolemic rats). Each study was further divided into three groups based on diet ***, functional diet(contained extract of black cumin prepared by using conventional solvent) and nutraceutical diet(contained extract of black cumin prepared by supercritical fluid extraction system).Results: During whole trial, an abating trend was observed in the level of serum cholesterol with maximum reduction(12.8%) in nutraceutical group of study Ⅲ. Low density lipoprotein and triglyceride level was also lowered maximum in study Ⅲ as17.1% and 11.6%, respectively. Whereas, highest decline in glucose level was in nutraceutical group of study Ⅱ as 11.2%.Conclusions: Inclusion of black cumin extracts in diet significantly lowers the occurrence of hyperglycaemia and hypercholesterolaemia. Furthermore, hypoglycaemic and hypocholesterolemic potential of nutraceutical diet is more prominent as compared to functional diet.

关键词： Black cumin Functional food Nutraceuticals Supercritical extract Hyperglycaemia Hypercholesterolaemia

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SI Engine Fueled with Gasoline, CNG and CNG-HHO Blend: Comparative Evaluation of Performance, Emission and Lubrication Oil Deterioration

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Journal of Thermal Science 2021年第4期30卷 1199-1211页

作者： USMAN muhammad HAYAT nasir BHUTTA muhammad Mahmood Aslam Department of Mechanical Engineering University of Engineering and TechnologyLahore 54890Pakistan

Hydroxy gas (HHO) is one of the potential alternative fuels for spark ignition (SI) engine,notably due to simultaneous increase in engine performance and reduction in exhaust ***,impact of HHO gas on lubrication oil for longer periods of engine operation has not yet been *** study focuses on investigation of the effect of gasoline,CNG and CNG-HHO blend on lubrication oil deterioration along with engine performance and emissions in SI *** unit produces HHO gas at 4.72 L/min by using 6 g/L of KOH in the aqueous *** was supplied to the test engine at a pressure of 0.11 MPa using an electronically controlled solenoid *** tests were carried out at different speeds at 80%open throttle condition and various performance parameters such as brake power (BP),brake specific fuel consumption(BSFC),brake thermal efficiency (BTE),exhaust gas temperature and exhaust emissions (HC,CO_(2),CO and NO_(x))were *** addition,various lubrication oil samples were extracted over 120 h of engine running while topping for drain out volume and samples were analyzed as per ASTM ***-HHO blend exhibited better performance i.e.,15.4%increase in average BP in comparison to CNG,however,15.1%decrease was observed when compared to ***-HHO outperformed gasoline and CNG in the case of HC,CO_(2),CO and brake specific fuel consumption (31.1%decrease in comparison to gasoline).On the other hand,CNG-HHO produced higher average NO_(x) (12.9%) when compared to CNG ***,lubrication oil condition(kinematic viscosity,water contents,flash point and total base number (TBN)),wear debris (Iron (Fe),Aluminum(Al),Copper (Cu),Chromium (Cr)) and additives depletion (Zinc (Zn),Calcium (Ca)) presented a significant degradation in the case of CNG-HHO blend as compared to gasoline and *** oil analyses illustrated 19.6%,12.8%and 14.2%decrease in average viscosity,flash point and TBN for CNG-HHO blend ***,

关键词： spark ignition engine compressed natural gas hydrogen lubrication oil deterioration emission

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Photochemical reactions as synthetic tool for pharmaceutical industries

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Chinese Chemical Letters 2024年第9期35卷 9-31页

作者： Shehla Khalid muhammad Bilal nasir Rasool muhammad Imran Department of Chemistry Government College UniversityFaisalabad 38000Pakistan School of Chemistry and Chemical Engineering Shandong UniversityJi’nan 250100China Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

In the quest for new agrochemicals and pharmaceuticals,chemists seek access to reliable and mild synthetic techniques to allow for the systematic modification of chemical structures,exploration of unexplored chemical space,and facilitation of practical synthesis in their search for novel agrochemicals and *** this regard,photocatalytic reactions enabled the synthesis of intricate and more functionalized *** review overviews the developed synthetic methodologies and their utility in the chemical synthesis of *** review also offers in-depth insights into contemporary photoredox reactions such as allylic additions,cyclization,reductive cross-coupling,C–H activation,ring opening,oxidative cross-coupling,dehydrogenation,desulphonation,and *** provides a positive outlook for the promising future of this field.

关键词： Photocatalyst Photochemical reactions Drugs Natural products Late-stage functionalization

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Enhanced catalytic features of sol-gel immobilized MnP isolated from solid state culture of Pleurotus ostreatus IBL-02

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Chinese Chemical Letters 2013年第4期24卷 344-346页

作者： muhammad Asgher Hafiz muhammad nasir Iqbal Industrial Biotechnology Laboratory Department of Chemistry and BiochemistryUniversity of Agriculture

An indigenous and industrially important manganese peroxidase （MnP） isolated from solid state culture of Pleurotus ostreatus IBL-02 was 2.1-fold purified and immobilized using sol-gel matrix of trimethoxysilane and proplytetramethoxysilane. Lower KM, higher Vmax, hyper-activation, enhanced acidic and thermal stability up to 70 ℃, were the improved]enhanced catalytic features of the presently sol-gel immobilized MnP. A maximum of 100% decolorization was achieved within a short time period for the different real dyes containing textile industry effluents i.e. Nishat textile （NIT）, K＆N textile （KIT）, Sitara textile （SIT）, and Crescent textile （CRT）.

关键词： P. ostreatus IBL-02MnPSol-gelTextile effluentDecolorization

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Outage Probability Analysis of Free Space Communication System Using Diversity Combining Techniques

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Computers, Materials & Continua 2022年第12期73卷 6001-6017页

作者： Hasnain Kashif muhammad nasir Khan Department of Electrical Engineering The University of LahoreLahore54000Pakistan

Recently,free space optical(FSO)communication is gaining much attention towards the research *** reason for this attention is the promises of high data-rate,license-free deployment,and non-interfering *** can,however,give rise to major system difficulties concerning alignment and atmospheric *** is the degradation in the signal quality because of atmospheric channel impairments and *** worst effect is due to fog ***,Radio Frequency(RF)links are able to transmit the data in foggy conditions but not in *** overcome these issues related to both the FSO and RF links.A free space communication system(FSCS)is proposed,in which the hybrid technology is based on the individual FSO and RF *** is a capable solution to overcome the difficulties of the existing systems(FSO and RF)as well as to enhance the overall link reliability and *** this paper,FSCS is investigated in terms of performance throughput(i.e.,outage probability and bit-error-rate(BER))by implementing the receive diversity combining *** analysis of the outage probability of the proposed system along with the individual FSO and RF system is *** results are presented to support the *** is shown that the proposed system outperforms the individual FSO andRF system and gives a power gain of 3dB over a distinct number of receive antennas.

关键词： Atmospheric turbulence free space communication system power management signal independent noise line of sight

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Performance evaluation of multicast relay network using LDPC and convolutional channel codes along-with XOR network coding

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The Journal of China Universities of Posts and Telecommunications 2012年第4期19卷 122-128页

作者： Tariq Aziz nasir Saleem muhammad Iqba School of Information and Communication Beijing University of Posts and Telecommunications

In this paper, we have compared the performance of joint network channel coding （JNCC） for multicast relay network using low density parity check （LDPC） codes and Convolutional codes as channel codes while exclusive or （XOR） network coding used at the intermediate relay nodes. Multicast relay transmission is a type of transmission scheme in which two fixed relay nodes contribute in the second hop of end-to-end transmission between base transceiver station （BTS） and a pair of mobile stations. We have considered one way and two way multicast scenarios to evaluate the bit error rate （BER） and throughput performance. It has been shown that when using XOR network coding at the intermediate relay nodes, the same transmission becomes possible in less time slots hence throughput performance can be improved. Moreover we have also discussed two possible scenarios in the proposed system model, in which both diversity and multiplexing gain has been considered. It is worth notifying that BER and throughput achieved for LDPC codes is better than Convolutional codes for all the schemes discussed.

关键词： cooperative relaying network coding multicast relay networks LDPC codes convolutional codes

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Prediction of Extremist Behaviour and Suicide Bombing from Terrorism Contents Using Supervised Learning

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Computers, Materials & Continua 2022年第3期70卷 4411-4428页

作者： nasir Mahmood muhammad Usman Ghani Khan Department of Computer Science University of Engineering and Technology54890Lahore

This study proposes an architecture for the prediction of extremist human behaviour from projected suicide *** linking‘dots’of police data comprising scattered information of people,groups,logistics,locations,communication,and spatiotemporal characters on different social media groups,the proposed architecture will spawn beneficial *** useful information will,in turn,help the police both in predicting potential terrorist events and in investigating previous ***,this architecture will aid in the identification of criminals and their associates and *** is psychological warfare,which,in the broadest sense,can be defined as the utilisation of deliberate violence for economic,political or religious *** this study,a supervised learning-based approach was adopted to develop the proposed *** dataset was prepared from the suicide bomb blast data of Pakistan obtained from the South Asia Terrorism Portal(SATP).As the proposed architecture was simulated,the supervised learning-based classifiers na飗e Bayes and Hoeffding Tree reached 72.17%*** of the additional benefits this study offers is the ability to predict the target audience of potential suicide bomb blasts,which may be used to eliminate future threats or,at least,minimise the number of casualties and other property losses.

关键词： Extremism terrorism suicide bombing crime prediction pattern recognition machine learning supervised learning

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Analysis of LDPC Code in Hybrid Communication Systems

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Computers, Materials & Continua 2023年第1期74卷 769-781页

作者： Hasnain Kashif muhammad nasir Khan Zubair Nawaz Department of Electrical Engineering The University of LahoreLahore54000Pakistan Department of Data Science University of PunjabLahore54000Pakistan

Free-space optical(FSO)communication is of supreme importance for designing next-generation *** the past decades,the radio frequency(RF)spectrum has been the main topic of interest for wireless *** RF spectrum is becoming denser and more employed,making its availability tough for additional *** communication,exploited for messages or indications in historical times,is now becoming famous and useful in combination with error-correcting codes(ECC)to mitigate the effects of fading caused by atmospheric turbulence.A free-space communication system(FSCS)in which the hybrid technology is based on FSO and *** is a capable solution to overcome the downsides of current schemes and enhance the overall link reliability and *** proposed FSCS with regular low-density parity-check(LDPC)for coding techniques is deliberated and evaluated in terms of signal-to-noise ratio(SNR)in this *** extrinsic information transfer(EXIT)methodology is an incredible technique employed to investigate the sum-product decoding algorithm of LDPC codes and optimize the EXIT chart by applying curve *** this research work,we also analyze the behavior of the EXIT chart of regular/irregular LDPC for the *** also investigate the error performance of LDPC code for the proposed FSCS.

关键词： Free-space communication system low-density parity-check errorcorrecting codes extrinsic information transfer

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