检索结果-南通市图书馆

Protein glycation:a wolf in sweet sheep’s clothing behind neurodegeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 975-976页

作者： Ana B.Uceda Francisco Leal-Pérez miquel Adrover Institut Universitari d’Investigacióen Ciències de la Salut(IUNICS) Institut d’InvestigacióSanitària Illes Balears(IdISBa) Departament de Química Universitat de les Illes BalearsCtraPalma de MallorcaSpain

At the beginning of the 16th century,Paracelsus coined the maxim:“the dose makes the poison”.This principle can be applied to all living organisms,including organs and *** brain and its glial and neuronal cells are ... 详细信息

关键词： organs sheep sweet

Crohnology: A tale of time and times and inflammatory bowel diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第36期14卷 5489-5490页

作者： Fernando Gomollón Javier P Gisbert miquel ngel Gassull Hospital Clínico Universitario Zaragoza Spain Centro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas CIBEREHD IACS Spain Hospital Universitario de la Princesa CIBEREHD Madrid Spain Instituto de Investigación en Ciéncias de la Salud Fundación Germans Trias i Pujol CIBEREHD Badalona Spain

Time, times and timing are key words in inflammatory bowel diseases （IBD）. The leifmotif of this issue or World Journal of Gastroenterology is time. We have asked experts to review on the epidemiology of these diseases over time, the changes in innate immunity that could be present in the first time, and then the timing of key treatments. The correct time of using azathioprine, mercaptopurine, infliximab, cyclosporine and surgery are reviewed. We have chosen experts with not only great clinical expertise but also personal interest in clinical and basic investigation. Our goal in this monograph is to get an idea not only of the present but of the immediate future in some of the key management issues in IBD. To this end, we think that the authors are the most adequate.

关键词： Inflammatory bowel diseases Epidemiology Innate immunity Treatment

No Effects of Meteorological Factors on the SARS-CoV-2 Infection Fatality Rate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2021年第11期34卷 871-880页

作者： SOLANES Aleix LAREDO Carlos GUASP Mar fullana miquel Angel FORTEA Lydia GARCIA-OLIVE Ignasi SOLMI Marco SHIN Jae II URRA Xabier RADUA Joaquim Institut d'lnvestigacions Biomediques August Pi i Sunyer(IDIBAPS) BarcelonaSpain Department of Psychiatry and Forensic Medicine Autonomous University of BarcelonaBarcelonaSpain Neurosciences Unit Hospital ClinicBarcelonaSpain Adult Psychiatry and Psychology Department Institute of NeurosciencesHospital ClinicBarcelonaSpain Biomedical Network Research Centre on Mental Health(CIBERSAM) Instituto de Salud Carlos IIIMadridSpain Department of Medicine University of BarcelonaBarcelonaSpain Department of Medicine Autonomous University of BarcelonaBarcelonaSpain Pneumology Department Hospital Germans Trias i PujolBadalonaSpain Neurosciences Department University of PaduaPaduaItaly Padua Neuroscience Center PaduaItaly Department of Psychosis Studies Institute of PsychiatryPsychology and NeuroscienceKing's College LondonLondonUK Department of Pediatrics College of MedicineYonsei UniversitySeoul 03722Korea Centre for Psychiatric Research and Education Department of Clinical NeuroscienceKarolinska InstitutetStockholmSweden

Objective Previous studies have shown that meteorological factors may increase COVID-19 mortality,likely due to the increased transmission of the ***,this could also be related to an increased infection fatality rate(IFR).We investigated the association between meteorological factors(temperature,humidity,solar irradiance,pressure,wind,precipitation,cloud coverage)and IFR across Spanish provinces(n=52)during the first wave of the pandemic(weeks 10–16 of 2020).Methods We estimated IFR as excess deaths(the gap between observed and expected deaths,considering COVID-19-unrelated deaths prevented by lockdown measures)divided by the number of infections(SARS-CoV-2 seropositive individuals plus excess deaths)and conducted Spearman correlations between meteorological factors and IFR across the *** We estimated 2,418,250 infections and 43,237 *** IFR was 0.03%in<50-year-old,0.22%in 50–59-year-old,0.9%in 60–69-year-old,3.3%in 70–79-year-old,12.6%in 80–89-year-old,and26.5%in≥*** did not find statistically significant relationships between meteorological factors and adjusted ***,we found strong relationships between low temperature and unadjusted IFR,likely due to Spain’s colder provinces’aging *** The association between meteorological factors and adjusted COVID-19 IFR is *** age differences or ignoring COVID-19-unrelated deaths may severely bias COVID-19 epidemiological analyses.

关键词： Climate COVID-19 Infection fatality rate SARS-CoV-2 Temperature Weather

Low field microwave absorption and magnetization process in CoFeNi electroplated wires

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2008年第4期17卷 1430-1435页

作者： H.García-miquel G.V.Kurlyandskay E.T.S.I.Telecomunicación Dpto.Ing.ElectrónicaUniversidad Politcnica de ValenciaCamino de Vera s/nValencia 46022Spain Universidad del País Vasco UPV-EHU Dept.Electricidad y ElectrónicaApdo.644Bilbao 48080Spain Department of Physics Ferromagnetic Resonance GroupUniversity of MarylandCollege ParkMaryland 20742-4111USA

Ferromagnetic resonance （FMR）, Ferromagnetic antirresonance （FMAR） and low field magnetoimpedance （MI） are the characteristic features of high frequency losses in applied fields. While some results on FMR and FMAR in CoFeNi electroplated wires were reported earlier, here we present microwave absorption in CuBe wires electroplated by 1 μm FeCoNi magnetic layer at very low fields. These data are comparatively analysed together with longitudinal hysteresis loops in order to reveal the correlation between power absorption and magnetization processes. Microwave studies are made by using the cavity perturbation method at 9.65 GHz for a DC field parallel to the sample axis, and with microwave magnetic field hrf parallel or perpendicular to the wire axis. Two peaks have been observed in all samples, one is due to FMR, and the other is, at very low fields, related to MI. The MI peaks represent minima in power absorption. By comparing with the hysteresis loop we remark the close correspondence between the MI phenomena in the axial mode and the concomitant magnetization process.

关键词： microwave absorption magnetoimpedance electroplated wires

Are we giving azathioprine too late? The case for early immunomodulation in inflammatory bowel disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第36期14卷 5512-5518页

作者： María Josefina Etchevers Montserrat Aceituno miquel Sans Department of Gastroenterology Hospital Posadas Buenos Aires Argentina Department of Gastroenterology Hospital Clínic i Provincial/IDIBAPS Barcelona CIBER Enfermedades Hepáticas y Digestivas Spain

Inflammatory bowel disease (IBD) includes two entities, Crohn’s disease and ulcerative colitis. Both are chronic conditions with frequent complications and surgical procedures and a great impact on patient’s quality of life. The thiopurine antimetabolites azathioprine and 6-mercaptopurine are widely used in IBD patients. Current indications include maintenance therapy, steroid-dependant disease, fistula closure, prevention of infliximab immunogenicity and prevention of Crohn’s disease recurrence. Surprisingly, the wide use of immunosuppressants in the last decades has not decreased the need of surgery, probably because these treatments are introduced at too late stages in disease course. An earlier use of immunossupressants is now advocated by some authors. The rational includes: (1) failure to modify IBD natural history of present therapeutic approach, (2) demonstration that azathioprine can induce mucosal healing, a relevant prognostic factor for Crohn’s disease and ulcerative colitis, and (3) demonstration that early immunossupression has a very positive impact on pediatric, recently diagnosed Crohn’s disease patients. We are now awaiting the results of new studies, to clarify the contribution of azathioprine, as compared to infliximab (SONIC Study), and to demonstrate the usefulness of azathioprine in recently diagnosed adult Crohn’s disease patients (AZTEC study).

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Immunosuppressants Azathioprine

Familial aggregation in inflammatory bowel disease:Is it genes or environment?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第22期17卷 2715-2722页

作者： Tiago Nunes Gionata Fiorino Silvio Danese miquel Sans Department of Gastroenterology Hospital Clinic i Provincial/IDIBAPS CIBER EHD 08036 Barcelona Spain Division of Gastroenterology IRCCS Istituto Clinico Humanitas Rozzano Milan 20089 Italy

Inflammatory bowel disease (IBD) develops in genetically susceptible individuals due to the influence of environmental factors, leading to an abnormal recognition of microbiota antigens by the innate immune system which triggers an exaggerated immune response and subsequent bowel tissue damage. IBD has been more frequently found in families, an observation that could be due to either genetic, environmental or both types of factors present in these families. In addition to expanding our knowledge on IBD pathogenesis, defining the specific contribution to familial IBD of each one of these factors might have also clinical usefulness. We review the available evidence on familial IBD pathogenesis.

关键词： Inflammatory bowel disease Familial aggregation Familial clustering Environmental factors Genetics Genome wide association studies

Depressive symptoms in neurodegenerative diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2015年第8期3卷 682-693页

作者： miquel Baquero Nuria Martín Servei de Neurologia Hospital Universitari i Politècnic La Fe

Depressive symptoms are very common in chronic conditions. This is true so for neurodegenerative diseases. A number of patients with cognitive decline and dementia due to Alzheimer's disease and related conditions like Parkinson's disease, Lewy body disease, vascular dementia, frontotemporal degeneration amongst other entities, experience depressive symptoms in greater or lesser grade at some point during the course of the illness. Depressive symptoms have aparticular significance in neurological disorders, specially in neurodegenerative diseases, because brain, mind, behavior and mood relationship. A number of patients may develop depressive symptoms in early stages of the neurologic disease, occurring without clear presence of cognitive decline with only mild cognitive deterioration. Classically, depression constitutes a reliable diagnostic challenge in this setting. However, actually we can recognize and evaluate depressive, cognitive or motor symptoms of neurodegenerative disease in order to establish their clinical significance and to plan some therapeutic strategies. Depressive symptoms can appear also lately, when the neurodegenerative disease is fully developed. The presence of depression and other neuropsychiatric symptoms have a negative impact on the quality-of-life of patients and caregivers. Besides, patients with depressive symptoms also tend to further decrease function and reduce cognitive abilities and also uses to present more affected clinical status, compared with patients without depression. Depressive symptoms are treatable. Early detection of depressive symptoms is very important in patients with neurodegenerative disorders, in order to initiate the most adequate treatment. We review in this paper the main neurodegenerative diseases, focusing in depressive symptoms of each other entities and current recommendations of management and treatment.

关键词： Neurodegenerative diseases Alzheimer Depressive symptoms Frontotemporal degeneration Vascular dementia Lewy body disease Depression Dementia

Multi-agent system simulation for urban policy design:open space land use change problem

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Modeling, Simulation, and Scientific Computing 2016年第2期7卷 20-37页

作者： Roman Buil miquel Angel Piera Egils Ginters Logistics and Aeronautics Unit Universitat Autonoma de Barcelona c.Emprius2 Sabadell 08202Spain Vidzeme University of Applied Sciences Cesu Street 4 Valmiera LV-4201Latvia

Multi-agent system(MAS)models have been increasingly applied to the simulation of complex phenomena in different areas,providing successful and credible *** behavior related to a specific urban activity(i.e.,recreation activities in a park,using bicycle for mobility purposes)can be modeled as an agent(actor)with several affinities and preferences which are dependent on aspects that affect the activity.A particular application of a MAS approach is in area of urban policy design,in which policies should be designed considering citizens needs,preferences and *** an open space in a city is available(i.e.,an industry is moved to an industrial area),a land use policy should contribute to identify the new use for the urban *** are different land use policies that can be applied depending on which services or facilities must be empowered in the *** is important to identify the correct policy in order to satisfy present citizens needs but considering also the future needs in a social changing context.A socio-technological simulation model has been developed to allow citizens to get a better understanding of the urban problem,its dynamics and explore the sustainability of the different solutions.,enhancing citizens to participate in the urban decisions through new technologies(i.e.,e-participation).This paper illustrates an open space MAS simulation model for land use design policies in which citizens can check their opinion and get a better understanding of the different choices and its acceptability by the community considering not only present neighborhood profiles,but also future neighborhood *** is the first step before the development of the final software including a user friendly interface to let citizens with different cultural profiles to perform simulations as an essential and neutral tool to reach consensus during the decision-making process in urban policy design.

关键词： Agent simulation,urban policy open space e-governance e-participation

The Janus face of N-terminal lysines in α-synuclein

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第10期15卷 1840-1841页

作者： Ana Belén Uceda Laura Mari?o miquel Adrover Institut Universitari d’Investigació en Ciències de la Salut (IUNICS) Institut d’Investigació Sanitària Illes Balears (Id ISBa) Departament de Química Universitat de les Illes Balears

Parkinson’s disease(PD)is the second most prevalent progressive neurodegenerative disorder after Alzheimer’s *** usually starts with a tremor in the extremities(usually in the hands)and gradually evolves with other symptoms such as bradykinesia,muscle stiffness,impaired posture,loss of automatic movements or speech *** symptoms worsen as the condition progresses and eventually lead to death.

关键词： impaired Alzheimer eventually