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Microscopic study on stress-strain relation of granular materials

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Chinese Science Bulletin 2009年第23期54卷 4349-4357页

作者： liu SiHong YAO YangPing SUN QiCheng LI TieJun liu minzhi State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 China Department of Civil Engineering Beihang University Beijing 100191 China State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing 100084 China

A biaxial shearing test on granular materials is numerically simulated by distinct element method (DEM). The evolution of the microstructures of granular materials during isotropic compression and shearing is investigated, on which a yield function is derived. The new yield function has a similar form as the one used in the modified Cam-clay model and explains the yield characteristics of granular materials under the isotropic compression and shear process through the change of the contact distribution N(θ) defining the contacts at particle contact angle θ.

关键词：微观结构应力应变关系颗粒物质颗粒材料各向同性剪切过程离散单元法产量性状

Establishment of a selective evaluation method for DPP4 inhibitors based on recombinant human DPP8 and DPP9 proteins

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Acta Pharmaceutica Sinica B 2014年第2期4卷 135-140页

作者： Jinglong liu Yi Huan Caina Li minzhi liu Zhufang Shen State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Diabetes Research CenterInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Dipeptidyl peptidase 4(DPP4)is recognised as an attractive anti-diabetic drug target,and several DPP4 inhibitors are already on the *** members of the same gene family,dipeptidyl peptidase 8(DPP8)and dipeptidyl peptidase 9(DPP9)share high sequence and structural homology as well as functional activity with ***,the inhibition of their activities was reported to cause severe ***,the development of DPP4 inhibitors that do not have DPP8 and DPP9 inhibitory activity is critical for safe anti-diabetic *** achieve this goal,we established a selective evaluation method for DPP4 inhibitors based on recombinant human DPP8 and DPP9 proteins expressed by Rosetta *** this method,we used purified recombinant 120 kDa DPP8 or DPP9 protein from the Rosetta expression *** optimum concentrations of the recombinant DPP8 and DPP9 proteins were 30 ng/mL and 20 ng/mL,respectively,and the corresponding concentrations of their substrates were both 0.2 mmol/*** method was highly reproducible and reliable for the evaluation of the DPP8 and DPP9 selectivity for DPP4 inhibitor candidates,which would provide valuable guidance in the development of safe DPP4 inhibitors.

关键词： DPP4 DPP8 DPP9 Inhibitor Selective evaluation method

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信息化背景下智慧社区的建设研究

数字通信世界 2024年第1期 7-9页

作者：崔宏尧刘敏智于志宏李杰殷秀莉衡水职业技术学院河北衡水053000

文章从信息化背景下智慧社区的建设入手,探讨了智慧社区建设的现状和存在的问题,分析了智慧社区建设所面临的挑战,并提出了相应的解决方案,旨在为智慧社区的建设和发展提供参考和借鉴。

关键词：信息技术大数据智慧社区服务模式社区管理

Effect of Coated PHB on Properties of Abradable Seal Coating

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Journal of Wuhan University of Technology(Materials Science) 2014年第3期29卷 417-421页

作者：程旭东 XIANG Hongyu YE Weiping MENG Xiaoming MIN Jie liu minzhi ZHANG Pu LU Wei State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology College of Materials Science and Engineering Wuhan University of Technology

As pore-forming materials, the coated polyop-hydroxybenzoate（short for PHB） and h-BN can be applied in the preparation of abradable seal coatings at high temperature. The characteristics of coating such as morphology, thermal stability and composition were studied by SEM, EDS and FTIR. The results show that the modified PHB will change the remained carbon amount, porosity and pore morphology of the coating, which can affect the properties of coatings. If the pore is small enough in uniform distribution, the coating with 5 MPa bond strength, 30-55 HR45Y superficial hardness and certain of carbon can be suitable to well abradability.

关键词： coated-PHB pore morphology seal coating

SCF FEATURE OF AUSTENITIC STAINLESS STEEL IN BOILING MgCl_2SOLUTION

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Acta Metallurgica Sinica(English Letters) 1992年第12期5卷 451-456页

作者： CHEN Liangshi GAO Xuejie FENG Tao liu minzhi Corrosion Science Laboratory,Institute of Corrosion and Protection of Metals,Academia,Sinica Shenyang,China Inst of Corrosion and Protection of metals Acad Sinica Shenyang China

Corrosion fatigue under the load of low frequency and bigh mean stress has been generally defined as stress corrosion fatigue(SCF).It is a specific failure process due to the inter- action between stress corrosion cracking(SCC) and corrsion fatigue(CF),the effects of which on fracture characteristics,including crack initiation and *** life and cracking mode have not been investigated *** purpose of this pa- per was to study the environment-sensitive fracture behaviour of OCr18Ni9Ti austenitic stainless steel under the load of different fiequencies and high mean stress in boiling MgCl_2 *** interaction between SCC and CF would be emphasized.

关键词： stress corrosion eracking corrosion fatigue erack growth rate eracking mode austenitic stainless steel

The human-derived novel gut commensal Luoshenia tenuis regulates body weight and food intake in mice

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Food Science and Human Wellness 2024年第2期13卷 830-841页

作者： Yu Jiang Mengxuan Du Lisheng Xie minzhi Jiang Yaokun Zhang Mingxia Bi Chang liu Hongwei liu Shuangjiang liu State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China College of Life Science Hebei UniversityBaoding 071000China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Many studies have revealed that gut microbes modulate host *** this study,we characterized the therapeutic effects of a novel gut commensal Luoshenia tenuis against host metabolic ***,by in silico analysis,we demonstrated that the *** was prevalent in the gut microbiomes of healthy humans but were depleted specifically in obesity *** in vitro cultivation revealed that *** produced short chain fatty acids that were verified to modulate host metabolism and some other volatile metabolites to benefit hosts by anti-inflammation and ***,gavage of the *** significantly decreased the body weight gain and food intake of high-fat diet-feeding C57BL/6J mice,which was in parallel with the changed expression level of genes related to satiety and feeding *** then performed the gavage trial using diet induced obese mice,and it revealed that the administration of *** alleviated significantly the abnormal glucose and lipid metabolisms and reduced the inflammatory *** summary,this study revealed a previously-unknown human gut commensal microbe that benefited host metabolism,and set the stage for the development of novel next-generation probiotic applicable for treatment of obesity and related metabolic disorders.

关键词： Luoshenia tenuis Gut microbe Feeding behavior Obesity Next-generation probiotic

Preliminary study of analgesic effect of scorpion venom on central Mervous　system

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吉林大学学报(医学版) 1994年第4期20卷 323-325页

作者： He Yan,liu minzhi,Wei Junjie (Department of Physiology and Inorganic Chemistry) 白求恩医科大学生理系吉林长春白求恩医科大学无机化学系吉林长春

ＰｒｅｌｉｍｉｎａｒｙｓｔｕｄｙｏｆａｎａｌｇｅｓｉｃｅｆｆｅｃｔｏｆｓｃｏｒｐｉｏｎｖｅｎｏｍｏｎｃｅｎｔｒａｌｎｅｒｖｏｕｓｓｙｓｔｅｍＨｅＹａｎ，ＬｉｕＭｉｎｚｈｉ，ＷｅｉＪｕｎｊｉｅ（Ｄｅｐａｒｔｍｅｎｔｏｆ... 详细信息

ＰｒｅｌｉｍｉｎａｒｙｓｔｕｄｙｏｆａｎａｌｇｅｓｉｃｅｆｆｅｃｔｏｆｓｃｏｒｐｉｏｎｖｅｎｏｍｏｎｃｅｎｔｒａｌｎｅｒｖｏｕｓｓｙｓｔｅｍＨｅＹａｎ，ＬｉｕＭｉｎｚｈｉ，ＷｅｉＪｕｎｊｉｅ（ＤｅｐａｒｔｍｅｎｔｏｆＰｈｙｓｉｏｌｏｇｙａｎｄＩｎｏｒ...

关键词： orpion venom analgesics/pharmacology rain/drug efects

THE ANALGESIA EFFECT OF RED NUCLEUS AND STRENGTHENING EFFECT THERE OF TO THE ACUPUNCTURE ANALGESIA

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针刺研究 1989年第Z1期 76-77页

作者： liu minzhi liu Xianguo liu Baiyun Department, of Physiology, N. Bethune University of Medical Sciences, Changchun

In general, it is believed that the red nucleus (RN) was related in controlof somatic movement and muscle tonus. Recently there have been few reportson its modulation of sensory function. The present study manifests the ana-lgesic effect of RN and the relationship between RN and acupuncture analgesia. The pain modulation function of RN was researched with tail flick reflexof rats as the standard of the pain threshold. The pain threshold of tailflick reflex was raised significantly by bilateral microinjection of L-glutamate

关键词： NRM THE ANALGESIA EFFECT OF RED NUCLEUS AND STRENGTHENING EFFECT THERE OF TO THE ACUPUNCTURE ANALGESIA

Analysis of the Cut-thickness in the Process of Gear Shaping

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工程科学（英文版） 2005年第3期3卷 85-87页

作者： Wang minzhi liu Yusong Hu Jingxiang Dept. of Mech. ＆ Elect. Eng Hunan Institute of EngineeringXiangtan 411101

For helping find out the cause of the extrusion wound of gear and the abnormal abrasion wear in the process of gear shaping, this disquisition studies the varying law of the cut-thickness of chips in gear shaping and ... 详细信息

关键词：齿轮传动反常磨损齿轮修整切削厚度