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Does laparoscopic resection for colorectal cancer liver metastasis have a long-term oncologic advantage?

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 246-248页

作者： Yasushi Hasegawa minoru kitago Yuta Abe Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyoJapan

The long-term advantages of laparoscopic liver resection(LLR)over open liver resection(OLR)for colorectal cancer liver metastasis(CLM)have not been *** et al.(1)recently published an interesting article in the Annals of Surgery,titled“Survival Advantage of Laparoscopic Versus Open Resection for Colorectal Liver Metastases:A Meta-analysis of Individual Patient Data from Randomized Trials and Propensity-score Matched Studies.”The authors performed a meta-analysis of individual participant data from two randomized trials and thirteen propensity score-matched studies that compared long-term outcomes between patients undergoing LLR and OLR for CLM.A total of 1,275 patients who underwent LLR and 1,873 patients who underwent OLR were *** found that LLR was associated with a lower risk of death and concluded that LLR had a long-term survival benefit compared to OLR.

关键词： metastasis Surgery liver

Pre-hepatectomy type Ⅳ collagen 7S predicts post-hepatectomy liver failure and recovery

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World Journal of Gastroenterology 2020年第7期26卷 725-739页

作者： Masatsugu Ishii Osamu Itano Masahiro Shinoda minoru kitago Yuta Abe Taizo Hibi Hiroshi Yagi Ayano Takeuchi Hanako Tsujikawa Tokiya Abe Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery International University of Health and Welfare School of MedicineChiba 286-8686Japan Department of Pediatric Surgery and Transplantation Kumamoto UniversityKumamoto 860-8556Japan Department of Public Health Keio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Liver resection is an effective treatment for benign and malignant liver ***,a method for preoperative evaluation of hepatic reserve has not yet been *** reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic *** determining eligibility for hepatectomy,the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative *** To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function *** This study was a retrospective cohort *** retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December *** post-hepatectomy liver failure(PHLF)was defined using the International Study Group of Liver Surgery’s definition of ***-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of2.8 g/dL,respectively,and the time taken for Child-Pugh score to return to Child-Pugh class *** Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver *** analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S≤6 ng/mL than in those with type IV collagen 7S>6 ng/*** additional analyses,similar results were observed in patients without chronic viral hepatitis associated with *** Preoperative type IV collagen 7S is a preoperative predictor of PHLF and longterm postoperative liver function *** can also be used in patients without chron

关键词： Hepatectomy Liver failure Type Ⅳ collagen 7S Liver fibrosis Postoperative complications Long-term postoperative liver function recovery

Two cases of pancreatic ductal adenocarcinoma with intrapancreatic metastasis

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World Journal of Gastroenterology 2016年第41期22卷 9222-9228页

作者： Yusuke Fujita minoru kitago Yohei Masugi Osamu Itano Masahiro Shinoda Yuta Abe Taizo Hibi Hiroshi Yagi Yoko Fujii-Nishimura Michiie Sakamoto Yuko Kitagawa Department of Surgery Keio University School of Medicine Department of Pathology Keio University School of Medicine

There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma(PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature.

关键词： Carcinoma Pancreatic ductal Neoplasm micrometastasis Recurrence Carcinogenesis

First successful perinatal management of pregnancy after ABO-incompatible liver transplantation

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World Journal of Gastroenterology 2017年第3期23卷 547-550页

作者： Hisanobu Higashi Hideaki Obara Kei Miyakoshi Masahiro Shinoda minoru kitago Naoki Shimojima Yuta Abe Taizo Hibi Hiroshi Yagi Kentaro Matsubara Yohei Yamada Osamu Itano Ken Hoshino Tatsuo Kuroda Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Department of Pediatric Surgery Keio University School of MedicineTokyo 160-8582Japan

Many papers have reported on pregnancy and delivery after liver transplantation, but there have been no reports on pregnancy after ABO-incompatible liver transplantation. This paper reports the first successful pregnancy and delivery of a newborn after ABOincompatible liver transplantation for fulminant hepatic failure. The patient was a 39-year-old female. She had an ABO-incompatible liver transplantation, donated from her husband, due to subacute fulminant hepatitis of unknown etiology. She was taking tacrolimus, methylprednisolone, and mizoribine orally for the maintenance of immunosuppression at the time of discharge. She was discharged uneventfully on postoperative day 38 without any rejection episodes. At 1 year and 6 mo after transplantation, she indicated a wish to become pregnant. Therefore, treatment with mycophenolate mofetil was interrupted at that time. After two miscarriages, she finally became pregnant and delivered transvaginally 3 years after the transplantation. All of the pregnancies were conceived naturally. The newborn was female with a birth weight of 3146 g; the Apgar scores were 9 and 10. Delivery was performed smoothly, and the newborn exhibited no malformations. The mother and the newborn were discharged uneventfully. We suggest that pregnancy is possible for recipients after ABO-incompatible liver transplantation.

关键词： Pregnancy Liver transplantation Delivery Fulminant hepatic failure ABO-incompatible Living donor

Peritoneal dissemination of pancreatic cancer caused by endoscopic ultrasound-guided fine needle aspiration:A case report and literature review

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World Journal of Gastroenterology 2021年第3期27卷 294-304页

作者： Hideaki Kojima minoru kitago Eisuke Iwasaki Yohei Masugi Yohji Matsusaka Hiroshi Yagi Yuta Abe Yasushi Hasegawa Shutaro Hori Masayuki Tanaka Yutaka Nakano Yusuke Takemura Seiichiro Fukuhara Yoshiyuki Ohara Michiie Sakamoto Shigeo Okuda Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Department of Radiology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)is a biopsy technique widely used to diagnose pancreatic tumors because of its high sensitivity and *** needle-tract seeding caused by EUS-FNA has been recently reported,dissemination of pancreatic cancer cells is generally considered to be a rare complication that does not affect patient ***,the frequency of dissemination and needle-tract seeding appears to have been *** present a case of peritoneal dissemination of pancreatic cancer due to preoperative *** SUMMARY An 81-year-old man was referred to the Department of Surgery of our hospital in Japan owing to the detection of a pancreatic mass on computed tomography during medical ***-gastric EUS-FNA revealed that the mass was an adenocarcinoma;hence laparoscopic distal pancreatectomy with lymphadenectomy was *** intraoperative peritoneal dissemination and liver metastasis were visually detected,and pelvic lavage cytology was negative for carcinoma *** postoperative surgical specimen was negative for carcinoma cells at the dissected margin and the cut end margin;however,pathological findings revealed adenocarcinoma cells on the peritoneal surface proximal to the needle puncture site,and the cells were suspected to be disseminated via ***,the patient received adjuvant therapy with S-1(tegafur,gimeracil,and oteracil potassium);however,computed tomography performed 5 mo after surgery revealed liver metastasis and cancerous *** patient received palliative therapy and died 8 mo after the *** The indications of EUS-FNA should be carefully considered to avoid iatrogenic dissemination,especially for cancers in the pancreatic body or tail.

关键词： Case report Pancreatic carcinoma Endoscopic ultrasound-guided fine needle aspiration Peritoneal dissemination Cancerous peritonitis Biopsy

Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature

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World Journal of Gastroenterology 2019年第15期25卷 1899-1906页

作者： Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano minoru kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa Department of Surgery Keio University School of Medicine Department of Pathology Keio University School of Medicine Division of Hematology Department of Medicine Keio University School of Medicine

BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and *** This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation.

关键词： Cytomegalovirus gastrointestinal disease Colon perforation Antigenemia negative Liver transplantation Case report

Helicobacter cinaedi bacteremia with cellulitis after ABO-incompatible living-donor liver transplantation: Case report

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World Journal of Gastroenterology 2015年第25期21卷 7911-7915页

作者： Kohei Mishima Hideaki Obara Kayoko Sugita Masahiro Shinoda minoru kitago Yuta Abe Taizo Hibi Hiroshi Yagi Kentaro Matsubara Takehiko Mori Yaoko Takano Hiroshi Fujiwara Osamu Itano Naoki Hasegawa Satoshi Iwata Yuko Kitagawa Department of Surgery Keio University School of Medicine Center for Infectious Diseases and Infection Control Keio University School of Medicine Division of Hematology the Department of Medicine Keio University School of Medicine Department of Infectious Diseases Keio University School of Medicine

Helicobacter cinaedi(H. cinaedi), a Gram-negative spiral-shaped bacterium, is an enterohepatic nonHelicobacter pylori Helicobacter species. We report the first case of H. cinaedi bacteremia with cellulitis after liver transplantation. A 48-year-old male, who had been a dog breeder for 15 years, underwent ABO-incompatible living-donor liver transplantation for hepatitis C virus-induced decompensated cirrhosis using an anti-hepatitis B core antibody-positive graft. The patient was preoperatively administered rituximab and underwent plasma exchange twice to overcome blood type incompatibility. After discharge, he had been doing well with immunosuppression therapy comprising cyclosporine, mycophenolate mofetil, and steroid according to the ABO-incompatible protocol of our institution. However, 7 mo after transplantation, he was admitted to our hospital with a diagnosis of recurrent cellulitis on the left lower extremity, and H. cinaedi was detected by both blood culture and polymerase chain reaction analysis. Antibiotics improved his symptoms, and he was discharged at day 30 after admission. Clinicians should be more aware of H. cinaedi in immunocompromised patients, such as ABO-incompatible transplant recipients.

关键词： Helicobacter cinaedi Bacteremia Cellulitis Liver transplantation Hepatitis C Living-donor ABOincompatible HBc-Ab-positive donor

Humanoid robot heads for human-robot interaction:A review

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Science China(Technological Sciences) 2024年第2期67卷 357-379页

作者： LI Yi ZHU LiXiang ZHANG ZiQian GUO MingFei LI ZhiXin LI YanBiao HASHIMOTO minoru Key Laboratory of Special Purpose Equipment and Advanced Processing Technology of Ministry of Education Zhejiang University of TechnologyHangzhou 310023China Zhejiang Provincial Key Laboratoryof Special Purpose Equipment and Advanced Processing Technology Zhejang Universityof Technology Hangzhou 310023 China Faculy of Textile Science and Technology Shinshu UniversityUeda 386-8567Japan

The humanoid robot head plays an important role in the emotional expression of human-robot interaction(HRI).They are emerging in industrial manufacturing,business reception,entertainment,teaching assistance,and tour *** recent years,significant progress has been made in the field of humanoid ***,there is still a lack of humanoid robots that can interact with humans naturally and *** review comprises a comprehensive survey of state-of-the-art technologies for humanoid robot heads over the last three decades,which covers the aspects of mechanical structures,actuators and sensors,anthropomorphic behavior control,emotional expression,and human-robot ***,the current challenges and possible future directions are discussed.

关键词： humanoid robot head anthropomorphic behaviors emotional expression human-robot interaction

Swimmer with submerged SiO_(2)/Al/LiNbO_(3) surface acoustic wave propulsion system

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Biomimetic Intelligence & Robotics 2024年第2期4卷 71-77页

作者： Deqing Kong Ryo Tanimura Fang Wang Kailiang Zhang minoru Kuribayashi Kurosawa Manabu Aoyagi Department of Engineering Muroran Institute of TechnologyMuroran 050-8585Japan Tianjin Key Laboratory of Film Electronic and Communication Devices School of Integrated Circuit Science and EngineeringTianjin University of TechnologyTianjin 300384China School of Engineering Tokyo Institute of TechnologyYokohama 226-8501Japan

Acoustic propulsion system presents a novel underwater propulsion approach in small scale *** study introduces a submerged surface acoustic wave(SAW)propulsion system based on the SiO_(2)/Al/LiNbO_(3) *** 19.25 MHz,the SAW propulsion system is proposed and investigated by the propulsion force calculation,PIV measurements and propulsion measurements.3.3 mN propulsion force is measured at 27.6 V_(pp).To evaluate the miniature swimmer,the SAW propulsion systems with multiple frequencies are *** 2.2 W,the submerged SAW propulsion system at 38.45 MHz demonstrates 0.83 mN/mm^(2) propulsion *** 96.13 MHz and 24 V_(pp),the movements of miniature swimmer with a fully submerged SAW propulsion system are recorded and analyzed to a maximum of 177 mm/*** of miniaturization,high power density,and simple structure,the SAW propulsion system can be expected for some microrobot applications,such as underwater drone,pipelinerobotand intravascularrobot.

关键词： Acoustofluidics Surface acoustic wave Swimmer Underwater propulsion system