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Programmed cell death ligand-1(PD-L1) expression by immunohistochemistry: could it be predictive and/or prognostic in non-small cell lung cancer?

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Cancer Biology & Medicine 2016年第2期13卷 157-170页

作者： Mari mino-kenudson Department of Pathology Massachusetts General Hospital & Harvard Medical School

Blockade of immune checkpoints has recently emerged as a novel therapeutic strategy in various tumors. In particular,monoclonal antibodies targeting programmed cell death 1(PD-1) or its ligand(PD-L1) have been most studied in lung cancer,and PD-1 inhibitors are now established agents in the management of non-small cell lung cancer(NSCLC). The reports on highprofile clinical trials have shown the association of PD-L1 expression by immunohistochemistry(IHC) with higher overall response rates to the PD-1/PD-L1 axis blockade suggesting that PD-L1 expression may serve as a predictive marker. Unfortunately,however, each PD-1 or PD-L1 inhibitor is coupled with a specific PD-L1 antibody, IHC protocol and scoring system for the biomarker assessment, making the head-to-head comparison of the studies difficult. Similarly, multiple clinical series that correlated PD-L1 expression with clinicopathologic and/or molecular variables and/or survival have reported conflicting *** discrepancy could be explained by the differences in ethnicity and/or histologic types included in the studies, but it appears to be attributed in part to the differences in PD-L1 IHC methods. Thus, orchestrated efforts to standardize the PD-L1 IHC are warranted to establish the IHC as a predictive and/or prognostic biomarker in NSCLC.

关键词： PD-L1 PD- 1 immunohistochemistry predictive biomarker

Comparison of conventional and inverted A^2/O processes:Phosphorus release and uptake behaviors

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Journal of Environmental Sciences 2012年第4期24卷 571-578页

作者： Rong Qi Tao Yu Zheng Li Dong Li Takashi mino Tadashi Shoji kochi Fujie Min Yang State key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Socio-Cultural Environmental Studies Graduate School of Frontier SciencesThe University of TokyoKashiwaJapan Graduate School of Environment and Information Sciences Yokohama National UniversityYokohamaKanagawa 240-850Japan

Two full-scale systems operated in parallel, a conventional A2/O system consisting of anaerobic, anoxic and oxic compartments in succession and an inverted system consisting of anoxic, anaerobic and oxic compartments without internal recycle, were compared in terms of their phosphorus removal performance, with an emphasis on phosphate （P） release behaviors, using both operational data and simulation results. The inverted system exhibited better long-term phosphorus removal performance （0.2 ± 0.3 vs. 0.7 ±0.7 mg/L）, which should be attributed to the higher P release rate （0.79 vs. 0.60 kg P/（kg ***）） in the non-aerated compartments. The P release occurred in both the anoxic and anaerobic compartments of the inverted system, resulting in more efficient P release. Although the abundances of the ＇Candidatus Accumulibacter phosphatis＇ population in the two systems were quite similar （（19.1 ＋ 3.27）% and （18.4 ＋ 4.15）% of the total microbe （DAPI stained particles） population in the inverted and conventional systems, respectively, by fluorescence in situ hybridization （FISH））, the high-concentration DAPI staining results show that the abundances of the whole polyphosphate accumulating organisms （PAOs） in the aerobic ends were quite different （the average ratios of the poly-P granules to total microbes （DAPI stained particles） were （45 ±4.18）% and （35 ± 5.39）%, respectively）. Both the operational data and simulation results showed that the inverted system retained more abundant PAO populations due to its special configuration, which permitted efficient P release in the non-aerated compartment and better P removal,

关键词： phosphate release and uptake A2/O process inverted A2/O process activated sludge model

Simulation of long-term nutrient removal in a full-scale closed-loop bioreactor for sewage treatment： an example of Bayesian inference

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Frontiers of Environmental Science & Engineering 2015年第3期9卷 534-544页

作者： Zheng LI Rong QI Wei AN Takashi mino Tadashi SHOJI Willy VERSTRAETE Jian GU Shengtao LI Shiwei XU Min YANG State key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100086 China Socio-Cultural Environmental Studies the University of Tokyo Kashiwa City 277-8563 Japan Environmental Science Research Laboratory Central Research Institute of Electric Power Industry Chiba 270-1194 Japan Laboratory of Microbial Ecology and Technology (LabMET) Ghent University Gent 9000 Belgium Beijing Drainage Group Co. Ltd Beijing 100044 China

In this study, the performance of nitrogen and phosphorus removal in a full-scale closed-loop bioreactor （oxidation ditch） system was simulated using the ASM2d model. Routine data describing the process for two years were compiled for calibration and validation. To overcome the identifiability problem, the classic Bayesian inference approach was utilized for parameter estimation. The calibrated model could describe the long-term trend of nutrient removal and short-term variations of the process performance, showing that the Bayesian method was a reliable and useful tool for the parameter estimation of the activated sludge models. The anoxic phosphate uptake by polyphosphate accumulating organisms （PAO） contributed 71.2% of the total Poly-P storage, which reveals the dominance of denitrifying phosphorus removal process under the oxygen limiting conditions. It was found that 58.7% of the anoxic Poly-P storage and denitrification by PAO in the reactor was achieved in the aerated compartment, implying that the PAO＇s anoxic activity was significantly stimulated by the low dissolved oxygen （DO） level in this compartment due to the oxygen gradient caused by brush aerator.

关键词： activated sludge model Bayesian inference biological nutrient removal closed-loop bioreactor oxidation ditch denitrifying polyphosphate accumulating organisms

I MATERIALI PREISTORICI DELLA EX COLLEZIONE CARLOTTI DELL'ISTITUTO BONSIGNORI DEPOSITATI PRESSO IL MUSEO CIVICO DI REMEDELLO(BS)——Ⅰ.Catalogo dei reperti metallici

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Natural Disaster Reduction in China 1976年第1期 165-186页

作者： mino PERINI LUCIANO SALZANI Del Museo Civico di Remedello(Brescia). Del Museo Civico di Storia Naturale di Verena.

SUMMARY-This article gives a first account on the prehistoric material collected inthe Remedello *** this first work,the Authors show and list the metal artifactsfrom the《Carlotti》*** il Museo Civieo di Remedello esiste una cospicua collezione dimateriali preistorici,il cui nucleo principale è stato ceduto,nel 1965,*** Carlotti di Cavriana all'Istituto Tecnico Bonsignori di Remedel-

关键词： Ta Del IV I MATERIALI PREISTORICI DELLA EX COLLEZIONE CARLOTTI DELL’ISTITUTO BONSIGNORI DEPOSITATI PRESSO IL MUSEO CIVICO DI REMEDELLO BS La IL

应用逆阻型IGBT的移相控制电流型全桥零电流开关DC/DC变换器

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中国电机工程学报 2006年第12期26卷 45-49页

作者：朱选才徐德鸿 Hidetoshi Umida kazuaki mino 浙江大学电气工程学院浙江省杭州市310027 Fuji Electric Advanced Technology Co. Ltd. Tokyo191-8502

介绍了一种使用新型的逆阻型IGBT(RB-IGBT)的电流型移相控制的全桥ZCSDC/DC变换器。介绍了逆阻型IGBT结构和特点,和普通IGBT不同,此新型IGBT具有双向阻断能力,适用于电流型电路。在该文所提到的电路中,通过引入谐振元件和利用电路中原... 详细信息

介绍了一种使用新型的逆阻型IGBT(RB-IGBT)的电流型移相控制的全桥ZCSDC/DC变换器。介绍了逆阻型IGBT结构和特点,和普通IGBT不同,此新型IGBT具有双向阻断能力,适用于电流型电路。在该文所提到的电路中,通过引入谐振元件和利用电路中原有的寄生参数如变压器漏感,同时加入开关管的开关重叠时间,可以使得IGBT获得零电流关断条件,消除由于IGBT关断时候拖尾电流造成的关断损耗。该文分析了变换器的工作原理以及零电流关断条件,最后通过一个4kW实验装置的实验结构验证了前面的分析。

关键词：电力电子逆阻型IGBT 移相控制零电流开关

活性污泥DNA样品的保存条件对聚磷菌FQ-PCR结果的影响

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环境工程学报 2017年第3期11卷 1362-1368页

作者：范念斯齐嵘 mino Takashi FUkUSHIMA Toshikazu 杨敏中国科学院生态环境研究中心环境水质学国家重点实验室北京100085 东京大学工学系研究科水环境技术研究中心柏市113-8656

对目标微生物的准确定量是研究微生物群落的组成与功能的重要前提。荧光定量PCR技术作为目前流行的核酸定量分析技术,具有操作时间短,敏感性高,特异性强等特点,但也存在由客观因素导致实验结果出现显著误差的缺点。针对目前环境微生物... 详细信息

对目标微生物的准确定量是研究微生物群落的组成与功能的重要前提。荧光定量PCR技术作为目前流行的核酸定量分析技术,具有操作时间短,敏感性高,特异性强等特点,但也存在由客观因素导致实验结果出现显著误差的缺点。针对目前环境微生物定量方法中容易忽略的污泥样品DNA保存步骤与上机时间等环节,详细探讨了保存条件、上机批次对聚磷菌(PAOs)荧光定量PCR结果的影响。结果显示保存温度、保存时间均对标准质粒和污泥DNA样品中PAOs定量结果产生影响:模板DNA的浓度及保存时间会影响标准曲线Ct值的重复性;同一样品在相同保存温度(4℃)、不同保存时间、不同批次条件下的定量结果存在显著性差异(P0.05)。因此,在对活性污泥样品进行定量分析时,DNA样品应平行保存于-20℃条件,尽量避免反复冻融,并确保对比的生物样品保存及上机条件完全一致,从而减少定量结果误差。

关键词：荧光定量PCR PAOs DNA 保存方法

城市污水SBR法短程生物脱氮系统硝化菌群的定量分析

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北京工业大学学报 2007年第8期33卷 843-848页

作者：杨庆彭永臻曾薇杨岸明 Hiroyasu Satoh Takashi mino 北京工业大学北京市水质科学与水环境恢复工程重点试验室北京100022 Institute of Environmental Studies University of TokyoTokyo 113-8656Japan

为了研究实时控制对短程生物脱氮中试系统内硝化菌群结构组成的影响,在考察系统常温条件下处理城市污水时短程硝化效果的同时,采用FISH、PCR-DGGE和PCR-克隆序列(Cloning Sequencing)分子生物学方法对SBR中试系统(有效容积为54 m^3)硝... 详细信息

为了研究实时控制对短程生物脱氮中试系统内硝化菌群结构组成的影响,在考察系统常温条件下处理城市污水时短程硝化效果的同时,采用FISH、PCR-DGGE和PCR-克隆序列(Cloning Sequencing)分子生物学方法对SBR中试系统(有效容积为54 m^3)硝化菌群中的氨氧化菌(AOB)和亚硝酸氧化菌(NOB)进行定性与定量化分析.FISH结果表明,在短程脱氮系统中,AOB相比于NOB已成为明显的优势菌群,占总菌群的3%～12%;且没有检测出***-DGGE结果表明,SBR短程脱氮中试系统中的AOB均以Nitrosomonas-like为主.污泥样品的PCR-Cloning-Sequencing结果表明,所有的克隆相似于Nitrosomonas,其中60%以上的克隆相似于Nitro- somonas europaea.

关键词： SBR 短程生物脱氮 Fish PCR-DGGE PCR-克隆序列

Optimization of the Mix-Design System for the Sub-ballast Railroad

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Journal of Traffic and Transportation Engineering 2017年第5期5卷 246-259页

作者： Martinez Soto Fernando Di mino Gaetano Department of Civil Environmental and Materials Engineering (DICAM) University of Palermo 90128 Palermo Italy Department of Civil Environmental Aerospace Materials Engineering (DICAM) University of Palermo 90128 Palermo Italy

Bituminous sub-ballast is an alternative solution to the unbound granular sub-ballast used in the railway track due to several benefits that it can provide. Indeed, it contributes to maintain the moisture content in the subgrade unchanged during all year. This decreases the subgrade deterioration process. Moreover, the presence of bituminous sub-ballast can also reduce vertical stiffness variations on the track; it can have a positive effect in the maintenance needs at transition sections （bridge-embankment） and in the attenuation of the vibrations induced by the rail traffic. Despite the importance of the presence of the bituminous sub-ballast to conceive the construction and/or rehabilitation of sustainable infrastructure, in literature, there are only fragmentary information regarding the definition of benchmark criteria for their mix design. The superpave mix design approach used in road domain is applied systematically in the railway domain, without being adjusted for different load configuration of the rail track system. This research work aims at defining the benchmark criteria for the bituminous sub-ballast mix design to reduce the approximations involved in the recipe optimization due to the limitation of applying the superpave system in the railway domain. The methodology proposed aims at selecting the RESAL （rail equivalent single axle load） and therefore, transforming the entire traffic spectrum on the track lines in number of ESALs. Afterwards, the Ndesign has been calculated as function of the rail traffic level. Finally, a case study of bituminous sub-ballast mix design has been investigated for a first verification of the methodology proposed.

关键词： Sub-ballast superpave railway bituminous layer ESAL Ndesign.

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集成EMI滤波器原理与设计

电工技术学报 2011年第9期26卷 160-166页

作者：温志伟伍晓峰徐德鸿 Okuma Yasuhiro mino kazuaki 浙江大学电气工程学院杭州310027 Fuji Electric Systems Co.Ltd Tokyo Japan Fuji Electric Advanced Technology Co.Ltd Tokyo Japan

利用柔性多层带材,提出了一种Electromagnetic Interference(EMI)滤波器的集成结构。该结构单独设计了差模绕组,并将滤波器中所有无源元件都集成在同一磁心中。文章通过建立集成滤波器的分布模型,从差、共模电流分布和磁路的角度,分别... 详细信息

利用柔性多层带材,提出了一种Electromagnetic Interference(EMI)滤波器的集成结构。该结构单独设计了差模绕组,并将滤波器中所有无源元件都集成在同一磁心中。文章通过建立集成滤波器的分布模型,从差、共模电流分布和磁路的角度,分别阐述了差、共模电感的集成原理,并给出了计算公式和集成结构的设计要点。实验部分比较了在不同差模电感下,差模插入损耗特性和EMI测试结果。实验表明,集成滤波器比分立滤波器体积更小,高频特性改善显著。

关键词：无源集成柔性多层带材 EMI滤波器