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中国肺癌杂志 2011年第8期14卷 695-698页

作者：李小江贾英杰张文治张莹李宝乐黄敏娜包芳芳吴建国娄怡天津中医药大学第一附属医院肿瘤科天津300193 天津市神经外科研究所神经细胞实验室天津300060 天津中医药大学天津300193

Wnt信号通路在维持肺癌干细胞的增殖和克隆形成方面发挥着重要作用,可通过影响其关键蛋白质抑制肺癌干细胞增殖,为肺癌的治疗提供新的路径。本文旨在通过总结2005年-2010年肺癌干细胞及Wnt通路的研究现状,探讨Wnt通路与肺癌干细胞的关系。

关键词： Wnt信号通路肺肿瘤干细胞

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影响鸡坏死性肠炎病例复制的关键因素

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中国兽医学报 2021年第1期41卷 186-191页

作者：袁伟康戚南山廖申权 mudassar mohiuddin 李跃龙吕敏娜吴彩艳李娟林栩慧蔡海明胡俊菁于林增肖文婉张健騑曹正孙芸芸孙铭飞顾有方安徽科技学院动物科技学院安徽安阳233100 广东省农业科学院动物卫生研究所农业部兽用药物与诊断技术广东科学观测实验站广东省畜禽疫病防治研究重点实验室广东广州510640 广东省农产品质量安全中心广东广州510640

坏死性肠炎(necrotic enteritis,NE)是家禽中最重要的肠道疫病之一,呈世界性流行,严重危害养鸡业发展。人工复制鸡坏死性肠炎病例是研究该病发病机制及筛选有效药物的重要手段,然而在实际试验过程中,通常受实验动物、感染菌株、诱导病... 详细信息

坏死性肠炎(necrotic enteritis,NE)是家禽中最重要的肠道疫病之一,呈世界性流行,严重危害养鸡业发展。人工复制鸡坏死性肠炎病例是研究该病发病机制及筛选有效药物的重要手段,然而在实际试验过程中,通常受实验动物、感染菌株、诱导病原等多方面因素影响而难以成功复制病例。鉴于此,现综述了影响鸡坏死性肠炎病例成功复制的关键因素,包括攻毒使用的实验动物、菌株毒素、菌株培养条件、诱导病因等,同时探讨了如何通过调整这些因素来改善人工复制鸡坏死性肠炎病例的严重程度,分析了鸡坏死性肠炎病例的病变评分系统,以期为鸡坏死性肠炎的实验室研究及综合防控提供理论基础。

关键词：鸡坏死性肠炎产气荚膜梭菌病例复制影响因素

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鸡球虫毒力致弱方法及其在鸡球虫病弱毒活疫苗研发上的应用

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畜牧与兽医 2021年第11期53卷 135-140页

作者：尹理君廖申权孙铭飞宋忠峰侯晓礁李福元吕敏娜吴彩艳李娟林栩慧蔡海明胡俊菁于林增肖文婉张健騑戚南山顾有方安徽科技学院动物科技学院安徽凤阳233100 广东省农业科学院动物卫生研究所/岭南现代农业科学与技术广东省实验室茂名分中心/农业农村部兽用药物与诊断技术广东科学观测实验站/广东省畜禽疫病防治研究重点实验室广东广州510640 北京生泰尔科技股份有限公司北京市中兽药工程技术研究中心北京100260

鸡球虫病是由艾美耳属球虫感染引起的一种危害严重的肠道寄生原虫病,每年给全球养鸡业造成巨大经济损失。活疫苗是替代抗球虫药防控鸡球虫病的有效手段,而减毒活疫苗安全性能更高,免疫原性更好,更加稳定,有效防控鸡球虫病的暴发。通过... 详细信息

鸡球虫病是由艾美耳属球虫感染引起的一种危害严重的肠道寄生原虫病,每年给全球养鸡业造成巨大经济损失。活疫苗是替代抗球虫药防控鸡球虫病的有效手段,而减毒活疫苗安全性能更高,免疫原性更好,更加稳定,有效防控鸡球虫病的暴发。通过理化致弱、鸡胚传代和早熟选育方法诱导虫株毒力减弱是常用的鸡球虫毒力致弱手段,但目前尚缺乏相关方法的系统性综述。鉴于此,为综合了解当前鸡球虫毒力致弱方法的研究进展及其在鸡球虫病弱毒活疫苗的应用研究,本文通过查阅、搜集和整理国内外文献相关研究内容,对鸡球虫强毒株致弱措施和方法及其在鸡球虫病弱毒苗应用现状进行综述,为新一代鸡球虫病弱毒活疫苗的研究提供理论依据。

关键词：鸡球虫病致弱方法早熟选育弱毒活疫苗

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Evaluation of Thermal Comfort in the Design of Student Hostel at Federal University of Technology minna,Nigeria

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Journal of Construction Research 2021年第2期3卷 56-62页

作者： Akande,O.K. Lembi,J.J. momoh,m.S. Department of Architecture Federal University of Technology MinnaNigeria

Buildings are designed to offer protection to the occupants against harsh outdoor environment thereby enhancing optimal indoor *** the years,there have been a rise in population of students applying for admission into tertiary institution,which has led to an increase in the number of students that resides at the university *** rise in the number of students,has brought about overcrowding and stretching of facilities,with spaces which were originally intended for four students are now been habited by six to eight students thereby causing imbalance in the general indoor climatic *** study is aimed at investigating thermal comfort in student’s accommodation in tertiary institutions towards achieving a better thermal condition in the hostel *** objective is to evaluate the thermal performance in the student hostel accommodation,and also to identify passive ways of controlling thermal performance in student dwelling buildings at Federal University of Technology minna main campus,Gidan *** the purpose of this research work,primary data were collected through the use questionnaire,case studies and *** data were collected from available literature,internet,and studying of similar existing *** study revealed that most student hostel possessed few elements of passive cooling technique which in turn deprives students a quality conducive *** research recommends that soft landscaping elements should be adopted and deciduous trees planted in the environment for cooling effect during hot and humid period,provision of two openings in each room if *** can be achieved through proper building orientation,use of high thermal mass to reduce heat absorption,use of high thermal mass with night cooling,roof,ceiling and attic *** in a hot climate area requires lots of consideration,which is mentioned above so as to incorporate a general conducive indoor thermal comfort for the u

关键词： Building orientation Passive cooling Thermal comfort Thermal performance

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Photon and Fast Neutron Transmission Parameters of metakaolin Doped Concrete

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Journal of Building material Science 2021年第2期3卷 58-66页

作者： O.I.Olarinoye m.m.Idris m.Kure Department of Physics Federeal University of TechnologyMinnaNigeria Department of Physics Nasarawa State UniversityKeffiNigeria

Radiation-shielding properties of metakaolin doped concrete samples were investigated in this *** gamma photon mass attenuation coefficients and exposure buildup factor of the samples were determined theoretically using WinXcom and EXABCal software respectively for the energy range of 15 keV-15 meV and fast neutron removal cross section for the concrete sample was *** indicated that,oxides of silicon,aluminum,calcium and iron determined through the energy dispersive X-ray fluorescence spectrometric analysis constitute more than 85%of the chemical composition of the concrete *** oxides contribute 85.46,86.47,87.55,88.75,and 86.15%of the total chemical oxides in mK00,mK05,mK10,mK15,and mK20 *** of the prepared mK doped concrete were in the range of 2.575-2.667 g/*** stress of prepared mK doped concretes increased consistently with the curing period for each concrete *** grew from 8.71-10.63,8.84-10.83,9.44-11.22,10.89-11.53,and 10.76-11.43 mPa for mK00,mK05,mK10,mK15,and mK20 respectively as the period extends from 7 to 28 *** attenuation coefficient decrease steadily with an increase in energy up to about 0.1 meV and the decrease become smaller beyond this energy with increasing energy for all the *** neutron removal cross section results indicate that mK10(0.07693 cm-1)has the highest value ofΣR followed by mK15(0.07628 cm-1)and mK20(0.07537 cm-1)while mK00(0.07380 cm-1)and mK05(0.07404 cm-1)have approximately the same *** was found that mK10 concrete has the best gamma radiation and fast neutron shielding ability among the mK doped concrete under study.

关键词： metakaoline Photons Thermal neutrons Concrete EXABCal

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Anti-trypanosomal Activity of Bufonidae(Toad)Venom Crude Extract on Trypanosoma brucei brucei in Swiss mice

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Journal of Zoological Research 2022年第2期4卷 31-47页

作者： Ezeobi,A.J. Pam,V.A. Uzoigwe,N.R. Omalu,I.C.J. Ombugadu,A. Ahmed,H.O. Ameh,S.F. Tanko,N.S. Adejoh,V.A. Attah,A.S. Ayim,J.O. Daramola,O.S. Aimankhu,P.O. maikenti,J.I. Ajah,L.J. Ayuba,S.O. Aliyu,A.A. Ashigar,m.A. Odey,S.A. Anyebe,G.E. Kure,m.S. Department of Zoology Faculty of ScienceFederal University of LafiaP.M.B.146LafiaNasarawa StateNigeria Department of Animal Biology(Parasitology and Tropical Diseases Research Unit) Federal University of TechnologyMinnaNiger StateNigeria Department of Toxicology and Pharmacology National Institute of Pharmaceutical Research and DevelopmentFederal Capital TerritoryAbujaNigeria Department of Chemistry Faculty of ScienceFederal University of LafiaP.M.B.146LafiaNasarawa StateNigeria

Trypanosomiasis afflicts about 6~7 million people globally and to a large extent impedes livestock production in ***,trypanosomal parasites undergo genetic mutation and have developed resistance over a wide range of *** utilization of animals and plants products has presented therapeutic potential for identifying novel anti-trypanosomal *** study evaluated toad venom for anti-trypanosomal potency in-vivo in Swiss *** were collected from July to August *** acute oral toxicity and biochemical characterization of the toad venom were *** experimental mice were administered various doses(130 mg/kg,173 mg/kg and 217 mg/kg)of the toad venom crude extract and 0.75 mg/mL of Diamizan Plus standard drug for the treatment of trypanosomiasis,once daily for 3 *** in-vivo anti-trypanosomal activity was evaluated by a curative test,after infecting the mice with Trypanosoma brucei *** pre-patent period was 72 hours before treatment *** overall results showed that trypanosomal load was highest in the control group while the group treated with Diamizan drug had the least trypanosomal *** such,the mean trypanosomal load in relation to treatments showed a very high significant difference(Pmean trypanosomal load in Swiss mice in relation to the highest dosage of toad venom versus Diamizan drug showed a very high significant difference(Pmean change in relation to the haematological parameters across treatments groups varied significantly(P0.05)across treatment *** over 50%reduction in the trypanosomal load in the 130 mg/kg group in comparison with the control group brings to bare the anti-trypanosomal potency of the toad *** anti-trypanosomal activity demonstrated by the toad venom has provided basis for development of new therapeutic agents from different toad *** study recommends further stu

关键词： Bufonidae Toxicity Biochemical characterization of toad venoms Anti-trypanosomal potency of toad venom Trypanosoma brucei brucei Swiss mice Haematological parameters

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