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A functional hydrogenase mimic that catalyzes robust H_(2) evolution spontaneously in aqueous environment

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Nano Research 2024年第5期17卷 3942-3949页

作者： Ningning Song Zhanjun Guo Shuo Wang Yongli Li Yunpeng Liu Meishuai Zou minmin liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Although great progress has been made in improving hydrogen production,highly efficient catalysts,which are able to produce hydrogen in a fast and steady way at ambient temperature and pressure,are still in large ***,we report a[NiCo]-based hydrogenase mimic,NiCo_(2)O_(4) nanozyme,that can catalyze robust hydrogen evolution spontaneously in water without external energy input at room *** hydrogenase nanozyme facilitates water splitting reaction by forming a three-center Ni-OH-Co bond analogous to the[NiFe]-hydrogenase reaction by using aluminum as electron donor,and realizes hydrogen evolution with a high production rate of 915 L·h^(-1) per gram of nanozymes,which is hundreds of times higher than most of the natural hydrogenase or hydrogenase ***,the NiCo_(2)O_(4) nanozyme can robustly disrupt the adhesive oxidized layer of aluminum and enable the full consumption of electrons from *** contrast to the often-expensive synthetic catalysts that rely on rare elements and consume high energy,we envision that this NiCo_(2)O_(4) nanozyme can potentially provide an upgrade for current hydrogen evolution,accelerate the development of scale-up hydrogen production,and generate a clean energy future.

关键词： hydrogenase mimic nanozyme hydrogen evolution reaction aluminum activation water-splitting

Enhancing the peroxidase-like activity of MoS_(2)-based nanozymes by introducing attapulgite for antibacterial application and sensitive detection of glutathione

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Nano Research 2024年第8期17卷 7415-7426页

作者： Feng Feng Yihe Zhang Xiao Zhang Bin Mu Jiahe Zhang Wenjie Qu Wangshu Tong minmin liang Qi An Zhanjun Guo Lu Zhao Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastesNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Clay Mineral Applied Research of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Experimental Center of Advanced Materials School of Materials Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Nanozymes are next-generation of nanomaterials with enzyme-like *** particular,nanozymes with peroxidase(POD)-like activity have been utilized in various fields,including antibacterial,detection,degradation,***,their extensive applications were limited by their low catalytic activity ***,we have presented a composite nanozyme based on attapulgite(ATP)(Fe-ATP-MoS_(2)(FAM)),which exhibited enhanced POD-like activity(185.33 U·mg^(−1)),4.25 times higher than that of Fe-MoS_(2)(FM)(43.63 U·mg^(−1)).The density functional theory(DFT)calculations indicated that the addition of ATP increased the electron density of metal centers(Mo and Fe).More importantly,Michaelis–Menten kinetics revealed that the introduction of ATP significantly enhanced the binding affinities of substrates through the pores of ATP,forming a highly concentrated substrate microenvironment and thus promoting its POD-like ***,from molecular size and kinetic analysis,we proposed that the changes in substrate size before and after oxidation also significantly affected its Michaelis-constant(Km)***,we utilized FAM in the applications of highly effective antibacterial application and sensitive detection of glutathione(GSH).In conclusion,this work provides a novel approach for designing a highly efficient nanozyme based on natural mineral composites.

关键词： attapulgite peroxidase electron density affinity antibacterial

Oriented Generation of Novel Thermo-Sensitive Genic Male Sterile Lines with Improved Grain Shape and Outcrossing Rate in Early-Season Rice

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Rice science 2024年第2期31卷 129-133,I0001-I0016页

作者： ZHANG Huali CHEN Junyu LI Ruiqing WANG Huimei DAI Dongqing liang minmin WU Mingyue MA liangyong State Key Laboratory of Rice Biology and Breeding/Chinese National Center for Rice Improvement China National Rice Research InstituteHangzhou 310006China

Two-line hybrid rice with excellent quality is preferred in the Chinese ***,there is a trade-off between reducing costs for hybrid seed production and lowering the outcrossing rate of the sterile line,which is largely determined by the stigma exsertion rate(SER).In this study,we constructed mutants of male sterility lines with improved grain length(GL)and SER in three elite early-season indica rice varieties through targeted manipulation of the TMS5 and GS3 genes using CRISPR/Cas9-mediated multiplex *** obtained a series of marker-free gs3 single mutants and gs3tms5 double mutants with significantly higher SER,longer grains,and increased 1000-grain weight compared with the wild type(WT).Importantly,the typically thermo-sensitive genic male sterile(TGMS)trait with a higher SER was observed in gs3tms5 mutants,and their F1 hybrids exhibited remarkable improvements in grain shape and yield-related *** findings provided an efficient method to generate new valuable TGMS germplasm with improved SER through the mutagenesis of GS3 and TMS5 synergistically,and demonstrated that GS3 had pleiotropic effects on grain size,SER,and grain quality in early-season indica rice.

关键词： sterile elite season

Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification

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Nano Research 2024年第3期17卷 1785-1791页

作者： Juanji Hong Zhanjun Guo Dihan Duan Yi Zhang Xin Chen Yongjiu Li Zheng Tu Lei Feng Lei Chen Xiyun Yan Lizeng Gao minmin liang Demin Duan Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China Chongqing kangjuquanhong biology science and technology Co. ltdChongqing 400026China Key Laboratory of Forensic Genetics Institute of Forensic ScienceMinistry of Public SecurityBeijing 100038China CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academic of ScienceBeijing 100101China

During criminal case investigations,blood evidence tracing is critical for criminal ***,the blood stains are often cleaned or covered up after the crime,resulting in trace residue and difficult ***,a highly sensitive and specific method for the rapid detection of human blood stains remains *** solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and *** construct reliable nanozyme strips,we synthesized CoFe_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and conjugated antibody as a detection probe in nanozyme *** developed CoFe_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a concentration as low as 1 ng/mL,which is 100 times lower than the commercially available colloidal gold strips(100 ng/mL).Moreover,this CoFe_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood ***,we applied the developed CoFe_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current commercial colloidal gold strip failed to *** results suggest that the CoFe_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry.

关键词： CoFe_(2)O_(4)nanozyme nanozyme strip peroxidase-like activity human hemoglobin blood evidence

Recent progress in single-atom nanozymes research

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Nano Research 2023年第2期16卷 1878-1889页

作者： Bing Jiang Zhanjun Guo minmin liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China

Single-atom nanozyme(SAzyme)is the hot topic of the current nanozyme *** intrinsic properties,such as high activity,stability,and low cost,present great substitutes to natural ***,its fundamental characteristics,i.e.,maximized atom utilizations and well-defined geometric and electronic structures,lead to higher catalytic activities and specificity than traditional *** have been applied in many biomedical areas,such as anti-tumor therapy,biosensing,antibiosis,and anti-oxidation ***,we will discuss a series of representative examples of SAzymes categorized by their biomedical applications in this *** the end,we will address the future opportunities and challenges SAzymes facing in their designs and applications.

关键词： single-atom nanozymes natural enzymes enzyme-like activity biomedical applications

Multiscale structural design of MnO_(2)@GO superoxide dismutase nanozyme for protection against antioxidant damage

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Nano Research 2023年第8期16卷 10763-10769页

作者： Yue Yu Yinuo Zhang Yu Wang Wenxing Chen Zhanjun Guo Ningning Song minmin liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China Shanghai Synchrotron Radiation Facilities Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghai 201204China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Rational design of metallic active sites and its microenvironment is critical for constructing superoxide dismutase(SOD)***,we reported a novel SOD nanozyme design,with employing graphene oxide(GO)as the framework,andδ-MnO_(2)as the active sites,to mimic the natural *** MnO_(2)@GO nanozyme exhibited multiscale laminated structures with honeycomb-like morphology,providing highly specific surface area for·O_(2)−adsorption and confined spaces for subsequent catalytic ***,the nanozyme achieved superlative SOD-like catalytic performance with inhibition rate of 95.5%,which is 222.6%and 1605.4%amplification over GO and MnO_(2)nanoparticles,***,such unique hierarchical structural design endows MnO_(2)@GO with catalytic specificity,which was not present in the individual component(GO or MnO_(2)).This multiscale structural design provides new strategies for developing highly active and specific SOD nanozymes.

关键词： MnO_(2)@graphene oxide(MnO_(2)@GO)nanozyme superoxide dismutase(SOD)-like activity activity specificity antioxidation

Full reaction mechanism of hydrogen peroxide catalyzed by reductive CoP nanoparticles:the enzyme-like activity

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Science China Chemistry 2023年第4期66卷 1221-1227页

作者： Kaiwei Wan Chang Long Bing Jiang minmin liang Zhiyong Tang Hui Wang Xinghua Shi Laboratory of Theoretical and Computational Nanoscience CAS Key Laboratory of Nanosystem and Hierarchical FabricationCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Molecular Electrochemistry Laboratory Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 610054China Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China

The hydrogen peroxide(H2O2)catalyzed by nanoparticles(NPs)demonstrates potential broad applications in the field of biomedicine and environmental ***,a systematic understanding of the catalytic mechanism severely limited the rational design of NPs with better enzyme-like activity and ***,compared with the widely concerned Fe3O4NPs,the decomposition process of H_(2)O_(2) on reductive Co P NPs and p H-regulated peroxidase-and catalase-like activities with 3,3′,5,5′-tetramethylbenzidine(TMB)as reductive substrates were *** results show that OH·radical intermediates generated from the decomposition of H2O2*/OOH*at acidic conditions and complexed with TMB via H-bonds(complexed OH·)are the principal oxidant of TMB rather than free OH·as ***,the produced O*/OH*on Co P NPs shows negligible oxidation activity due to the strong reducibility of *** high coverage of O*/OH*from the dissociation of H2O2(H2O)at neutral(alkaline)p H conditions on Co P NPs enhances the dehydrogenation of H_(2)O_(2) to O2,leading to the transition between peroxidase-and catalase-like activities.

关键词： CoP nanoparticle peroxidase,catalase DFT calculations heterogeneous catalysis

Advances in Single-Atom Nanozymes Research

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Chinese Journal of Chemistry 2021年第1期39卷 174-180页

作者： Bing Jiang minmin liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China

Nanozymes with intrinsic enzyme-like properties have attracted significant interest owing to their capability to address the limitations of traditional enzymes such as fragility,high cost and dificult mass ***,the currently reported nanozymes are generally less active than natural *** recent years,with the rapid development of nanoscience and nanotechnology,single-atom nanozymes(SAzymes)with well-defined electronic and geometric structures have shown a promise to serve as direct surrogates of traditional enzymes by mimicking the highly evolved catalytic center of natural *** this review,we will introduce the enzymatic characteristics and recent advances of SAzymes,and summarize their significant applications from in vitro detection to in vivo monitoring and therapy.

关键词： Nanozyme Single-atom nanozyme Biomedical application

Functional Superoxide Dismutase Mimics Become Diverse: From Simple Compounds on Prebiotic Earth to Nanozymes

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生物化学与生物物理进展 2018年第2期45卷 148-169页

作者： Leon Bixenmann Jiuyang He minmin liang Wolfgang Tremel Institut für Anorgmtische Chemie und Anolytisehe ChemieJobhanne Gutenberg UniversitiitMainz 55128Germany Key Laboratory of Protein and Peptide Pharmaceutical CAS-University of Tokyo Jnint Laboratory of Structural Virology and lmmunology Institu

Inorganic solids with enzyme-like activity are promising to overcome many restrictions of native enzymes in *** attractive are nanoparticles with superoxide dismutase(SOD)activity,due to their ability to reduce the damaging properties of reactive oxygen species within cells and *** review discusses the necessary requirements for nanoparticles to have SOD activity and reveals a close relationship between catalysis on prebiotic earth and the recent SOD *** review also aims to highlight the progress in the development of SOD mimicking *** give a broad overview of nanoparticles with SOD activity,based on their material make-up,to underline their increasing diversity.

关键词： Superoxide