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2019年-2022年儿科、产科及妇科住院患者院内感染病原体分布及耐药性分析

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江苏卫生事业管理 2024年第2期35卷 216-221页

作者：张胜男吴岷岷徐文君王洁杨力钟天鹰南京医科大学附属妇产医院、南京市妇幼保健院感染管理办公室江苏南京210004 南京医科大学附属妇产医院、南京市妇幼保健院人事处江苏南京210004 南京医科大学附属妇产医院、南京市妇幼保健院院长办公室江苏南京210004

目的:积极开展儿科、产科和妇科院内感染病原体分布、耐药性的调查,对经验性治疗妇儿院内感染有重要意义,也为院内感染防控提供参考依据。方法:选取2019-2022年入住我院儿科、产科及妇科诊断为医院感染的患者作为研究对象,收集这3个科... 详细信息

目的:积极开展儿科、产科和妇科院内感染病原体分布、耐药性的调查,对经验性治疗妇儿院内感染有重要意义,也为院内感染防控提供参考依据。方法:选取2019-2022年入住我院儿科、产科及妇科诊断为医院感染的患者作为研究对象,收集这3个科室院内感染率、感染部位等信息,参照《全国临床检验操作规程》中的方法进行细菌分离和鉴定,使用法国生物梅里埃公司VITEK-2Compact全自动细菌鉴定仪和珠海迪尔DL-96全自动细菌测定系统进行细菌鉴定和药敏试验,依据美国临床实验室标准化委员会(CLSI)标准判断结果。结果:2019-2022年纳入研究对象的227124例儿科、产科及妇科患者中,累计发生院内感染770例,院内感染发生率为0.34%。770例院内感染患者中,儿科以菌血症和胃肠道感染多见,分别占31.87%和26.02%;产科以男女性生殖道的其它感染和上呼吸道感染多见,分别占15.98%和14.79%;妇科以腹(盆)腔内组织和急性盆腔炎多见,分别占24.32%和23.94%。770例院内感染患者的临床标本共分离、培养出病原体458株,儿科以表皮葡萄球菌和肺炎克雷伯菌为主,分别占23.12%和20.10%;产科以大肠埃希菌和粪肠球菌为主,分别占23.33%和20.00%;妇科以大肠埃希菌为主,占53.25%。儿科肺炎克雷伯菌对亚胺培南和美罗培南无耐药,产科大肠埃希菌对亚胺培南和美罗培南无耐药,妇科大肠埃希菌对亚胺培南和美罗培南耐药率均为1.11%,儿科表皮葡萄球菌对万古霉素和利奈唑胺无耐药,产科和妇科粪肠球菌对万古霉素和利奈唑胺无耐药。结论:2019-2022年儿科、产科及妇科院内感染发生率为0.34%,我院儿科院内感染率(1.17%)高于产科(0.12%)和妇科(0.43%)。抗菌药物妇科应用率显著高于产科应用率,且非一联用药为主,这就导致妇科院内感染病原体的耐药率高于产科。积极监测儿科、产科和妇科院内感染情况,并及时分析、总结院内感染病原体的分布和耐药性,对于院内感染诊断和抗菌药物治疗性应用均有一定的临床指导意义。

关键词：儿科产科妇科院内感染耐药性

The Research of Real-time Mapping in the Restoration of Lacquer Based on X3D

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信息工程期刊（中英文版） 2013年第6期3卷 111-115页

作者： minmin Xiang wu Xu Lifen Zhao Nan Chen School of Electronic and Information Engineering Yunnan University of Nationalities Kunming Yunnan 650031 China

Oriented Generation of Novel Thermo-Sensitive Genic Male Sterile Lines with Improved Grain Shape and Outcrossing Rate in Early-Season Rice

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Rice science 2024年第2期31卷 129-133,I0001-I0016页

作者： ZHANG Huali CHEN Junyu LI Ruiqing WANG Huimei DAI Dongqing LIANG minmin wu Mingyue MA Liangyong State Key Laboratory of Rice Biology and Breeding/Chinese National Center for Rice Improvement China National Rice Research InstituteHangzhou 310006China

Two-line hybrid rice with excellent quality is preferred in the Chinese ***,there is a trade-off between reducing costs for hybrid seed production and lowering the outcrossing rate of the sterile line,which is largely determined by the stigma exsertion rate(SER).In this study,we constructed mutants of male sterility lines with improved grain length(GL)and SER in three elite early-season indica rice varieties through targeted manipulation of the TMS5 and GS3 genes using CRISPR/Cas9-mediated multiplex *** obtained a series of marker-free gs3 single mutants and gs3tms5 double mutants with significantly higher SER,longer grains,and increased 1000-grain weight compared with the wild type(WT).Importantly,the typically thermo-sensitive genic male sterile(TGMS)trait with a higher SER was observed in gs3tms5 mutants,and their F1 hybrids exhibited remarkable improvements in grain shape and yield-related *** findings provided an efficient method to generate new valuable TGMS germplasm with improved SER through the mutagenesis of GS3 and TMS5 synergistically,and demonstrated that GS3 had pleiotropic effects on grain size,SER,and grain quality in early-season indica rice.

关键词： sterile elite season

FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signaling in Arabidopsis

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Molecular Plant 2024年第5期17卷 772-787页

作者： Baiyan Lu Shengnan Wang Hanqian Feng Jing Wang Kaixing Zhang Yilin Li Ping wu minmin Zhang Yanshu Xia Chao Peng Chao Li School of Life Sciences East China Normal UniversityShanghai 200241China National Facilty for Protein Science Shanghai Zhangjang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The phytohormone auxin plays a pivotal role in governing plant growth and *** the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX(TIR1/AFB)receptors function in both the nucleus and cytoplasm,the mechanism governing the distribution of TIR1/AFBs between these cellular compartments remains *** this study,we demonstrate that auxin-mediated oxidation of TIR1/AFB2 is essential for their targeting to the *** showed that small active molecules,reactive oxygen species(ROS)and nitric oxide(NO),are indispensable for the nucleo-cytoplasmic distribution of TIR1/AFB2 in trichoblasts and root *** studies revealed that this process is regulated by the FERONIA receptor kinase–NADPH oxidase signaling ***,ROS and NO initiate oxidative modifications in TIR1C140/516 and AFB2C135/511,facilitating their subsequent nuclear *** oxidized forms of TIR1C140/516 and AFB2C135/511 play a crucial role in enhancing the function of TIR1 and AFB2 in transcriptional auxin ***,our study reveals a novel mechanism by which auxin stimulates the transport of TIR1/AFB2 from the cytoplasm to the nucleus,orchestrated by the FERONIA–ROS signaling pathway.

关键词： FERONIA TIR1/AFBs oxidative modification nucleo-cytoplasmic distribution root hair development

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基于MCU机电弹力补充原理的恒力控制系统

机电工程技术 2024年第1期53卷 145-150页

作者：吴民民刘三军湖北民族大学智能科学与工程学院湖北恩施445000

现有力控打磨系统多采用基于PLC(Programmable Logic Controller)控制气动泵的结构,存在反应慢、精度低等问题。提出了一款基于MCU(Micro Processor Unit)带动丝杆控制弹簧结构的恒力控制系统,能够将气动系统的力控精度由2~10 N提高到0.... 详细信息

现有力控打磨系统多采用基于PLC(Programmable Logic Controller)控制气动泵的结构,存在反应慢、精度低等问题。提出了一款基于MCU(Micro Processor Unit)带动丝杆控制弹簧结构的恒力控制系统,能够将气动系统的力控精度由2~10 N提高到0.2~0.5 N量级,反应时间由1~3 s提高到几十ms。首先对丝杆控制弹簧的机械结构进行数学建模,给出了系统响应时间随着电机转速与扭矩、丝杆比、弹簧倔强系数、斜坡角度等物理量的变化的闭式解,随后从模型中分析了提出的系统结构将反应时间降低为几十ms所需的条件以及将力控精度达到零点几牛的关键因素。为了实现上述性能,提出了一种基于弹力补充原理的恒力控制方案,仿真和实验发现该方案比传统PID(Proportional Integeal Differential)的控制方案更接近理论上的响应速度以及力控精度,可广泛应用于工业打磨和抛光,实现更精细的打磨要求。

关键词：恒力控制系统力控精度反应时间弹力补充

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Bone metastasis is a late-onset and unfavorable event in survivors of gastric cancer after radical gastrectomy:Results from a clinical observational cohort

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Cancer Pathogenesis and Therapy 2024年第1期2卷 50-57页

作者： Cheng Zhang Xiaopeng Zhang Chong Feng Yahui Yang minmin Xie Ying Feng Zhijun wu Hui Xu Changhao wu Tai Ma Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Anhui Provincial Cancer Institute/Anhui Provincial Office for Cancer Prevention and Control HefeiAnhui 230022China Department of Noncommunicable Diseases and Health Education Hefei Center for Disease Control and PreventionHefeiAnhui 230091China Department of Oncology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221006China Department of Oncology Ma’anshan Municipal People’s HospitalMa’anshanAnhui 243099China Department of Biochemistry and Physiology Faculty of Health and Medical SciencesUniversity of SurreyGuildford GU27HXUnited Kingdom

Background The timing and incidence of recurrent bone metastasis(BM)after radical gastrectomy in patients with gastric cancer(GC)as well as the survival of these patients were not fully *** aim of this study was to analyze the data of an observational GC cohort and identify patients who underwent curative gastrectomy and had recurrent BM to describe and clarify the pattern and profile of BM evolution after *** Data were retrieved from a hospital-based GC cohort,and patients who underwent upfront radical gastrectomy were *** time points of specific organ metastatic events were recorded,and the person-year incidence rate of metastatic events was *** latency period of BM events after gastrectomy was measured and compared with that of the other two most common metastatic events,liver metastasis(LM)and distant lymph node metastasis(LNM),using analysis of *** score matching and subgroup analysis were used for sensitivity *** A total of 1324 GC cases underwent radical gastrectomy between January 2011 and December *** these,67 BM,218 LM,and 248 LNM occurred before the last *** incidence of BM events was 1.7/100 person-years,which was approximately 3-fold lower than that of LM and distant LNM events(5.5 and 6.3 per 100 person-years,respectively).BM events had a significantly longer latency(median time,16.5 months)than LM and LNM events(11.1 and 12.0 months,respectively).Recurrent BM led to a worse prognosis(median survival,4.5 months)than those of LM and LNM events(median survival,7.7 and 7.1 months,respectively).However,no difference in overall survival after gastrectomy was observed among the *** Compared with other common metastatic events,BM in GC after gastrectomy is a late-onset event indicating poor survival.

关键词： Stomach neoplasms Neoplasm metastasis Incidence Survival analysis Propensity score

巴贡水电站混凝土面板堆石坝沉降变形观测分析

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水利水电技术 2010年第8期41卷 25-27页

作者：吴敏敏刘先行中国铁道科学研究院北京100081 中国水电建设集团国际工程有限公司北京100048

巴贡水电站位于马来西亚沙捞越州布拉嘎镇上游 37 km处,坝址处河流年平均流量1 249 m~3/s,正常蓄水位228 m,相应库容438亿m~3,水坝控制流域面积14 750 km~2.水电站总装机容量为2 400 MW

关键词：巴贡水电站混凝土面板堆石坝沉降变形变形观测分析

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风化花岗岩地层中地铁盾构隧道施工关键技术

铁道建筑 2022年第3期62卷 132-135页

作者：吴敏敏刘先行中电建路桥集团有限公司北京100160 中国电建集团国际工程有限公司北京100036

新加坡地铁汤东线T217标段从不同风化程度花岗岩中穿过,且地面上是新加坡外交部和多个国家驻新加坡大使馆,地理环境敏感,对施工要求高。本文从盾构机刀盘和驱动系统、泥水舱压力平衡系统、泥浆输出监控系统、泥水分离系统和辅助设备五... 详细信息

新加坡地铁汤东线T217标段从不同风化程度花岗岩中穿过,且地面上是新加坡外交部和多个国家驻新加坡大使馆,地理环境敏感,对施工要求高。本文从盾构机刀盘和驱动系统、泥水舱压力平衡系统、泥浆输出监控系统、泥水分离系统和辅助设备五个方面介绍了盾构机系统的选型设计。针对不同工况,施工前确定了五组泥浆关键性能指标,用以指导泥浆制备与调整。在全~中等风化花岗岩混合层中掘进时,推进力保持在24~26 MN,刀盘转速在2.6~2.8 r/min;地面最大沉降7 mm,出现在P170环(外交部和舍伍德路公寓之间);地层损失率约1.01%,满足设计要求,对地面建筑物和地下设施基本无影响。

关键词：地铁隧道施工技术理论分析现场实测风化花岗岩盾构选型泥浆制备地表沉降

人脐带间充质干细胞治疗大鼠子宫内膜损伤的研究

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现代妇产科进展 2019年第7期28卷 523-527页

作者：吴敏敏骆婕陶莹广东药科大学附属第一医院妇产科

目的:探讨人脐带间充质干细胞(hUC-MSCs)移植对子宫内膜损伤大鼠的治疗作用及可能作用机制。方法:用无水乙醇诱导大鼠子宫内膜损伤模型,分为模型组、对照组、干细胞治疗组、雌激素治疗组。HE染色法观察子宫内膜组织学变化,测定子宫内膜... 详细信息

目的:探讨人脐带间充质干细胞(hUC-MSCs)移植对子宫内膜损伤大鼠的治疗作用及可能作用机制。方法:用无水乙醇诱导大鼠子宫内膜损伤模型,分为模型组、对照组、干细胞治疗组、雌激素治疗组。HE染色法观察子宫内膜组织学变化,测定子宫内膜厚度,免疫组化法检测血管内皮生长因子(VEGF)、雌激素受体(ERα)以及整合素β3表达。结果:对照组的子宫内膜厚度高于其他组(P<0.05),其余组间差异不明显。与对照组相比,模型组的VEGF、ERα、整合素β3表达均降低(P<0.05);与模型组相比,干细胞治疗组、雌激素治疗组的VEGF、ERα、整合素β3表达均升高(P<0.05);与雌激素治疗组相比,干细胞治疗组的VEGF、ERα、整合素β3表达均升高(P<0.05)。结论:hUC-MSCs移植和雌激素治疗均可不同程度地修复大鼠子宫内膜损伤组织,改善子宫内膜容受性,干细胞移植疗效优于单纯雌激素治疗。

关键词：子宫内膜损伤人脐带间充质干细胞血管内皮生长因子雌激素受体整合素β3