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Synergistic Interdecadal Evolution of Precipitation over Eastern China and the Pacific Decadal Oscillation during 1951-2015

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Advances in Atmospheric Sciences 2024年第1期41卷 53-72页

作者： minmin wu Rong-Hua ZHANG Junya HU Hai ZHI Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Laosan Laboratory Qingdao 266237China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China University of Chinese Academy of Sciences Beijing 100029China

By using the multi-taper method(MTM)of singular value decomposition(SVD),this study investigates the interdecadal evolution(10-to 30-year cycle)of precipitation over eastern China from 1951 to 2015 and its relationship with the North Pacific sea surface temperature(SST).Two significant interdecadal signals,one with an 11-year cycle and the other with a 23-year cycle,are identified in both the precipitation and SST fields.Results show that the North Pacific SST forcing modulates the precipitation distribution over China through the effects of the Pacific Decadal Oscillation(PDO)-related anomalous Aleutian low on the western Pacific subtropical high(WPSH)and Mongolia high(MH).During the development stage of the PDO cold phase associated with the 11-year cycle,a weakened WPSH and MH increased the precipitation over the Yangtze River Basin,whereas an intensified WPSH and MH caused the enhanced rain band to move northward to North China during the decay stage.During the development stage of the PDO cold phase associated with the 23-year cycle,a weakened WPSH and MH increased the precipitation over North China,whereas an intensified WPSH and the weakened MH increased the precipitation over South China during the decay stage.The 11-year and 23-year variabilities contribute differently to the precipitation variations in the different regions of China,as seen in the 1998flooding case.The 11-year cycle mainly accounts for precipitation increases over the Yangtze River Basin,while the 23-year cycle is responsible for the precipitation increase over Northeast China.These results have important implications for understanding how the PDO modulates the precipitation distribution over China,helping to improve interdecadal climate prediction.

关键词： MTM-SVD PDO SST anomalies interdecadal variability precipitation over China

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Recent Enhancement in Co-Variability of the Western North Pacific Summer Monsoon and the Equatorial Zonal Wind

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Advances in Atmospheric Sciences 2023年第9期40卷 1597-1616页

作者： minmin wu Xugang PENG Baiyang CHEN Lei WANG Jinwen WENG Weijian LUO Laboratory for Coastal Ocean Variation and Disaster Prediction College of Ocean and MeteorologyGuangdong Ocean UniversityZhanjiang 524088China Key Laboratory of Climate Resourcesand Environment in Continental Shelf Sea and Deep Sea of Department of Education of Guangdong ProvinceGuangdong Ocean UniversityZhanjiang 524088China Key Laboratory of Space Ocean Remote Sensing and Application Ministry of Natural ResourcesBeijing 100081China

The western North Pacific summer monsoon(WNPSM)is an important subcomponent of the Asian summer monsoon.The equatorial zonal wind(EZW)in the lower troposphere over the western Pacific may play a critical role in the evolution of the El Niño-Southern Oscillation(ENSO).The possible linkage between the EZW over the western Pacific and the offequatorial monsoonal winds associated with the WNPSM and its decadal changes have not yet been fully understood.Here,we find a non-stationary relationship between the WNPSM and the western Pacific EZW,significantly strengthening their correlation around the late 1980s/early 1990s.This observed shift in the WNPSM–EZW relationship could be explained by the changes in the related sea surface temperature(SST)configurations across the tropical oceans.The enhanced influence from the springtime tropical North Atlantic,summertime tropical central Pacific,and maritime continent SST anomalies may be working together in contributing to the recent intensified WNPSM–EZW co-variability.The observed recent strengthening of the WNPSM–EZW relationship may profoundly impact the climate system,including prompting more effective feedback from the WNPSM on subsequent ENSO evolution and bolstering a stronger biennial tendency of the WNPSM–ENSO coupled system.The results obtained herein imply that the WNPSM,EZW,ENSO,and the tropical North Atlantic SST may be closely linked within a unified climate system with a quasi-biennial rhythm occurring during recent decades,accompanied by a reinforcement of the WNPSM–ENSO interplay quite possibly triggered by enhanced tropical Pacific–Atlantic cross-basin interactions.These results highlight the importance of the tropical Atlantic cross-basin influences in shaping the spatial structure of WNPSM-related wind anomalies and the WNPSM–ENSO interaction.

关键词： western North Pacific summer monsoon equatorial zonal wind interdecadal variability monsoon-ENSO interaction cross-basin interactions biennial variability

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JAG1 enhances angiogenesis in triple-negative breast cancer through promoting the secretion of exosomal lncRNA MALAT1

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Genes & Diseases 2023年第5期10卷 2167-2178页

作者： Junping Liu Yutong Shi minmin wu Fengmei Zhang Mengqi Xu Zhiqiang He Min Tang Key Laboratory of Laboratory Medical Diagnostics Designated by the Chinese Ministry of Education Chongqing Medical UniversityChongqing 400016China

Despite significant improvements in five-year survival rates due to early diagnosis and combination therapy, triple-negative breast cancer (TNBC) treatment remains a major challenge. Finding new and effective targets for diagnosis and drug therapy is urgent for TNBC patients. Jagged-1 (JAG1), one of the canonical ligands of the Notch signaling pathway, is involved in vascular budding and is a poor prognostic factor of TNBC. In this study, combined with quantitative real-time PCR, database analysis, animal experiments, and other means, JAG1 was confirmed to be related to the poor prognosis of TNBC patients. JAG1 was highly expressed in MDA-MB-231 Bone (231B) cells, with stronger invasion and metastasis ability than MDA-MB-231 (231) cells. Treatment of human vascular endothelial cells (HUVEC) with TNBC conditioned medium showed that TNBC JAG1 promoted the angiogenesis of HUVEC. Next, we detected the exosomes extracted from TNBC conditioned medium and found that JAG1 promoted the exosome secretion from 231 cells via ALIX-RAB11A/RAB35. In addition, we also found that the exosomes from JAG1 overexpressed TNBC cells contained more long non-coding RNA (lncRNA) MALAT1 , and MALAT1 promoted angiogenesis of HUVEC by targeting miR-140-5p . Finally, the angiogenesis-promoting effect of JAG1 in TNBC was further investigated by matrix gel assay. In conclusion, we reveal that JAG1 has a pro-invasion effect on TNBC and is involved in microenvironment angiogenesis by promoting exosome secretion and the MALAT1-miR-140-5p-JAG1/VEGFA pathway.

关键词： Angiogenesis Exosome JAG1 lncRNAMALAT1 Triple-negative breast cancer

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Recent Weakening in Interannual Variability of Mean Tropical Cyclogenesis Latitude over the Western North Pacific during Boreal Summer

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Journal of Meteorological Research 2020年第6期34卷 1183-1198页

作者： minmin wu Lei WANG Baiyang CHEN Laboratory for Coastal Ocean Variation and Disaster Prediction College of Ocean and MeteorologyGuangdong Ocean UniversityZhanjiang 524088 Key Laboratory of Climate Resources and Environment in Continental Shelf Sea and Deep Sea of Department of Education of Guangdong ProvinceGuangdong Ocean UniversityZhanjiang 524088 Marine Resources Big Data Center of South China Sea Southern Marine Science and Engineering Guangdong Laboratory(Zhanjiang)Zhanjiang 524025

The intensity of the interannual variability(IIV)of the mean tropical cyclone(TC)genesis latitude over the western North Pacific(WNP)has been weakening significantly since the late 1990 s.It is found that the IIV of the mean TC genesis latitude depends largely on the strength of the out-of-phase relationship between TC genesis numbers in the north(north of 15°N)and south(south of 15°N)of the WNP.A weaker(stronger)north–south TC see-saw has led to a smaller(larger)IIV of the mean TC genesis latitude after(before)the late 1990 s.Different configurations of sea surface temperature(SST)anomalies are found to be responsible for the decadal changes in the north–south TC see-saw and dipole structure.Before the late 1990 s,the joint effect of SST anomalies over the tropical Pacific and tropical North Indian Ocean dominated,rendering the obvious north–south TC see-saw and larger IIV of the mean TC genesis latitude.After the late 1990 s,however,the dominant SST anomalies associated with TC genesis shift to the tropical central Pacific(CP)and tropical North Atlantic Ocean,which have weakened the north–south TC seesaw and reduced the IIV of the mean TC genesis latitude.These observed decadal changes in the configuration of SST anomalies are considered to be closely associated with the shift of the El Ni?o–Southern Oscillation(ENSO)from eastern Pacific(EP)type to the CP type during the recent decades.The results suggest that the increased influences from the tropical Atlantic Ocean have become more important to the variations of TC activity in the WNP during the recent decades.These results may have important implications for assessing the latitudinal distributions of TC-induced hazards.

关键词： tropical cyclone cyclogenesis latitude decadal change shifting El Nino–Southern Oscillation(ENSO) western North Pacific(WNP) tropical Atlantic sea surface temperature(SST)

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氧化修饰高密度脂蛋白激活活性氧启动p38信号促使大鼠卵巢颗粒细胞凋亡

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中国组织工程研究 2024年第19期28卷 3055-3060页

作者：郭琴吴敏敏陶莹广东药科大学附属第一医院/第一临床医学院妇产科广东省广州市510080

背景:多囊卵巢综合征患者体内高密度脂蛋白发生了部分氧化修饰,而氧化修饰高密度脂蛋白与排卵障碍的关系及其机制尚不清楚。目的:探讨氧化修饰高密度脂蛋白对卵巢颗粒细胞凋亡的影响,并分析其可能的作用机制。方法:构建多囊卵巢综合征... 详细信息

背景:多囊卵巢综合征患者体内高密度脂蛋白发生了部分氧化修饰,而氧化修饰高密度脂蛋白与排卵障碍的关系及其机制尚不清楚。目的:探讨氧化修饰高密度脂蛋白对卵巢颗粒细胞凋亡的影响,并分析其可能的作用机制。方法:构建多囊卵巢综合征大鼠模型,取心脏血并分离血清,进一步分离高密度脂蛋白,采用高密度脂蛋白炎症指数、丙二醛水平和脂蛋白琼脂糖凝胶电泳法检验其氧化程度。分离正常大鼠卵巢颗粒细胞,分别给予模型大鼠血清分离的高密度脂蛋白和氧化修饰高密度脂蛋白处理,CCK-8法检测细胞活力,流式细胞术检测细胞凋亡,H2DCF-DA染色检测活性氧生成水平,Western blot检测p38信号活性。卵巢颗粒细胞分别给予活性氧抑制剂N-乙酰半胱氨酸(NAC)和四甲基哌啶(Tempol)和p38抑制剂SB203580预处理后,再给予氧化修饰高密度脂蛋白处理,然后检测细胞凋亡、活性氧生成和p38信号活性。结果与结论:多囊卵巢综合征模型大鼠血清中高密度脂蛋白部分发生氧化修饰。模型大鼠血清分离的高密度脂蛋白和氧化修饰高密度脂蛋白抑制卵巢颗粒细胞活力和促进细胞凋亡(均P0.05)。结果表明:多囊卵巢综合征能促使高密度脂蛋白发生部分氧化修饰,氧化修饰高密度脂蛋白能通过激活活性氧-p38信号通路促使大鼠卵巢颗粒细胞凋亡。

关键词：多囊卵巢综合征氧化修饰高密度脂蛋白卵巢颗粒细胞凋亡活性氧 p38

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Pollution characteristics, sources and lung cancer risk of atmospheric polycyclic aromatic hydrocarbons in a new urban district of Nanjing, China

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Journal of Environmental Sciences 2017年第5期29卷 118-128页

作者： Tao Wang Zhonghuan Xia minmin wu Qianqian Zhang Shiqi Sun Jing Yin Yanchi Zhou Hao Yang Jiangsu Provincial Key Laboratory of Materials Cycling and Pollution Control School of Environment Nanjing Normal University Nanjing 210023 China Key Laboratory of Virtual Geographic Environment (Nanjing Normal University) Ministry of Education Nanjing 210023 China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023 China State Key Laboratory Cultivation Base of Geographical Environment Evolution (Jiangsu Province) Nanjing 210023 China

This paper focused on the pollution characteristics, sources and lung cancer risk of atmospheric polycyclic aromatic hydrocarbons （PAHs） in a new urban district of Nanjing, China. Gaseous and aerosol PM2.5 （particulate matter with aerodynamic diameter smaller than 2.S μm） samples were collected in spring of 2015. Sixteen PAHs were extracted and analyzed after sampling. Firstly, arithmetic mean concentrations of PAHs and BaPeq （benzo[a]pyrene equivalent） were calculated. The mean concentrations of PAHs were 29.26 ± 14.13,18.14 ± 5.37 and 48.47 ± 16.03 ng/m3 in gas phase, particle phase and both phases, respectively. The mean concentrations of BaPeq were 0.87 ± 0.51, 2.71 ± 2.17 and 4.06 ± 2.31 ng/m3 in gas phase, particle phase and both phases, respectively. Secondly, diagnostic ratios and principal component analysis were adopted to identify the sources of PAHs and the outcomes were the same： traffic exhaust was the predominant source followed by fuel combustion and industrial process. Finally, incremental lung cancer risk （ILCR） induced by whole year inhalation exposure to PAHs for population groups of different age and gender were estimated based on a Monte Carlo simulation. ILCR values caused by particle phase PAHs were greater than those caused by gas phase PAHs. ILCR values for adults were greater than those for other age groups. ILCR values caused by total （gas ＋ particle） PAHs for diverse groups were all greater than the significant level （10-6）, indicating high potential lung cancer risk. Sensitivity analysis results showed that cancer slope factor for BaP inhalation exposure and BaPeq concentration had greater impact than body weight and inhalation rate on the ILCR.

关键词： PAHs BaPeq Ring distribution Source identification ILCR

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基于MCU机电弹力补充原理的恒力控制系统

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机电工程技术 2024年第1期53卷 145-150页

作者：吴民民刘三军湖北民族大学智能科学与工程学院湖北恩施445000

现有力控打磨系统多采用基于PLC(Programmable Logic Controller)控制气动泵的结构,存在反应慢、精度低等问题。提出了一款基于MCU(Micro Processor Unit)带动丝杆控制弹簧结构的恒力控制系统,能够将气动系统的力控精度由2~10 N提高到0.... 详细信息

现有力控打磨系统多采用基于PLC(Programmable Logic Controller)控制气动泵的结构,存在反应慢、精度低等问题。提出了一款基于MCU(Micro Processor Unit)带动丝杆控制弹簧结构的恒力控制系统,能够将气动系统的力控精度由2~10 N提高到0.2~0.5 N量级,反应时间由1~3 s提高到几十ms。首先对丝杆控制弹簧的机械结构进行数学建模,给出了系统响应时间随着电机转速与扭矩、丝杆比、弹簧倔强系数、斜坡角度等物理量的变化的闭式解,随后从模型中分析了提出的系统结构将反应时间降低为几十ms所需的条件以及将力控精度达到零点几牛的关键因素。为了实现上述性能,提出了一种基于弹力补充原理的恒力控制方案,仿真和实验发现该方案比传统PID(Proportional Integeal Differential)的控制方案更接近理论上的响应速度以及力控精度,可广泛应用于工业打磨和抛光,实现更精细的打磨要求。

关键词：恒力控制系统力控精度反应时间弹力补充

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品管圈活动在新生儿重症监护病房机械通气患儿中的应用效果

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中国民康医学 2024年第5期36卷 190-192页

作者：郑惠元王研研巫敏敏驻马店市中心医院新生儿重症医学科河南驻马店463000

目的:观察品管圈活动在新生儿重症监护病房(NICU)机械通气患儿中的应用效果。方法:选取2020年6月至2021年6月该院NICU收治的64例机械通气患儿设为对照组,实施常规护理;另选取2021年7月至2022年7月该院NICU收治的64例机械通气患儿设为观... 详细信息

目的:观察品管圈活动在新生儿重症监护病房(NICU)机械通气患儿中的应用效果。方法:选取2020年6月至2021年6月该院NICU收治的64例机械通气患儿设为对照组,实施常规护理;另选取2021年7月至2022年7月该院NICU收治的64例机械通气患儿设为观察组,实施品管圈活动。比较两组皮肤损伤发生率、住院时间、机械通气时间及家长护理满意度。结果:观察组皮肤损伤发生率为3.12%(2/64),低于对照组的14.06%(9/64),差异有统计学意义(P<0.05);观察组机械通气、住院时间均短于对照组,差异有统计学意义(P<0.05);观察组健康教育、沟通态度、操作技术、护理服务等各项家长护理满意度评分均高于对照组,差异有统计学意义(P<0.05)。结论:品管圈活动应用于NICU机械通气患儿,可降低其皮肤损伤发生率,缩短机械通气时间和住院时间,提高家长满意度,效果优于常规护理。

关键词：品管圈活动新生儿重症监护病房机械通气皮肤损伤家长护理满意度

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孕中早期血浆铁蛋白浓度和三酰甘油浓度升高与妊娠期糖尿病风险的相关性

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公共卫生与预防医学 2024年第4期35卷 153-157页

作者：陈迎春陈明吴敏敏李艺琳江汉大学附属医院武汉市第六医院检验科湖北武汉430015 华中科技大学附属武汉市中心医院检验科湖北武汉430014

目的研究孕中早期联合血浆铁蛋白和三酰甘油(triglyceride,TG)浓度与妊娠期糖尿病(gestational diabetes mellitus,GDM)风险的关系。方法选取2021年1月至2023年1月在武汉市第六医院进行定期产检的1 000例孕妇作为研究对象。采用非限... 详细信息

目的研究孕中早期联合血浆铁蛋白和三酰甘油(triglyceride,TG)浓度与妊娠期糖尿病(gestational diabetes mellitus,GDM)风险的关系。方法选取2021年1月至2023年1月在武汉市第六医院进行定期产检的1 000例孕妇作为研究对象。采用非限制性立方样条分析铁蛋白和三酰甘油的临界值。根据临界值将其分为4组,采用logistic回归模型分析联合铁蛋白和TG与GDM风险之间的关系。结果共有158名(15.80%)参与者确诊为GDM。GDM组孕妇孕中早期的铁蛋白、TG水平均明显高于非GDM组,(P65.7 ng/mL)和高TG(>1.9mmoL/L)的孕妇发生GDM的风险最大。

关键词：铁蛋白妊娠期糖尿病孕中早期三酰甘油

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2019年-2022年儿科、产科及妇科住院患者院内感染病原体分布及耐药性分析

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江苏卫生事业管理 2024年第2期35卷 216-221页

作者：张胜男吴岷岷徐文君王洁杨力钟天鹰南京医科大学附属妇产医院、南京市妇幼保健院感染管理办公室江苏南京210004 南京医科大学附属妇产医院、南京市妇幼保健院人事处江苏南京210004 南京医科大学附属妇产医院、南京市妇幼保健院院长办公室江苏南京210004

目的:积极开展儿科、产科和妇科院内感染病原体分布、耐药性的调查,对经验性治疗妇儿院内感染有重要意义,也为院内感染防控提供参考依据。方法:选取2019-2022年入住我院儿科、产科及妇科诊断为医院感染的患者作为研究对象,收集这3个科... 详细信息

目的:积极开展儿科、产科和妇科院内感染病原体分布、耐药性的调查,对经验性治疗妇儿院内感染有重要意义,也为院内感染防控提供参考依据。方法:选取2019-2022年入住我院儿科、产科及妇科诊断为医院感染的患者作为研究对象,收集这3个科室院内感染率、感染部位等信息,参照《全国临床检验操作规程》中的方法进行细菌分离和鉴定,使用法国生物梅里埃公司VITEK-2Compact全自动细菌鉴定仪和珠海迪尔DL-96全自动细菌测定系统进行细菌鉴定和药敏试验,依据美国临床实验室标准化委员会(CLSI)标准判断结果。结果:2019-2022年纳入研究对象的227124例儿科、产科及妇科患者中,累计发生院内感染770例,院内感染发生率为0.34%。770例院内感染患者中,儿科以菌血症和胃肠道感染多见,分别占31.87%和26.02%;产科以男女性生殖道的其它感染和上呼吸道感染多见,分别占15.98%和14.79%;妇科以腹(盆)腔内组织和急性盆腔炎多见,分别占24.32%和23.94%。770例院内感染患者的临床标本共分离、培养出病原体458株,儿科以表皮葡萄球菌和肺炎克雷伯菌为主,分别占23.12%和20.10%;产科以大肠埃希菌和粪肠球菌为主,分别占23.33%和20.00%;妇科以大肠埃希菌为主,占53.25%。儿科肺炎克雷伯菌对亚胺培南和美罗培南无耐药,产科大肠埃希菌对亚胺培南和美罗培南无耐药,妇科大肠埃希菌对亚胺培南和美罗培南耐药率均为1.11%,儿科表皮葡萄球菌对万古霉素和利奈唑胺无耐药,产科和妇科粪肠球菌对万古霉素和利奈唑胺无耐药。结论:2019-2022年儿科、产科及妇科院内感染发生率为0.34%,我院儿科院内感染率(1.17%)高于产科(0.12%)和妇科(0.43%)。抗菌药物妇科应用率显著高于产科应用率,且非一联用药为主,这就导致妇科院内感染病原体的耐药率高于产科。积极监测儿科、产科和妇科院内感染情况,并及时分析、总结院内感染病原体的分布和耐药性,对于院内感染诊断和抗菌药物治疗性应用均有一定的临床指导意义。

关键词：儿科产科妇科院内感染耐药性

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