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Synergistic Interdecadal Evolution of Precipitation over Eastern China and the Pacific Decadal Oscillation during 1951-2015

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Advances in Atmospheric Sciences 2024年第1期41卷 53-72页

作者： minmin wu Rong-Hua ZHANG Junya HU Hai ZHI Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Laosan Laboratory Qingdao 266237China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China University of Chinese Academy of Sciences Beijing 100029China

By using the multi-taper method(MTM)of singular value decomposition(SVD),this study investigates the interdecadal evolution(10-to 30-year cycle)of precipitation over eastern China from 1951 to 2015 and its relationship with the North Pacific sea surface temperature(SST).Two significant interdecadal signals,one with an 11-year cycle and the other with a 23-year cycle,are identified in both the precipitation and SST fields.Results show that the North Pacific SST forcing modulates the precipitation distribution over China through the effects of the Pacific Decadal Oscillation(PDO)-related anomalous Aleutian low on the western Pacific subtropical high(WPSH)and Mongolia high(MH).During the development stage of the PDO cold phase associated with the 11-year cycle,a weakened WPSH and MH increased the precipitation over the Yangtze River Basin,whereas an intensified WPSH and MH caused the enhanced rain band to move northward to North China during the decay stage.During the development stage of the PDO cold phase associated with the 23-year cycle,a weakened WPSH and MH increased the precipitation over North China,whereas an intensified WPSH and the weakened MH increased the precipitation over South China during the decay stage.The 11-year and 23-year variabilities contribute differently to the precipitation variations in the different regions of China,as seen in the 1998flooding case.The 11-year cycle mainly accounts for precipitation increases over the Yangtze River Basin,while the 23-year cycle is responsible for the precipitation increase over Northeast China.These results have important implications for understanding how the PDO modulates the precipitation distribution over China,helping to improve interdecadal climate prediction.

关键词： MTM-SVD PDO SST anomalies interdecadal variability precipitation over China

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Oriented Generation of Novel Thermo-Sensitive Genic Male Sterile Lines with Improved Grain Shape and Outcrossing Rate in Early-Season Rice

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Rice science 2024年第2期31卷 129-133,I0001-I0016页

作者： ZHANG Huali CHEN Junyu LI Ruiqing WANG Huimei DAI Dongqing LIANG minmin wu Mingyue MA Liangyong State Key Laboratory of Rice Biology and Breeding/Chinese National Center for Rice Improvement China National Rice Research InstituteHangzhou 310006China

Two-line hybrid rice with excellent quality is preferred in the Chinese market.However,there is a trade-off between reducing costs for hybrid seed production and lowering the outcrossing rate of the sterile line,which is largely determined by the stigma exsertion rate(SER).In this study,we constructed mutants of male sterility lines with improved grain length(GL)and SER in three elite early-season indica rice varieties through targeted manipulation of the TMS5 and GS3 genes using CRISPR/Cas9-mediated multiplex systems.We obtained a series of marker-free gs3 single mutants and gs3tms5 double mutants with significantly higher SER,longer grains,and increased 1000-grain weight compared with the wild type(WT).Importantly,the typically thermo-sensitive genic male sterile(TGMS)trait with a higher SER was observed in gs3tms5 mutants,and their F1 hybrids exhibited remarkable improvements in grain shape and yield-related traits.Our findings provided an efficient method to generate new valuable TGMS germplasm with improved SER through the mutagenesis of GS3 and TMS5 synergistically,and demonstrated that GS3 had pleiotropic effects on grain size,SER,and grain quality in early-season indica rice.

关键词： sterile elite season

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Bone metastasis is a late-onset and unfavorable event in survivors of gastric cancer after radical gastrectomy:Results from a clinical observational cohort

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Cancer Pathogenesis and Therapy 2024年第1期2卷 50-57页

作者： Cheng Zhang Xiaopeng Zhang Chong Feng Yahui Yang minmin Xie Ying Feng Zhijun wu Hui Xu Changhao wu Tai Ma Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Anhui Provincial Cancer Institute/Anhui Provincial Office for Cancer Prevention and Control HefeiAnhui 230022China Department of Noncommunicable Diseases and Health Education Hefei Center for Disease Control and PreventionHefeiAnhui 230091China Department of Oncology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221006China Department of Oncology Ma’anshan Municipal People’s HospitalMa’anshanAnhui 243099China Department of Biochemistry and Physiology Faculty of Health and Medical SciencesUniversity of SurreyGuildford GU27HXUnited Kingdom

Background The timing and incidence of recurrent bone metastasis(BM)after radical gastrectomy in patients with gastric cancer(GC)as well as the survival of these patients were not fully understood.The aim of this study was to analyze the data of an observational GC cohort and identify patients who underwent curative gastrectomy and had recurrent BM to describe and clarify the pattern and profile of BM evolution after surgery.Methods Data were retrieved from a hospital-based GC cohort,and patients who underwent upfront radical gastrectomy were selected.The time points of specific organ metastatic events were recorded,and the person-year incidence rate of metastatic events was calculated.The latency period of BM events after gastrectomy was measured and compared with that of the other two most common metastatic events,liver metastasis(LM)and distant lymph node metastasis(LNM),using analysis of variance.Propensity score matching and subgroup analysis were used for sensitivity analysis.Results A total of 1324 GC cases underwent radical gastrectomy between January 2011 and December 2021.Of these,67 BM,218 LM,and 248 LNM occurred before the last follow-up.The incidence of BM events was 1.7/100 person-years,which was approximately 3-fold lower than that of LM and distant LNM events(5.5 and 6.3 per 100 person-years,respectively).BM events had a significantly longer latency(median time,16.5 months)than LM and LNM events(11.1 and 12.0 months,respectively).Recurrent BM led to a worse prognosis(median survival,4.5 months)than those of LM and LNM events(median survival,7.7 and 7.1 months,respectively).However,no difference in overall survival after gastrectomy was observed among the groups.Conclusions Compared with other common metastatic events,BM in GC after gastrectomy is a late-onset event indicating poor survival.

关键词： Stomach neoplasms Neoplasm metastasis Incidence Survival analysis Propensity score

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FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signaling in Arabidopsis

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Molecular Plant 2024年第5期17卷 772-787页

作者： Baiyan Lu Shengnan Wang Hanqian Feng Jing Wang Kaixing Zhang Yilin Li Ping wu minmin Zhang Yanshu Xia Chao Peng Chao Li School of Life Sciences East China Normal UniversityShanghai 200241China National Facilty for Protein Science Shanghai Zhangjang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The phytohormone auxin plays a pivotal role in governing plant growth and development.Although the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX(TIR1/AFB)receptors function in both the nucleus and cytoplasm,the mechanism governing the distribution of TIR1/AFBs between these cellular compartments remains unknown.In this study,we demonstrate that auxin-mediated oxidation of TIR1/AFB2 is essential for their targeting to the nucleus.We showed that small active molecules,reactive oxygen species(ROS)and nitric oxide(NO),are indispensable for the nucleo-cytoplasmic distribution of TIR1/AFB2 in trichoblasts and root hairs.Further studies revealed that this process is regulated by the FERONIA receptor kinase–NADPH oxidase signaling pathway.Interestingly,ROS and NO initiate oxidative modifications in TIR1C140/516 and AFB2C135/511,facilitating their subsequent nuclear import.The oxidized forms of TIR1C140/516 and AFB2C135/511 play a crucial role in enhancing the function of TIR1 and AFB2 in transcriptional auxin responses.Collectively,our study reveals a novel mechanism by which auxin stimulates the transport of TIR1/AFB2 from the cytoplasm to the nucleus,orchestrated by the FERONIA–ROS signaling pathway.

关键词： FERONIA TIR1/AFBs oxidative modification nucleo-cytoplasmic distribution root hair development

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Recent Enhancement in Co-Variability of the Western North Pacific Summer Monsoon and the Equatorial Zonal Wind

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Advances in Atmospheric Sciences 2023年第9期40卷 1597-1616页

作者： minmin wu Xugang PENG Baiyang CHEN Lei WANG Jinwen WENG Weijian LUO Laboratory for Coastal Ocean Variation and Disaster Prediction College of Ocean and MeteorologyGuangdong Ocean UniversityZhanjiang 524088China Key Laboratory of Climate Resourcesand Environment in Continental Shelf Sea and Deep Sea of Department of Education of Guangdong ProvinceGuangdong Ocean UniversityZhanjiang 524088China Key Laboratory of Space Ocean Remote Sensing and Application Ministry of Natural ResourcesBeijing 100081China

The western North Pacific summer monsoon(WNPSM)is an important subcomponent of the Asian summer monsoon.The equatorial zonal wind(EZW)in the lower troposphere over the western Pacific may play a critical role in the evolution of the El Niño-Southern Oscillation(ENSO).The possible linkage between the EZW over the western Pacific and the offequatorial monsoonal winds associated with the WNPSM and its decadal changes have not yet been fully understood.Here,we find a non-stationary relationship between the WNPSM and the western Pacific EZW,significantly strengthening their correlation around the late 1980s/early 1990s.This observed shift in the WNPSM–EZW relationship could be explained by the changes in the related sea surface temperature(SST)configurations across the tropical oceans.The enhanced influence from the springtime tropical North Atlantic,summertime tropical central Pacific,and maritime continent SST anomalies may be working together in contributing to the recent intensified WNPSM–EZW co-variability.The observed recent strengthening of the WNPSM–EZW relationship may profoundly impact the climate system,including prompting more effective feedback from the WNPSM on subsequent ENSO evolution and bolstering a stronger biennial tendency of the WNPSM–ENSO coupled system.The results obtained herein imply that the WNPSM,EZW,ENSO,and the tropical North Atlantic SST may be closely linked within a unified climate system with a quasi-biennial rhythm occurring during recent decades,accompanied by a reinforcement of the WNPSM–ENSO interplay quite possibly triggered by enhanced tropical Pacific–Atlantic cross-basin interactions.These results highlight the importance of the tropical Atlantic cross-basin influences in shaping the spatial structure of WNPSM-related wind anomalies and the WNPSM–ENSO interaction.

关键词： western North Pacific summer monsoon equatorial zonal wind interdecadal variability monsoon-ENSO interaction cross-basin interactions biennial variability

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JAG1 enhances angiogenesis in triple-negative breast cancer through promoting the secretion of exosomal lncRNA MALAT1

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Genes & Diseases 2023年第5期10卷 2167-2178页

作者： Junping Liu Yutong Shi minmin wu Fengmei Zhang Mengqi Xu Zhiqiang He Min Tang Key Laboratory of Laboratory Medical Diagnostics Designated by the Chinese Ministry of Education Chongqing Medical UniversityChongqing 400016China

Despite significant improvements in five-year survival rates due to early diagnosis and combination therapy, triple-negative breast cancer (TNBC) treatment remains a major challenge. Finding new and effective targets for diagnosis and drug therapy is urgent for TNBC patients. Jagged-1 (JAG1), one of the canonical ligands of the Notch signaling pathway, is involved in vascular budding and is a poor prognostic factor of TNBC. In this study, combined with quantitative real-time PCR, database analysis, animal experiments, and other means, JAG1 was confirmed to be related to the poor prognosis of TNBC patients. JAG1 was highly expressed in MDA-MB-231 Bone (231B) cells, with stronger invasion and metastasis ability than MDA-MB-231 (231) cells. Treatment of human vascular endothelial cells (HUVEC) with TNBC conditioned medium showed that TNBC JAG1 promoted the angiogenesis of HUVEC. Next, we detected the exosomes extracted from TNBC conditioned medium and found that JAG1 promoted the exosome secretion from 231 cells via ALIX-RAB11A/RAB35. In addition, we also found that the exosomes from JAG1 overexpressed TNBC cells contained more long non-coding RNA (lncRNA) MALAT1 , and MALAT1 promoted angiogenesis of HUVEC by targeting miR-140-5p . Finally, the angiogenesis-promoting effect of JAG1 in TNBC was further investigated by matrix gel assay. In conclusion, we reveal that JAG1 has a pro-invasion effect on TNBC and is involved in microenvironment angiogenesis by promoting exosome secretion and the MALAT1-miR-140-5p-JAG1/VEGFA pathway.

关键词： Angiogenesis Exosome JAG1 lncRNAMALAT1 Triple-negative breast cancer

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Recent Weakening in Interannual Variability of Mean Tropical Cyclogenesis Latitude over the Western North Pacific during Boreal Summer

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Journal of Meteorological Research 2020年第6期34卷 1183-1198页

作者： minmin wu Lei WANG Baiyang CHEN Laboratory for Coastal Ocean Variation and Disaster Prediction College of Ocean and MeteorologyGuangdong Ocean UniversityZhanjiang 524088 Key Laboratory of Climate Resources and Environment in Continental Shelf Sea and Deep Sea of Department of Education of Guangdong ProvinceGuangdong Ocean UniversityZhanjiang 524088 Marine Resources Big Data Center of South China Sea Southern Marine Science and Engineering Guangdong Laboratory(Zhanjiang)Zhanjiang 524025

The intensity of the interannual variability(IIV)of the mean tropical cyclone(TC)genesis latitude over the western North Pacific(WNP)has been weakening significantly since the late 1990 s.It is found that the IIV of the mean TC genesis latitude depends largely on the strength of the out-of-phase relationship between TC genesis numbers in the north(north of 15°N)and south(south of 15°N)of the WNP.A weaker(stronger)north–south TC see-saw has led to a smaller(larger)IIV of the mean TC genesis latitude after(before)the late 1990 s.Different configurations of sea surface temperature(SST)anomalies are found to be responsible for the decadal changes in the north–south TC see-saw and dipole structure.Before the late 1990 s,the joint effect of SST anomalies over the tropical Pacific and tropical North Indian Ocean dominated,rendering the obvious north–south TC see-saw and larger IIV of the mean TC genesis latitude.After the late 1990 s,however,the dominant SST anomalies associated with TC genesis shift to the tropical central Pacific(CP)and tropical North Atlantic Ocean,which have weakened the north–south TC seesaw and reduced the IIV of the mean TC genesis latitude.These observed decadal changes in the configuration of SST anomalies are considered to be closely associated with the shift of the El Ni?o–Southern Oscillation(ENSO)from eastern Pacific(EP)type to the CP type during the recent decades.The results suggest that the increased influences from the tropical Atlantic Ocean have become more important to the variations of TC activity in the WNP during the recent decades.These results may have important implications for assessing the latitudinal distributions of TC-induced hazards.

关键词： tropical cyclone cyclogenesis latitude decadal change shifting El Nino–Southern Oscillation(ENSO) western North Pacific(WNP) tropical Atlantic sea surface temperature(SST)

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Cobalt doping amount determines dominant reactive species in peroxymonosulfate activation via porous carbon catalysts co-doped by cobalt and nitrogen

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Journal of Environmental Sciences 2024年第4期138卷 212-226页

作者： Xiang Li Limeng wu Aiqin Zhang Shaohua wu Yan Lin Chunping Yang Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Academy of Environmental and Resource Sciences School of Environmental Science and EngineeringGuangdong University of Petrochemical TechnologyMaoming 525000China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China

Switching the reaction routes in peroxymonosulfate(PMS)-based advanced oxidation processes have attracted much attention but remain challenging.Herein,a series of Co-N/C catalysts with different compositions and structures were prepared by using bimetallic zeolitic imidazolate frameworks based on ZIF-8 and ZIF-67(x Zn/Co-ZIFs).Results show that Co doping amount could mediate the transformation of the activation pathway of PMS over CoN/C.When Co doping amount was less than 10%,the constructed x Co-N/C/PMS system(x≤10%)was singlet oxygen-dominated reaction;however further increasing Co doping amount would lead to the generation and coexistence of sulfate radicals and high-valent cobalt,besides singlet oxygen.Furthermore,the nitrogen-coordinated Co(Co-NX)sites could serve as main catalytically active sites to generate singlet oxygen.While excess Co doping amount caused the formation of Co nanoparticles from which leached Co ions were responsible for the generation of sulfate radicals and high-valent cobalt.Compared to undoped N/C,Co doping could significantly enhance the catalytic performance.The 0.5%Co-N/C could achieve the optimum degradation(0.488 min^(-1))and mineralization abilities(78.4%)of sulfamethoxazole among the investigated Co-N/C catalysts,which was superior to most of previously reported catalysts.In addition,the application prospects of the two systems in different environmental scenarios(pH,inorganic anions and natural organic matter)were assessed and showed different degradation behaviors.This study provides a strategy to regulate the reactive species in PMS-based advanced oxidation process.

关键词： Peroxymonosulfate Sulfate radical Singlet oxygen Cobalt Zeolitic imidazolate framework Advanced oxidation process

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The physiological role of the unfolded protein response in the nervous system

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Neural Regeneration Research 2024年第11期19卷 2411-2420页

作者： Shuangchan wu Wensheng Lin Department of Neuroscience University of MinnesotaMinneapolisMNUSA Institute for Translational Neuroscience University of MinnesotaMinneapolisMNUSA

The unfolded protein response(UPR)is a cellular stress response pathway activated when the endoplasmic reticulum,a crucial organelle for protein folding and modification,encounters an accumulation of unfolded or misfolded proteins.The UPR aims to restore endoplasmic reticulum homeostasis by enhancing protein folding capacity,reducing protein biosynthesis,and promoting protein degradation.It also plays a pivotal role in coordinating signaling cascades to determine cell fate and function in response to endoplasmic reticulum stress.Recent research has highlighted the significance of the UPR not only in maintaining endoplasmic reticulum homeostasis but also in influencing various physiological processes in the nervous system.Here,we provide an overview of recent findings that underscore the UPR’s involvement in preserving the function and viability of neuronal and myelinating cells under physiological conditions,and highlight the critical role of the UPR in brain development,memory storage,retinal cone development,myelination,and maintenance of myelin thickness.

关键词： myelin neuron oligodendrocyte Schwann cell unfolded protein response

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LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

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Chinese Medical Journal 2024年第2期137卷 190-199页

作者： Muchen wu Jing wu Kai Liu Minjie Jiang Fang Xie Xuehong Yin Jushan wu Qinghua Meng Department of Liver Disease Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of General Surgery Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex pathogenesis.Clinical hypoglycemia is common in patients with ACLF and often predicts a worse prognosis.Accumulating evidence suggests that glucose metabolic disturbance,especially gluconeogenesis dysfunction,plays a critical role in the disease progression of ACLF.Lon protease-1(LONP1)is a novel mediator of energy and glucose metabolism.However,whether gluconeogenesis is a potential mechanism through which LONP1 modulates ACLF remains unknown.Methods:In this study,we collected liver tissues from ACLF patients,established an ACLF mouse model with carbon tetrachloride(CCl 4),lipopolysaccharide(LPS),and D-galactose(D-gal),and constructed an in vitro hypoxia and hyperammonemia-triggered hepatocyte injury model.LONP1 overexpression and knockdown adenovirus were used to assess the protective effect of LONP1 on liver injury and gluconeogenesis regulation.Liver histopathology,biochemical index,mitochondrial morphology,cell viability and apoptosis,and the expression and activity of key gluconeogenic enzymes were detected to explore the underlying protective mechanisms of LONP1 in ACLF.Results:We found that LONP1 and the expressions of gluconeogenic enzymes were downregulated in clinical ACLF liver tissues.Furthermore,LONP1 overexpression remarkably attenuated liver injury,which was characterized by improved liver histopathological lesions and decreased serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in ACLF mice.Moreover,mitochondrial morphology was improved upon overexpression of LONP1.Meanwhile,the expression and activity of the key gluconeogenic enzymes were restored by LONP1 overexpression.Similarly,the hepatoprotective effect was also observed in the hepatocyte injury model,as evidenced by improved cell viability,reduced cell apoptosis,and improved gluconeogenesis level and activity,while LONP1 knockdown worsened liver injury and gluconeogenesis disorders.Conclusion:We demonstrated that gluconeogenesis dysfunc

关键词： Acute-on-chronic liver failure Lon protease-1 Gluconeogenesis disturbance Mitochondrial dysfunction Metabolism

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