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Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

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Nano Research 2024年第10期17卷 9141-9151页

作者： Jeong Yu Lee Shonit Nair Sharma Sung-Yu Hong Young-Guk Ko Yangsoo Jang minjae do Michael Christopher Stark Qiwen Peng Benjamin Allen Mossburg Bo Chan Seo Yuhan Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 305-701Republic of Korea Department of Anesthesiology Perioperativeand Pain MedicineCenter for Accelerated Medical Innovation&Center for NanomedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Cardiovascular Product Evaluation Center Yonsei University College of MedicineSeoul 120-752Republic of Korea Division of Cardiology Department of Internal MedicineSeverance Cardiovascular HospitalYonsei University College of MedicineSeoul 120-752Republic of Korea

Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery *** advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention *** balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion ***,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a ***,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional *** the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH *** exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon *** with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the *** results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.

关键词： drug-eluting balloon layer-by-layer coating coronary artery disease paclitaxel

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Oxygen vacancy engineering for tuning the catalytic activity of LaCoO_(3) perovskite

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Journal of Rare Earths 2024年第3期42卷 506-514,I0003页

作者： Jeong Hyun Cho minjae Kim Inchan Yang Kyung Tae Park Chang Houn Rhee Hai Woong Park Ji Chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and TechnologyWanju-gunJeollabuk-do 55324Republic of Korea Iron&Steel Process Engineering Research Group POSCOPohang 37859Republic of Korea Hydrogen Research Center Research Institute of Industrial Science&Technology(RIST)Pohang 37673Republic of Korea

Herein, we attempted to engineer oxygen vacancies on the surface of LaCoO_(3) perovskite through simple post-treatments(acid or reductive thermal treatments). Acid treatment induces oxygen vacancies through the selective etching of the La cations, whereas thermal treatment in a reducing atmosphere generates oxygen vacancies by directly removing lattice oxygen. The characterization results confirm that the number of surface oxygen vacancies, which are crucial in various catalytic oxidation reactions,considerably increases in the LaCoO_(3) catalysts treated with acid or reducing gas. Acid treatment enriches the oxygen vacancies while maintaining the structure of the LaCoO_(3) catalysts, which can not be achieved through reductive thermal treatment. Therefore, the acid treatment is considered a promising technique for oxygen vacancy engineering of perovskite catalysts for tuning their catalytic activities. Furthermore,the catalytic activities of the posttreated LaCoO_(3) catalysts for CO oxidation were evaluated and are noted to be considerably better than those of the pristine LaCoO_(3) catalyst due to their abundant oxygen vacancies. Consequently, we conclude that the oxygen vacancies of perovskite catalysts can be effectively engineered via two simple methods and play a significant role in CO oxidation.

关键词： LaCoO_(3)perovskite Acid treatment Reductive thermal treatment Oxygen vacancy CO oxidation Rare earths

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Dimensionality-driven metal to Mott insulator transition in two-dimensional 1T-TaSe2

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National Science Review 2024年第3期11卷 108-118页

作者： Ning Tian Zhe Huang Bo Gyu Jang Shuaifei Guo Ya-Jun Yan Jingjing Gao Yijun Yu Jinwoong Hwang Cenyao Tang Meixiao Wang Xuan Luo Yu Ping Sun Zhongkai Liu dong-Lai Feng Xianhui Chen Sung-Kwan Mo minjae Kim Young-Woo Son Dawei Shen Wei Ruan Yuanbo Zhang State Key Laboratory of Surface Physics New Cornerstone Science Laboratory and Department of PhysicsFudan University Shanghai Qi Zhi Institute Shanghai Research Center for Quantum Sciences Institute for Nanoelectronic Devices and Quantum Computing Fudan University Zhangjiang Fudan International Innovation Center Fudan University State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology(SIMIT)Chinese Academy of Sciences School of Physical Science and Technology ShanghaiTech University Korea Institute for Advanced Study School of Emerging Technology and Department of Physics University of Science and Technology of China Advanced Light Source Lawrence Berkeley National Laboratory ShanghaiTech Laboratory for Topological Physics Key Laboratory of Materials Physics Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of Sciences High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Collaborative Innovation Centre of Advanced Microstructures Nanjing University Department of Physics University of Science and Technology of China and Key Laboratory of Strongly Coupled Quantum Matter Physics Chinese Academy of Sciences National Synchrotron Radiation Laboratory University of Science and Technology of China

Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena. In the extreme two-dimensional limit, electron-electron interaction often dominates over other electronic energy scales, leading to strongly correlated effects such as quantum spin liquid and unconventional *** dominance is conventionally attributed to the lack of electron screening in the third dimension. Here, we discover an intriguing metal to Mott insulator transition in 1T-TaSe2that defies conventional wisdom. Specifically, we find that dimensionality crossover, instead of reduced screening, drives the transition in atomically thin 1T-TaSe2. A dispersive band crossing the Fermi level is found to be responsible for the bulk metallicity in the material. Reducing the dimensionality,however, effectively quenches the kinetic energy of these initially itinerant electrons, and drives the material into a Mott insulating *** dimensionality-driven metal to Mott insulator transition resolves the long-standing dichotomy between metallic bulk and insulating surface of 1T-TaSe2. Our work further reveals a new pathway for modulating two-dimensional materials that enables exploring strongly correlated systems across uncharted parameter space.

关键词： two-dimensional materials 1T-TaSe2 dimensionality crossover metal to Mott insulator transition

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HPLC法测定雪地茶中鳞片衣酸和羊角衣酸的含量

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中国民族民间医药 2024年第14期33卷 28-31页

作者：袁艺榕 minjae Kim Joonho Lee Yoojae Maeng 乐金生活健康化妆品研发(上海)有限公司上海200233

目的:建立高效液相色谱法(HPLC)同时测定雪地茶中2种缩酚酸(鳞片衣酸、羊角衣酸)含量的方法。方法:采用Eclipse XDB-C_(18)(4.6 mm×250 mm,5μm)色谱柱,乙腈(A)-0.075%磷酸水溶液(B)为流动相,梯度洗脱(0~40 min,35%A→55%A;40~41 min,5... 详细信息

目的:建立高效液相色谱法(HPLC)同时测定雪地茶中2种缩酚酸(鳞片衣酸、羊角衣酸)含量的方法。方法:采用Eclipse XDB-C_(18)(4.6 mm×250 mm,5μm)色谱柱,乙腈(A)-0.075%磷酸水溶液(B)为流动相,梯度洗脱(0~40 min,35%A→55%A;40~41 min,55%A→100%A;41~49 min,100%A;49~60 min,100%A→35%A),流速为1.0 mL·min^(-1),检测波长213 nm,柱温40℃,进样量10μL。结果:鳞片衣酸在0.15~0.55 mg·mL^(-1)范围内线性关系良好(R^(2)=1),方法的平均回收率为94.15%,RSD为0.21%(n=6)。羊角衣酸在0.05~0.55 mg·mL^(-1)范围内线性关系良好(R^(2)=0.9997),方法的平均回收率为97.83%,RSD为0.16%(n=6)。结论:建立的该含量测定方法结果准确,重复性和分离度好,可用于同时测定雪地茶中两种缩酚酸的含量,为雪地茶药材的质量控制提供了科学依据,对其质量标准的建立具有一定的参考意义。

关键词：雪地茶高效液相色谱法鳞片衣酸羊角衣酸含量测定

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Bandwidth-Efficient Transmission Method for User View-Oriented Video Services

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Computers, Materials & Continua 2020年第12期65卷 2571-2589页

作者： minjae Seo Jong-Ho Paik Department of Computer Seoul Women’s UniversitySeoul01797Korea Department of Software Convergence Seoul Women’s UniversitySeoul01797Korea

The trend in video viewing has been evolving beyond simply providing a multi-view ***,a function that allows selection and viewing of a clip from a multi-view service that captures a specific range or object has been *** particular,the free-view service is an extended concept of multi-view and provides a freer ***,since numerous videos and additional data are required for its construction,all of the clips constituting the content cannot be simultaneously *** certain clips are selected and provided to the *** the video is not the preferred video,change request is made,and a delay occurs during retransmission from the *** due to frequent re-requests degrade the overall quality of *** free-view services,selectively transmitting the video according to the user’s desired viewpoint and region of interest within the limited network of available videos is *** this study,we propose a method of screening and providing the correct video based on objects in the *** on the method of recognizing the object in each clip,we designed a method of setting its priority based on information about the object’s location for each *** the transmission and receiving process using this information,the selected video can be rapidly recognized and ***,we present a service system configuration method and propose video selection examples for free-view services.

关键词： Free-viewpoint video multi-view video coding scene change object co-detection transmission method

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Optimal Age Replacement Policy with Replacement Occurrence While the Warranty is in Effect

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Journal of Shanghai Jiaotong university(Science) 2015年第3期20卷 374-379页

作者： PARK minjae JUNG Ki Mun PARK dong Ho College of Business Administration Hongik University Department of Informational Statistics Kyungsung University Industry Academic Cooperation Foundation Hallym University

This study considers an age replacement policy(ARP) for a repairable product with an increasing failure rate with and without a product warranty. As for the warranty policy to consider in association with such an age replacement policy, we adapt a renewable minimal repair-replacement warrant(MRRW) policy with 2D factors of failure time of the product and its corresponding repair time. The expected cost rate during the life cycle of the product is utilized as a criterion to find the optimal policies for both with and without the product warranty. We determine the optimal replacement age that minimizes the objective function which evaluates the expected cost rate during the product cycle and investigate the impact of several factors on the optimal replacement age. The main objective of this study lies on the generalization of the classical age replacement policy to the situation where a renewable warranty depending on 2D factors is in effect. We present some interesting observations regarding the effect of relevant factors based on numerical analysis.

关键词： age replacement policy(ARP) expected cost rate failure times renewable minimal repairreplacement warranty(MRRW) warranty servicing times

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Liquid-like adsorbent assembled by CNTs: Serving as renewable CO_(2) capture materials for indoor air

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Journal of Energy Chemistry 2021年第12期30卷 574-584,I0014页

作者： Jae Won Lee minjae Kim Han Sol Jung Ronghuan Xu Seonggon Kim Yong Tae Kang School of Mechanical Engineering Korea UniversitySeoul 02841South Korea

In this study,a CO_(2) capture material in the form of liquid-like adsorbents(LLAs) is developed to overcome the limitations of conventional types of *** increase in indoor activities necessitates the capture of CO_(2) in enclosed indoor *** spaces require safe and stable materials for CO_(2) capture because humans are present in these *** adsorbents are mainly used because liquid absorbents are unsuitable owing to noise and scattering *** LLA,the liquid absorbent assembled by carbon nanotubes(CNTs) is solidified and prevented from flowing and scattering *** present to maintain 95% of initial capacity after recycling 20 times,and have characteristics that can be regenerated in a low temperature heat source(80 to 120℃) and moisture *** work not only provides indoor useable CO_(2) capture materials,but also offers a new prospect in the field of adsorbents.

关键词： CO_(2)capture CNT Silicone oil Adsorbents Indoor air

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Different intraoperative decisions for undiagnosed paraganglioma:Two case reports

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World Journal of Clinical Cases 2022年第30期10卷 11059-11065页

作者： dongho Kang Bo-eun Kim minjae Hong Joungmin Kim Seongtae Jeong Seongheon Lee Department of Anesthesiology and Pain Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469South Korea

BACKGROUND Paragangliomas may be preoperatively misdiagnosed as non-functioning retroperitoneal tumors and are sometimes suspected only at the time of intraoperative *** preoperative alpha blockade preparation,a hypertensive crisis during tumor manipulation and hypotension after tumor removal may result in critical ***,primary consideration should be given to the continuation or discontinuation of surgery on the basis of the possibility of gentle surgical manipulation and hemodynamic *** report two cases of paragangliomas detected *** SUMMARY A 65-year-woman underwent laparoscopic small-bowel wedge resection.A hypertensive crisis occurred during manipulation of the mass,and an unrecognized catecholamine-producing paraganglioma was *** surgeon and anesthesiologists believed that tumor excision could be performed with minimal manipulation of the tumor because the tumor was in a favorable *** hemodynamic instability did not occur with aggressive use of vasoactive drugs.A week later,a 54-year-man underwent open resection of a 3-cm-sized retroperitoneal mass and showed the same findings during mass *** this patient,continuous manipulation of the mass seemed inevitable due to adhesion between the right adrenal gland and the mass in a narrow surgical *** surgeon and anesthesiologists decided to cancel the surgical procedure and planned to perform a reoperation after alpha blockade *** weeks later,the tumor was uneventfully removed with small doses of vasoactive *** When an undiagnosed paraganglioma is suspected intraoperatively,reoperation after adequate preparation should be considered as an option to avoid fatal outcomes.

关键词： Paraganglioma Undiagnosed diseases Hypertensive crisis Preoperative alpha blockade Surgery cancellation Neuroendocrine tumors Case report

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Evaluation of an erosion-sediment transport model for a hillslope using laboratory flume data

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Journal of Arid Land 2014年第6期6卷 647-655页

作者： Anya Catherine CARGUELLES minjae JUNG Kristine Joy BMALLARI GiJung PAK Hafzullah AKSOY Levent M KAVVAS Ebru ERIS JaeYoung YOON YoungJoon LEE SeonHwa HONG Department of Environmental Engineering Korea University Sejong 339-700Korea Program in Environmental Technology and Policy Korea University Sejong 339-700Korea Department of Civil Engineering Istanbul Technical University Maslak 34469IstanbulTurkey Department of Civil and Environmental Engineering University of California DavisCalifornia 95616USA Department of Civil Engineering Ege University Bornova 35100IzmirTurkey Geum-River Environment Research Center National Institute of Environmental Research OkcheonChungbuk 373-804Korea

Climate change can escalate rainfall intensity and cause further increase in sediment transport in arid lands which in turn can adversely affect water quality. Hence, there is a strong need to predict the fate of sediments in order to provide measures for sound erosion control and water quality management. The presence of micro- topography on hillslopes influences processes of runoff generation and erosion, which should be taken into account to achieve more accurate modelling results. This study presents a physically based mathematical model for erosion and sediment transport coupled to one-dimensional overland flow equations that simulate rainfall-runoff generation on the rill and interrill areas of a bare hillslope. Modelling effort at such a fine resolution considering the flow con- nection between Jnterrill areas and rills is rarely verified. The developed model was applied on a set of data gath- ered from an experimental setup where a 650 cm×136 cm erosion flume was pre-formed with a longitudinal rill and interrJll having a plane geometry and was equipped with a rainfall simulator that reproduces natural rainfall characteristics. The flume can be given both longitudinal and lateral slope directions. For calibration and validation, the model was applied on the experimental results obtained from the setup of the flume having 5% lateral and 10% longitudinal slope directions under rainfall intensities of 105 and 45 mm/h, respectively. Calibration showed that the model was able to produce good results based on the R2 （0.84） and NSE （0.80） values. The model performance was further tested through validation which also produced good statistics （R2=0.83, NSE=0.72）. Results in terms of the sedigraphs, cumulative mass curves and performance statistics suggest that the model can be a useful and an important step towards verifying and improving mathematical models of erosion and sediment transport.

关键词： climate change erosion rill and interrill physically based model sediment transport

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Lithium plating-free 1 Ah-level high-voltage lithium-ion pouch battery via ambi-functional pentaerythritol disulfate

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能源化学:英文版 2023年第8期83卷 229-238,I0007页

作者： Dung Tien Tuan Vu Jinsol Im Jae-Hee Kim Jisoo Han Gyeong Jun Chung Giang Thi Huong Nguyen Junhyeok Seo minjae Kim Eui-Hyung Hwang Young-Gil Kwon Jae Wook Shin Kuk Young Cho Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National UniversityDaejeon 34134Republic of Korea Department of Materials Science&Chemical Engineering Hanyang UniversityAnsan 15588Republic of Korea Fine Chem Co.Ltd. Daejeon 34365Republic of Korea d CSIM Co.Ltd. Yesan 32400Republic of Korea dongwha Electrolyte Nonsan 32925Republic of Korea

Elevating the charge cut-off voltage beyond traditional 4.2 V is a commonly accepted technology to increase the energy density of Li-ion batteries(LIBs) but the risk of Li-dendrites and fire hazard increases as well. The use of ambi-functional additive, which forms stable solid electrolyte interphase(SEI) simultaneously at both cathode and anode, is a key to enabling a dendrites-free and well-working high-voltage LIB. Herein, a novel ambi-functional additive, pentaerythritol disulfate(PEDS), at 1 wt% without any other additive is demonstrated. We show the feasibility and high impacts of PEDS in forming lithium sulfateincorporated robust SEI layers at NCM523 cathode and graphite anode in 1 Ah-level pouch cell under4.4 V, 25 °C and 0.1 C rate, which mitigates the high-voltage instability, metal-dissolution and cracks on NCM523 particles, and prevents Li-dendrites at graphite anode. Improved capacity retention of 83%after 300 cycles is thereby achieved, with respect to 69% with base electrolyte, offering a promising path toward the design of practical high-energy LIBs.

关键词： Lithium-ion pouch cell Lithium plating-free High-voltage Ambi-functional additive SEI layer

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