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Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease:pathologic roles and therapeutic implications

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Translational Neurodegeneration 2021年第4期10卷 643-665页

作者： Hyeon soo Kim Sujin Kim Soo Jung Shin Yong Ho Park Yunkwon Nam Chae won Kim Kang won Lee Sung-Min Kim In Duk Jung Hyun Duk Yang Yeong-Min Park minho moon Department of Biochemistry College of MedicineKonyang UniversityDaejeon 35365Republic of Korea Research Institute for Dementia Science Konyang UniversityDaejeon 35365Republic of Korea Dandi Bioscience Inc 6th Floor of Real Company Building66Achasan-roSungdong-guSeoulRepublic of Korea Harvard Neurology Clinic 294 Gwanggyojungang-roSuji-guYongin 16943Republic of Korea Department of Immunology School of MedicineKonkuk University268ChungwondaeroChungju-siChungcheongbuk-doRepublic of Korea

Alzheimer's disease(AD)is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive decline.Failures in the development of therapeutics targeting amyloid-β(Aβ)and tau;principal proteins inducing pathology in AD,suggest a paradigm shift towards the development of new therapeutic targets.The gram-negative bacteria and lipopolysaccharides(LPS)are attractive new targets for AD treatment.Surprisingly,an altered distribution of gram-negative bacteria and their LPS has been reported in AD patients.Moreover,gram-negative bacteria and their LPS have been shown to affect a variety of AD-related pathologies,such as Aβ homeostasis,tau pathology,neuroinflammation,and neurodegeneration.Moreover,therapeutic approaches targeting gram-negative bacteria or gram-negative bacterial molecules have significantly alleviated AD-related pathology and cognitive dysfunction.Despite multiple evidence showing that the gram-negative bacteria and their LPS play a crucial role in AD pathogenesis,the pathogenic mechanisms of gram-negative bacteria and their LPS have not been clarified.Here,we summarize the roles and pathomechanisms of gram-negative bacteria and LPS in AD.Furthermore,we discuss the possibility of using gram-negative bacteria and gram-negative bacterial molecules as novel therapeutic targets and new pathological characteristics for AD.

关键词： Alzheimer's disease Gram-negative bacteria Lipopolysaccharide Exotoxin Amyloid beta Tau

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Large-area plastic nanogap electronics enabled by adhesion lithography

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npj Flexible Electronics 2018年第1期2卷 143-152页

作者： James Semple Dimitra G.Georgiadou Gwenhivir Wyatt-moon minho Yoon Akmaral Seitkhan Emre Yengel Stephan Rossbauer Francesca Bottacchi Martyn A.McLachlan Donal D.C.Bradley Thomas D.Anthopoulos Department of Physics&Centre for Plastic Electronics Imperial College LondonPrince Consort RoadSouth KensingtonLondon SW72AZUK Division of Physical Sciences and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Department of Materials&Centre for Plastic Electronics Imperial College LondonExhibition RoadSouth KensingtonLondon SW72AZUK Departments of Engineering Science and Physics and Division of Mathematical Physical and Life SciencesOxford University9 Parks RoadOxford OX13PDUK

Large-area manufacturing of flexible nanoscale electronics has long been sought by the printed electronics industry.However,the lack of a robust,reliable,high throughput and low-cost technique that is capable of delivering high-performance functional devices has hitherto hindered commercial exploitation.Herein we report on the extensive range of capabilities presented by adhesion lithography(a-Lith),an innovative patterning technique for the fabrication of coplanar nanogap electrodes with arbitrarily large aspect ratio.We use this technique to fabricate a plethora of nanoscale electronic devices based on symmetric and asymmetric coplanar electrodes separated by a nanogap<15 nm.We show that functional devices including self-aligned-gate transistors,radio frequency diodes and rectifying circuits,multi-colour organic light-emitting nanodiodes and multilevel non-volatile memory devices,can be fabricated in a facile manner with minimum process complexity on a range of substrates.The compatibility of the formed nanogap electrodes with a wide range of solution processable semiconductors and substrate materials renders a-Lith highly attractive for the manufacturing of large-area nanoscale opto/electronics on arbitrary size and shape substrates.

关键词： lithography attractive electronics

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Development of large acceptance multi-purpose spectrometer in Korea for symmetry energy

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Nuclear Science and Techniques 2018年第12期29卷 6-14页

作者： Byungsik Hong Jung Keun Ahn Gyeonghwan Bak Jamin Jo minho Kim Eun Joo Kim Young Jin Kim Young Jun Kim Minjung Kweon Hanseul Lee Hyo Sang Lee Jong-Won Lee Jung Woo Lee Kyong Sei Lee Byul moon Dong Ho moon Benard Mulilo Jaebeom Park Min Sang Ryu Hyunha Shim LAMPS Collaboration Department of Physics Korea University Seoul 02841Republic of Korea Department of Physics Chonnam National UniversityGwangju 61186 Republic of Korea Division of Science Education Chonbuk National UniversityJeonju 54896 Republic of Korea Rare Isotope Science Project Institute for Basic ScienceDaejeon 34047 Republic of Korea Department of Physics Inha University Incheon 22212Republic of Korea

The Rare Isotope Accelerator complex for ONline experiments(RAON) is a new radioactive ion beam accelerator facility under construction in Korea. The large acceptance multi-purpose spectrometer(LAMPS) is one of the experimental devices for nuclear physics at RAON. It focuses on the nuclear symmetry energy at supra-saturation densities. The LAMPS Collaboration has developed and constructed various detector elements, including a time projection chamber(TPC) and a forward neutron detector array. From the positron beam test, the drift velocity of the secondary electrons in the TPC is 5:3±0:2 cm/ls with P10 gas mixture, and the position resolution for pads with dimensions of 4×15 mm^2 is in the range of$ 0.6–0.8 mm, depending on the beam position. From the neutron beam test, the energy resolution of the prototype neutron detector module is determined to be 3.4%, and theposition resolution is estimated to be better than 5.28 cm.At present, the construction of the LAMPS neutron detector system is in progress.

关键词：分光计精力用途朝鲜对称开发核物理学合作发展

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