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Associations of autoantibodies and clinical profile of the patients with systemic sclerosis

rheumatology & Autoimmunity 2022年第3期2卷 141-149页

作者： Shahin Mahmud minhaj r.choudhury Iftekhar H.Bandhan Md.Sahidul Islam MdAbu Shahin Syed A.Haq Mohammad M.Zaman Department of Clinical Neurology National Institute of Neurosciences and HospitalAgargaonDhakaBangladesh Department of rheumatology Bangabandhu Sheikh Mujib Medical UniversityDhakaBangladesh Data Management World Health OrganizationDhakaBangladesh research and Publication World Health OrganizationDhakaBangladesh

Background:Systemic sclerosis is characterized by the involvement of organs and the presence of specific *** objectives of this study were to identify the autoantibodies and to determine their association with the selected clinical features of the disease among Bangladeshi systemic sclerosis ***:This cross-sectional study was performed at the rheumatology outpatient clinic of Bangabandhu Sheikh Mujib Medical *** against nine systemic sclerosis-specific antigens were tested using an enzyme-linked immunoassay immunoblot *** clinical features of patients with positive and negative autoantibody were examined by χ^(2) or Fisher's exact ***:A total of 71 patients with systemic sclerosis(66;93.0%female)were *** mean age at disease onset was 33.2 ***-seven(80.3%)patients had diffuse cutaneous *** of nine autoantibodies,four were positive,anti-topoisomerase-I(57.7%),anti-U1 ribonucleic protein(21.1%),anti-rNA polymerase Ⅲ(18.3%),and anticentromere antibodies(4.2%).Eleven(15.5%)patients were negative for any antibodies and 11 patients were positive for at least two ***-U3-rNP,anti-PMScl,anti-Ku,and anti-Th/To auto antibodies were absent in all ***-rNA polymerase III was associated with raised pulmonary arterial systolic pressure(PASP)and anti-U1-rNP with decreased forced vital capacity(FVC).Conclusions:Anti-topoisomerase-I was the commonest autoantibody in patients with systemic sclerosis in ***-rNA polymerase III antibody had significant association with raised PASP and anti-U1-rNP with decreased FVC.

关键词： autoantibodies clinical profile systemic sclerosis

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Human leukocyte antigen B polymorphism and association between HLA-B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh

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rheumatology & Autoimmunity 2022年第1期2卷 15-21页

作者： Md Kamrul H.Sajib Shamim Ahmed Syed A.Haq minhaj r.choudhury Mohammed Uddin Furkan Uddin Muhammad S.A.Khan Mohammad M.Zaman Department of rheumatology Dhaka Medical College HospitalDhakaBangladesh Department of rheumatology Bangabandhu Sheikh Mujib Medical UnivesityDhakaBangladesh Department of Human Genetics Mohammed Bin Rashid University of Medicine and Health SciencesCollege of MedicineDubaiUAE Genetics and Genomic Department NeuroGen HealthcareDhakaBangladesh Department of Medicine Sheikh Hasina Institute of Burn and Plastic SurgeryDhakaBangladesh Advisor(research and Publication) World Health OrganizationDhakaBangladesh

Objectives:To determine the association of Human leukocyte antigen B(HLA‑B)alleles with ankylosing spondylitis and the allelic association of HLAB27 with endoplasmic reticulum aminopeptidase 1(ErAP1)single-nucleotide polymorphism(SNP)rs30187 in patients with ankylosing spondylitis(AS).Methods:We studied 48 consecutively enrolled well-defined AS patients and 48 healthy controls recruited from the outpatient clinic of the rheumatology department of Bangabandhu Sheikh Mujib Medical University(BSMMU),Dhaka,*** genotype HLA-B alleles from peripheral blood DNA,we designed sequence-specific primers for polymerase chain ***'s sequencing method was used to detect the ErAP1 rs30187 *** HLA-B allele distributions were compared between cases and *** infer an allelic association between HLA-B27 and ErAP1,allele distributions from both loci were compared using ***-squared test or Fisher's exact test was used to quantify the association,and their strength of association was tested by odds ratio(Or)with 95%confidence interval(CI).results:The frequency of HLA-B27 was found to be higher in AS patients(60.4%)than in healthy controls(8.3%).HLA-B27 allele had an Or of 16.8(95%CI=5.2–54.4)for the development of ***,4%of AS patients had both HLA-B27 and *** significant association was found between ErAP1 rs30187 SNP and HLA-B27 in patients with AS(Or=1.7,95%CI=0.5–5.6).Conclusions:HLA-B27 was significantly associated with AS in patients in ***,no association between ErAP1 rs30187 SNP and HLA-B27 was observed.

关键词： AS Bangladesh ErAP1 rs30187 SNP HLA-B HLA-B27

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HLA-DQ and-Dr alleles in patients with SLE:A tertiary hospital-based case–control study in Bangladesh

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rheumatology & Autoimmunity 2023年第1期3卷 43-49页

作者： Muhammad S.A.Khan Shamim Ahmed Iftekhar H.Bandhan Farhana Zaman MdKamrul H.Sajib Shirin Tarafder minhaj r.choudhury Syed A.Haq Mohammad M.Zaman Sheikh Hasina National Institute of Burn and Plastic Surgery DhakaBangladesh Department of rheumatology Bangabandhu Sheikh Mujib Medical UniversityDhakaBangladesh Upazilla Health Complex BancharampurB-BariaBangladesh Department of Community Medicine Universal Medical CollegeDhakaBangladesh Department of rheumatology Dhaka Medical College HospitalDhakaBangladesh Green Life Center for rheumatic Care and research DhakaBangladesh World Health Organization DhakaBangladesh

Background:Systemic lupus erythematosus(SLE)is a systemic autoimmune disease characterized by the involvement of multiple organs and autoantibody *** study aimed to determine the association of human leukocyte antigen(HLA)-DQ and-Dr alleles with SLE at a tertiary hospital in ***:This case-control study was conducted in the Department of rheumatology,Bangabandhu Sheikh Mujib Medical University(BSMMU),Dhaka,*** patients who fulfilled the 1997 revised American College of rheumatology classification criteria for SLE were considered cases(n=41).The controls(n=32)were selected from the hospital staff of BSMMU,including doctors and nurses who did not suffer from any known rheumatic diseases,and there was no such disease in their first-degree *** chain reaction using a sequence-specific primer(PCrSSP)in a low-resolution typing method was carried out on blood samples collected for HLA-DQ and-Dr allele ***:The cases and controls had comparable mean ages(31 vs.32 years),and most cases were female(95.1%vs.34.4%).The most frequent clinical manifestations were mucocutaneous(85.4%),followed by musculoskeletal(70.7%)and constitutional symptoms(58.5%).The cases had a significantly higher frequency of HLA-Dr2 allele compared with healthy controls(70.7%vs.43.8%;odds ratio:3.1;95%confidence interval:1.2-8.2).In addition,HLADQ6 allele was found to have a significant association with mucocutaneous manifestations of the cases(88.9%,P=0.03).Conclusions:Bangladeshi adults having HLA-Dr2 may be more susceptible to ***-DQ6 allele might be associated with mucocutaneous manifestations of SLE.

关键词： alleles Bangladesh HLA-DQ HLA-Dr systemic lupus erythematosus

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