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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

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Frontiers of Medicine 2023年第3期17卷 503-517页

作者： mingyue tan Qi Pan Qi Wu Jianfa Li Jun Wang Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Urology Center Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Urology The Sixth Affiliated Hospital of Wenzhou Medical University(The People’s Hospital of Lishui)Lishui 323000China

Aldolase B(ALDOB),a glycolytic enzyme,is uniformly depleted in clear cell renal cell carcinoma(ccRCC)*** previously showed that ALDOB inhibited proliferation through a mechanism independent of its enzymatic activity in ccRCC,but the mechanism was not unequivocally *** showed that the corepressor C-terminal-binding protein 2(CtBP2)is a novel ALDOB-interacting protein in *** CtBP2-to-ALDOB expression ratio in clinical samples was correlated with the expression of CtBP2 target genes and was associated with shorter *** inhibited CtBP2-mediated repression of multiple cell cycle inhibitor,proapoptotic,and epithelial marker ***,ALDOB overexpression decreased the proliferation and migration of ccRCC cells in an ALDOB-CtBP2 interaction-dependent ***,our findings showed that ALDOB recruited acireductone dioxygenase 1,which catalyzes the synthesis of an endogenous inhibitor of CtBP2,4-methylthio 2-oxobutyric *** functions as a scaffold to bring acireductone dioxygenase and CtBP2 in close proximity to potentiate acireductone dioxygenase-mediated inhibition of CtBP2,and this scaffolding effect was independent of ALDOB enzymatic ***,increased ALDOB expression inhibited tumor growth in a xenograft model and decreased lung metastasis in *** findings reveal that ALDOB is a negative regulator of CtBP2 and inhibits tumor growth and metastasis in ccRCC.

关键词： ALDOB kidney cancer cell proliferation

The hippo kinases MST1/2 in cardiovascular and metabolic diseases:A promising therapeutic target option for pharmacotherapy

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Acta Pharmaceutica Sinica B 2023年第5期13卷 1956-1975页

作者： Yunfei Yin mingyue tan Lianhua Han Lei Zhang Yue Zhang Jun Zhang Wanqian Pan Jiaxiang Bai Tingbo Jiang Hongxia Li Department of Cardiology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Orthopedics the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Orthopedics the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of Chin1Hefei 230001China

Cardiovascular diseases(CVDs)and metabolic disorders are major components of noncommunicable diseases,causing an enormous health and economic burden *** are common risk factors and developmental mechanisms among them,indicating the far-reaching significance in exploring the corresponding therapeutic ***1/2 kinases are well-established proapoptotic effectors that also bidirectionally regulate autophagic *** studies have demonstrated that MST1/2 influence the outcome of cardiovascular and metabolic diseases by regulating immune *** addition,drug development against them is in full *** this review,we mainly describe the roles and mechanisms of MST1/2 in apoptosis and autophagy in cardiovascular and metabolic events as well as emphasis on the existing evidence for their involvement in immune ***,we summarize the latest progress of pharmacotherapy targeting MST1/2 and propose a new mode of drug combination therapy,which may be beneficial to seek more effective strategies to prevent and treat CVDs and metabolic disorders.

关键词： MST1/2 kinases Regulation Apoptosis Autophagy Immune Cardiovascular diseases Metabolic diseases Therapy

Thermodynamic database of multi-component Mg alloys and its application to solidification and heat treatment

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Journal of Magnesium and Alloys 2016年第4期4卷 249-264页

作者： Guanglong Xu Ligang Zhang Libin Liu Yong Du Fan Zhang Kai Xu Shuhong Liu mingyue tan Zhanpeng Jin School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

An overview about one thermodynamic database of multi-component Mg alloys is given in this *** thermodynamic database includes thermodynamic descriptions for 145 binary systems and 48 ternary systems in 23-component(Mg–Ag–Al–Ca–Ce–Cu–Fe–Gd–K–La–Li–Mn–Na–Nd–Ni–Pr–Si–Sn–Sr–Th–Y–Zn–Zr)***,the major computational and experimental tools to establish the thermodynamic database of Mg alloys are briefly ***,among the investigated binary and ternary systems,representative binary and ternary systems are shown to demonstrate the major feature of the ***,application of the thermodynamic database to solidification simulation and selection of heat treatment schedule is described.

关键词： Thermodynamic database Phase diagram Mg alloys Solidification Heat treatment

普罗布考对原发性高血压患者血清MDA含量和SOD活性的影响

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中南大学学报（医学版） 2012年第5期37卷 458-462页

作者：荣惠谭茗月中南大学湘雅二医院心内科长沙410011

目的:探讨普罗布考对高血压患者血清丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性的影响和意义。方法:筛选40例原发性高血压患者随机分两组,分别接受以下药物治疗:苯磺酸左旋氨氯地平2.5 mg/d+贝那普利10 mg/d(n=20,对照组)或苯磺酸左旋... 详细信息

目的:探讨普罗布考对高血压患者血清丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性的影响和意义。方法:筛选40例原发性高血压患者随机分两组,分别接受以下药物治疗:苯磺酸左旋氨氯地平2.5 mg/d+贝那普利10 mg/d(n=20,对照组)或苯磺酸左旋氨氯地平2.5 mg/d+贝那普利10 mg/d+普罗布考组500 mg/d(n=20,试验组),同时入选健康体检者作为健康组(n=20),随访4周。比较3组血压、血脂和肝肾功能。采用黄嘌呤氧化酶法测定血清SOD活性,采用硫代巴比妥酸法测定MDA含量。结果:高血压组患者血清MDA水平明显高于健康组,而SOD活性显著低于健康组;治疗后试验组及对照组血清MDA水平均下降,SOD活性均升高。试验组MDA下降更明显,SOD升高更明显(均P<0.05)。结论:普罗布考可以改善高血压患者氧化应激状态,下调其血清MDA水平并改善SOD活性,合并降压治疗可能更有助于血压控制。

关键词：原发性高血压氧化应激丙二醛超氧化物歧化酶普罗布考

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加强农产品品牌传播浅析

品牌与标准化 2023年第S1期 63-65页

作者：谭茗月首都经济贸易大学(文化与传播学院)

加强农产品品牌传播是农产品产业发展和乡村振兴战略的重要环节，要高度重视农产品品牌传播度重要性。目前，我国农产品品牌传播取得了明显成效，但还存在一些问题，需要采取系列措施加以解决，切实发挥农产品品牌在乡村振兴高质量发展... 详细信息

加强农产品品牌传播是农产品产业发展和乡村振兴战略的重要环节，要高度重视农产品品牌传播度重要性。目前，我国农产品品牌传播取得了明显成效，但还存在一些问题，需要采取系列措施加以解决，切实发挥农产品品牌在乡村振兴高质量发展中的重要作用。

关键词：农产品品牌传播

新形势下做好国有企业新闻宣传工作的思考——基于对国有企业门户网站的研究

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新闻研究导刊 2023年第4期14卷 101-103页

作者：谭茗月首都经济贸易大学文化与传播学院北京100070

国有企业新闻宣传工作对国有企业发展意义重大,需要主动适应新形势,与时俱进,优化升级,为国有企业党的建设和改革发展提供有力的思想保证、精神力量和舆论支持。文章以国有企业门户网站新闻宣传工作为切入点,采用集团网站全面浏览、二... 详细信息

国有企业新闻宣传工作对国有企业发展意义重大,需要主动适应新形势,与时俱进,优化升级,为国有企业党的建设和改革发展提供有力的思想保证、精神力量和舆论支持。文章以国有企业门户网站新闻宣传工作为切入点,采用集团网站全面浏览、二级企业网站随机浏览和数据统计的方法,以2022年8月底以前的信息为依据,对92家国有企业网站上的企业文化、社会责任、宣传报道、主题宣传、党建工作、人力资源等板块,重点对新闻中心和主题宣传两个板块进行全面分析和深入研究,指出国有企业新闻宣传工作有利于推进党建工作、促进国有企业改革发展、开展思想政治工作、建设企业文化、树立企业形象、凝聚奋斗力量。文章提出国有企业门户网站新闻宣传工作中的亮点和存在的不足,在此基础上,建议国有企业改进网站新闻宣传工作中存在的不足,加大力度增强新闻宣传的政治性、正面性、全面性、优质性、时效性和多样性,提升新闻宣传的传播力、引导力、影响力和公信力;并且建议优化国有企业新闻宣传工作,需要深化认识、完善体制机制、加强人才队伍建设,需要落实全员、全过程、全方位的保障措施。

关键词：新形势国有企业门户网站新闻宣传

The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs:A multicenter retrospective real-world study

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Current Urology 2024年第4期18卷 283-286页

作者： Zijie Xu Chujiang He Jianwei Cao Jianhong Wu Dawei Wang Jun Da Dongliang Xu mingyue tan Xiaofeng Gao Yonghan Peng Jie Chen Rong Chen Pengfei Wu Juntao Jiang Lei Chen Shujie Xia Yi Shao Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Urology Xin Hua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Municipal Hospital Urology Specialist Alliance ShanghaiChina Department of Urology Huadong HospitalFudan UniversityShanghaiChina Department of Urology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Urology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Urology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Urology Changhai HospitalNaval Medical UniversityShanghaiChina Department of Urology Shanghai Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Urology Shanghai Sixth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Urology Shanghai Tenth People's HospitalTongji University School of MedicineShanghaiChina

Objective The objective of this study is to assess the effectiveness and safety of ureteroscopic lithotripsy and flexible ureteroscopy(fURS)for treating patients on anticoagulant(AC)or antiplatelet(AP)*** and Methods The study included 213 patients with urinary stones who underwent ureteroscopic lithotripsy or fURS between January 2019 and October 2022 at the Shanghai Municipal Hospital Urology Specialist *** these patients,15 received AC therapy,193 received AP therapy,and 5 received both AC and AP *** were divided into 3 groups based on the real-world management of antithrombotic drugs:the continuation group(n=62),the discontinuation group(n=91),and the discontinuation and bridge heparin group(n=60).Intraoperative and postoperative outcomes were compared among the 3 *** Age,sex,body mass index,stone location,stone size,stone side,and residual fragments were not different among the *** of the patients received blood transfusions or had thromboembolic events,emergencies for gross hematuria,significant bleeding-related complications,or unplanned secondary ureteroscopic *** mean duration of hospital stay of the continuation group(3.97 days)was significantly lower than that of the discontinuation group(5.99 days)and the discontinuation and bridge heparin group(5.75 days)(p<0.001).Conclusions Ureteroscopic lithotripsy and fURS can be performed safely and effectively in patients on AC or AP drugs,resulting in reduced duration of hospital stay.

关键词： Ureteroscopic lithotripsy Flexible ureteroscopy Anticoagulant drugs Antiplatelet drugs

早期康复在ICU呼吸衰竭患者护理中的应用效果及对睡眠质量的影响观察

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世界睡眠医学杂志 2023年第3期10卷 667-670页

作者：谭明月湖北省谷城县人民医院谷城441700

目的:探究在ICU呼吸衰竭患者护理中应用早期康复进行干预的临床效果及对睡眠质量的影响。方法:选取2018年2月至2020年10月谷城县人民医院收治的ICU呼吸衰竭患者76例作为研究对象,按照随机数字表法分为对照组和观察组,每组38例。对照组... 详细信息

目的:探究在ICU呼吸衰竭患者护理中应用早期康复进行干预的临床效果及对睡眠质量的影响。方法:选取2018年2月至2020年10月谷城县人民医院收治的ICU呼吸衰竭患者76例作为研究对象,按照随机数字表法分为对照组和观察组,每组38例。对照组采用传统康复护理,观察组采用早期康复护理,对2组护理后临床疗效及睡眠质量进行探讨、分析和对比。结果:观察组治疗成效优于对照组;并发症发生率低于对照组;睡眠质量、生命质量及满意度优于对照组;术后并发症低于对照组,2组结果比较,差异有统计学意义(P<0.05)。结论:在ICU呼吸衰竭患者治疗中应用早期康复联合干预,可以明显提升临床治疗成效,降低ICU监护中风险事件的发生,保证患者的生命质量及睡眠质量,应用价值显著,值得临床推广、借鉴和应用。

关键词：呼吸衰竭 ICU 睡眠

Bi2S3@BiOBr的原位合成及其可见光催化性能

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功能材料 2019年第11期50卷 11075-11078页

作者：卢朋辉罗秀珍谭明月高碧芬华侨大学材料科学与工程学院福建厦门361021 漳州卫生职业学院福建漳州363000

采用溶剂热法合成BiOBr空心微球,并利用简单的离子交换原位生成Bi2S3,得到类核-壳结构的Bi2S3@BiOBr复合光催化剂。利用X射线衍射(XRD)、扫描电子显微镜(FE-SEM)和紫外-可见漫反射光谱(UV-Vis DRS)等手段对催化剂进行表征,并对其进行光... 详细信息

采用溶剂热法合成BiOBr空心微球,并利用简单的离子交换原位生成Bi2S3,得到类核-壳结构的Bi2S3@BiOBr复合光催化剂。利用X射线衍射(XRD)、扫描电子显微镜(FE-SEM)和紫外-可见漫反射光谱(UV-Vis DRS)等手段对催化剂进行表征,并对其进行光电化学性能测试。实验表明,BiOBr与Bi2S3形成的异质结促进了光生载流子的转移和分离。Bi2S3@BiOBr在可见光作用下可以有效降解甲基橙,当Bi2S3的摩尔分数为8%时,样品具有最好的光催化性能。·O2-和h+是Bi2S3@BiOBr光催化降解甲基橙的主要活性物种。

关键词： BiOBr Bi2S3 光催化异质结微球