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Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

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npj Flexible Electronics 2022年第1期6卷 840-853页

作者： Ju Young Lee sang Hoon Park Yujin Kim Young Uk Cho Jaejin Park Jung-Hoon Hong Kyubeen Kim Jongwoon Shin Jeong Eun Ju In Sik Min mingyu sang Hyogeun Shin Ui-Jin Jeong Yuyan Gao Bowen Li Aizhan Zhumbayeva Kyung Yeun Kim Eun-Bin Hong Min-Ho Nam Hojeong Jeon Youngmee Jung Huanyu Cheng Il-Joo Cho Ki Jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-KIST Convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous

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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： mingyu Zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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Effects of carbon content on the microstructure and tensile properties of a low-density steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 391-401页

作者： Yongxuan Shang mingyu Fan Shuyong Jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Metal Material for Marine Equipment and Application Iron&Steel Research Institute of Ansteel Group CorporationAnshan 114009China

Carbon can change the phase components of low-density steels and influence the mechanical *** this study,a new method to control the carbon content and avoid the formation ofδ-ferrite by decarburization treatment was *** microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically ***-Jaoul(C-J)analysis was employed to examine the work hardening characteristics during the tensile *** decarburization by heat treatments,the carbon content within the austenite phase decreased,while Mn and Al were almost unchanged;this made the steel with full austenite transform into the austenite and ferrite dual ***,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the *** addition,the formation of other carbides *** loss induced a decrease in strength due to the weakening of the carbon solid *** the steel with the single austinite,the deformation mode of austenite was the dislocation planar glide,resulting in the formation of *** the dual-phase steel,the deformation occurred by the dislocation planar glide of austenite first,with the increase in strain,the cross slip of ferrite took place,forming dislocation cells in *** the late stage of deformation,the work hardening of austinite increased rapidly,while that of ferrite increased slightly.

关键词： low-density steels carbon content decarburization strengthening mechanisms work hardening behavior

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Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： mingyu Wang Jue Tang Mansheng Chu Quan Shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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蓝靛果叶斑病病原高粱附球菌(Epicoccum sorghinum)分离鉴定及生物学特性

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北方园艺 2023年第5期 39-46页

作者：闫浩浩米耀族桑明玉臧海莲李春艳东北农业大学资源与环境学院黑龙江哈尔滨150030

以黑龙江省哈尔滨市香坊区采集的蓝靛果发病植株为试材,通过病原菌分离培养、致病性测定、形态学鉴定和rDNA-ITS、LSU、TUB和RPB2序列分析,确定其分类地位,以期为将来实施有效的化学和生物防治提供重要病原菌株来源。结果表明:该病原菌... 详细信息

以黑龙江省哈尔滨市香坊区采集的蓝靛果发病植株为试材,通过病原菌分离培养、致病性测定、形态学鉴定和rDNA-ITS、LSU、TUB和RPB2序列分析,确定其分类地位,以期为将来实施有效的化学和生物防治提供重要病原菌株来源。结果表明:该病原菌为高粱附球菌(Epicoccum sorghinum),可在PDA、OA和MEA培养基上生长,最适培养基为OA。最适培养条件为生长温度25℃,pH 7,碳源为乳糖和葡萄糖,氮源为牛肉膏,并且全光照条件有利于菌丝生长。

关键词：蓝靛果叶斑病高粱附球菌分离鉴定生物学特性

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侵犯商业秘密罪评价标准的修正与规范解读

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海南大学学报（人文社会科学版） 2025年第1期43卷 185-194页

作者：冯明昱张勇南京师范大学法学院江苏南京210023 华东政法大学刑事法学院上海200042

《刑法修正案(十一)》完成了侵犯商业秘密罪由数额犯到情节犯的全面转型,但未跟进更新的司法解释易使得司法实务将情节犯作数额犯化处理,仅关注数额要素对于犯罪评价的影响。侵犯商业秘密罪所保护的是复合法益:一是商业秘密权利人对商... 详细信息

《刑法修正案(十一)》完成了侵犯商业秘密罪由数额犯到情节犯的全面转型,但未跟进更新的司法解释易使得司法实务将情节犯作数额犯化处理,仅关注数额要素对于犯罪评价的影响。侵犯商业秘密罪所保护的是复合法益:一是商业秘密权利人对商业秘密享有的私权利,二是市场竞争秩序,后者又可还原为具体的个人法益——商业秘密权。以此为逻辑起点,侵犯商业秘密罪的评价体系应当坚持区分性、形式与实质相统一、强保护的原则,建构综合评价体系。各要素不可单独作为入罪标准,而应综合考量,建构起以数额要素为主,非数额要素为辅的“情节严重”解释体系。

关键词：侵犯商业秘密罪情节犯数额犯

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血管化类器官的构建策略

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中国组织工程研究 2025年第13期29卷 2774-2783页

作者：刘明昱范文娟海南医学院海南省海口市571199 漯河医学高等专科学校河南省漯河市462002

背景:有效促进类器官内部血管发生是目前类器官培养中的焦点问题,作为一种新近发展的生物培养技术,血管化的类器官在研究活体组织的发育、疾病形成的机制、组织替代疗法以及药物筛选等方面,都有很大的研究和应用价值。目的:对近年来类... 详细信息

背景:有效促进类器官内部血管发生是目前类器官培养中的焦点问题,作为一种新近发展的生物培养技术,血管化的类器官在研究活体组织的发育、疾病形成的机制、组织替代疗法以及药物筛选等方面,都有很大的研究和应用价值。目的:对近年来类器官血管化的方法或策略进行归纳总结,分析类器官血管化形成机制以及构建策略,以期为更加深入地研究类器官的发生机制和为临床转化提供可靠的思路。方法:检索PubMed及中国知网数据库收录的相关文献。英文检索词为“organoids,Vascularization,Vascular,Vascular development,vessel”,中文检索词为“血管发生,血管生成,类器官,干细胞,血管化,预血管化”,最终纳入77篇文献进行归纳总结。结果与结论:①类器官血管化形成机制涉及3个关键因素,即种子细胞、细胞因子与细胞外基质。种子细胞为血管化类器官提供了关键的细胞来源,细胞因子为类器官内部的血管发生起了重要的信号引导作用,细胞外基质为血管细胞提供了外在的生长环境,促进类器官血管化的发生。②血管化类器官的构建策略包括细胞自我重组、微血管碎片渗入、宿主体内移植以及微流控芯片等。体外诱导多能干细胞向血管内皮祖细胞分化能顺利与邻近组织整合并具有血管生成的潜力,故可利用多能干细胞的自我重组功能构建血管化类器官。微血管碎片保留了其细胞复杂性、天然结构和表型可塑性,更利于模拟天然微血管从而促进类器官的血管化。宿主体内移植是目前类器官实现完整血液灌流的最佳方法,而微流控芯片则为实现类器官体外血液供应提供了解决方案。③类器官的多种构建策略如多类干细胞共分化、信号分子的精准调控、微血管渗入和活体宿主移植等,一定程度上在类器官中引入血管成分,使得类器官在功能和成熟度上更接近相应组织。然而缺乏血流灌注仍然是一个难题,迄今为止,仅宿主体内移植才能在类器官中实现有效的血流灌注,因此类器官在血管化方面仍面临许多挑战。

关键词：类器官血管化血管发生自我重组共培养种子细胞体内移植内皮细胞干细胞综述

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Electrostatic Structure of the Electron Phase-space Holes Generated by the Electron Two-stream Instability with a Finite Width

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空间科学学报 2017年第5期37卷 517-523页

作者： sang Longlong WU mingyu LU Quanming CAS Key Laboratory of Geospace Environment School of Earth and Space Sciences University of Science and Technology of China

Space satellite observations in an electron phase-space hole(electron hole) have shown that bipolar structures are discovered at the parallel cut of parallel electric field, while unipolar structures spring from the parallel cut of perpendicular electric field. Particle-in-cell(PIC) simulations have demonstrated that the electron bi-stream instability induces several electron holes during its nonlinear evolution. However, how the unipolar structure of the parallel cut of the perpendicular electric field formed in these electron holes is still an unsolved problem,especially in a strongly magnetized plasma(Ω_e >ω_(pe), where Ω_e is defined as electron gyrofrequency and ω_(pe) is defined as plasma frequency, respectively). In this paper, with two-dimensional(2D) electrostatic PIC simulations, the evolution of the electron two-stream instability with a finite width in strongly magnetized plasma is investigated. Initially, those conditions lead to monochromatic electrostatic waves, and these waves coalesce with each other during their nonlinear evolution. At last, a solitary electrostatic structure is formed. In such an electron hole, a bipolar structure is formed in the parallel cut. of parallel electric field, while a unipolar structure presents in the parallel cut of perpendicular electric field.

关键词： Electron phase-space hole Two-stream instability PIC simulation

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墨鱼干碱水-纯水组合复水工艺优化及复水前后质构特性

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食品工业科技 2025年第1期46卷 181-189页

作者：顾俊浩尹明雨王锡昌上海海洋大学食品学院上海201306

目的:探究墨鱼干复水最优工艺参数及其复水前后的质构变化。方法:通过先用碱水后用纯水的组合复水方式进行处理,以复水率和蛋白损失率为优化指标进行条件优化,随后对墨鱼干复水前后的质构特性以及蛋白质二级结构、组织形态等相关指标进... 详细信息

目的:探究墨鱼干复水最优工艺参数及其复水前后的质构变化。方法:通过先用碱水后用纯水的组合复水方式进行处理,以复水率和蛋白损失率为优化指标进行条件优化,随后对墨鱼干复水前后的质构特性以及蛋白质二级结构、组织形态等相关指标进行分析。结果:碱水处理墨鱼干的最佳条件为:碳酸钠浓度0.50%、时间2.0 h、温度50℃、料液比1:20 g/mL;在此基础上,进行纯水处理的最佳条件为:时间1.0 h、温度50℃、料液比为1:20 g/mL。两步处理后,墨鱼干的复水率为261.10%±7.10%,蛋白损失率为16.80%±0.74%。复水处理使墨鱼干的硬度、胶着性和咀嚼性显著降低,而弹性则显著上升(P<0.05),并使肌原纤维蛋白的结构折叠,且肌纤维的间隙增加。结论:本研究明确墨鱼干最优复水参数并改善其质构特性,为墨鱼干的高质化加工利用提供理论参考。

关键词：墨鱼干复水工艺复水率蛋白损失率质构特性

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Stokes'first problem for a viscoelastic fluid with the generalized Oldroyd-B model

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Acta Mechanica Sinica 2007年第5期23卷 463-469页

作者： Haitao Qi mingyu Xu Department of Applied Mathematics and Statistics Shandong University at Weihai Weihai 264209 China School of Mathematics and System Science Shandong University Jinan 250100 China

The flow near a wall suddenly set in motion for a viscoelastic fluid with the generalized Oldroyd-B model is studied. The fractional calculus approach is used in the constitutive relationship of fluid model. Exact analytical solutions of velocity and stress are obtained by using the discrete Laplace transform of the sequential fractional derivative and the Fox H-function. The obtained results indicate that some well known solutions for the Newtonian fluid, the generalized second grade fluid as well as the ordinary Oldroyd-B fluid, as limiting cases, are included in our solutions.

关键词： Generalized Oldroyd-B fluid Stokes' first problem Fractional calculus Exact solution Fox H-function

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