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Spatial patterns of residents’ daily activity space and its influencing factors based on the CatBoost model: A case study of Nanjing, China

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Frontiers of Architectural Research 2022年第6期11卷 1193-1204页

作者： Jiemin Zheng mingxing hu Chenghui Wang Shuting Wang Bing Han hui Wang School of Architecture Southeast UniversityNanjing210096China College of Landscape Architecture Nanjing Forestry UniversityNanjing210037China

The complexity and fragmentation of people’s activity space are challenging to ***,the relevant studies are mostly concerned on the relationship between the social attributes and the activity space of residents in a single or several communities,or the spatiotemporal laws of activity space on a macro *** research on the spatial characteristics of residents’activity space still needs to be *** present study analyses the spatial patterns of residents’activity space based on mobile phone signaling data to fill the gap of previous studies that assessed residents’activity space across small geographic ***,according to the spatial scope and direction of an activity space and residents’activity coverage rate,spatial patterns can be divided into three types:compact,extended,and directional extension *** CatBoost method is then used to statistically analyze the influencing variables of spatial patterns,and the order of importance of the following influencing factors is determined:the built environment is more influential than social and economic *** study aims to strengthen the understanding of residents’activity space at the spatial level and provide a basis for the optimization of communities with different spatial patterns.

关键词： Spatial patterns Activity space CatBoost Influencing factors Mobile phone signaling data

A tactical nanomissile mobilizing antitumor immunity enables neoadjuvant chemo-immunotherapy to minimize postsurgical tumor metastasis and recurrence

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Acta Pharmaceutica Sinica B 2023年第2期13卷 804-818页

作者： Tao He mingxing hu Shunyao Zhu Meiling Shen Xiaorong Kou Xiuqi Liang Lu Li Xinchao Li Miaomiao Zhang Qinjie Wu Changyang Gong State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041China

Neoadjuvant chemotherapy has become an indispensable weapon against high-risk resectable cancers,which benefits from tumor ***,the utility of chemotherapeutics alone as a neoadjuvant agent is incapable of generating durable therapeutic benefits to prevent postsurgical tumor metastasis and ***,a tactical nanomissile(TALE),equipped with a guidance system(PD-L1 monoclonal antibody),ammunition(mitoxantrone,Mit),and projectile bodies(tertiary amines modified azobenzene derivatives),is designed as a neoadjuvant chemo-immunotherapy setting,which aims at targeting tumor cells,and fast-releasing Mit owing to the intracellular azoreductase,thereby inducing immunogenic tumor cells death,and forming an in situ tumor vaccine containing damage-associated molecular patterns and multiple tumor antigen epitopes to mobilize the immune *** formed in situ tumor vaccine can recruit and activate antigen-presenting cells,and ultimately increase the infiltration of CD8^(+)T cells while reversing the immunosuppression ***,this approach provokes a robust systemic immune response and immunological memory,as evidenced by preventing 83.3%of mice from postsurgical metastasis or recurrence in the B16-F10 tumor mouse ***,our results highlight the potential of TALE as a neoadjuvant chemo-immunotherapy paradigm that can not only debulk tumors but generate a long-term immunosurveillance to maximize the durable benefits of neoadjuvant chemotherapy.

关键词： Neoadjuvant Chemotherapy Immunotherapy Mitoxantrone Vaccine Azobenzene derivatives Reduction responsive Melanoma

Discovery of the first potent proteolysis targeting chimera(PROTAC) degrader of indoleamine 2,3-dioxygenase 1

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1943-1953页

作者： mingxing hu Weilin Zhou Yijie Wang Dongping Yao Tinghong Ye Yuqin Yao Bin Chen Gongping Liu Xifei Yang Wei Wang Yongmei Xie State Key Laboratory of Biotherapy and Cancer Center Department of Laboratory MedicineWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengdu 610041China Department of Pathophysiology School of Basic Medicine and the Collaborative Innovation Center for Brain ScienceKey Laboratory of Ministry of Education of China and Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Innovation Center of Neuroregeneration Nantong UniversityNantong 226019China Key Laboratory of Modern Toxicology of Shenzhen Shenzhen Centre for Disease Control and PreventionShenzhen 518055China

Cancer immunotherapy is revolutionizing oncology and has emerged as a promising strategy for the treatment of multiple *** 2,3-dioxygenase 1(IDO1),an immune checkpoint,plays an important role in tumor immune escape through the regulation of multiple immune cells and has been regarded as an attractive target for cancer *** Targeting Chimeras(PROTAC)technology has emerged as a new model for drug research and development for its advantageous ***,we reported the application of PROTAC technology in targeted degradation of IDO 1,leading to the discovery of the first IDO1 PROTAC degrader 2 c,which induced significant and persistent degradation of IDO1 with maximum degradation(Dmax)of 93%in HeLa ***-blot based mechanistic studies indicated that IDO 1 was degraded by 2 c through the ubiquitin proteasome system(UPS).Label-free real-time cell analysis(RTCA)indicated that 2 c moderately improved tumorkilling activity of chimeric antigen receptor-modified T(CAR-T)***,these data provide a new insight for the application of PROTAC technology in tumor immune-related proteins and a promising tool to study the function of IDO1.

关键词： IDO1 PROTAC Protein degradation Ubiquitin proteasome system Tumor immune escape

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高铁呼南通道邵永铁路引入邵阳地区方案研究

铁道工程学报 2024年第6期41卷 6-11页

作者：谢淑润胡明星武汉铁路职业技术学院武汉430205 中铁第四勘察设计院集团有限公司武汉430063

研究目的:呼南通道作为“八纵八横”国家高铁主通道之一,邵阳至永州铁路是呼南通道的重要组成部分。本文基于邵阳地区既有铁路、客流特点、城市规划等因素,研究提出邵永铁路在邵阳地区的引入方案,再根据运输能力适应、既有设备利用、工... 详细信息

研究目的:呼南通道作为“八纵八横”国家高铁主通道之一,邵阳至永州铁路是呼南通道的重要组成部分。本文基于邵阳地区既有铁路、客流特点、城市规划等因素,研究提出邵永铁路在邵阳地区的引入方案,再根据运输能力适应、既有设备利用、工程投资节省、运营成本控制、未来持续发展等需求,进一步细化比选,形成邵永铁路引入邵阳地区的优选推荐方案。研究结论:(1)根据邵阳地区既有铁路概况,以及邵阳市城市总体规划和客运需求,研究提出邵永铁路引入邵阳站和新设邵阳南站两大系列方案;(2)通过比较分析各项具体方案的线路布局、工程投资、运输质量、未来发展等控制因素,推荐采用按线路别引入邵阳站娄邵场调整到发线分工的方案,并预留未来娄邵高铁引入邵阳站的条件;(3)本研究结果可应用于高铁呼南通道邵永段的勘察设计中,对引入工程的建设具有指导作用。

关键词：呼南通道邵永铁路邵阳地区方案研究

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短程硫黄/硫铁矿自养反硝化脱氮性能研究

大连理工大学学报 2024年第3期64卷 258-265页

作者：胡明星张捍民大连理工大学工业生态与环境工程教育部重点实验室辽宁大连116024

为了解决异养反硝化处理低n(C)/n(N)废水需外加有机碳源和硫黄自养反硝化硫酸盐产量较高的问题,启动了短程硫黄/硫铁矿自养反硝化反应器并探究其脱氮性能,通过批式试验考察了n(S)/n(N)、初始pH、硫铁矿和石灰石等因素对脱氮性能的影响.... 详细信息

为了解决异养反硝化处理低n(C)/n(N)废水需外加有机碳源和硫黄自养反硝化硫酸盐产量较高的问题,启动了短程硫黄/硫铁矿自养反硝化反应器并探究其脱氮性能,通过批式试验考察了n(S)/n(N)、初始pH、硫铁矿和石灰石等因素对脱氮性能的影响.结果表明,短程硫黄自养反硝化总氮(TN)去除率稳定在96%以上,比完全硫黄自养反硝化的实际硫酸盐产量减少大约40%.在氮容积负荷(以NO_(2)^(-)-N计)为0.40 kg/(m^(3)·d)时,短程硫铁矿自养反硝化的TN去除率高达98%,进一步解决了以S^(0)为电子供体时硫酸盐产量较高的问题.短程硫黄自养反硝化在n(S)/n(N)=2.5、初始pH=8时脱氮效果较好;FeS_(2)+NaHCO_(3)组合脱氮效果最好;CaCO_(3)在减少出水中硫酸盐产量和碱度缓释方面具有优势.Thiobacillus是硫自养反硝化反应器的主要功能菌属,相对丰度在13.2%以上.

关键词：硫黄硫铁矿短程硫自养反硝化低n(C)/n(N)废水微生物群落分析

Exploration of the spatial pattern of urban residential land use with geographically weighted regression technique: a case study of Nanjing,China

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Journal of Southeast University(English Edition) 2015年第1期31卷 149-156页

作者：胡明星吴江朱选东南大学建筑学院南京210096 浙江省城乡规划设计研究院杭州310007 School of Earth Atmosphere and Environment Monash University

As the traditional methods and technical means cannot meet the quantitative research needs of the urban land use patterns, quantitative research methods for the urban land use pattern are established via the GIS （geographic information system ） technique combined with the related theories and models. Taking the city of Nanjing as an example, a spatial database of urban land use and other environmental and socio-economic data is constructed. A multiple linear regression model is developed to determine the statistically significant factors affecting the residential land use distributions. To explain the spatial variations of urban land use patterns, the geographically weighted regression （GWR） is employed to establish spatial associations between these significant factors and the distribution of urban residential land use. The results demonstrate that the GWR can provide an effective approach to the exploration of the urban land use spatial patterns and also provide useful spatial information for planning residential development and other types of urban land use.

关键词： urban residential land use GIS (geographic information system) multiple linear regression geographically weighted regression

Leukotriene D4 induces amyloid-β generation via CysLT1R-mediated NF-κB pathways in primary neurons

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中国药理通讯 2013年第2期30卷 37-38页

作者： Xiaoyun Wang SusuTang Yanlong Yongqi Li mingxing Liao Mei hu hui Ji Hao Hong Department of Pharmacology Laboratory for Diabetes & Brain Diseases China Pharmaceutical University

维普期刊数据库评论

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维普期刊数据库

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基于LWE的高效身份基分级加密方案

计算机研究与发展 2017年第10期54卷 2193-2204页

作者：叶青胡明星汤永利刘琨闫玺玺河南理工大学计算机科学与技术学院河南焦作454000

格上可固定维数陷门派生的身份基分级加密(hierarchical identity-based encryption,HIBE)体制,因其具有在陷门派生前后格的维数保持不变的特性而受到广泛关注,但这种体制普遍存在陷门派生复杂度过高的问题.针对这一问题,分别给出随机... 详细信息

格上可固定维数陷门派生的身份基分级加密(hierarchical identity-based encryption,HIBE)体制,因其具有在陷门派生前后格的维数保持不变的特性而受到广泛关注,但这种体制普遍存在陷门派生复杂度过高的问题.针对这一问题,分别给出随机预言模型和标准模型下的改进方案.首先利用MP12陷门函数的特性提出一种优化的Zq可逆矩阵提取算法,再基于该优化算法结合固定维数的陷门派生算法和MP12陷门函数完成方案的建立和陷门派生阶段,然后与对偶Regev算法相结合完成随机预言模型下HIBE方案的构造.并且利用二进制树加密系统将该方案改进为标准模型下的HIBE方案.两方案安全性均可归约至LWE问题的难解性,其中随机预言模型下的方案满足适应性安全,而标准模型下的方案满足选择性安全,并给出严格的安全性证明.对比分析表明:在相同的安全性下,随机预言模型下的方案较同类方案在陷门派生复杂度方面显著降低,而标准模型下的方案是同类最优方案的1/6,且格的维数、陷门尺寸和密文扩展率等参数均有所降低,计算效率明显优化.

关键词：格基于身份的分级加密陷门派生容错学习随机预言模型标准模型

中国与“一带一路”沿线国家木质林产品贸易潜力研究

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林业经济问题 2018年第5期38卷 25-30,102页

作者：张慧胡明形北京林业大学经济管理学院北京100083

利用2007—2016年中国与"一带一路"沿线国家的贸易数据,采用贸易结合度、互补性指数分别从出口、进口两个方面研究中国与"一带一路"沿线72个国家在6类木质林产品上的贸易联系紧密性及互补性,重点找出具有贸易潜力的地区、国家及产品。... 详细信息

利用2007—2016年中国与"一带一路"沿线国家的贸易数据,采用贸易结合度、互补性指数分别从出口、进口两个方面研究中国与"一带一路"沿线72个国家在6类木质林产品上的贸易联系紧密性及互补性,重点找出具有贸易潜力的地区、国家及产品。研究表明:中国木质林产品的贸易市场与贸易潜力市场分布不相符;中国具有贸易潜力的出口木质林产品主要是人造板、家具,而进口产品主要是原木、锯材、木浆;"一带一路"多数国家属于"潜力开拓型",各国具有进出口贸易潜力的木质林产品差异较大。因此,应合理科学规划,与重点地区、国家在重点产品上开展贸易合作,挖掘贸易潜力。

关键词： “一带一路” 木质林产品贸易结合度互补性指数贸易潜力