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ADVANCES IN TRANSFORMATION RATCHETING AND RATCHETING-FATIGUE INTERACTION OF NITI SHAPE MEMORY ALLOY

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Acta Mechanica Solida Sinica 2013年第3期26卷 221-236页

作者： Guozheng kang School of Mechanics and Engineering Southwest Jiaotong University

The accumulation of inelastic deformation occurring in NiTi shape memory alloy under the stress-controlled cyclic loading condition is named transformation ratcheting, since it is mainly caused by the solid-solid transformation from austenite to martensite phase and vice versa. The transformation ratcheting and its effect on the fatigue life （i.e., transformation-fatigue interaction） are key issues that should be addressed in order to assess the fatigue of NiTi shape memory alloy more accurately. In this paper, the advances in the studies on the transformation ratcheting and rateheting-fatigue interaction of super-elastic NiTi shape memory alloy in recent years are reviewed： First, experimental observation of the uniaxial transformation ratcheting and ratcheting-fatigue interaction of super-elastic NiTi alloy under the stress-controlled cyclic loading conditions is treated, and the detrimental effect of transformation ratcheting on the fatigue life is addressed; Secondly, two types of cyclic constitutive models （i.e., a macroscopic phenomeno- logical model and a micromechanical one based on crystal plasticity） constructed to describe the transformation ratcheting of super-elastic NiTi alloy are discussed; Furthermore, an energy-based failure model is provided and dealt with by comparing its predicted fatigue lives with experimental ones; Finally, some suggestions about future work are made.

关键词： NiTi shape memory alloy transformation ratcheting constitutive model fatigue,failure model

Lattice Boltzmann method simulating hemodynamics in the three-dimensional stenosed and recanalized human carotid bifurcations

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Science China(Physics,Mechanics & Astronomy) 2015年第1期58卷 117-124页

作者： kang XiuYing Physics Department Beijing Normal University

By using the lattice Boltzmann method(LBM)pulsatile blood flows were simulated in three-dimensional moderate stenosed and recanalized carotid bifurcations to understand local hemodynamics and its relevance in arterial atherosclerosis formation and *** helical flow patterns,secondary flow and wall dynamical pressure spatiotemporal distributions were investigated,which leads to the disturbed shear forces in the carotid artery *** wall shear stress distributions indicated by time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI),and the relative residence time(RRT)in a cardiac cycle revealed the regions where atherosclerotic plaques are prone to form,extend or *** study also illustrates the point that locally disturbed flow may be considered as an indicator for early atherosclerosis *** the present work demonstrates the robust and highly efficient advantages of the LBM for the hemodynamics study of the human blood vessel system.

关键词： atherosclerosis carotid bifurcation lattice Boltzmann method wall shear stress helical flow pattern

Effects of Flame Temperature and Absorption Coefficient on Premixed Flame Interactions with Radiation

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Journal of Thermal Science 2021年第3期30卷 1046-1056页

作者： kang Sang Hun Department of Aerospace System Engineering Sejong UniversitySeoul 05006Republic of Korea

The effects of the flame temperature and the absorption coefficient on interactions between radiative heat transfer and the flame behavior were numerically investigated using high-fidelity numerical code with the discrete ordinates *** study the effects of the flame temperature and the absorption coefficient,three different flame temperatures and four different absorption coefficient conditions were selected,so twelve test cases were studied in *** the numerical test results,radiation effects resulted in preheating of the reactant gases and heat loss from the product gases.A higher flame temperature resulted in stronger preheating effects in reactants near the *** to the preheating effects,with the appropriate absorption coefficient,the peak temperature appeared at the flame *** flame temperatures resulted in larger reabsorption effects in the product *** peak temperature at the flame front and the flame speed were influenced by the combined effects of preheating and radiative heat loss at the flame *** on the conditions,due to those effects,the peak temperature and the flame speed could increase or *** the absorption coefficient was sufficiently large,the temperature decrease was reduced in the product zone.

关键词： radiation high-fidelity numerical simulation discrete ordinates method premixed flame

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改善机械故障监测和维护的人工智能方法

价值工程 2025年第1期44卷 154-156页

作者：康晨祺青岛城市学院青岛251600

工业4.0时代,传统维护方式难以满足机械故障监测的高效、精准需求。本研究针对预测性维护(PdM),利用工业物联网(IIoT)技术自动采集数据。构建人工神经网络(ANN)模型,分析S型激活函数,采用均方误差(MSE)等评估性能。针对数据不均衡,结合... 详细信息

工业4.0时代,传统维护方式难以满足机械故障监测的高效、精准需求。本研究针对预测性维护(PdM),利用工业物联网(IIoT)技术自动采集数据。构建人工神经网络(ANN)模型,分析S型激活函数,采用均方误差(MSE)等评估性能。针对数据不均衡,结合专家知识分析。实验显示,ANN模型准确度87%,提升维护效率与准确性。PdM策略优势显著,为制造业提供高效、低成本维护方案,奠定科学评估基础,有望推动机械故障监测与维护领域进步。

关键词：故障诊断人工智能机械维护质量控制预测

神经营养因子3经受体切换促进大鼠脊髓损伤后神经功能的恢复

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中国组织工程研究 2025年第11期29卷 2268-2276页

作者：丛岩于健孙志德康大伟承德医学院附属医院急诊科河北省承德市067000

背景:神经营养因子是治疗脊髓损伤的新方法,调控自噬是其发挥作用的机制之一,但具体的信号通路尚不明确。目的:探讨神经营养因子3如何通过P75NTR/Trk C受体切换来调节少突胶质细胞的自噬以及促进脊髓损伤后神经功能恢复的作用,进一步明... 详细信息

背景:神经营养因子是治疗脊髓损伤的新方法,调控自噬是其发挥作用的机制之一,但具体的信号通路尚不明确。目的:探讨神经营养因子3如何通过P75NTR/Trk C受体切换来调节少突胶质细胞的自噬以及促进脊髓损伤后神经功能恢复的作用,进一步明确具体的分子机制。方法:将24只SD大鼠随机分为3组:假手术组、脊髓损伤组和神经营养因子3组,通过大鼠后肢神经功能评分来评估神经营养因子3对脊髓损伤大鼠的治疗效果,采用Western blot检测各组大鼠脊髓组织中神经营养因子3、Olig1、MBP蛋白以及自噬标记蛋白LC3B的表达水平。在细胞实验中,将少突胶质细胞接种在培养皿中,分为糖氧剥夺组、糖氧剥夺+神经营养因子3组、糖氧剥夺+神经营养因子3+P75NTR质粒组、糖氧剥夺+神经营养因子3+Trk C质粒组、糖氧剥夺+3-甲基腺嘌呤(自噬抑制剂)组及糖氧剥夺+雷帕霉素(自噬激活剂)组。光学显微镜观察少突胶质细胞形态变化,TUNEL染色观察细胞凋亡现象,Western blot检测Trk C受体、P75NTR、LC3B表达及PI3K/AKT/m TOR和AMPK/m TOR信号途径的磷酸化状态。结果与结论:(1)动物实验显示,与假手术组相比,脊髓损伤后神经营养因子3的表达显著增加(P<0.05);与脊髓损伤组相比,外源性神经营养因子3治疗能够加快大鼠神经功能的恢复(P<0.05),并增加Olig1和MBP蛋白的表达(P<0.05);(2)细胞实验发现,3 h是损伤早期与中后期的分界点,与糖氧剥夺组相比,糖氧剥夺+神经营养因子3组少突胶质细胞能够更长时间地维持其形态,Trk C受体在早期表达水平较低而中后期显著上调(P<0.05),P75NTR则在早期上调而中后期下调(P<0.05),自噬水平呈现出先升高后降低的趋势(P<0.05);(3)通过对比糖氧剥夺+神经营养因子3组、糖氧剥夺+雷帕霉素组和糖氧剥夺+3-甲基腺嘌呤组的细胞形态和TUNEL染色结果,发现单独促进或抑制自噬对少突胶质细胞的存活均有不利影响,而类似神经营养因子3这样调节自噬的方法则能最大限度地维持细胞存活;(4)神经营养因子3在早期通过P75NTR/AMPK/m TOR信号通路促进自噬,而在后期通过Trk C/PI3K/AKT/m TOR信号通路抑制自噬。根据上述结果,得到如下结论,即神经营养因子3可以通过P75NTR/Trk C受体的切换能够双向调控少突胶质细胞的自噬,从而维持细胞存活,有助于脊髓损伤后大鼠的神经功能恢复。

关键词：神经营养因子3 自噬少突胶质细胞受体切换凋亡脊髓损伤

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Microforging Effect on the Microstructure and Magnetic Properties of FeSiB-based Nanoflakes

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Journal of Materials Science & Technology 2012年第4期28卷 303-307页

作者： Wooseung kang Department of Metallurgical & Materials Engineering INHA Technical College 253 Yonghyun-Dong Nam-Gu Incheon 402-752 South Korea

The effect of microforging on the processing of nanocrystalline FeSiB alloy flakes was studied in terms of microstructure and magnetic properties. The flakes microforged from amorphous precursor showed submicron thicknesses with the crystal size of about 15 nrn. The crystallite size during microforging was primarily determined by plastic deformation rather than fracturing and agglomeration. Unlike the general trend of coercivity reduction with annealing, the coercivity of the nanocrystalline flakes was slightly increased with increasing annealing temperature, which can be explained with the diffusion anisotropy of the magnetic moments resulting from the formation of Fe-atoms pairs. The magnetic rernanence （Mr） of the planar nanocrystalline flakes was measured to be about 26% of the saturation magnetization （Ms）, a significant increase from 2% of the initial amorphous precursor.

关键词： Microforging Nanoflakes Submicron thickness Magnetic properties

Trace Lasso Regularization for Adaptive Sparse Canonical Correlation Analysis via Manifold Optimization Approach

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Journal of the Operations Research Society of China 2024年第3期12卷 573-599页

作者： kang-kang Deng Zheng Peng Beijing International Center for Mathematical Research Peking UniversityBeijing100871China School of Mathematics and Computational Science Xiangtan UniversityXiangtan411105China

Canonical correlation analysis(CCA)describes the relationship between two sets of variables by finding a linear combination that maximizes the correlation ***,in high-dimensional settings where the number of variables exceeds sample size,or in the case that the variables are highly correlated,the traditional CCA is no longer *** this paper,a new matrix regularization is introduced,which is an extension of the trace Lasso in the vector *** we propose an adaptive sparse version of CCA(ASCCA)to overcome these disadvantages by utilizing the trace Lasso *** adaptability of ASCCA is that the sparsity regularization of canonical vectors depends on the sample data,which is more realistic in practical *** ASCCA model is further reformulated to an optimization problem on the Riemannian *** we adopt a manifold inexact augmented Lagrangian method to solve the resulting optimization *** performance of the ASCCA model is compared with some existing sparse CCA techniques in different simulation settings and real datasets.

关键词： Canonical correlation analysis Sparsity of canonical vectors Trace Lasso regularization Manifold optimization

《沧浪诗话》“正法眼”说的诗学意义——兼论“法眼”与“诗眼”

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三峡大学学报（人文社会科学版） 2025年第1期47卷 7-12页

作者：康光磊山西警察学院基础部山西太原030401

在《沧浪诗话》中,“正法眼”及相近表述所蕴含的诗学主张构成了严羽独特的“正法眼”说,它将难以琢磨、言说和触摸的最高诗道以禅喻的方式揭示出来,丰富了中国传统诗学话语体系,提升了古典诗学对于诗歌难言之妙的阐释力,在诗学史上有... 详细信息

在《沧浪诗话》中,“正法眼”及相近表述所蕴含的诗学主张构成了严羽独特的“正法眼”说,它将难以琢磨、言说和触摸的最高诗道以禅喻的方式揭示出来,丰富了中国传统诗学话语体系,提升了古典诗学对于诗歌难言之妙的阐释力,在诗学史上有着不容忽视的意义。通过厘定“正法眼”说相关术语的内涵,阐释“正法眼”说与严羽“诗识观”“妙悟说”等诗学主张有机融合的内在理路,进而提出“正法眼”说是逻辑自洽、内证严密的完整体系。通过“法眼”与“诗眼”的辨析,指出严羽既重视“诗中之眼”的局部锤炼,更重视“诗家之眼”的整体观照,从而彰显“正法眼”说在严羽“以禅喻诗”体系中独特的诗学意义。

关键词： “正法眼”说《沧浪诗话》诗学价值法眼诗眼