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人工智能在慢性病运动康复中的应用进展

当代体育科技 2024年第22期14卷 8-12页

作者：施明磊西华师范大学体育学院四川南充637000

慢性病是一类病情复杂、发作缓慢、影响深远、久治不愈的综合性疾病,具有病程时间长、功能损害和社会危害严重等特点。近年来,人工智能与医疗领域的结合逐渐深入,对慢性病的预防、治疗和康复发挥着重要作用。研究综述人工智能在慢性病... 详细信息

慢性病是一类病情复杂、发作缓慢、影响深远、久治不愈的综合性疾病,具有病程时间长、功能损害和社会危害严重等特点。近年来,人工智能与医疗领域的结合逐渐深入,对慢性病的预防、治疗和康复发挥着重要作用。研究综述人工智能在慢性病运动康复领域的应用现状,分析目前在技术研发、临床实践、法律和道德层面存在的问题,并提出进一步的可行策略,以期为人工智能技术在慢性病康复中的进一步发展提供可行建议。

关键词：人工智能慢性病运动康复运动处方

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Research progress in assessment and strategies for sustainable food system within planetary boundaries

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Science China Earth Sciences 2024年第2期67卷 375-386页

作者： minglei WANG Wenjiao shi Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing100049China

Meeting the increasing food demand in a manner that ensures both resources and environmental sustainability poses a global *** conceptual framework of planetary boundaries(PBs)has emerged as a crucial reference in the study of sustainable food system,with specific focuses on key dimensions such as land use change,freshwater use,nitrogen(N)and phosphorus(P)cycles,and greenhouse gas(GHG)*** this study,we summarized the threshold applications of PBs in sustainable food system research at both the global and national(China)*** on these thresholds,we evaluated the sustainability conditions of the food system,considering resources such as cropland,freshwater,N and P applications,as well as environmental impacts including N and P losses,and GHG *** addition,we explored the impacts of single or combined management strategies on sustainable food *** strategies included dietary changes,improvements in technologies and management,reductions in food loss and waste,and optimization in agricultural production ***,we outlined future research directions in sustainable food system,including enhancing research on the interaction mechanisms among PBs elements within food systems,conducting downscaling studies of PBs elements at national and regional levels,and ensuring the rationality of policy-making for sustainable food systems in *** study can provide a theoretical foundation and strategies guidance for sustainable food system and agricultural land use management in the future both globally and in China.

关键词： Food system Resource use Environmental impacts Sustainable strategy Planetary boundaries

High-throughput experimental methods for investigating biomolecular condensates

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Quantitative Biology 2021年第3期9卷 255-266页

作者： Taoyu Chen Qi Lei minglei shi Tingting Li Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China MOE Key Laboratory of Bioinformatics Bioinformatics Division and Center for Synthetic&Systems BiologyTNLISTSchool of MedicineTsinghua UniversityBeijing 100084China

Background:The concept of biomolecular condensate was put forward recently to emphasize the ability of certain cellular compartments to concentrate molecules and comprise proteins and nucleic acids with specific biological functions,from ribosome genesis to RNA *** to their unique role in biological processes,it is crucial to investigate their compositions,which is a primary determinant of condensate ***:Since a wide range of macromolecules comprise biomolecular condensates,it is necessary for researchers to investigate them using high-throughput methodologies while low-throughput experiments are not efficient *** high-throughput methods usually purify interacting protein libraries from condensates before being scanned in mass *** is possible to extract organelles as a whole for specific condensates for further analysis,however,most condensates do not have a distinguishable marker or are sensitive to shear force to be extracted as a *** tagging allows a comprehensive view of interacting proteins of target molecule yet only proteins with strong bonds may be pulled *** labeling serves as a complementary method to label more dynamic proteins with weaker interactions,increasing sensitivity while decreasing ***-based fluorescent screening takes another path by scanning images automatically to illustrate the condensing state of biomolecules within membraneless organelles,which is a unique feature unlike the previous mass spectrometry-based ***:This review presents a rough glimpse into high-throughput methodologies for biomolecular condensate investigation to encourage usage of bioinformatic tools by researchers in relevant fields.

关键词： biomolecular condensates high-throughput phase separation interaction

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湖域明挖隧道深基坑开挖与支护稳定分析

佳木斯大学学报（自然科学版） 2024年第2期42卷 97-101页

作者：胡健张瑞坤石名磊田新涛江苏现代路桥有限公司江苏南京210000 江苏华宁工程咨询有限公司江苏南京210018 东南大学交通学院江苏南京210096

阳澄湖隧道基坑工程具有土方开挖量大、地质条件差以及所处位置特殊,紧靠京沪高铁丹昆特大桥的特点,严重影响基坑开挖安全和开挖进度。工程设计采用分级放坡开挖,边坡采用网喷+土钉联合支护结合井点降水的开挖支护方案。针对基坑稳定问... 详细信息

阳澄湖隧道基坑工程具有土方开挖量大、地质条件差以及所处位置特殊,紧靠京沪高铁丹昆特大桥的特点,严重影响基坑开挖安全和开挖进度。工程设计采用分级放坡开挖,边坡采用网喷+土钉联合支护结合井点降水的开挖支护方案。针对基坑稳定问题,采用理正岩土软件对基坑边坡两个典型断面的整体稳定性、抗隆起稳定性和抗突涌稳定性进行验算。同时使用FLAC3D数值模拟软件对基坑开挖过程进行了模拟,对基坑开挖引起的地表沉降、边坡变形、塑性区开展等结果进行计算,验证了基坑施工的稳定性。

关键词：明挖隧道深基坑整体稳定性数值模拟 FLAC3D

Computational Screening of Phase-separating Proteins

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 13-24页

作者： Boyan Shen Zhaoming Chen Chunyu Yu Taoyu Chen minglei shi Tingting Li Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Institute of Systems Biomedicine School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China MOE Key Laboratory of Bioinformatics Bioinformatics Division and Center for Synthetic&Systems BiologyBNRistSchool of MedicineTsinghua UniversityBeijing 100084China

Phase separation is an important mechanism that mediates the compartmentalization of proteins in *** that can undergo phase separation in cells share certain typical sequence features,like intrinsically disordered regions(IDRs)and multiple modular *** analysis tools are commonly used in the screening of these ***,current phase separation predictors are mostly designed for IDR-containing proteins,thus inevitably overlook the phase-separating proteins with relatively low IDR *** other than amino acid sequence could provide crucial information for identifying possible phase-separating proteins:protein–protein interaction(PPI)networks show multivalent interactions that underlie phase separation process;post-translational modifications(PTMs)are crucial in the regulation of phase separation behavior;spherical structures revealed in immunofluorescence(IF)images indicate condensed droplets formed by phase-separating proteins,distinguishing these proteins from non-phaseseparating ***,we summarize the sequence-based tools for predicting phaseseparating proteins and highlight the importance of incorporating PPIs,PTMs,and IF images into phase separation prediction in future studies.

关键词： Phase separation Prediction Protein–protein interaction Protein post-translational modification Immunofluorescence image

Genome-wide identifcation of the histone acetyltransferase gene family in Citrus clementina and its potential roles in citrate metabolism

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Food Quality and Safety 2024年第1期8卷 201-211页

作者： Xiahui Lin Yanna shi Shengchao Liu Xincheng Liu minglei Zhang Bo Zhang Shaojia Li Kunsong Chen College of Agriculture and Biotechnology Zhejiang UniversityZijingang CampusHangzhouChina Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityZijingang CampusHangzhouChina The State Agriculture Ministry Laboratory of Horticultural Plant Growth Development and Quality ImprovementZhejiang UniversityZijingang CampusHangzhouChina Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina Institute of Horticulture Jiangxi Academy of Agricultural SciencesNanchangChina

Histone acetyltransferase(HAT)catalyzes histone acetylation and is involved in plant growth and development and stress ***,37 CitHAT genes were identifed in Citrus *** physicochemical properties,chromosomal location,gene structure,conserved domain and motif,and cis-acting elements were *** were classifed into four subfamilies based on protein sequence homology,which was strongly supported by gene structure,conserved domain,and motif *** cis-acting elements in gene promoter regions were predicted to be associated with the regulation of plant growth,stress resistance,and response to *** and transcriptomic analyses of citrus callus with mock treatment and HAT inhibitor treatment revealed that increased citric acid content in inhibitor treatment may be attributed to differential expression of CitPEPCK2 and CitGS2,which may be due to the hypo-acetylation of histone *** expression patterns of CitHATs in citrus fruit development stages showed that CitHAG11 and CitHAG28 exhibited a negative correlation with citric acid *** study associates the potential function of histone acetyltransferases in citrate metabolism and extends the molecular mechanism of citrate metabolism in fruits.

关键词： Citrus histone acetyltransferases citric acid citrate metabolism histone acetylation.

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低路堤下长江漫滩相沉积土的工程特性评价

东南大学学报（自然科学版） 2008年第5期38卷 844-849页

作者：刘维正石名磊东南大学交通学院南京210096

针对长江漫滩典型沉积土的薄壁样,通过一系列室内物理力学试验,利用固有压缩曲线(ICL)作为描述原状土压缩特性的基准框架,探讨了该区域土层的基本特性.结果表明,长江漫滩相天然沉积软土具有强结构性.根据结构性土的孔隙比e由固有孔隙比e... 详细信息

针对长江漫滩典型沉积土的薄壁样,通过一系列室内物理力学试验,利用固有压缩曲线(ICL)作为描述原状土压缩特性的基准框架,探讨了该区域土层的基本特性.结果表明,长江漫滩相天然沉积软土具有强结构性.根据结构性土的孔隙比e由固有孔隙比eR与附加孔隙比es所组成,且在屈服后阶段,es与固结压力σv′成反比关系,及屈服前零压缩的理想状态,确定了原位屈服应力与原位压缩曲线.结合CPTU原位测试结果,从天然压缩特性和固结性状方面,分析得出了在低路堤结构下,附加应力未达到原位结构屈服应力,地基处于屈服前状态,长江漫滩相沉积土平均固结指标较大,地基沉降稳定快.为充分利用天然沉积土的结构强度,地基处理适宜浅层处置方案.

关键词：固结特性压缩性土结构性长江漫滩低路堤

土体侧移作用下被动桩受力变形的简化解析计算

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东南大学学报（自然科学版） 2016年第2期46卷 392-399页

作者：张浩石名磊郭院成郑州大学土木工程学院郑州450001 东南大学交通学院南京210096

为了分析邻近堆载作用下或失稳土坡中被动桩的力学特性,根据桩土侧向相互作用机理,将被动桩划分为自由段、被动段和主动段.将土体侧移作用下桩身附加被动荷载的分布模式假定为二次函数,基于Euler-Bernouli梁理论和Winkler地基模型,提出... 详细信息

为了分析邻近堆载作用下或失稳土坡中被动桩的力学特性,根据桩土侧向相互作用机理,将被动桩划分为自由段、被动段和主动段.将土体侧移作用下桩身附加被动荷载的分布模式假定为二次函数,基于Euler-Bernouli梁理论和Winkler地基模型,提出了土体侧移作用下被动桩的通用简化计算模型.然后,分别建立了各桩段的微分控制方程组,结合桩段界面连续条件和桩顶、桩底边界条件,求得桩身响应的解析解.最后,通过算例分析验证了该解析解的可靠性,并对被动桩受力响应的主要影响因素进行了分析.结果表明,随着土体侧向位移作用于桩身被动侧荷载水平的增大和地基土抗力的下降,桩身弯矩和水平位移逐渐增大.

关键词：被动桩土体侧移桩土相互作用土压力法解析解

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海相沉积粉质中间土的物理状态

东南大学学报（自然科学版） 2005年第6期35卷 935-939页

作者：石名磊刘建华东南大学交通学院南京210096

长江河口地区通启高速公路工程地质研究发现,该区域广泛分布海相粉质中间土,其液性指数与一般海相软粘土相似,具有较高的原位强度、较低的塑性和显著的结构性,而其粒度分布、强度特性、压缩性和塑性图与海相软粘土明显不同.采用主成分... 详细信息

长江河口地区通启高速公路工程地质研究发现,该区域广泛分布海相粉质中间土,其液性指数与一般海相软粘土相似,具有较高的原位强度、较低的塑性和显著的结构性,而其粒度分布、强度特性、压缩性和塑性图与海相软粘土明显不同.采用主成分与主分量分析,对海相粉质中间土的多指标反映其土性信息的能力进行了分析.分析结果表明,采用液性指数划分其稠度的传统方法不尽合理,而采用F孔隙函数确定其物理状态更加合理.根据物理状态指标与工程力学特性的相关性,建立孔隙函数划分中间土物理状态新方法.通启高速公路工程实践表明,海相粉质中间土具有良好的力学特性,不应隶属于软粘土地基.

关键词：天然沉积海相土主成分与主分量分析孔隙函数液性指数稠度