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DEAD-box helicase 17(DDX17)protects cardiac function by promoting mitochondrial homeostasis in heart failure

Signal Transduction and Targeted Therapy 2024年第6期9卷 2774-2790页

作者： mingjing yan Junpeng Gao Ming Lan Que Wang Yuan Cao Yuxuan Zheng Yao yang Wenlin Li Xiaoxue Yu Xiuqing Huang Lin Dou Bing Liu Junmeng Liu Hongqiang Cheng Kunfu Ouyang Kun Xu Shenghui Sun Jin Liu Weiqing Tang Xiyue Zhang Yong Man Liang Sun Jianping Cai Qing He Fuchou Tang Jian Li Tao Shen The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijing 100730China Peking University Fifth School of Clinical Medicine Beijing 100730China Department of Laboratory Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Biomedical Pioneering Innovation Center School of Life SciencesPeking UniversityBeijing 100871China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Cardiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Peking Union Medical College Beijing 100730China Department of Health Care Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Department of Pathology and Pathophysiology and Department of Cardiology at Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310058China Department of Cardiovascular Surgery Peking University Shenzhen HospitalShenzhen 518036China Experimental Technology Center for Life Sciences at Beijing Normal University Beijing 100875China

DEAD-box helicase 17(DDX17)is a typical member of the DEAD-box family with transcriptional cofactor *** DDX17 is abundantly expressed in the myocardium,its role in heart is not fully *** generated cardiomyocyte-specific Ddx17-knockout mice(Ddx17-cKO),cardiomyocyte-specific Ddx17 transgenic mice(Ddx17-Tg),and various models of cardiomyocyte injury and heart failure(HF).DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte ***-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte apoptosis,leading to progressive cardiac dysfunction,maladaptive remodeling and progression to heart *** of DDX17 expression in cardiomyocytes protects cardiac function under pathological *** studies showed that DDX17 can bind to the transcriptional repressor B-cell lymphoma 6(BCL6)and inhibit the expression of dynamin-related protein 1(DRP1).When DDX17 expression is reduced,transcriptional repression of BCL6 is attenuated,leading to increased DRP1 expression and mitochondrial fission,which in turn leads to impaired mitochondrial homeostasis and heart *** also investigated the correlation of DDX17 expression with cardiac function and DRP1 expression in myocardial biopsy samples from patients with heart *** findings suggest that DDX17 protects cardiac function by promoting mitochondrial homeostasis through the BCL6-DRP1 pathway in heart failure.

关键词： DDX17 homeostasis cardiac

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Aging and aging-related diseases:from molecular mechanisms to interventions and treatments

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Signal Transduction and Targeted Therapy 2023年第1期8卷 77-116页

作者： Jun Guo Xiuqing Huang Lin Dou mingjing yan Tao Shen Weiqing Tang Jian Li The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijing 100730China

Aging is a gradual and irreversible pathophysiological *** presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases,including neurodegenerative diseases,cardiovascular diseases,metabolic diseases,musculoskeletal diseases,and immune system *** the development of modern medicine has promoted human health and greatly extended life expectancy,with the aging of society,a variety of chronic diseases have gradually become the most important causes of disability and death in elderly *** research on aging focuses on elucidating how various endogenous and exogenous stresses(such as genomic instability,telomere dysfunction,epigenetic alterations,loss of proteostasis,compromise of autophagy,mitochondrial dysfunction,cellular senescence,stem cell exhaustion,altered intercellular communication,deregulated nutrient sensing)participate in the regulation of ***,thorough research on the pathogenesis of aging to identify interventions that promote health and longevity(such as caloric restriction,microbiota transplantation,and nutritional intervention)and clinical treatment methods for aging-related diseases(depletion of senescent cells,stem cell therapy,antioxidative and anti-inflammatory treatments,and hormone replacement therapy)could decrease the incidence and development of aging-related diseases and in turn promote healthy aging and longevity.

关键词： diseases alterations aging

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Controlled flight of a self-powered micro blimp driven by insect-sized flapping-wing thrusters

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Chinese Journal of Aeronautics 2024年第6期37卷 127-136页

作者： Xian YU Zhiwei LIU Jiaming LENG mingjing QI Xiaojun yan School of Energy and Power Engineering Beihang UniversityBeijing 100191China Collaborative Innovation Center of Advanced Aero-Engine Beijing 100191China National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics Beihang UniversityBeijng 100191China Beijing Key Laboratory of Aero-Engine Structure and Strength Beihang UniversityBeijing 100191China

Micro aerial platforms face significant challenges in achieving long controlled endurance as most of the energy is consumed to overcome the weight of the *** this study,we present a controllable micro blimp that addresses this issue through the use of a helium-filled *** micro blimp has a long axis of 23 cm and is propelled by four insect-sized flapping-wing thrusters,each weighing 80 mg and with a wingspan of 3.5 *** distributed thrusters enable controlled motions and provide the micro blimp with an advantage in flight endurance compared to multirotors or flapping-wing micro aerial vehicles at the same size *** enhance the performance of the controlled flight,we propose a wireless control module that enables manipulation from a distance of up to 100 ***,a smartphone application is developed to send instructions to the circuit board,allowing the blimp to turn left and right,ascend and descend,and achieve a combination of these movements *** findings demonstrate that this micro blimp is one of the smallest controlled self-powered micro blimps to date.

关键词： Microairvehicle Aircraft control Self-powered micro blimp Flapping-wing thruster Wireless flight

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基于三维空洞卷积残差神经网络的高光谱影像分类方法

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光学学报 2020年第16期40卷 147-156页

作者：颜铭靖苏喜友北京林业大学信息学院北京100083

高光谱影像是典型的高维数据,在光谱维和空间维都包含了大量信息。针对高光谱影像分类时光谱维数据量巨大的特点,提出一种基于三维空洞卷积残差神经网络的高光谱影像分类方法。该方法以高光谱像元立方体作为数据输入,使用三维卷积核同... 详细信息

高光谱影像是典型的高维数据,在光谱维和空间维都包含了大量信息。针对高光谱影像分类时光谱维数据量巨大的特点,提出一种基于三维空洞卷积残差神经网络的高光谱影像分类方法。该方法以高光谱像元立方体作为数据输入,使用三维卷积核同时提取高光谱数据的空间维和光谱维特征,并通过在卷积核中引入空洞结构,在不增加网络参数量和不消减数据特征的情况下提高卷积核的感受野,从而提高神经网络的分类的精度。该方法利用残差结构避免了由网络层数加深导致的梯度消失问题,最终使用Softmax分类器完成高光谱像元的分类工作。实验结果表明:所提方法在Indian Pines和Salinas数据集上分别取得了97.303%和97.236%的总体分类精度,与各对照组相比具有更好的分类效果,由此证明所提方法可以提升高光谱影像的分类性能。

关键词：遥感高光谱影像分类空洞卷积三维卷积残差神经网络

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不可凝气体对中压安注系统的影响分析研究

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核科学与工程 2023年第6期43卷 1243-1249页

作者：闫明晶许晨德王茹中广核工程有限公司核电安全监控技术与装备国家重点实验室广东深圳518172 深圳中广核工程设计有限公司广东深圳518172

2008年,NRC发布公开信GL2008-01“Managing Gas Accumulation in Emergency Core Cooling,Decay Heat Removal,and Containment Spray Systems”,要求核电厂执照申请者必须提供电厂对不可凝气体的应对措施,并证明电厂的设计建造等满足公开信的要求。核电厂发生丧失冷却剂事故下,安全注入系统启动,将含硼水注入到反应堆冷却剂系统,防止堆芯裸露,限制燃料包壳温度的峰值。核电厂正常运行期间,安全注入系统处于满水备用状态。如果系统内产生、积聚不可凝气体,可能导致事故后安全注入系统无法立即投使,进而影响核电厂的安全运行。因此,必须对核电厂安全注入系统不可凝气体问题引起足够的重视。目前,关于该领域的研究工作主要涉及不可凝气体在流体系统中集聚可能影响泵性能甚至导致其无法执行安全功能,主要导致的故障包括:泵气缚、泵突然抱死和泵机械性能降级。对于泵后的系统管道含不可凝气体的水锤现象研究较少。因此研究安全注入系统不可凝气体的水锤分析问题,分析潜在不可凝气体对安全注入系统注入功能的影响对核电厂的安全运行具有重要意义。

关键词：安全注入系统不可凝水锤

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风机荷载作用下频率比对砂土动力响应的影响

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同济大学学报（自然科学版） 2024年第5期52卷 738-748页

作者：张艳贾敏才蒋明镜谢志伟同济大学土木工程学院上海200092 同济大学岩土及地下工程教育部重点实验室上海200092 同济大学土木工程防灾减灾全国重点实验室上海200092 苏州科技大学土木工程学院江苏苏州215009

海上风机在运行过程中风荷载与波浪荷载频率耦合作用对土体动力特性的影响不容忽略,为了探究这种影响,采用多向循环动单剪系统(VDDCSS)对砂土进行了一系列试验研究,分析了双向剪切频率比f_(r)对砂土动应变、动孔压比以及动强度的影响。... 详细信息

海上风机在运行过程中风荷载与波浪荷载频率耦合作用对土体动力特性的影响不容忽略,为了探究这种影响,采用多向循环动单剪系统(VDDCSS)对砂土进行了一系列试验研究,分析了双向剪切频率比f_(r)对砂土动应变、动孔压比以及动强度的影响。试验结果表明:剪应变发展受双向频率耦合及应力组合效应的影响。循环应力比(C_(SR))为0.15时,双向频率耦合效应大于应力组合作用;随着应力水平的增加(C_(SR)=0.20或0.25),频率耦合效应和应力组合作用均得到了加强。在低应力水平时,破坏试样的孔压曲线呈“上凹型”且频率比对试样孔压发展影响不大。而随着应力水平增加(C_(SR)=0.20或0.25),孔压最终值u_(max)随之增大。除f_(r)=1.00与10.00对应试样外,土体动强度随f_(r)与C_(SR)值增大而减少。f_(r)=5.00对应试样应变大、孔压值高、强度低的原因与此比值下土体受双向频率耦合与应力组合的叠加效果增强有关。

关键词：循环单剪频率比动应变动孔压动强度

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面向月面原位资源利用的嫦娥五号月壤样品颗粒形态特征研究

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同济大学学报(自然科学版) 2024年第8期52卷 1180-1187页

作者：李佳王超李志远谢欢蒋明镜晏雄锋许雄冯永玖童小华同济大学上海市航天测绘遥感与空间探测重点实验室同济大学测绘与地理信息学院苏州科技大学土木工程学院

月壤颗粒形态特征对月面原位挖掘、运输、3D打印等具有重要影响，我国自主获取的嫦娥五号样品可为月球科研站建设等提供月壤关键参数信息。以月面原位资源利用过程关注的月壤颗粒形态特征为目标，利用体视光学显微镜获取了同济大学获批... 详细信息

月壤颗粒形态特征对月面原位挖掘、运输、3D打印等具有重要影响，我国自主获取的嫦娥五号样品可为月球科研站建设等提供月壤关键参数信息。以月面原位资源利用过程关注的月壤颗粒形态特征为目标，利用体视光学显微镜获取了同济大学获批的嫦娥五号月壤颗粒样品图像，构建了一套图像处理和颗粒识别方法，并提出方向差异指数表征颗粒表面粗糙程度，实现了自动提取颗粒边缘并计算其粒度和形态指标。结果表明，所研究嫦娥五号样品颗粒粒径范围为4.36～792.30μm，均值纵横比为0.66，均值圆形度为0.806，均值方向差异指数为0.111。小粒径颗粒占比大，10μm以下颗粒占44.19%。颗粒方向差异指数呈近似正态分布，表明大量颗粒表面粗糙程度近似，并存在少量表面较为光滑和粗糙的颗粒。小粒径颗粒大小与纵横比、圆形度均呈负相关，与表面粗糙程度相关性低，大粒径颗粒大小与形态没有相关性。研究还发现嫦娥五号样品比Apollo 11和Apollo 15样品的颗粒的圆形度更小，形态更不规则。

关键词：嫦娥五号样品月壤颗粒粒度分析形态特征

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压水堆核电站低压安注泵压降系数智能化计算的研究

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中国电力 2017年第1期50卷 121-124页

作者：闫明晶翟巴菁代亚培中广核工程有限公司广东深圳518124

为了保证数据的同步时效性,测量参数由就地临时仪表更改为变送器采集,并在控制系统内将数据进行智能运算,进而测得低压安注泵吸入口压降系数。利用已知的低压安注泵从换料水箱吸水进行冷段注工况下流量与扬程,根据模型进行推演得到低压... 详细信息

为了保证数据的同步时效性,测量参数由就地临时仪表更改为变送器采集,并在控制系统内将数据进行智能运算,进而测得低压安注泵吸入口压降系数。利用已知的低压安注泵从换料水箱吸水进行冷段注工况下流量与扬程,根据模型进行推演得到低压安注泵从核岛地坑吸水进行冷段注工况下流量与扬程,并对核岛地坑至泵吸入口的压降进行保守计算得到低压安注泵可用汽蚀余量。压水堆核电站低压安注泵地坑吸入口压降系数智能化计算的研究在智能电站系统得到成功应用,为研究核电站LOCA事故工况安注泵安全运行提供了重要的原始数据输入,数据精确、精准、可信。

关键词：核电站压水堆低压安注泵压降系数智能化

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Passive attitude stabilization of ionic-wind-powered micro air vehicles

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Chinese Journal of Aeronautics 2023年第7期36卷 412-419页

作者： Hengyu ZHANG Jiaming LENG Zhiwei LIU mingjing QI Xiaojun yan School of Energy and Power Engineering Beihang UniversityBeijing 100191China

The ionic-wind-powered Micro Air Vehicles(MAVs)can achieve a higher thrust-toweight ratio than other ***,this kind of MAV has not yet achieved controlled flight because of the unstable thrust produced by the ionic wind and the dynamic instability related to the small *** this paper,a passive attitude stabilization method of the ionic-wind-powered MAV using air dampers is *** key factors that influence the performance of the air dampers,including the layout,position,and area of the air dampers,are theoretically *** appropriate optimal position of the air dampers is also obtained by Monte Carlo stochastic *** the proposed passive attitude stabilization method is applied to the ionic-wind-powered MAVs of different wingspan(2 cm and 6.3 cm).Finally,the experimental results show that using the proposed method,attitude stabilization is achieved for the first time for the ionic-wind-powered ***,the altitude control of an ionic-wind-powered MAV with a wingspan of 6.3 cm is also demonstrated.

关键词： Air dampers Altitude control Ionic wind propulsion Micro air vehicle Monte Carlo methods Stability

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An Experimental and Numerical Study on the Ballistic Performance of Multi-Layered Moderately-Thick Metallic Targets against 12.7-mm Projectiles

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 165-197页

作者： Kailei Wang mingjing Li Peng yan Leiting Dong School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China

Themain goal of this work is to study the ballistic performance ofmulti-layered moderately-thick metallic *** target configurations have been considered in thiswork,with various types of interlayer connection(spaced,contacted and adhesive)and the number of layers(four and eight),and the influence of target configurations on ballistic performance has been studied experimentally and *** the experiments,the targets were impacted by 12.7-mm projectiles at a velocity around 820 m/*** experimental results show that,with similar total thickness,the contacted and adhesive targets exhibit better ballistic performance than the monolithic targets,and the four-layered targets are better than the eight-layered targets with the same connection *** explore the ballistic resistance mechanism,numerical method has been used to simulate the penetration process of each *** numerical results indicate that petal formation and friction have significant influence on targets’ballistic *** has stronger influence on themulti-layered targets than on themonolithic *** to the numerical results,about 14%of projectile’s initial kinetic energy is dissipated by friction during penetrating the four-layered contacted target,which is proved to be the most effective type of target studied in *** results also indicate that,in contrast to common understanding,friction plays an important role even when the impact velocity is significantly higher than the ballistic *** outcome of this work may provide useful information for a better understanding of ballistic resistant mechanisms and more efficient utilization of multi-layered metallic targets in armor structural design.

关键词： Multi-layered targets 12.7-mm projectile friction

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