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Exploring formation mechanism and source attribution of ozone during the 2019 Wuhan Military World Games:Implications for ozone control strategies

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Journal of Environmental Sciences 2024年第2期136卷 400-411页

作者： Lei Zhang Lili Wang Runyu Wang Nan Chen Yuan Yang Ke Li Jie Sun Dan Yao Yuesi Wang minghui tao Yang Sun Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China University of the Chinese Academy of Sciences Beijing 100049China Hubei Ecological Environment Monitoring Center Station Wuhan 430072China Guizhou Research and Designing Institute of Environmental Sciences Guizhou Academy of Environmental Science and DesignGuiyang 550081China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China School of Environment Key Laboratory for Yellow River and Huai River Water Environment and Pollution ControlMinistry of EducationHenan Normal UniversityXinxiang 453007China Key Laboratory of Regional Ecology and Environmental Change School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China

A series of emission reduction measures were conducted in Wuhan,Central China,to ensure good air quality during the 7th Military World Games(MWG)in October *** better understand the implications for ozone(O_(3))pollution control strategies,we applied integrated analysis approaches based on the de-weathered statistical model,parameterization methods,chemical box model,and positive matrix factorization *** the MWG,concentrations of O_(3),NO_x,and volatile organic compound(VOCs),OFP(O_(3)formation potential),L_(OH)(OH radical loss rate)were 83μg/m^(3),43μg/m^(3),26 ppbv,188μg/m^(3),and 3.9 s^(-1),respectively,which were 26%,18%,3%,15%,and 13%lower than pre-MWG values and 6%,39%,30%,33%,and 50%lower than post-MWG values,*** removing meteorological influence,O_(3)and its precursors during the MWG decreased largely compared with post-MWG values,and only O_(3),NO_(2),and oxygenated VOCs(OVOCs)declined compared with pre-MWG values,which revealed the emission reduction measures during the MWG played an important role for O_(3)*** six VOCs sources,the mass contributions of biomass burning and solvents usage during the MWG decreased largely compared with pre-MWG values.O_(3)production was sensitive to VOCs and the key species were aromatics,OVOCs,and alkenes,which originated mainly from solvents usage,biomass burning,industrial-related combustion,and vehicle *** O_(3)concentration during the strict control was mainly caused by OVOCs reduction due to biomass burning ***,the O_(3)abatement strategies of Wuhan should be focused on the mitigation of high-reactivity VOCs.

关键词： VOCs Ozone Wuhan Military World Games Source apportionment Relative incremental reactivity Random forest

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Net effect of air pollution controls on health risk in the Beijing-Tianjin-Hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing Lin Peter K.K.Louie Alexis K.H.Lau Jimmy C.H.Fung Zibing Yuan minghui tao Xuguo Zhang Md.Shakhaoat Hossain Chengcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public Health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the Beijing–Tianjin–Hebei(BTH)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTH(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide Health risk Carbon neutrality Mega-events

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儿童哮喘与睡眠呼吸障碍的相关性

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儿科药学杂志 2024年第3期30卷 50-53页

作者：陶明慧(综述) 丁玲彭东红(审校) 重庆医科大学附属儿童医院儿童发育疾病研究教育部重点实验室国家儿童健康与疾病临床医学研究中心儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室重庆400014

哮喘作为儿童常见的呼吸系统疾病之一,是一种以慢性气道炎症及气道高反应性为特征的异质性疾病。流行病学研究[1-3]显示,1990-2010年我国儿童哮喘患病率为1.09%~3.02%,每10年约增加50%;各年龄组患病率均呈上升趋势[4]。哮喘严重影响儿... 详细信息

哮喘作为儿童常见的呼吸系统疾病之一,是一种以慢性气道炎症及气道高反应性为特征的异质性疾病。流行病学研究[1-3]显示,1990-2010年我国儿童哮喘患病率为1.09%~3.02%,每10年约增加50%;各年龄组患病率均呈上升趋势[4]。哮喘严重影响儿童的健康、学习和生活,给家庭和社会带来沉重的精神和经济负担。尽管目前有基于证据的评估和治疗指南,仍有>20%的儿童哮喘未达良好控制,可能与患儿家属依从性差、治疗不规范、对共患病诊治不足等有关[5]。

关键词：睡眠呼吸障碍气道高反应性流行病学研究异质性疾病治疗指南呼吸系统疾病慢性气道炎症儿童哮喘

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The emerging roles of lysine-specific demethylase 4A in cancer:Implications in tumorigenesis and therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 645-663页

作者： Guanjun Yang Changyun Li Fan tao Yanjun Liu minghui Zhu Yu Du Chenjie Fei Qiusheng She Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingboZhejiang 315211China School of Life Science and Engineering Henan University of Urban ConstructionPingdingshanHenan 467044China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesNingbo UniversityNingboZhejiang 315211China Key Laboratory of Aquacultural Biotechnology Ministry of Education Ningbo UniversityNingboZhejiang 315211China

Lysine-specific demethylase 4 A(KDM4A,also named JMJD2A,KIA0677,or JHDM3A)is a demethylase that can remove methyl groups from histones H3K9me2/3,H3K36me2/3,and H1.4K26me2/*** evidence suggests that KDM4A is not only involved in body homeostasis(such as cell proliferation,migration and differentiation,and tissue development)but also associated with multiple human diseases,especially ***,an increasing number of studies have shown that pharmacological inhibition of KDM4A significantly attenuates tumor progression in vitro and in vivo in a range of solid tumors and acute myeloid *** there are several reviews on the roles of the KDM4 subfamily in cancer development and therapy,all of them only briefly introduce the roles of KDM4A in cancer without systematically summarizing the specific mechanisms of KDM4A in various physiological and pathological processes,especially in tumorigenesis,which greatly limits advances in the understanding of the roles of KDM4A in a variety of cancers,discovering targeted selective KDM4A inhibitors,and exploring the adaptive profiles of KDM4A ***,we present the structure and functions of KDM4A,simply outline the functions of KDM4A in homeostasis and non-cancer diseases,summarize the role of KDM4A and its distinct target genes in the development of a variety of cancers,systematically classify KDM4A inhibitors,summarize the difficulties encountered in the research of KDM4A and the discovery of related drugs,and provide the corresponding solutions,which would contribute to understanding the recent research trends on KDM4A and advancing the progression of KDM4A as a drug target in cancer therapy.

关键词： Cancer therapy Drug resistance Histone demethylation JmjC domain KDM4A

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Evaluation of satellite land surface albedo products over China using ground-measurements

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International Journal of Digital Earth 2021年第11期14卷 1493-1513页

作者： Yunbo Lu Lunche Wang Bo Hu Ming Zhang Wenmin Qin Jiaojiao Zhou minghui tao Key Laboratory of Regional Ecology and Environmental Change School of Geography and Information EngineeringChina University of GeosciencesWuhanPeople’s Republic of China Hunan Key Laboratory of Remote Sensing of Ecological Environment in Dongting Lake Area School of Geography and Information EngineeringChina University of GeosciencesWuhanPeople’s Republic of China State Key Laboratory of Atmospheric Boundary Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingPeople’s Republic of China

Land surface albedo(LSA)is an important parameter in surface energy balance and global climate *** has been used in the fields of energy budgets,climate dynamics,and land surface *** apply satellite LSA products more widely,the product accuracy needs to be evaluated at different scales and under atmospheric and surface *** study validates and analyzes the errors of the LSA datasets from the Global LAnd Surface Satellites(GLASS)product,the European Space Agency’s Earth Observation Envelope Programme(GlobAlbedo),the Quality Assurance for Essential Climate Variables(QA4ECV)project,the Gap-filled Snow-free Bidirectional Reflectance Distribution Function(BRDF)parameters product(MCD43GF),and the Satellite Application Facility on Climate Monitoring(CM SAF)Albedo dataset from the AVHRR data(CLARA-SAL)against the Chinese Ecosystem Research Network(CERN)measurements at different spatiotemporal scales over China from 2005 to *** results show that LSA estimated by GLASS agrees well with the CERN measurements on a continental *** GLASS product is characterized by a correlation coefficient of 0.80,a root-mean-square error of 0.09,and a mean absolute error of *** consistency between GLASS,GlobAlbedo,and CLARA-SAL is slightly lower over the regions with high aerosol optical depth(AOD)(*** Basin,northern China)and high cloud cover compared with that in regions with lower AOD and low cloud *** estimation errors are related to varying atmospheric and surface conditions and increase with increasing AOD and cloud cover and decreasing enhanced vegetation ***,algorithms under complex atmospheric and surface conditions(*** AOD,sparse vegetation)should be optimized to improve the accuracy of LSA products.

关键词： Land surface albedo satellite products validation atmospheric factor spatial pattern

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Space view of the decadal variation for typical air pollutants in the Pearl River Delta （PRD） region in China

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Frontiers of Environmental Science & Engineering 2016年第5期10卷 129-142页

作者： Zifeng WANG Min SHAO Liangfu CHEN minghui tao Liuju ZHONG Duohong CHEN Meng FAN Yang WANG Xinhui WANG State Key Laboratory of Remote Sensing Science Jointly Sponsored by Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China College of Environmental Sciences and Engineering Peking University Beijing 100876 China Guangdong Environmental Monitoring Center Guangzhou 510308 China

The Pearl River Delta （PRD） is one of the most industrialized, urbanized and populated regions in China, and thus has been long suffering from severe air pollutions. Space data provide a unique perspective for investigating the atmospheric environment at a regional scale. By utilizing multiple satellite retrievals from 2005 to 2013, this study presented, for the first time, the spatial patterns and temporal trends of typical air pollutants over PRD and its vicinity. As viewed from space, aerosol optical depth （AOD）, NO2 and SO2 all had their higher values at the central part of PRD, and showed clear descending gradients as moving to the outskirt of this region. As to the inter-annual variation, all these pollutants had decreasing trends in PRD during the study period, which generally agreed with the relevant in situ measurements. However, the satellite retrievals differed from ground measurements when addressing NO2 and SO2 in the vicinity of PRD. This work also provides the inter-comparison among PRD and three other metropolitan clusters in China： PRD had relatively high AOD, moderate NO2 and low SO2 levels, and it was the only region achieving the effective reduction of NO2 and SO2 during last decade. Unlike the previous three pollutants, HCHO observed by satellite showed very special patterns： it had a relatively homogeneous spatial distribution over both of PRD and its vicinity, and presented an opposite increasing trend from 2005 to 2010. Moreover, PRD had the highest HCHO level among all the metropolitan clusters, hinting a considerable contribution of biogenic origins of HCHO in PRD.

关键词： The Pearl River Delta (PRD) Satellite monitoring Regional air quality Long-term trend HCHO

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Satellite record of the transition of air quality over China

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Big Earth Data 2018年第2期2卷 190-196页

作者： Liangfu Chen minghui tao Zifeng Wang Jinhua tao Chao Yu Ying Zhang Meng Fan Jinabin Gu Lin Su State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijingChina Laboratory of Critical Zone Evolution School of Earth SciencesChina University of GeosciencesWuhanChina

The rapid development of atmospheric satellite instruments since 1990s provides unprecedented large amount of observational datasets concerning global atmospheric *** continu-ous and long-term large-scale satellite products such as aerosol optical depth,tropospheric NO 2 and SO 2 enable effective and objective evaluation of air *** columnar aerosol opti-cal parameters can be used to indicate particle pollution near surface after *** contrast,satellite results of trace gas pollutants such as NO 2 and SO 2 from fossil fuel combustion with short lifetime around half one day are used to estimate anthro-pogenic *** is shown that the overall anthropogenic emissions in China have largely declined since strict emission reduction policy implemented since ***,coarse pixel resolution of the trace gases,limited information and retrieval bias of aerosol properties tend to hinder further application of satellite in air quality *** launched satellite missions with advanced detection abilities will greatly enhance global atmo-spheric observations with much more datasets available.

关键词： Satellite air quality China aerosol trace gases

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基于卫星遥感的近地面PM_(2.5)浓度反演进展

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遥感学报 2022年第9期26卷 1757-1776页

作者：向娟陶明辉郭玲陈良富陶金花桂露中国地质大学(武汉)地理与信息工程学院武汉430074 天津气象服务中心天津300074 中国科学院空天信息创新研究院遥感科学国家重点实验室北京100101

细颗粒物PM_(2.5)(Fine Particulate Matter)是影响空气质量和公共健康的关键因素之一。高时空分辨率的PM_(2.5)数据是公共健康风险评估和流行病学研究的基本需求。相较于地面站点,卫星遥感技术具有连续观测、宽覆盖和低成本的优势,基... 详细信息

细颗粒物PM_(2.5)(Fine Particulate Matter)是影响空气质量和公共健康的关键因素之一。高时空分辨率的PM_(2.5)数据是公共健康风险评估和流行病学研究的基本需求。相较于地面站点,卫星遥感技术具有连续观测、宽覆盖和低成本的优势,基于卫星气溶胶光学厚度AOD(Aerosol Optical Depth)反演PM_(2.5)质量浓度的方法已成为热点。本研究概述了卫星AOD产品反演PM_(2.5)浓度的原理,介绍了用于PM_(2.5)反演的主要卫星AOD产品及其反演精度;总结了现有的PM_(2.5)估算方法及其优缺点,指出目前PM_(2.5)反演研究存在的问题;提出未来PM_(2.5)反演方向主要集中在高时空分辨率的PM_(2.5)浓度重建、基于激光雷达数据的三维PM_(2.5)浓度反演及PM_(2.5)化学组分反演等方向。比例因子法、物理机理模型和统计模型这3种方法都能在不同时期不同程度地准确估算PM_(2.5)浓度,代表了那个时期较为前沿的研究热点,但比例因子法和物理机理模型因其自身的局限性而应用较少,而统计模型因其独特的时间或时空异质性的可描述性和强大的非线性描述能力的优势而被广泛应用并不断改进。目前PM_(2.5)反演研究存在的问题主要有3种:(1)卫星AOD的非随机缺失问题造成估算的PM_(2.5)数据缺失;(2)反演模型的精度问题;(3)PM_(2.5)的化学成分估算问题。基于此,本文为了准确揭示近地面PM_(2.5)的时空变化趋势,提高基于卫星AOD产品的近地面PM_(2.5)反演研究的准确性,提出了几点未来的研究方向:首先,新型的高空间(如风云四号、高分五号)、高时间分辨率(Himawari-8/9)卫星AOD产品在PM_(2.5)的精细化估算研究上具有很大优势,这对于高时空分辨率的PM_(2.5)浓度重建具有重要意义;其次,随着大气探测技术的发展,星载、机载及地基激光雷达都能够获取垂直分布信息,搭载在无人机上的颗粒物传感器可实现PM_(2.5)垂直方向上的监测,将其与光学遥感卫星数据及地面监测数据结合,可实现三维的PM_(2.5)浓度反演;最后,PM_(2.5)化学组分信息对于分析污染成因、暴露特征等尤其重要,其时空变化趋势研究是一个重要的发展方向,然而,地面PM_(2.5)组分观测站网仍不完善,如何克服卫星遥感估算中对地面站网的依赖,实现PM_(2.5)化学成分的高精度反演需要进一步研究。通过本研究,有助于进一步了解不同PM_(2.5)估算方法的原理机制及其优缺点,为基于卫星AOD产品反演近地面PM_(2.5)浓度的新的发展方向提供启示,提升近地面PM_(2.5)浓度反演的精度及时空分辨率。

关键词： PM_(2.5) 卫星遥感 AOD 估算方法

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Huangqi Guizhi Wuwu Decoction suppresses inflammation and bone destruction in collagen-induced arthritis mice

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Chinese Herbal Medicines 2024年第2期16卷 274-281页

作者： Jiamin Bao Yongjia Song minghui Hang Hao Xu Qiang Li Pengyu Wang tao Chen Mengxiong Xia Qi Shi Yongjun Wang Xiaoyun Wang Qianqian Liang School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai 200032China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of EducationShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: Rheumatoid arthritis(RA) is a chronic inflammatory and destructive arthritis, characterized by inflammatory infiltration and bone destruction. Huangqi Guizhi Wuwu Decoction(HGWD) is traditional Chinese medicine, which has been applied in the treatment of RA in clinical. The aim of this study was to investigate the therapeutic effect of HGWD on collagen-induced arthritis(CIA) mouse ***: DBA/1J female mice were used to establish the collagen-induced arthritis(CIA) model. HGWD was administered intragastrically once a day for four weeks starting on the 22nd day after the first immunization. The body weight, hind paw thickness and clinical score were measured every five days. Gait analysis, histopathological staining, enzyme-linked immunosorbent assay(ELISA), ultrasound imaging and micro-computed tomography imaging were performed to determine the effects of HGWD treatment on inflammation and bone structure in this model. Moreover, Real-time PCR and Western blot analysis were used to detect inflammatory factors m RNA and protein levels after HGWD intervention in RAW264.7 ***: HGWD attenuated symptoms of arthritis, suppressed inflammatory synovium area and the serum levels of inflammatory factors, inhibited joint space enlargement in the knee and ankle joints,reduced numbers of osteoclasts, protected bone destruction, as well as improved motor *** decreased the expression of m RNA for inflammatory factors and the protein expression levels of p-NF-ΚB and ***: These results suggested that HGWD suppresses inflammation, attenuates bone erosion and maintains motor function in collagen-induced arthritis mice.

关键词： bone destruction collagen-induced arthritis Huangqi Guizhi Wuwu Decoction inflammation rheumatoid arthritis

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一种全局低偏的视觉/惯性/弱定位辅助融合导航系统

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光子学报 2024年第4期53卷 209-220页

作者：徐宇枫刘沅秩秦明辉赵辉陶卫上海交通大学电子信息与电气工程学院感知科学与工程学院上海200240

以视觉惯性为核心的导航技术在长期运行工况下误差会不断累积,进而产生严重的轨迹偏移。针对该问题,提出一种全局低偏的视觉/惯性/弱定位辅助融合导航系统。该系统以视觉惯性里程计高频率、高局部精度特性为基础,在室内外不同场景中,提... 详细信息

以视觉惯性为核心的导航技术在长期运行工况下误差会不断累积,进而产生严重的轨迹偏移。针对该问题,提出一种全局低偏的视觉/惯性/弱定位辅助融合导航系统。该系统以视觉惯性里程计高频率、高局部精度特性为基础,在室内外不同场景中,提供可选的全局信息辅助方案,融合卫星导航原始信息、超声基站测距信息以及视觉靶标定位辅助信息,实现室内外一体化全局低偏导航。搭建数据平台采集现实数据,基于激光点云匹配方法生成轨迹真值,将本文方法与VINS-Mono方法和ORBSLAM3方法进行导航精度评估对比,证明所提出的系统在全天候室内外不同光照环境中鲁棒性最好,在局部和全局都具备最优的导航精度。

关键词：视觉惯性里程计全球卫星导航系统超声定位视觉靶标室内外一体化

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