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3D layer-by-layer amorphous MoS_(x) assembled from[Mo_(3)S_(13)]^(2-)clusters for efficient removal of tetracycline:Synergy of adsorption and photo-assisted PMS activation

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Chinese Chemical Letters 2024年第9期35卷 369-375页

作者： Yue Li minghao Fan Conghui Wang Yanxun Li Xiang Yu Jun Ding Lei Yan Lele Qiu Yongcai Zhang Longlu Wang School of Chemical and Printing-Dyeing Engineering Henan International Joint Laboratory of Rare Earth Composite MaterialsHenan University of EngineeringXinzheng 451191China School of Material Science and Engineering Henan Polytechnic UniversityJiaozuo 454001China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China College of Electronic and Optical Engineering&College of Microelectronics Institute of Flexible Electronics(Future Technology)Nanjing University of Posts&TelecommunicationsNanjing 210023China

Peroxymonosulfate(PMS)activation and photocatalysis are effective technologies to remove organic pollutants,but the adsorption effect of the catalyst is usually unheeded in degradation ***,a bifunctional catalyst of amorphous MoS_(x)(a-MoS_(x))with 3D layer-by-layer superstructure was synthesized by assembling basic active units[Mo_(3)S_(13)]^(2-)of MoS_(2).The large interlayer spacing and high exposure of active sites render a-MoS_(x)to have excellent synergy of adsorption and photo-assisted PMS activation for tetracycline(TC)*** and DFT calculation show that TC can be efficiently enriched on a-MoS_(x)by pore filling,π-πinteraction,hydrogen bonding and high adsorption ***,PMS can be quickly activated through electron transfer with a-MoS_(x),resulting in high TC degradation efficiency of 96.6%within 20 *** addition,the synergistic mechanism of adsorption and photo-assisted PMS activation was explored,and the degradation pathway of TC was *** work is inspirational for constructing bifunctional catalysts with superior synergistic adsorption and catalytic capabilities to remove refractory organic pollutants in water.

关键词： Bifunctional catalyst [Mo_(3)S_(13)]^(2-) Adsorption Photo-assisted PMS activation Active sites

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Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring

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Nanotechnology and Precision Engineering 2024年第1期7卷 18-31页

作者： Jiahui Xu minghao Wang Minyi Jin Siyan Shang Chuner Ni Yili Hu Xun Sun Jun Xu Bowen Ji Le Li Yuhua Cheng Gaofeng Wang School of Electronics&Information MOE Engineering Research Center of Smart Microsensors and MicrosystemsHangzhou Dianzi UniversityHangzhou 310018China Wenzhou Institute of Hangzhou Dianzi University Wenzhou 310018China Key Laboratory of Intelligent Operation and Maintenance Technology&Equipment for Urban Rail Transit of Zhejiang Province College of EngineeringInstitute of Precision Machinery and Smart StructureZhejiang Normal UniversityJinhua 321004China Institute of Guizhou Aerospace Measuring and Testing Technology Guiyang 550009China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and ***,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial ***,aﬂexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is *** porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and *** to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aﬂat pressure sensor without a porous MNA ***-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the *** addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode *** importantly,it was found that the sensor could accurately monitor the motion of aﬁnger,wrist joint,arm,face,abdomen,eye,and Adam’s ***,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s ***,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×*** to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer.

关键词： Capacitive pressure sensor Microneedle array Porous PDMS Interdigital electrode

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Progress in Mechanical Modeling of Implantable Flexible Neural Probes

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1205-1231页

作者： Xiaoli You Ruiyu Bai Kai Xue Zimo Zhang minghao Wang Xuanqi Wang Jiahao Wang Jinku Guo Qiang Shen Honglong Chang Xu Long Bowen Ji Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an710072China National Key Laboratory of Unmanned Aerial Vehicle Technology Northwestern Polytechnical UniversityXi’an710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an710072China School of Automobile Chang’an UniversityXi’an710018China MOE Engineering Research Center of Smart Microsensors and Microsystems College of Electronics and InformationHangzhou Dianzi UniversityHangzhou310018China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710129China

Implanted neural probes can detect weak discharges of neurons in the brain by piercing soft brain tissue,thus as important tools for brain science research,as well as diagnosis and treatment of brain ***,the rigid neural probes,such as Utah arrays,Michigan probes,and metal microfilament electrodes,are mechanically unmatched with brain tissue and are prone to rejection and glial scarring after implantation,which leads to a significant degradation in the signal quality with the implantation *** recent years,flexible neural electrodes are rapidly developed with less damage to biological tissues,excellent biocompatibility,and mechanical compliance to alleviate *** them,the mechanical modeling is important for the optimization of the structure and the implantation *** this review,the theoretical calculation of the flexible neural probes is firstly summarized with the processes of buckling,insertion,and relative interaction with soft brain tissue for flexible probes from outside to ***,the corresponding mechanical simulation methods are organized considering multiple impact factors to realize minimally invasive ***,the technical difficulties and future trends of mechanical modeling are discussed for the next-generation flexible neural probes,which is critical to realize low-invasiveness and long-term coexistence in vivo.

关键词： Mechanical modeling flexible neural probes invasive theoretical calculation simulation

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基于Frenet坐标下改进人工势场法的无人车局部路径规划

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兵工学报 2024年第7期45卷 2097-2109页

作者：姬鹏郭明皓河北工程大学机械与装备工程学院河北邯郸056038

人工势场法由于运算量小、精度高,广泛应用于无人车的局部路径规划。针对传统人工势场法存在目标不可达、局部最小值及陷入U型障碍物的问题,提出一种基于Frenet坐标系下改进人工势场法的路径规划算法。构建Frenet坐标系来表述车辆避障运... 详细信息

人工势场法由于运算量小、精度高,广泛应用于无人车的局部路径规划。针对传统人工势场法存在目标不可达、局部最小值及陷入U型障碍物的问题,提出一种基于Frenet坐标系下改进人工势场法的路径规划算法。构建Frenet坐标系来表述车辆避障运动,简化规划模型,解决路径规划中车辆与所在道路相对位置不易表述的问题。提出安全椭圆模型和预测距离的概念来调整势场影响区域,加入基于Frenet坐标系下的参考线势场及动态速度势场改进斥力场函数,解决车辆在静态和动态下的避障问题。利用数学仿真软件进行仿真,以不同车速在直道和弯道场景中对所提出的路径规划方法进行静态和动态避障仿真实验。研究结果表明:不同车速下的前轮转角、横摆角速度均控制在较小范围内,改进算法可以有效解决传统人工势场法的缺陷,同时与快速搜索随机树(Rapidly-exploring Random Tree,RRT)算法相比,其在避障过程中路径规划计算效率提高了42.8%,改进算法优势明显。

关键词：无人车局部路径规划人工势场法 Frenet坐标系

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Oyster-derived Anticoagulant Peptide Mitigates Thrombin-induced Barrier Dysfunction and Prothrombotic Phenotype in Human Pulmonary Microvascular Endothelial Cells

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Food Science and Human Wellness 2024年

作者： Shuzhen Cheng Siyi Wang Ximing Yang minghao Xie Qi Yang Lushun Yuan Ming Du National Engineering Research Center of Seafood， Collaborative Innovation Center of Seafood Deep Processing， Dalian Polytechnic University Department of Vascular Surgery， Shanghai General Hospital， Shanghai Jiao Tong University SKL of Marine Food Processing & Safety Control， School of Food Science and Technology， Dalian Polytechnic University

Thrombin blockers have been shown to be effective for various pathological conditions， but their use is limited due to the potential for serious bleeding adverse effects. This study introduced a novel bioactive peptide (P-2-CG) from oyster， that mitigated thrombin-mediated barrier dysfunction and prothrombotic phenotypes in human pulmonary microvascular endothelial cells (HPMECs). P-2-CG significantly attenuated the increase in endothelial monolayer permeability induced by thrombin through the possible attenuation of RhoA activation and it promoted barrier recovery by enhancing endothelial cell adhesion. Additionally， P-2-CG was found to decrease the pro-thrombotic phenotype induced by thrombin in HPMEC by reducing the extrinsic trigger TF mRNA expression， which resulted in prolonged plasma clotting time， decreased FXa activation， and reduced thrombin generation. Moreover， P-2-CG inhibited thrombosis efficiently by blocking ICAM-1 and VCAM-1 expression via tyrosine phosphorylation of RelA/p65. P-2-CG inhibits thrombin mediated inflammation and provides a potential therapeutic option for treating endothelial dysfunction and thrombosis.

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Speed Control of Brushed DC Motor Based on LADRC and ADRC

Speed Control of Brushed DC Motor Based on LADRC and ADRC

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第35届中国过程控制会议

作者： minghao Liao Shurong Li College of Artificial Intelligence Beijing University of Posts and Telecommunications

This paper presents a comprehensive study on the application of Active Disturbance Rejection Control(ADRC) and Linear ADRC(LADRC) techniques for the control of brushed direct current(DC) motors. The objective is to enhance the performance of these motors in terms of speed regulation and disturbance rejection. The paper demonstrates how these advanced control strategies can effectively cope with uncertainties inherent in brushed DC motors, resulting in improved precision and stability. Comparative analysis with traditional control methods highlights the superiority of ADRC and LADRC in achieving faster response times and higher robustness against external disturbances and parameter variations. Theoretical discussions are substantiated with experimental results, showcasing the practical benefits and feasibility of implementing ADRC and LADRC in real-world motor control applications. This study contributes to the field of electrical engineering by providing insights into the potential of ADRC and LADRC for enhancing the performance of brushed DC motors, which are widely used in various industrial and automotive applications.

关键词： ADRC LADRC Brushed DC Robustness

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Microglia in brain aging:An overview of recent basic science and clinical research developments

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Journal of Biomedical Research 2024年第2期38卷 122-136页

作者： Haixia Fan Minheng Zhang Jie Wen Shengyuan Wang minghao Yuan Houchao Sun Liu Shu Xu Yang Yinshuang Pu Zhiyou Cai Chongqing Medical University Chongqing 400042China Department of Neurology Chongqing General HospitalChongqing 400013China Chongqing Key Laboratory of Neurodegenerative Diseases Chongqing 400013China Department of Neurology the First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Gerontology the First People's Hospital of JinzhongJinzhongShanxi 030009China

Aging is characterized by progressive degeneration of tissues and organs,and it is positively associated with an increased mortality *** brain,as one of the most significantly affected organs,experiences age-related changes,including abnormal neuronal activity,dysfunctional calcium homeostasis,dysregulated mitochondrial function,and increased levels of reactive oxygen *** changes collectively contribute to cognitive *** is also a key risk factor for neurodegenerative diseases,such as Alzheimer's disease and Parkinson's *** many years,neurodegenerative disease investigations have primarily focused on neurons,with less attention given to microglial ***,recently,microglial homeostasis has emerged as an important mediator in neurological disease ***,we provide an overview of brain aging from the perspective of the *** doing so,we present the current knowledge on the correlation between brain aging and the microglia,summarize recent progress of investigations about the microglia in normal aging,Alzheimer's disease,Parkinson's disease,Huntington's disease,and amyotrophic lateral sclerosis,and then discuss the correlation between the senescent microglia and the brain,which will culminate with a presentation of the molecular complexity involved in the microglia in brain aging with suggestions for healthy aging.

关键词： microglia brain aging Alzheimer's disease Parkinson's disease Huntington's disease

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Integration of HiBiT into enteroviruses:A universal tool for advancing enterovirus virology research

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Virologica Sinica 2024年第3期39卷 422-433页

作者： Rui Yu Xiaohong Li Peng Zhang minghao Xu Jitong Zhao Jingjing Yan Chenli Qiu Jiayi Shu Shuo Zhang miaomiao Kang Xiaoyan Zhang Jianqing Xu Shuye Zhang School of Medicine Shanghai UniversityShanghai200444China Clinical Center for Biotherapy Zhongshan HospitalFudan UniversityShanghai200433China Guangzhou Institutes of Biomedicine and Health The Chinese Academy of SciencesGuangzhou510530China Institutes of Biomedical Sciences Fudan UniversityShanghai200032China Shanghai Geriatric Medical Center Shanghai201104China Clinical Center for Biotherapy Zhongshan Hospital/Zhongshan Hospital(Xiamen)Fudan University361015China Shanghai Public Health Clinical Center Fudan UniversityShanghai201508China

The utilization of enteroviruses engineered with reporter genes serves as a valuable tool for advancing our understanding of enterovirus biology and its applications,enabling the development of effective therapeutic and preventive *** this study,our initial attempts to introduce a NanoLuc luciferase(NLuc)reporter gene into recombinant enteroviruses were unsuccessful in rescuing viable *** hypothesized that the size of the inserted tag might be a determining factor in the rescue of the ***,we inserted the 11-amino-acid HiBiT tag into the genomes of enterovirus A71(EV-A71),coxsackievirus A10(CVA10),coxsackievirus A7(CVA7),coxsackievirus A16(CVA16),namely EV-A71-HiBiT,CVA16-HiBiT,CVA10-HiBiT,CVA7-HiBiT,and observed that the HiBiT-tagged viruses exhibited remarkably high rescue ***,the HiBiT-tagged enteroviruses displayed comparable characteristics to the wild-type viruses.A direct comparison between CVA16-NLuc and CVA16-HiBiT recombinant viruses revealed that the tiny HiBiT insertion had minimal impact on virus infectivity and replication ***,these HiBiT-tagged enteroviruses demonstrated high genetic stability in different cell lines over multiple *** addition,the HiBiT-tagged viruses were successfully tested in antiviral drug assays,and the sensitivity of the viruses to drugs was not affected by the HiBiT ***,our findings provide definitive evidence that the integration of HiBiT into enteroviruses presents a universal,convenient,and invaluable method for advancing research in the realm of enterovirus ***,HiBiT-tagged enteroviruses exhibit great potential for diverse applications,including the development of antivirals and the elucidation of viral infection mechanisms.

关键词： Enterovirus Infectious clones Reporter genes Luciferase Drug screening

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Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer

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Science China Chemistry 2024年第2期67卷 652-663页

作者： Chong Li minghao Han Ji Gao Shuxian Wang Song-Bo Lu Yaxi Li Zhao Liu Chen Zhang Zhaojin Wang Fangliang Wang Yuang Sun Chun Loong Ho Kai Wang Yun Shen Kai Li Shenzhen Key Laboratory of Smart Healthcare Engineering Guangdong Provincial Key Laboratory of Advanced BiomaterialsDepartment of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen518055China Department of Chemical and Environmental Engineering University of California RiversideRiverside92521USA Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen518055China

The critical factor of spatial constraint,provided by the external confinement(e.g.,matrix),is often overlooked during photodynamic inactivation,despite playing a crucial role in determining the molecular photophysical process and subsequent antipathogen ***,as a proof-of-concept model,we employed two types of polymers with varying interaction energies with dopants to investigate the intrinsic relationship between spatial constraint and the essential excited-state behaviors of doped photosensitizer(4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)ethyl)-1-methylquinolin-1-ium iodine,TPP).Through experimental investigation and theoretical calculations,we found that TPP tends to remain in the excited state for a shorter dwell time under weaker spatial constraints due to less restricted molecular motion in polyurethane(PU) ***,the singlet oxygen(^(1)O_(2)) generated from doped-TPP shows a 9.23-fold enhancement in PU than in the polyvinylchloride(PVC) *** light irradiation,the PU@TPP nanofiber can efficiently eliminate the coronavirus MHV-A59(≥99.9997%) at a 220,000-fold higher concentration than the infected *** antibacterial efficacy has also been demonstrated,with a killing rate of ≥99%.

关键词： photodynamic antibacterial singlet oxygen triphenylamine nanofiber

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基于动态联邦蒸馏的医疗对话文本生成

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东南大学学报（自然科学版） 2024年第4期54卷 1030-1036页

作者：刘宇鹏林明豪哈尔滨理工大学计算机科学与技术学院哈尔滨150006

为了解决传统联邦蒸馏中由数据异质造成的知识误导现象,针对医疗对话文本生成这种复杂任务,提出了一种通过动态知识融合和客户端选择进行蒸馏的模型FedKS,对知识的积累和传递进行更加精细的建模.首先,在联邦学习中设计了一种有效的知识... 详细信息

为了解决传统联邦蒸馏中由数据异质造成的知识误导现象,针对医疗对话文本生成这种复杂任务,提出了一种通过动态知识融合和客户端选择进行蒸馏的模型FedKS,对知识的积累和传递进行更加精细的建模.首先,在联邦学习中设计了一种有效的知识聚合机制.其次,针对存在误导知识这一问题,提出了一种基于阈值的方法来优化每个客户端的本地模型更新选择.通过计算各客户端对全局模型性能的增益,决定是否采用知识蒸馏后的本地模型.FedKS模型可以有效解决由于误导知识导致的局部模型性能下降问题,从而实现高效的知识聚合和传递.基于多个数据集的实验表明,FedKS模型比现有基线模型训练收敛速度更快,性能更优异,并能够支持异质模型.

关键词：联邦蒸馏知识聚合客户端选择知识误导

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