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经尿道前列腺等离子切除术治疗良性前列腺增生伴高血压的效果研究

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实用临床医药杂志 2024年第15期28卷 90-94页

作者：王明镑陈昌沙刘榕臻许剑锋福建省晋江市医院/上海市第六人民医院福建医院泌尿外科福建泉州362000 福建省晋江市医院/上海市第六人民医院福建医院医学影像科福建泉州362000

目的比较经尿道前列腺等离子切除术(TUPKRP)与药物治疗对伴高血压的良性前列腺增生人群血压及血压节律变化的影响。方法回顾性纳入2021年6月—2023年6月本院103例良性前列腺增生患者为研究对象,依据治疗方案的不同将其分为药物治疗组47... 详细信息

目的比较经尿道前列腺等离子切除术(TUPKRP)与药物治疗对伴高血压的良性前列腺增生人群血压及血压节律变化的影响。方法回顾性纳入2021年6月—2023年6月本院103例良性前列腺增生患者为研究对象,依据治疗方案的不同将其分为药物治疗组47例(采用替米沙坦联合非那雄胺治疗)和手术治疗组56例(采用替米沙坦联合TUPKRP治疗)。比较2组治疗前以及治疗3、6个月时血压水平(24 h平均舒张压、24 h平均收缩压、日间平均舒张压、日间平均收缩压、夜间平均舒张压和夜间平均收缩压)、血压节律变化(杓型血压)、前列腺症状、前列腺体积、残余尿量和性功能。结果手术治疗组治疗3、6个月时不同时段平均血压低于药物治疗组,差异有统计学意义(P0.05)。结论替米沙坦联合TUPKRP可降低伴高血压的良性前列腺增生患者血压水平,调节血压节律变化,改善前列腺症状,缩小前列腺体积,减少残余尿量,且对患者性功能影响较小。

关键词：良性前列腺增生高血压经尿道前列腺等离子切除术血压血压节律

Opportunities and challenges of digital twin technology in healthcare

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Chinese Medical Journal 2023年第23期136卷 2895-2896页

作者： mingbang wang Huijuan Hu Song Wu Key Laboratory of Medical Digital Twins Department of Experiment&ResearchSouth China HospitalMedical SchoolShenzhen UniversityShenzhenGuangdong 518116China Shanghai Key Laboratory of Birth Defects Division of NeonatologyChildren’s Hospital of Fudan UniversityNational Center for Children’s HealthShanghai 201102China Department of Urology South China HospitalHealth Science CenterShenzhen UniversityShenzhenGuangdong 518116China

To the Editor:The classic case considered to be the primary application of the digital twin approach is the Apollo 13 mission in *** 2003,the concept of the digital twin was presented by *** Grieves at the University of ***,the widespread dissemination of the digital twin concept is attributed to the National Aeronautics and Space Administration’s application of digital twin for aerospace vehicle health maintenance and assurance in 2011.[1]The improvement of new-generation information technology has led to a wider range of applications for digital twin technology,including healthcare.

关键词： digital attributed technology

Genomic landscapes of Chinese sporadic autism spectrum disordersrevealed by whole-genome sequencing

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Journal of Genetics and Genomics 2018年第10期45卷 527-538页

作者： Jinyu Wu Ping Yu Xin Jin Xiu Xu Jinchen Li Zhongshan Li mingbang wang Tao wang Xueli Wu Yi Jiang Wanshi Cai Junpu Mei Qingjie Min Qiong Xu Bingrui Zhou Hui Guo Ping wang Wenhao Zhou Zhengmao Hu Yingrui Li Tao Cai Yi wang Kun Xia Yong-Hui Jiang Zhong Sheng Sun Institute of Genomic Medicine Wenzhou Medical UniversityWenzhou 325000China BGI-Shenzhen Shenzhen 518083China Department of Child Healthcare Children's Hospital of Fudan UniversityShanghai 200032China State Key Laboratory of Medical Genetics Central South UniversityChangsha 410078China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China Department of Pediatrics and Neurobiology Duke University School of MedicineDurhamNC 27710USA

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical and genetic *** this study,we identified all classes of genomic variants from whole-genome sequencing (WGS) dataset of 32 Chinese trios with ASD,including de novo mutations,inherited variants,copy number variants (CNVs) and genomic structural variants.A higher mutation rate (Poisson test,P<2.2×10^(-16)) in exonic (1.37×10^(-8)) and 3'-UTR regions (1.42×10^(-8)) was revealed in comparison with that of whole genome (1.05×10^(-8)).Using an integrated model,we identified 87 potentially risk genes (P<0.01) from 4832 genes harboring various rare deleterious variants,including CHD8 and NRXN2,implying that the disorders may be in favor to *** particular,frequent rare inherited mutations of several microcephaly-associated genes (ASPM,WDR62,and ZNF335)were found in *** chromosomal structure analyses,we found four de novo CNVs and one de novo chromosomal rearrangement event,including a de novo duplication of UBE3A-containing region at 15q11.2-q13.1,which causes Angelman syndrome and microcephaly,and a disrupted TNR due to de novo chromosomal translocation t (1;5) (q25.1;q33.2).Taken together,our results suggest that abnormalities of centrosomal function and chromatin remodeling of the microcephaly-associated genes may be implicated in pathogenesis of *** of WGS as a new yet efficient technique to illustrate the full genetic spectrum in complex disorders,such as ASD,could provide novel insights into pathogenesis,diagnosis and treatment.

关键词： Autism spectrum disorders De novo mutations Microcephaly-associated genes Whole-genome sequencing

Uniformity Control of Scanned Beam in 300 MeV Proton and Heavy Ion Accelerator Complex at SESRI

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原子能科学技术 2024年第4期58卷 705-713页

作者： HOU Lingxiao YUAN Youjin SHEN Guodong RUAN Shuang LIU Jie ZHU Yunpeng wang Geng GUO Hongliang LYU mingbang GAO Daqing XU Zhiguo SHENG Lina YANG Jiancheng Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

In recent years,heavy ion accelerator technology has been rapidly developing worldwide and widely applied in the fields of space radiation simulation and particle ***,a very high uniformity in the irradiation area is required for the extracted ion beams,which is crucial because it directly affects the experimental precision and therapeutic ***,ultra-large-area and high-uniformity scanning are crucial requirements for spacecraft radiation effects assessment and serve as core specification for beamline terminal *** the 300 MeV proton and heavy ion accelerator complex at the Space Environment Simulation and Research Infrastructure(SESRI),proton and heavy ion beams will be accelerated and ultimately delivered to three irradiation *** order to achieve the required large irradiation area of 320 mm×320 mm,horizontal and vertical scanning magnets are used in the extraction beam ***,considering the various requirements for beam species and energies,the tracking accuracy of power supplies(PSs),the eddy current effect of scanning magnets,and the fluctuation of ion bunch structure will reduce the irradiation *** mitigate these effects,a beam uniformity optimization method based on the measured beam distribution was proposed and applied in the accelerator complex at *** the experiment,the uniformity is successfully optimized from 75%to over 90%after five iterations of adjustment to the PS *** this paper,the method and experimental results were introduced.

关键词： heavy ion accelerator beam uniformity scanning magnet MIC

10kV线路升级为20kV线路绝缘问题研究

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上海电气技术 2020年第4期13卷 22-25页

作者：王明邦王哲斐王臻陶松垒上海兆邦电力器材有限公司上海201315 浙江科技学院杭州310023

对10 kV线路升级为20 kV线路过程中的绝缘问题进行了研究,对电杆、横担、绝缘子、最小距离、导线、金具等进行了绝缘评估,确认可以直接沿用和不可以直接沿用的线路设施。对于无法直接沿用的线路设施,提出应用灌注型绝缘护罩和绝缘层加... 详细信息

对10 kV线路升级为20 kV线路过程中的绝缘问题进行了研究,对电杆、横担、绝缘子、最小距离、导线、金具等进行了绝缘评估,确认可以直接沿用和不可以直接沿用的线路设施。对于无法直接沿用的线路设施,提出应用灌注型绝缘护罩和绝缘层加厚机器人进行绝缘等级提升,进而满足20 kV线路的绝缘要求。

关键词：输配电绝缘技术改造研究

The reformation of catalyst:From a trial-and-error synthesis to rational design

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Nano Research 2024年第4期17卷 3261-3301页

作者： Ligang wang Jiabin Wu Shunwu wang Huan Liu Yao wang Dingsheng wang Department of Chemistry Tsinghua UniversityBeijing 100084China

The appropriate catalysts can accelerate the reaction rate and effectively boost the efficient conversion of various molecules,which is of great importance in the study of chemistry,chemical industry,energy,materials and environmental ***,efficient,environmentally friendly,and easy to operate synthesis methods have been used to prepare various types of *** previous studies have reported the synthesis and characterization of the aforementioned catalysts,more still remain in trial and error methods,without in-depth consideration and improvement of traditional synthesis ***,we comprehensively summarize and compare the preparation methods of the trial-and-error synthesis strategy,structure–activity relationships and density functional theory(DFT)guided catalysts rational design for nanomaterials and atomically dispersed *** also discuss in detail the utilization of the nanomaterials and single atom catalysts for converting small molecules(H_(2)O,O_(2),CO_(2),N_(2),etc.)into value-added products driven by electrocatalysis,photocatalysis,and ***,the challenges and outlooks of mass preparation and production of efficient and green catalysts through conventional trial and error synthesis and DFT theory are featured in accordance with its current development.

关键词： trial-and-error synthesis structure–activity relationships density functional theory(DFT)guidance nanomaterials atomically dispersed catalysts

Numerical Analysis of PRISM-PY Calculations for Hard-and Soft-Core Generic Polymer Models

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Chinese Journal of Polymer Science 2024年第4期42卷 532-543页

作者： Qiang wang Department of Chemical and Biological Engineering Colorado State University1370 Campus DeliveryFort CollinsCO80523-1370USA

Generic polymer models capturing the chain connectivity and excluded-volume interactions between polymer segments can be classified, according to whether or not the 3D integral of the latter diverges, into hard- and soft-core models. Taking homogeneous systems of compressible homopolymer melts (or equivalently homopolymer solutions in an implicit, good solvent) in the continuum as an example, we recently compared the correlation effects on the structural and thermodynamic properties of the hard- and soft-core models given by the polymer reference interaction site model (PRISM) theory with the Percus-Yevick (PY) closure (Polymers 2023, 15, 1180). Here we analyzed in detail the numerical errors and behavior of the interchain pair correlation functions (PCFs) given by the PRISM-PY calculations of these models using an efficient numerical approach that we proposed. Our numerical approach has the least number of independent variables to be iteratively solved, analytically treats the discontinuities caused by the non-bonded pair potential (such as that of the hard spheres) and takes only the inverse Fourier transform of the interchain indirect PCF between polymer segments (which is continuous and decays towards 0 with increasing wavenumber much faster than both the interchain direct and total PCFs), and is essential for us to accurately solve the PRISM-PY theory for chain length N as large as 106. To capture the correlation-hole effect, the real-space cut-off in the PRISM calculations should be proportional to the square root of N.

关键词： Generic polymer models Soft potentials Polymer reference interaction site model theory

Linear-Quadratic Pareto Cooperative Game for Mean-Field Backward Stochastic System

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Journal of Systems Science & Complexity 2024年第3期37卷 947-964页

作者： wang Yu School of Control Science and Engineering Shandong UniversityJinan 250061China

This paper focuses on a Pareto cooperative differential game with a linear mean-field backward stochastic system and a quadratic form cost functional. Based on a weighted sum optimality method, the Pareto game is equivalently converted to an optimal control problem. In the first place,the feedback form of Pareto optimal strategy is derived by virtue of decoupling technology, which is represented by four Riccati equations, a mean-field forward stochastic differential equation(MF-FSDE),and a mean-field backward stochastic differential equation(MF-BSDE). In addition, the corresponding Pareto optimal solution is further obtained. Finally, the author solves a problem in mathematical finance to illustrate the application of the theoretical results.

关键词： Backward stochastic differential equation linear-quadratic control mean-field Pareto optimality

A multi-source information fusion layer counting method for penetration fuze based on TCN-LSTM

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Defence Technology（防务技术） 2024年第3期33卷 463-474页

作者： Yili wang Changsheng Li Xiaofeng wang Nanjing University of Science and Technology Nanjing 210094JiangsuChina State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ferromagnetic materials,thereby posing challenges in accurately determining the number of *** address this issue,this research proposes a layer counting method for penetration fuze that incorporates multi-source information fusion,utilizing both the temporal convolutional network(TCN)and the long short-term memory(LSTM)recurrent *** leveraging the strengths of these two network structures,the method extracts temporal and high-dimensional features from the multi-source physical field during the penetration process,establishing a relationship between the multi-source physical field and the distance between the fuze and the target plate.A simulation model is developed to simulate the overload and magnetic field of a projectile penetrating multiple layers of target plates,capturing the multi-source physical field signals and their patterns during the penetration *** analysis reveals that the proposed multi-source fusion layer counting method reduces errors by 60% and 50% compared to single overload layer counting and single magnetic anomaly signal layer counting,*** model's predictive performance is evaluated under various operating conditions,including different ratios of added noise to random sample positions,penetration speeds,and spacing between target *** maximum errors in fuze penetration time predicted by the three modes are 0.08 ms,0.12 ms,and 0.16 ms,respectively,confirming the robustness of the proposed ***,the model's predictions indicate that the fitting degree for large interlayer spacings is superior to that for small interlayer spacings due to the influence of stress waves.

关键词： Penetration fuze Temporal convolutional network(TCN) Long short-term memory(LSTM) Layer counting Multi-source fusion