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IDV:Internet Domain Name Verification Based on Blockchain

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Computer Modeling in Engineering & Sciences 2021年第10期129卷 299-322页

作者： Ning Hu yu Teng Yan Zhao shi Yin yue Zhao Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China Zhong Zi Hua Ke Traffic Construction Technology Co. Ltd.Beijing100195China Science and Technology on Communication Security Laboratory Chengdu610041China

The rapid development of blockchain technology has provided new ideas for network security ***-based network security enhancement solutions are attracting widespread *** paper proposes an Internet domain name verification method based on *** authenticity of DNS(Domain Name System)resolution results is crucial for ensuring the accessibility of Internet *** to the lack of adequate security mechanisms,it has always been a challenge to verify the authenticity of Internet domain name resolution *** the solution represented by DNSSEC(Domain Name System Security Extensions)can theoretically solve the domain name verification problem,it has not been widely deployed on a global scale due to political,economic,and technical *** argue that the root cause of this problem lies in the significant centralization of the DNS *** centralized feature not only reduces the efficiency of domain name verification but also has the hidden risks of single point of failure and unilateral *** users may disappear from the Internet due to the results of fake,subverted,or misconfigured domain name *** paper presents a decentralized DNS cache verification method,which uses the consortium blockchain to replace the root domain name server to verify the authenticity of the domain *** with DNSSEC’s domain name verification process,the verification efficiency of this method has increased by 30%,and there is no single point of failure or unilateral control *** addition,this solution is incrementally deployable,and even if it is deployed on a small number of content delivery network servers,satisfactory results can be obtained.

关键词： Blockchain-based network security DNS security DNS decentralization CDN

The comparison of survival between active surveillance or watchful waiting and focal laser ablation in patients with low-risk prostate cancer

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Asian Journal of Andrology 2022年第5期24卷 494-499页

作者： Jia-Kun Li Chi-Chen Zhang shi Qiu Kun Jin Bo-yu Cai Qi-ming yuan Xing-yu Xiong Lian-Sha Tang Di Jin Xiang-Hong Zhou Yi-Ge Bao Lu Yang Qiang Wei Department of Urology Institute of UrologyWest China Hospital of Sichuan UniversityChengdu 610041China Department of Biotherapy Cancer CenterWest China Hospital of Sichuan UniversityChengdu 610041China

Prostate cancer(PCa)is the second-most common cancer among *** active surveillance or watchful waiting(AS/WW)and focal laser ablation(FLA)can avoid the complications caused by radical *** to make the choice between these options in clinical practice needs further ***,this study aims to compare and analyze their effects based on overall survival(OS)and cancer-specific survival(CSS)to obtain better long-term *** included patients with low-risk PCa from the Surveillance Epidemiology and End Results database of 2010–*** Cox proportional hazard analyses were conducted for OS and CSS in the two *** eliminate bias,this study applied a series of sensitivity ***,Kaplan–Meier curves were plotted to obtain survival status.A total of 18841 patients with low-risk PCa were included,with a median of 36-month *** to the multivariate Cox proportional hazard regression,the FLA group presented inferior survival benefits in OS than the AS/WW group(hazard ratio[HR]:2.13,95%confidence interval[CI]:1.37–3.33,P<0.05).After adjusting for confounders,the result persisted(HR:1.69,95%CI:1.02–2.81,P<0.05).According to the results of the sensitivity analysis,the inverse probability of the treatment weighing model indicated the same result in *** conclusion,AS/WW and FLA have the advantage of fewer side effects and the benefit of avoiding overtreatment compared with standard *** study suggested that AS/WW provides more survival benefits for patients with low-risk *** relevant researches and data will be needed for further clarity.

关键词： active surveillance cancer-specific survival focal laser ablation low-risk prostate cancer overall survival watchful waiting

Cross-Subject Emotion Recognition Brain-Computer Interface Based on fNIRS and DBJNet

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Cyborg and Bionic Systems 2023年第1期4卷 208-216页

作者： Xiaopeng Si Huang He Jiayue yu Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072People’s Republic of China Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjin 300072People’s Republic of China Tianjin International Engineering Institute Tianjin UniversityTianjin 300072People’s Republic of China

Functional near-infrared spectroscopy(fNIRS)is a noninvasive brain imaging technique that has gradually been applied in emotion recognition research due to its advantages of high spatial resolution,real time,and ***,the current research on emotion recognition based on fNIRS is mainly limited to within-subject,and there is a lack of related work on emotion recognition across ***,in this paper,we designed an emotion evoking experiment with videos as stimuli and constructed the fNIRS emotion recognition *** this basis,deep learning technology was introduced for the first time,and a dual-branch joint network(DBJNet)was constructed,creating the ability to generalize the model to new *** decoding performance obtained by the proposed model shows that fNIRS can effectively distinguish positive versus neutral versus negative emotions(accuracy is 74.8%,F1 score is 72.9%),and the decoding performance on the 2-category emotion recognition task of distinguishing positive versus neutral(accuracy is 89.5%,F1 score is 88.3%),negative versus neutral(accuracy is 91.7%,F1 score is 91.1%)proved fNIRS has a powerful ability to decode ***,the results of the ablation study of the model structure demonstrate that the joint convolutional neural network branch and the statistical branch achieve the highest decoding *** work in this paper is expected to facilitate the development of fNIRS affective brain-computer interface.

关键词： branch neutral category

Fermionic Zero Modes in Gauge and Gravity Backgrounds on a Sphere

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Communications in Theoretical Physics 2008年第6期49卷 1577-1579页

作者： LIU yu-Xiao ZHANG Li-Jie DUAN Yi-shi Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China Department of Physics Shanghai University Shanghai 200444 China

In this letter we study fermionic zero modes in gauge and gravity backgrounds taking a two-dimensional compact manifold S2 as extra dimensions. The result is that there exist massless Dirac fermions which have normalizable zero modes under quite general assumptions about these backgrounds on the bulk. Several special cases of gauge background on the sphere axe discussed and some simple fermionic zero modes are obtained.

关键词： extra dimensions fermionic zero modes

Transcriptome analysis reveals tumor antigen and immune subtypes of melanoma

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Oncology Research 2023年第3期31卷 389-403页

作者： JIAHENG XIE MENGMENG OU PAN yu DAN WU QIKAI TANG yuAN CAO JING HANG LU YIN TINGHONG XIANG ming WANG JINGPING shi Department of Burn and Plastic Surgery The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing210029China Department of Rheumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008China Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing210029China Fourth School of Clinical Medicine Nanjing Medical UniversityNanjing210029China Department of Ultrasound in Medicine The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing210029China

Purpose:To screen potential tumor antigens for melanoma vaccine development and identify different immune ***:Transcriptional data(HTSEQ-FPKM)and clinical information of a 472 Melanoma cohort GDC TCGA Melanoma(SKCM)were downloaded from the UCSC XENA website(http://***/).Subsequently,transcriptome data and clinical information of 210 melanoma cohort GSE65904 were downloaded from Gene Expression Omnibus(GEO),a large global public *** the transcriptome expression data matrices were log2 transformed for subsequent ***,TIMER,and IMMPORT databases are also used for *** function experiments were performed to validate the role of the IDO1 gene in melanoma cell line ***:Our study provides potential tumor antigens for vaccine development in melanoma patients:GZMB,GBP4,CD79A,APOBEC3F,IDO1,JCHAIN,LAG3,PLA2G2D,*** addition,we divide melanoma patients into two immune subtypes that have significant differences in tumor immunity and may have different responses to *** view of the unclear role of IDO1 in melanoma,we selected IDO1 for cell assay *** function assay showed that IDO1 was significantly overexpressed in the melanoma A375 cell *** IDO1 knockdown,the activity,invasion,migration and healing ability of A375 cell lines were significantly ***:Our study could provide a reference for the development of vaccines for melanoma patients.

关键词： Melanoma mRNA vaccine Immune microenvironment Immunotherapy Bioinformatics analysis

Antibody drug conjugate:the“biological missile”for targeted cancer therapy

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1066-1090页

作者： Zhiwen Fu shijun Li Sifei Han Chen shi yu Zhang Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China Hubei Province Clinical Research Center for Precision Medicine for Critical Illness Wuhan 430022People’s Republic of China Drug Delivery Disposition and DynamicsMonash Institute of Pharmaceutical SciencesMonash University(Parkville Campus)381 Royal ParadeParkvilleVIC 3052Australia Faculty of Pharmacy China Pharmaceutical University639 Longmian AvenueJiangning DistrictNanjing 211198People’s Republic of China

Antibody–drug conjugate(ADC)is typically composed of a monoclonal antibody(mAbs)covalently attached to a cytotoxic drug via a chemical *** combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells,which has become one of the hotspots for the research and development of anticancer *** the first ADC,Mylotarg®(gemtuzumab ozogamicin),was approved in 2000 by the US Food and Drug Administration(FDA),there have been 14 ADCs received market approval so far ***,over 100 ADC candidates have been investigated in clinical stages at *** kind of new anti-cancer drugs,known as“biological missiles”,is leading a new era of targeted cancer ***,we conducted a review of the history and general mechanism of action of ADCs,and then briefly discussed the molecular aspects of key components of ADCs and the mechanisms by which these key factors influence the activities of ***,we also reviewed the approved ADCs and other promising candidates in phase-3 clinical trials and discuss the current challenges and future perspectives for the development of next generations,which provide insights for the research and development of novel cancer therapeutics using ADCs.

关键词： Antibody drugs conjugate

First-principles calculations of LaNi_(5-x)Sn_xH_y intermetallics and intermediate phase

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Acta Metallurgica Sinica(English Letters) 2009年第5期22卷 330-338页

作者： Dong CHEN Jingdong CHEN Yinglu ZHAO Hailiang HUO Benhai yu Deheng shi College of Physics and Electronic Engineering Xinyang Normal University Xinyang 464000 China College of Physics and Electronic Engineering Ludong University Yantai 264025 China

The crystal and electronic structures of LaNi4.75Sn0.25 intermetallics and LaNi4.5Sn0.5Hy （y=2.0, 2.5） intermediate phase have been investigated by the fullpotential linearized augmented plane wave （FP-LAPW） method. Hydrogen occupation sites in LaNi4.5Sn0.5Hy have been determined based on Westlake＇s criterions：（1） the minimum hole radiuS is 0.04 nm; （2） the minimum H-H distance is 0.21 nm; as well as geometry optimizations and internal coordinates optimizations. We find that hydrogen atoms prefer to occupy the 12n＊, 6m, 12o, 6m＊ sites in LaNi4.5Sn0.5H2.0 and the 6m＊, 4h, 6m, 12o, 12n＊ sites in LaNi4.5Sn0.5H2.5. The specific coordinates of hydrogen atoms in LaNi4.5Sn0.5Hy are also determined. The results show that hydrogen atoms tend to keep away from tin atoms. The maximum hydrogen content decreases compared with LaNi5. The interactions between Sn and Ni with H play a dominate role in the stability of LaNi4.5Sn0.5-H system. Lattice expansion and increment of Fermi energy EF show that both Sn and H atoms decrease structural stability of these alloys.

关键词： Rare-earth intermetallics Hydrogen storage Site occupancy Electronic structure

立德树人视域下“护理伦理学”混合式课程构建

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教育教学论坛 2024年第19期 153-156页

作者：邵渝史红健蒋小剑湖南中医药大学护理学院湖南长沙410208

为探讨立德树人视域下“护理伦理学”线上线下混合式课程的实践与应用效果,在2021级护理学专业本科班级教学中实施教学改革,内容包括整合教学内容、构建课程思政、提升“两性一度”、开展翻转课堂。从专家评价、学生评价两个方面评估课... 详细信息

为探讨立德树人视域下“护理伦理学”线上线下混合式课程的实践与应用效果,在2021级护理学专业本科班级教学中实施教学改革,内容包括整合教学内容、构建课程思政、提升“两性一度”、开展翻转课堂。从专家评价、学生评价两个方面评估课程建设效果。校、院、教研室三级教学督导对课程建设整体评价良好,学生对课程满意度为91.4%。课程思政改革将育才与育德有效融合,有利于提升学生思想道德素养;线上线下混合式教学有利于提高教学效率,提升学生专业能力。

关键词：护理伦理课程思政立德树人混合式教学

Synthesis and characterization of conjugated polymer containing azobenzene and oxadiazole units

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Chinese Chemical Letters 2009年第2期20卷 235-237页

作者： yue Zhang shi Jun yu Lu Wang Cong Li College of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029 China

A novel conjugated polymer containing azobenzene and oxadiazole units was synthesized through multi-step synthesis. The structures and properties of monomer and polymer were characterized and evaluated with IR, ^1H NMR, UV, TGA and GPC, respectively. Polymer with long side chain of alkoxy shows good solubility, thermal stability and photoisomerization property.

关键词： Oxadiazole Conjugated polymer Synthesis Characterization