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Syntheses, Structures, Fluorescence and Magnetism of Six Lanthanide Metal-organic Frameworks Based on Silicon-centered Tetrahedral ligand

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Chemical Research in Chinese Universities 2013年第2期29卷 196-200页

作者： li Yang-xue xue ming GUO li-jia HUANG lin CHEN Si-ru QIU Shi-lun State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 P. R. China

Multifunctional lanthanide metal-organic frameworks（MOFs）, M（H4TCPS）（H20）l.5[M=Tb（JUC-95a）, Er（JUC-95b）, Dy（JUC-95c）, Tm（JUC-95d）, Y（JUC-95e） and Pr（JUC-95f）; H4TCPS=tetrakis（4-carboxyphenyl）silane] were synthesized via the reaction of the lanthanide metal ions（Ln3） with a rigid silicon-centered tetrahedral carbo- xylate ligand H4TCPS via a hydrothermal synthesis method. X-Ray diffraction（XRD） analyses reveal that they are extremely similar in structure and crystallized in a monoclinic system with space group C2/c. Two eight-coordinated metal centers and four tetrahedral H4TCPS groups constructed a paddle-wheel building block. The paddle-wheel buil- ding blocks assembled with each other via one oxygen bridge from a water molecule to lead to a 1D infinite inorganic rod-shaped chain, --Y--O--C--O--Y--, along the [001] direction. These 1D inorganic rod-shaped chains linked with the phenyl groups of the tetrahedral HaTCPS ligand to form a 3D framework. In addition, the luminescent and magnetic properties of these compounds show that they could be potential antiferromagnetic and fluorescent mate- rials.

关键词： Metal-organic framework Tetrakis(4-carboxyphenyl)silane Magnetic property Fluorescence

Natural Products and Derivatives Targeting at Cancer Energy Metabolism:A Potential Treatment Strategy

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Current Medical Science 2020年第2期40卷 205-217页

作者： Qi-qi WANGI ming-xue li Chen li Xiao-xia GU Meng-zhu ZHENG li-xia CHEN Hua li Wuya College of Inovation School of Pharmaceutical EngineeringKey Laboratory of Structure-Based Drug Design&DiscoveryMinistry of EducationShenyang Pharmaceutical UniversiryShenyang 110016China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal *** cells mainly adopt the glycolysis as energy source to maintain tumor cell growth and biosynthesis under aerobic *** on energy metabolism pathway in cancer cells has aroused the interest of cancer researchers all around the *** recent years,plentiful studics suggest that targeting the peculiar cancer energy metabolic pathways,including glycolysis,mitochondrial respiration,amino acid metabolism,and fatty acid oxidation may be an effective strategy to starve cancer cells by blocking essential *** products (NPs)are considered as the “treasure trove of small molecules drugs” and have played an extremely remarkable role in the discovery and development of anticancer *** numerous NPs have been reported to act on cancer energy metabolism ***,a comprehensive overview about cancer energy metabolism targets and their natural-occurring inhibitors is prepared.

关键词： cancer energy metabolism cancer therapy natural products binding targets,inhibitors

A lindqvist-type [W_(6)O_(19)]^(2-) organic–inorganic compound: synthesis, characterization, antibacterial activity and preliminary studies on the mechanism of action

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Tungsten 2022年第2期4卷 121-129页

作者： Meng Zhao Xi-Yu Zhu Yan-Zhen li Jiang-Nan Chang ming-xue li li-Hua Ma Xiao-Yuan Guo Henan Key Laboratory of Polyoxometalate Chemistry Institute of Molecular and Crystal EngineeringSchool of Chemistry and Chemical EngineeringHenan UniversityKaifeng475004China Agricultural Products’Quality and Safety Testing Center of Kaifeng Kaifeng Agriculture and Rural BureauHenan475004China

In this paper,a new organic–inorganic hybrid compound[Co(L)_(2)]2[W_(6)O_(19)](1)(HL=2-acetylpyridine thiosemicarbazone)was prepared and *** compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration(MIC)against Staphylococcus aureus(***,0.06μg·mL^(−1))and Escherichia coli(***,0.24μg·mL^(−1)),***,the potential mechanism of compound 1 was studied in *** potential causes of bacteria death were cell wall/membrane disruption,inhibition of intracellular respiratory chain dehydrogenases(RCD)activity,destruction of reactive oxygen species(ROS)and depletion of glutathione(GSH).

关键词： Isopolytungstate Thiosemicarbazone Bioactivity Mechanism of action

维普期刊数据库

Progress of Traditional Chinese Medicine Treating COVID-19

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 167-183页

作者： ming-xue li Yue-Ying Yang Yang liu Meng-Zhu Zheng Jun li li-Xia Chen Hua li Wuya College of Innovation Key Laboratory of Structure‑Based Drug Design and DiscoveryMinistry of EducationShenyang Pharmaceutical UniversityShenyang110016China School of Pharmacy Tongji Medical CollegeHubei Key Laboratory of Natural Medicinal Chemistry and Resource EvaluationSchool of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Urology and Pharmacology University of CaliforniaIrvineOrangeCA 92868USA

The new coronavirus pneumonia(coronavirus disease 2019[COVID-19]),caused by the new coronavirus(severe acute respiratory syndrome coronavirus 2[SARS-CoV-2]),mainly manifests by fever,dry cough,and *** emergence of SARS-CoV-2 poses a huge threat to people’s ***,so far,there are no effective treatment drugs and *** Chinese medicine(TCM)has played an important role and achieved good results for treating this *** than 85%of patients with SARS-CoV-2 infection in China have received TCM *** this article,we describe the progress of TCM for the COVID-19 therapy.

关键词： Chinese patent medicines coronavirus disease 2019 decoctions traditional Chinese medicine

维普期刊数据库

Solitary fibrous tumors in abdomen and pelvis:Imaging characteristics and radiologic-pathologic correlation

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World Journal of Gastroenterology 2014年第17期20卷 5066-5073页

作者： xue-ming li Jing Reng Peng Zhou Ying Cao Zhu-Zhong Cheng Yan Xiao Guo-Hui Xu Department of Radiology Sichuan Cancer Hospital

AIM: To describe the imaging features of solitary fibrous tumors (SFTs) in the abdomen and pelvis, and the clinical and pathologic correlations.

关键词： Abdominal imaging Solitary fibrous tumors Computed tomography Magnetic resonance imaging

OSTEOCLASTIC RESORPTION OF CANCELLOUS BONE TISSUES OF FEMORAL NECK IN HIP FRACTURE PATIENTS (A SCANNING ELECTRON MICROSCOPIC STUDY)

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中华创伤杂志 1997年第2期 71-76页

作者： CHAI Ben fu, TANG xue ming, li Hui Shanghai Institute of Traumatology and Orthopaedics Shanghai Second Medical University, Shanghai 200025

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关键词： HIP FRACTURE NECK FEMORAL PATIENTS CANCELLOUS BONE

Cyclosporine treatment in idiopathic membranous nephropathy nephrotic syndrome in adults： a retrospective study spanning 15 years

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Chinese Medical Journal 2011年第21期124卷 3490-3494页

作者： TAO Jian-ling liU li-li WEN Yu-bing GAO Rui-tong li Hang li ming-xi li xue-mei li xue-wang Division of Nephrology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing 100730 China

Background Cyclosporine is effective in treating nephrotic syndrome （NS） with idiopathic membranous nephropathy （IMN） in adults. But high relapse rate remains a major concern. The way to manipulate cyclosporine is inconclusive. The aim of this study was to introduce the way how to titrate the cyclosporine to maintain complete remission without relapse. Methods Patients with biopsy-proven IMN with NS treated with cyclosporine for at least 1 month from 1996 to 2011 at Peking Union Medical College Hospital were reviewed. Results Mean age of the 51 eligible patients was 52 years, with 39 men. Mean proteinuria was （7.47±3.14） g/d, serum albumin （24.50±6.29） g/L, and serum creatinine （82.62±21.18） μmol/L. Cyclosporine was commenced at a mean dose of （3.46±0.63） mg·kg^-1·d^-1. Oral prednisone （0.40±0.29） mg·kg^-1·d^-1 was given concomitantly in 38 patients. Cyclosporine was administered for a median of 16 months （range 1-93 months） and stopped in non-responders by month six. By month 3 （n=47）, the number in complete remission （CR） and partial remission （PR） was 3 and 24, which shifted to 12 and 17 by month 6 （n=41）. Male gender, heavy proteinuria, low serum albumin level, and high serum creatinine level were significant determinants in poor response by month six （P 〈0.05 in all variables compared with responders）. There was a significant reversible serum creatinine increase within 25% during month 3 to 12 （P 〈0.05 in all variables compared with baseline value）. Eleven patients maintained cyclosporine for more than 24 months with a cyclosporine dose of （1.04±1.06） mg·kg^-1·d^-1. Nine patients were in CR. Renal function, systolic and diastolic blood pressure remained stable. Renal impairment （〉30% rise of serum creatinine）, secondary infection, hypertension, gingival hyperplasia and liver impairment occurred in 6, 4, 10, 4, and 1 patients, respectively. Conclusions The observation time for cyclosporine to effectively induce CR of NS in IMN adults should be at least six month

关键词： cyclosporine idiopathic membranous nephropathy nephrotic syndrome treatment

Adsorption of Fe3O4-Polyoxometalates(POMs) nanoparticles

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Adsorption of Fe3O4-Polyoxometalates(POMs) nanoparticles

The preparation and research of Fe3O4-[CdL2·(H2O)2]2H2[P2Mo5O23]·2CH3OH composite nanoparticles

河南省化学会2016年学术年会

作者： Ning Fang Chun-Yan li ming-xue li Hong-ling liu Key Lab of Polyoxometalate Chemistry of Henan Province Institute of Molecular and Crystal EngineeringSchool of Chemistry and Chemical Engineering Henan University

In the field of magnetic recording material, special adsorption material, the basic material of magnetic fluid and magnetic pigment and so on, as function material, magnetic FeO nanoparticle behave many special function. [Cu(L)(HO)]H[Cu(L)(PMoO)·5HO possess not only acid adsorption performance but also oxido-reduction performance of metal oxide, it is a sort of difunctional material, which have better adsorption performance. In this paper, we report the synthesis of polymer-coated Fe3O4 nano-particles using triblock copolymer PEO-PPO-PEO as the surfactant[1] and comparing FeO with [Cu(L)(HO)]H[Cu(L)(PMoO)]·5HO by ultrasound, then we put the magnet near the beaker, and draw out the part of having magnetism,which having magnetism was allowed to evaporate at room temperature for further use. Methyl blue(MB) and safranine T(ST) are harmful if swallowed by human beings and animals, causing irritation to the skin, eye and respiratory tract. Therefore, an effective and optimal strategy to degrade the dyes rapidly must be developed[2].Fig.1 shows that 1 remove fully MB molecules in 12 min. Fig.2 shows that 1 remove fully ST molecules in 60 min. These results revealed that it was able to remove the MB and ST molecules efficient-ly in dark. Such rapid adsorption rate for 1 towards these dyes was suspected that large amounts of dyes are adsorbed on the surface of sample particles.(1=FeO-[(Cu L)(HO)]H[(Cu L)(PMoO3)]·5HO)

关键词： adsorption Fe3O4 nanoparticles Fe3O4-Polyoxometalates(POMs) nanoparticles

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The preparation and research of Fe3O4-[CdL2·(H2O)2]2H2[P2Mo...