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Comparison between uncut Roux-en-Y and Roux-en-Y reconstruction after distal gastrectomy for gastric cancer: A meta-analysis

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World Journal of Gastroenterology 2018年第24期24卷 2628-2639页

作者： ming-ming sun Yi-Yi Fan Sheng-Chun Dang Department of General Surgery The Affiliated Hospital of Jiangsu University

AIM To compare uncut Roux-en-Y(U-RY) gastrojejunostomy with Roux-en-Y(RY) gastrojejunostomy after distal gastrectomy(DG) for gastric *** A literature search was conducted in Pubmed, Embase, Web of Science, Cochrane Library, Science Direct, Chinese National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Database to identify studies comparing U-RY with RY after DG for gastric cancer until the end of December 2017. Pooled odds ratio or weighted mean difference with 95% confidence interval was calculated using either fixed-or random-effects models. Perioperative outcomes such as operative time, intraoperative blood loss, and hospital stay; postoperative complications such as anastomotic bleeding, stricture and ulcer, reflux gastritis/esophagitis, delayed gastric emptying, and Roux stasis syndrome; and postoperative nutritional status(serum hemoglobin, total protein, and albumin levels) were the main outcomes assessed. Metaanalyses were performed using RevM an 5.3 *** Two randomized controlled trials and four nonrandomized observational clinical studies involving 403 and 488 patients, respectively, were included. The results of the meta-analysis showed that operative time [weighted mean difference(WMD):-12.95; 95%CI:-22.29 to-3.61; P = 0.007] and incidence of reflux gastritis/esophagitis(OR: 0.40; 95%CI: 0.20-0.80; P = 0.009), delayed gastric emptying(OR: 0.29; 95%CI: 0.14-0.61; P = 0.001), and Roux stasis syndrome(OR: 0.14; 95%CI: 0.04-0.50; P = 0.002) were reduced; and the level of serum albumin(WMD: 0.71; 95%CI: 0.24-1.19; P = 0.003) was increased in patients undergoing U-RY reconstruction compared with those undergoing RY reconstruction. No differences were found with respect to intraoperative blood loss, hospital stay, anastomotic bleeding, anastomotic stricture, anastomotic ulcer, the levels of serum hemoglobin, and serum total protein. CONCLUSION U-RY reconstruction has some clinical advantages over RY reconstru

关键词： Roux-en-Y Gastric cancer Meta-analysis Distal gastrectomy Reconstruction Uncut

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Suppressive effect of Aurantii Fructus Immaturus and Atractylodis Macrocephalae Rhizoma on glutamic acid-induced autophagy of interstitial cells of Cajal

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Journal of Integrative Medicine 2020年第4期18卷 334-343页

作者： Shuai Yan Yin-zi Yue ming-ming sun Ben-sheng Wu Xiao-peng Wang Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Anorectal Surgery Suzhou TCM HospitalNanjing University of Chinese MedicineSuzhou 215009Jiangsu ProvinceChina First Clinical Medical School Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

Objective:To investigate the effects of Aurantii Fructus Immaturus(Zhishi,ZS)and Atractylodis Macrocephalae Rhizoma(Baizhu,BZ)-containing serum on glutamate-induced autophagy in rat colonic interstitial cells of Cajal(ICCs)and to analyze the underlying ***:Rat colonic ICCs cultured in vitro were identified by fluorescence and then stimulated with glutamic acid(5 mmol/L)for 24 h to establish a cell model of *** cells were then treated with different concentrations of ZSBZ-containing serum or rat *** viability of the ICCs was detected with cell counting kit-8 assays,and cell apoptosis rates were examined with flow *** ultrastructure and autophagosomes in the ICCs were observed using transmission electron *** effects of ZSBZ-containing serum on apoptosis-associated mediators were assessed by Western blotting and real-time quantitative polymerase chain *** addition,microtubule-associated protein light chain 3(LC3),p-phosphoinositide 3-kinase(p-PI3 K),p-Akt and p-mammalian target of rapamycin(pm TOR)expression was detected via Western blotting ***:Compared to those in the model group,ICC viability and apoptosis rates were significantly increased by ZSBZ-containing serum(P<0.05).In addition,the expression levels of Beclin-1,LC3,pPI3 K,p-Akt and p-mTOR were significantly lower(P<0.05)and Bcl-2 expression was higher in the ZSBZ-containing serum treatment groups than in the model group(P<0.05).Conclusion:Our findings demonstrated that ZSBZ protects glutamic acid-stimulated ICCs,and this beneficial effect may be mediated by a reduction in autophagy via inhibition of the PI3 K/Akt/mTOR pathway.

关键词： Herbal medicine,Chinese Autophagy Phosphoinositide 3-kinase Signal pathway

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Effect of ATF3-deletion on apoptosis of cultured retinal ganglion cells

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 691-695页

作者： ming-ming sun Ya-Chen Wang Yi Li Xiao-Dan Guo Yan-ming Chen Zhong-Zhi Zhang Ophthalmology Department the First Hospital of China Medical University Shenyang 110001 Liaoning ProvinceChina

AIM：To investigate the effect of activating transcription factor-3（ATF3）-deletion on apoptosis of cultured retinal ganglion cells（RGCs）.METHODS：Three ATF3 siR NA（ATF3-rat-651, ATF3-rat-319, ATF3-rat-520） were constructed, and were transiently transfected into RGC-5 cells. Quantitative real-time polymerase chain reaction（PCR） was used to examine ATF3 expression and the most effective ATF3 siR NA was selected for further studies. Flow cytometry was applied to investigate the effects of ATF3 deletion on RGC-5 apoptosis under elevated hydrostatic pressure. Quantitative realtime PCR and Western blot were performed to validate differentially expressed genes and proteins in ATF3-knockdown RGC-5 ***：ATF3 specific siR NA effectively down-regulated ATF3 expression and significantly inhibited cell apoptosis in RGC-5 cells. Quantitative real-time PCR and Western blot confirmed that ATF3 knockdown remarkably decreased Jun-B and increased c-Jun at both m RNA and protein levels in RGC-5 ***：ATF/cA MP-response element-binding family of transcription factors may be involved in the development of glaucoma and could be novel treatment targets for glaucoma.

关键词： ATF3 elevated hydrostatic pressure apoptosis glaucoma

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Inhibition on Apoptosis Induced by Elevated Hydrostatic Pressure in Retinal Ganglion Cell-5 via Laminin Upregulating β1-integrin/Focal Adhesion Kinase/Protein Kinase B Signaling Pathway

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Chinese Medical Journal 2016年第8期129卷 976-983页

作者： Yi Li Yan-ming Chen ming-ming sun Xiao-Dan Guo Ya-Chen Wang Zhong-Zhi Zhang Department of Ophthalmology First Affiliated Hospital China Medical University Shenyang Liaoning 110001 China

Background：Glaucoma is a progressive optic neuropathy characterized by degeneration of neurons due to loss of retinal ganglion cells （RGCs）.High intraocular pressure （HIOP）,the main risk factor,causes the optic nerve ***,the precise mechanism of HIOP-induced RGC death is not yet completely *** study was conducted to determine apoptosis of RGC-5 cells induced by elevated hydrostatic pressures,explore whether laminin is associated with apoptosis under pressure,whether laminin can protect RGCs from apoptosis and affirm the mechanism that regulates the process of RGCs ***：RGC-5 cells were exposed to 0,20,40,and 60 mmHg in a pressurized incubator for 6,12,and 24 h,*** effect of elevated hydrostatic pressure on RGC-5 cells was measured by Annexin V-fluorescein isothiocyanate/propidium iodide staining,3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide assay,and Western blotting of cleaved caspase-3 *** and expression oflaminin were detected by *** expression of β 1-integrin,phosphorylation of focal adhesion kinase （FAK） and protein kinase B （PKB,or AKT） were investigated with real-time polymerase chain reaction and Western blotting ***：Elevated hydrostatic pressure induced apoptosis in cultured RGC-5 *** with 40 mmHg for 24 h induced a maximum *** was declined in RGC-5 cells after exposing to 40 mmHg for 24 *** pretreating with laminin,RGC-5 cells survived from elevated ***,β1-integrin and phosphorylation of FAK and AKT were increased compared to 40 mmHg ***：The data show apoptosis tendency of RGC-5 cells with elevated hydrostatic *** can protect RGC-5 cells against high pressure via β 1-integrin/FAK/AKT signaling *** results suggest that the decreased laminin of RGC-5 cells might be responsible for apoptosis induced by elevated hydrostatic pressure,and laminin or activating β1-integrin/FA

关键词： Apoptosis Glaucoma Hydrostatic Pressure Laminin Retinal Ganglion Cells

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基于MOVES的车辆排放因子测试

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交通运输工程学报 2017年第1期17卷 140-148页

作者：黄文伟强明明孙龙林张欣北京交通大学机械与电子控制工程学院北京100044 深圳职业技术学院汽车与交通学院广东深圳518055 长安大学环境科学与工程学院陕西西安710064

应用机动车排放模拟器(MOVES)的微观层次对车辆的排放因子进行了数值模拟,采用便携式排放测试系统对试验车辆进行实际道路尾气排放测试,基于测试结果从排放因子角度对MOVES输出的模拟值进行验证。分析结果表明:在城市快速路上,大型货车C... 详细信息

应用机动车排放模拟器(MOVES)的微观层次对车辆的排放因子进行了数值模拟,采用便携式排放测试系统对试验车辆进行实际道路尾气排放测试,基于测试结果从排放因子角度对MOVES输出的模拟值进行验证。分析结果表明:在城市快速路上,大型货车CO_2、CO、NOx、HC、PM排放因子的模拟值与实测值的比值分别为1.40、0.72、1.01、1.05、1.05;在城市主干道上,大型货车CO、NOx、HC排放因子的模拟值与实测值的比值分别为0.70、1.07、1.07,而CO_2和PM排放因子的模拟值与实测值的比值分别为1.63和2.12;在城市高速路上,小型客车HC排放因子的模拟值与实测值的比值仅为0.34,而CO_2、CO、NOx排放因子的模拟值与实测值接近,其模拟值与实测值的比值分别为1.22、1.05、0.86;在城市主干道上,小型客车CO_2和NOx排放因子的模拟值与实测值接近,其模拟值与实测值的比值分别为1.20和1.10,而CO和HC排放因子的模拟值与实测值的比值分别为2.25和0.53。测试结果在一定程度上反映了MOVES预测车辆排放因子的准确性,表明使用MOVES模拟机动车排放因子时,需要对相应参数进行修正,才能更加真实地反映机动车排放水平。

关键词：排放因子机动车排放模拟器便携式排放测试系统微观层次

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Upconversion Spectrum of Tm-doped Fiber Pumped by Multiwavelengths from 760 nm to 810 nm

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Chinese Journal of Lasers 1998年第4期 55-59页

作者： ming Hai BAI ming sun Xiaoquan 1) DONG Xiaopeng 2) (Department of Physics, University of Science and Technology of China, Hefei 230026, China 1) Optoelectronics Research Center, Electronic Engineering Institute. Hefei 230037, Chi

１．ＩｎｔｒｏｄｕｃｔｉｏｎＡｐｐｌｉｃａｔｉｏｎｓｉｎｏｐｔｉｃａｌｄａｔａｓｔｏｒａｇｅ，ｃｏｌｏｒｄｉｓｐｌａｙｓａｎｄｂｉｏｍｅｄｉｃａｌｉｎｓｔｒｕｍｅｎｔｓｈａｖｅｍｏｔｉｖａｔｅｄｉｎｔｅｎｓｅｉｎｔ... 详细信息

１．ＩｎｔｒｏｄｕｃｔｉｏｎＡｐｐｌｉｃａｔｉｏｎｓｉｎｏｐｔｉｃａｌｄａｔａｓｔｏｒａｇｅ，ｃｏｌｏｒｄｉｓｐｌａｙｓａｎｄｂｉｏｍｅｄｉｃａｌｉｎｓｔｒｕｍｅｎｔｓｈａｖｅｍｏｔｉｖａｔｅｄｉｎｔｅｎｓｅｉｎｔｅｒｅｓｔｉｎｔｈｅｓｏｌｉｄｓｔ...

关键词： upconversion spectrum Tm doped fiber upconversion emission Ti∶sapphire laser pumping

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我国体育产业化进程中的社会成本分析

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武汉体育学院学报 2005年第12期39卷 31-33,57页

作者：孙天明许彩明孙文树陈丽中国矿业大学体育学院江苏徐州221008

运用经济学的理论分析了我国体育产业化过程的社会成本,其3个表现形式为:实施成本、摩擦成本和无形成本。分析认为,保证体育产业化顺利进行的途径有2条:一条是提高新的体育体系的效益,一条是降低体育产业化的成本。

关键词：体育产业化社会成本改革市场经济

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Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Li, Xufeng Chen, Chunyan Li, Zhenyang Yi, Peng Zou, Haihan Deng, Gao Fang, ming He, Junzhe sun, Xin Yu, Ronghai Shui, Jianglan Pan, Caofeng Liu, Xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

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玉露香梨可溶性固形物近红外漫透射光谱在线检测

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食品与机械 2016年第10期32卷 115-119,163页

作者：刘燕德朱丹宁吴明明孙旭东张智诚华东交通大学江西南昌330013 光机电技术及应用研究所江西南昌330013

应用近红外漫透射光谱技术探索玉露香梨可溶性固形物在线无损检测的可行性。358个试验样本被分成建模集和预测集(269∶89),分别用于建立模型和验证模型的预测能力。通过对玉露香梨样品近红外漫透射光谱分析发现,样品光谱在625,725,800n... 详细信息

应用近红外漫透射光谱技术探索玉露香梨可溶性固形物在线无损检测的可行性。358个试验样本被分成建模集和预测集(269∶89),分别用于建立模型和验证模型的预测能力。通过对玉露香梨样品近红外漫透射光谱分析发现,样品光谱在625,725,800nm处存在3个波峰,在673,765,825nm处存在3个波谷。通过对比不同预处理方法,发现漫透射近红外光谱分别经一阶微分、移动窗口平滑和多元散射校正组合预处理后建立的模型效果最好。结合组合预处理方法建立了偏最小二乘和偏最小二乘支持向量机预测模型,经比较,偏最小二乘支持向量机模型预测能力更强,模型预测均方根误差和相关系数分别为0.316%和0.949。对比发现主成分分析和径向基函数有利于提高最小二乘支持向量机模型的预测能力。试验结果表明采用近红外漫透射光谱技术结合最小二乘支持向量机算法,实现了玉露香梨可溶性固形物在线无损检测。

关键词：近红外光谱漫透射玉露香梨可溶性固形物最小二乘支持向量机

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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