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WATER WAVE SIMULATION IN CURVILINEAR COORDINATES USING A TIME-DEPENDENT MILD SLOPE EQUATION

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Journal of Hydrodynamics 2010年第6期22卷 796-803页

作者： TONG Fei-fei SHEN Yong-ming tang jun CUI Lei State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116023China School of Civil and Resource Engineering The University of Western Australia Crawley WA 6009 Australia

The purpose of this article is to model the detailed progress of wave propagation in curvilinear coordinates with an effective time-dependent mild slope equation. This was achieved in the following approach, firstly deriving the numerical model of the equation, i.e., Copeland＇s hyperbolic mild-slope equation, in orthogonal curvilinear coordinates based on principal of coordinate transformation, and then finding the numerical solution of the transformed model by use of the Alternative Directions Implicit （ADI） method with a space-staggered grid. To test the curvilinear model, two cases of a channel with varying cross section and a semi-circular channel were studied with corresponding analytical solutions. The model was further investigated through a numerical simulation in Ponce de Leon Inlet, USA. Good agreement is reached and therefore, the use of the present model is valid to calculate the progress of wave propagation in areas with curved shorelines, nearshore breakwaters and other complicated geometries.

关键词： curvilinear coordinates mild slope equation water wave analytical numerical modeling

A Selective TRPC3 Inhibitor Pyr3 Attenuates Myocardial Ischemia/Reperfusion Injury in Mice

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Current Medical Science 2020年第6期40卷 1107-1113页

作者： Min LU Xiao-xia FANG Dan-dan SHI Rui LIU Yan DING Qiu-fang ZHANG Han-qin WANG jun-ming tang Xi-ju HE Hubei Key Laboratory of Embryonic Stem Cell Research Hubei University of MedicineShiyan 442000China Department of Neurology Taihe HospitalHubei University of MedicineShiyan 442000China Department of Ultrasound Taihe HospitalHubei University of MedicineShiyan 442000China

An emerging body of evidence indicates that transient receptor potential TRP channels act as important mediators for a wide variety of physiological functions and are potential targets for drug *** previous study has identified transient receptor potential channel 3(TRPC3)and TRPC6 as cation channels through which most of the damaging calcium enters,aggravates pathological changes in vivo and increases ischemia/reperfusion(I/R)injury in *** study aimed to verify the effects of TRPC3 inhibitor Pyr3 on myocardial I/R injury in mice.C57BL/6J wild-type male mice(8 to 12 weeks old)were anesthetized with 3.3%chloral hydrate.A murine I(30 min)/R(24 h)injury model was established by temporary occlusion of the left anterior descending(LAD)coronary ***3 was administered at concentrations of 0,2.5,5,or 10 mg/kg via the right jugular vein 5 min before *** observed that the selective TRPC3 inhibitor,10 mg/kg Pyr3,significantly decreased the infarct size of left ventricle,and reduced the myocardial cell apoptosis rate and inflammatory response in *** a conclusion,TRPC3 can function as a candidate target for I/R injury prevention,and Pyr3 may directly bind to TRPC3 channel protein,inhibit TRPC3 channel activity,and improve TRPC3-related myocardial I/R ***3 may be used for clarification of TRPC3 functions and for treatments of TRPC3-mediated diseases.

关键词： ischemia/reperfusion injury TRPC3 Pyr3 apoptosis

BARMR1-mediated sorafenib resistance is derived through stem-like property acquisition by activating integrin-FAK signaling pathways

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1623-1625页

作者： Xing Rong Guo Meng Ye Shan Yu Huang Zong Li Zhang Yue Yuan Long jun Dai Jue Wang Xue Peng Zhou Fu Yun Ji jun ming tang Zhong Ji Meng Xu Zhi Ruan Hubei Key Laboratory of Embryonic Stem Cell Research Taihe HospitalHubei University of Medicine442000 ShiyanHubeiChina College of Basic Medicine Hubei University of Medicine442000 ShiyanHubeiChina Jiangsu Hengrui Medicine Co.Ltd LianyungangChina Department of Neurosurgery Taihe HospitalHubei University of MedicineShiyanChina Department of Surgery University of British ColumbiaVancouverBCCanada Hepatobiliary and Pancreatic Surgery Diagnosis and Treatment Center Taihe HospitalHubei University of MedicineShiyanChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Infectious Diseases Taihe HospitalHubei University of MedicineShiyanChina

Dear Editor,BARMR1(alternatively named FAM92A1 or FAM92A)gene was first identified in 2002 and is a highly conserved gene and widely expressed in most tissues in mammals.1 We first cloned the complete CDS sequence of BARMR1 in 2007,2 which encodes a protein with a Bin-Amphiphysin-Rvs(BAR)*** proteins are known to bind onto lipid membrane surface and generate membrane curvature and have been demonstrated to play diverse roles in cell growth,inflammation and cell migration.

关键词： inflammation property resistance

CHARACTERIZATION OF SOME SCHIFF BASES OF HETEROCYCLIC COMPOUNDS AND THEIR TRANSITION METAL COMPLEXES

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Chinese Chemical Letters 1991年第9期2卷 681-682页

作者： Geng ZHANG jun ming tang Quan Ling LOU Zan SHI Department of Chemistry,Henan Normal University,Xinxiang,453002

Some new Schiff bases were synthesized by the condensation of equimolar quantities of salicylaldehyde and 2-amino-5-phenylazo-pyridine or its derivatives in dry benzene(1):Metal complexes of the type ML_2and M'L_3 where M=Cu^(2+),Co^(2+),Ni^(2+),Mn^(2+)Pd^(2+),M'=Fe^(3+)and L=different newly synthesized monobasic Schiff bases were prepared in absolute ethanolic medium(2)and characterized by elementary analysis,conductance measurements,infrared spectra,electronic spectra,magnetic moments studies.

关键词： CHARACTERIZATION OF SOME SCHIFF BASES OF HETEROCYCLIC COMPOUNDS AND THEIR TRANSITION METAL COMPLEXES

Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU Lin LI Xue XIE jun DONG ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng tang Ding-Kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu tang Chun-Mao Yuan jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

The Assembly and Molecular Structure of a Novel One-dimensionalCyanide-bridged [Ni(pn)_2Ni(CN)_4]_n·nH_2 O Complex

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Chinese Chemical Letters 1999年第11期10卷 975-978页

作者： Xiu Ying ZHANG Dong GUO jun ming tang Shu Zhong ZHAN Qing Zi HAN Chen Xia DU Yu ZHU Rui Na YANG( Department of Chemistry, Henan Normal University, Xinxiang 453002)( Assaying and Testing Centre, Zhengzhou University, Zhengzhou 450052)( Henan Chemistr Department of Chemistry Henan Normal University Xinxiang 453002 China Assaying and Testing Centre Zhengzhou University Zhengzhou 450052 China Henan Chemistry Institute Zhengzhou 450052 China

The synthesis, structure and characterization of a new one-dimensional cyanide-bridgedcomplex [Ni(pn)_2Ni(CN)4]n'nH2O (where pn = 1,2-diaminopropane) are described. The structure ofthis complex consists of a one-dimen... 详细信息

关键词： Cyanide bridged complex polynuclear complex crystal structure.

Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China

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Military Medical Research 2022年第1期9卷 53-62页

作者： Yi Wu Xian-Hui Wang Xi-Hua Lif Li-Yuan Song Shi-Long Yu Zhi-Cheng Fang Yu-Quan Liu Le-Yong Yuan Chun-Yan Peng Shen-Yi Zhang Wang Cheng Hong-Chao Ma Li-Feng Wang jun-ming tang Yun-Fu Wang Fu-Yun Ji Department of Medical Biology School of Basic Medical ScienceHubei University of MedicineShiyan 442000HubeiChina Institute of Biomedical Research Hubei University of MedicineShiyan 442000HubeiChina Institute of Human Respiratory Disease Xinqiao HospitalThe Army Medical University(Third Military Medical University)400037 ChongqingChina Department of Emergency Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina department of Geriatric Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina Department of Immunology School of Basic Medical SciencesHubei University of MedicineShiyan 442000HubeiChina department of Laboratory Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina Hubei Key Laboratory of Embryonic Stem Cell Research School of Basic Medical ScienceHubei University of MedicineShiyan 442000HubeiChina Department of Neurology Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina.

Background:Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and coronavirus disease 2019(COVID-19)***,it is unclear whether mitochondrial DNA(mtDNA)variants,which define mtDNA haplogroups and determine oxidative phosphorylation performance and reactive oxygen species production,are associated with COVID-19 ***:A population-based case-control study was conducted to compare the distribution of mtDNA variations defining mtDNA haplogroups between healthy controls(n=615)and COVID-19 patients(n=536).COVID-19 patients were diagnosed based on molecular diagnostics of the viral genome by qPCR and chest X-ray or computed tomography *** exclusion criteria for the healthy controls were any history of disease in the month preceding the study *** variants defining mtDNA haplogroups were identified by PCR-RFLPs and HVS-I sequencing and determined based on mtDNA phylogenetic analysis using Mitomap ***’s t-test was used for continuous variables,and Pearson’s chi-squared test or Fisher’s exact test was used for categorical *** assess the independent effect of each mtDNA variant defining mtDNA haplogroups,multivariate logistic regression analyses were performed to calculate the odds ratios(OR)and 95%confidence intervals(CI)with adjustments for possible confounding factors of age,sex,smoking and diseases(including cardiopulmonary diseases,diabetes,obesity and hypertension)as determined through clinical and radiographic ***:Multivariate logistic regression analyses revealed that the most common investigated mtDNA variations(>10%in the control population)at C5178 a(in NADH dehydrogenase subunit 2 gene,ND2)and A249 d(in the displacement loop region,D-loop)/T6392 C(in cytochrome c oxidase I gene,CO1)/G10310 A(in ND3)were associated with a reduced risk of severe COVID-19(OR=0.590,95%CI 0.428–0.814,P=0.001;and OR=0.654,95%CI 0.45

关键词： Mitochondrial DNA variations Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 Risk Han Chinese

Abnormal precipitation behavior in T6 melt-spun AlMgCu ribbon

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Transactions of Nonferrous Metals Society of China 2014年第1期24卷 22-27页

作者：陈忠伟汤明军李士顺冯宗强西北工业大学凝固技术国家重点实验室西安710072

The constituent of precipitations phases of aged melt-spun AlMgCu ribbons was characterized by high-resolution transmission electron microscopy and microhardness test. The cooling rate of as melt-spun ribbon was estimated to be 1.60×105 K/s from the empirical relation. The samples were aged at 200 ＆#176;C for 16 h after solution treatment. Two precipitation phases, i.e. Al2CuMg and abnormal amorphous SiO2 were identified in the T6 melt-spun AlMgCu ribbon. The crystal structure and stoichiometric composition of Al2CuMg phase are in good agreement with the reference results [WANG et al （2007; 2005）]. The combined experiments show that the formation of abnormal amorphous SiO2 appears to be associated with the higher cooling rate in melt-spinning process and has no significant effect on the peak hardness.

关键词： AlCuMg alloy melt spinning precipitation amorphous