检索结果-南通市图书馆

Complication rates in emergent endoscopy for foreign bodies under different sedation modalities:A large single-center retrospective review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2021年第2期13卷 45-55页

作者： ming-han cha Rashi Sandooja Saher Khalid Nicole Lao Joseph Lim Roshan Razik Department of Internal Medicine Cleveland Clinic Akron GeneralAkronOH 44307United States Department of Gastroenterology Cleveland Clinic Akron GeneralAkronOH 44307United States

BACKGROUND Foreign object ingestion(FOI)and food bolus impaction(FBI)are common causes of emergent endoscopic *** choice of sedation used is often dictated by physician *** endoscopists frequently prefer to use monitored anesthesia care(MAC)and general anesthesia(GA)as opposed to conscious sedation(CS)due to the concern for inadequate airway ***,there is insufficient data examining the safety of different sedation modalities in emergent endoscopic management of FOI and *** To investigate the complication rates of emergent endoscopic extraction performed under different sedation *** We conducted a retrospective chart review of patients presenting with acute FBI and FOI between 2010 and 2018 in two hospitals.A standardized questionnaire was utilized to collect data on demographics,endoscopic details,sedation practices,hospital stay and adverse *** recognized during and within 24 h of the procedure were considered early,whereas patients presenting with a procedure-related adverse event within two weeks of the index event were considered delayed *** rates of patients who underwent emergent endoscopic retrieval were compared based on sedation types,namely CS,MAC and ***-square analysis and multiple logistic regression were used to compare complication rate based on sedation *** Among the 929 procedures analyzed,353 procedures(38.0%)were performed under CS,278 procedures(29.9%)under MAC and the rest(32.1%)under *** median age of the subjects was 52 years old,with 57.4%being *** majority of the procedures(64.3%)were FBI with the rest being FOI(35.7%).A total of 132 subjects(14.2%)had chronic comorbidities while 29.0%had psychiatric *** most commonly observed early complications were mucosal laceration(3.8%)and bleeding(2.6%).The most common delayed complication was aspiration pneumonia(1.8%).A total of 20 patients(5.6%)could not adequately be sed

关键词： Foreign body Food bolus impaction Endoscopy Sedation Anesthesia Complications

Catalytic Performance of Carbon Smoke over Ag-LSCF Composite Catalysts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 30-34页

作者： GUO Guanlun han ming LU Shaomin YU Jing JU Hongling 无 Hubei Key Laboratory of Advanced Technology for Automotive Components&Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China College of Mechanical and Transportation Southwest Forestry UniversityKunming 650000China

To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF *** conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO_(3) group,LaFeO_(3) group,and catalyst-free *** results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9℃at 10%,50%,and 90%carbon soot conversion,*** values are 24.8,20.2,and 23.1℃lower than those of the LSCF *** also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion *** characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.

关键词： metallic composites carbon smoke oxidation perovskite catalyst soot

Ca2+ cation-mediated microenvironment for electrochemical hydrodimerization of furfural

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Wei Du Shuangshuang cha Can Lei Mengxin Qu Zhongqiang Deng ming Gong Xinhe Bao Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University State Key Laboratory of Catalysis National Laboratory for Clean Energy Collaborative Innovation Center of Chemistry for Energy Materials Dalian Institute of Chemical Physics Chinese Academy of Sciences

Furfural is one of the most important biomass-based platform molecules as sustainable precursors for chemicals and fuels. The electrochemical hydrodimerization of furfural can generate hydrofuroin, which is a promising precursor for gasoline or jet ***, steering the selectivity toward hydrodimerization under near-neutral conditions that suppress polymerization and disproportionation of furfural remains challenging. Herein, we discovered that tuning the electrolyte cations could be an effective and alternative strategy for modulating furfural reduction to the traditional electrocatalyst design. Under the optimal Ca2+cations,hydrofuroin yield could be much improved from other cations with hydrofuroin selectivity of 95.5%. The systematic characterization of the ion-centered double layer reflected the suitable sizes and charges of hydrated Ca2+for suppressing the hydrogen evolution reaction from activation of surrounding water molecules as well as encouraging furfural accumulation via non-covalent interaction for directing the electron transfer to furfurals. Ions with smaller or larger sizes can either activate local water molecules or form a crowded ionic interface that casts an adverse effect on furfural enrichment. This work not only presents an effective strategy for facilitating biomass valorization via hydrodimerization but also emphasizes the essential role of the ion-centered microenvironment for steering the electrocatalytic pathways.

关键词：

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

维普期刊数据库

溶解有机质N/C比值的分布格局及其对湖泊增温和营养富集的响应

在线全文

学校读者我要写书评

暂无评论

湖泊科学 2025年第1期37卷 97-111页

作者：陈铭胡盎韩磊王建军湖南农业大学资源学院长沙410128 中国科学院南京地理与湖泊研究所湖泊与流域水安全重点实验室南京211135

溶解有机质(DOM)是水生生态系统的重要能量和营养源,其N/C等元素化学计量学能够反映湖泊沉积物营养物质来源,相关研究有助于揭示全球变暖和水体富营养化的影响机制。本研究聚焦高分辨率质谱技术所获DOM的N/C比值,通过Meta分析从宏观角... 详细信息

溶解有机质(DOM)是水生生态系统的重要能量和营养源,其N/C等元素化学计量学能够反映湖泊沉积物营养物质来源,相关研究有助于揭示全球变暖和水体富营养化的影响机制。本研究聚焦高分辨率质谱技术所获DOM的N/C比值,通过Meta分析从宏观角度考察全球湖泊、河流、海洋和泥炭地等多生境N/C比值的全球分布情况。结果表明,河流水体、沉积物和污水等生境的N/C均值(分别为0.050±0.062、0.050±0.014和0.083±0.084)均显著高于泥炭地(0.026±0.037);水体N/C比值主要受海拔(即温度)、pH、氨氮和溶解有机碳等显著影响,而泥炭地等陆地N/C比值主要受pH、总溶解有机氮和溶解有机碳的影响。进一步,依托云南老君山海拔梯度开展模拟温度变化和营养富集的微宇宙实验定量解析其影响机制,并根据沉积物DOM分子转换数将总分子划分为高活性和低活性两类,探究总分子及其两类组分的N/C比值对温度和营养富集的响应规律。溶解有机质N/C均值为0.112±0.020,其中高活性分子(0.119±0.017)显著高于低活性分子(0.109±0.034)。总分子N/C比值主要受亚硝酸盐和硝酸盐等营养盐的影响,相对总贡献率为63.43%;高活性分子N/C比值主要受营养盐和能量供应(比如溶解有机碳、总有机碳和叶绿素a等)的影响,而低活性分子N/C比值主要受营养盐的影响。结构方程模型分析表明,营养富集对总分子N/C比值的影响高于温度,主要通过能量供应和营养盐的间接作用而产生影响;对于高活性分子,营养盐主要通过能量供应的间接作用影响N/C比值;而对于低活性分子,主要通过营养盐发挥直接作用。本研究结果首次探讨了全球不同生境N/C比值的分布格局,揭示了沉积物溶解有机质N/C比值对全球变暖和营养富集的响应规律和机制,为更好理解和预测未来全球变化背景下溶解有机碳稳定性提供科学参考。

关键词：溶解有机质氮碳比湖泊沉积物全球变暖富营养化

维普期刊数据库

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词：

同方期刊数据库

Catalytic Performance of Carbon Smoke over Ag-LSCF Composite Catalysts

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期 30-34页

作者：郭冠伦 han ming LU Shaomin YU Jing 鞠洪玲 Hubei Key Laboratory of Advanced Technology for Automotive Components & Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of Technology College of Mechanical and Transportation Southwest Forestry University

To improve the catalytic performance of La0.6Sr0.4Co0.2Fe0.8O3（LSCF） towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF *** conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO3group,LaFeO3group,and catalyst-free *** results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9 ℃ at 10 %,50 %,and 90 % carbon soot conversion,*** values are 24.8,20.2,and 23.1 ℃ lower than those of the LSCF *** also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion *** characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.

关键词：

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-ming Wang han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Formation of Functional Cyclooctadiene Derivatives by Supramolecularly- Controlled Topochemical Reactions and Their Use as Highly Selective Fluorescent Biomolecule Probes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2020年第10期38卷 1040-1044页

作者： ming-ming Gan Ying-Feng han Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'anShaanxi 710127China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002Chino

Summary of main observation and conclusion Controlling the regio-and stereochemistry of the photoproducts in solution is far more challenging for polvenes than for ***,a supramolecularly-controlled topochemical reaction of conjugated dienes in homogeneous system is developed,ultimately providing two cyclooctadiene-cored tetraimidazolium molecular receptors *** cyclooctadiene derivatives exhibited highly sensi-tive and selective fluorescence sensing for thymine relative to other biologically relevant species in aqueous solution at physiological *** the cycloo-ctadiene moieties and imidazolium units play important roles in the selective recognition *** presented supramolecularly-controlled method allows the simple yet rare selective photoconversion of flexible cyclooctadiene derivatives in *** study offers a new synthetic strategy for the preparation of functional molecules with potential for use in biological applic ations.

关键词： solution. diene chemical