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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei chu Qi li Ruihua li Qingwen li Kai-Yu Tong Xiaosong Gu Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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民营企业党建嵌入公司治理的思路与模式

天津师范大学学报（社会科学版） 2011年第1期31卷 12-16页

作者：初明利张敏天津商业大学马克思主义学院

民营企业党建最突出的问题是未能融入企业经济活动中,特别是在公司治理结构中位置"缺失"。要改变民营企业党建"边缘化"这一现状,就应当针对民营企业公司治理的实际问题,加强党在民营企业外部治理环境建设方面的主导作用,探索民营企业党... 详细信息

民营企业党建最突出的问题是未能融入企业经济活动中,特别是在公司治理结构中位置"缺失"。要改变民营企业党建"边缘化"这一现状,就应当针对民营企业公司治理的实际问题,加强党在民营企业外部治理环境建设方面的主导作用,探索民营企业党建嵌入公司董事会、监事会等内部治理结构的创新模式,从而切实发挥党的基层组织在民营企业发展中的重要作用。

关键词：民营企业党建公司治理董事会

Endoscopic Approach to Remove Intra-extracranial Tumors in Various Skull Base Regions： 10-year Experience of a Single Center

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Chinese Medical Journal 2017年第24期130卷 2933-2940页

作者： Qiu-Hang Zhang Zhen-lin Wang Hong-chuan Guo Feng Kong Bo Yan ming-chu li Ge Chen Jian-Tao liang Yu-Hai Bao Feng ling Department of Neurosurgery Skull Base Surgery Center Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Otorhinolaryngology Head and Neck Surgery Skull Base Surgery Center Xuanwu Hospital Capital Medical University Beijing 100053 China

Background：Some problems have been found in the usually adopted combined approach for the removal of intra-extracranial tumors in skull ***,we described a pure endoscopic transnasal or transoral approach （ETA） for the removal of intra-extracranial tumors in various skull base ***：Retrospectively,clinical data,major surgical complications,pre-and postoperative images,and follow-up information of a series of 85 patients with intra-extracranial tumors in various skull base regions who were treated by surgery via ETA in our skull base center during the past 10 years were reviewed and ***：Gross total tumor removal was achieved in 80/85 cases （94.1%） in this *** 37 cases with tumors in anterior skull base and all 14 cases with tumors in jugular foramen received total tumor *** and three cases with tumors in clivus received total and subtotal tumor removal,*** and subtotal tumor removal was performed for 16 cases and 2 cases in lateral skull base,*** complications in this study included：cerebrospinal fluid leakage （n =3）,meningitis （n =3）,and new cranial nerve deficits （n =3;recovered in 3 months after surgery）.In the follow-up period of40-151 months （median：77 months）,seven patients （8.8%） out of the 80 cases of total tumor removal experienced ***：Complete resection of intra-extracranial growing tumors in various skull base regions can be achieved via the pure ETA in one stage in selected *** procedure for radical removal of tumors is feasible and safe.

关键词： Endoscopy: lntra-extracranial Growth Neoplasm Skull Base Surgery

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耐水解PLA改性材料的制备及其性能研究

塑料工业 2019年第10期47卷 65-68,133页

作者：褚明利李明哲吴广峰长春工业大学

研究了聚乳酸(PLA)改性材料的水解稳定性。在丙烯酸酯类增韧剂(ACR)增韧PLA基础上,协同加入聚碳化二亚胺(PCDI)和1,4-丁二醇二缩水甘油醚(BDE)扩链剂,从而制备综合性能优异的PLA复合材料。经过力学性能测试、端羧基含量测试、水解降解... 详细信息

研究了聚乳酸(PLA)改性材料的水解稳定性。在丙烯酸酯类增韧剂(ACR)增韧PLA基础上,协同加入聚碳化二亚胺(PCDI)和1,4-丁二醇二缩水甘油醚(BDE)扩链剂,从而制备综合性能优异的PLA复合材料。经过力学性能测试、端羧基含量测试、水解降解测试和DSC测试。结果表明,当PCDI和BDE含量分别为1.8%和1.0%时,共混物的冲击强度分别达到133.87和219.8 J/m,韧性提高明显;水解后拉伸强度下降率较小,分别为19.69%和28.16%,完全水解时间延长,水解稳定性提高。

关键词：聚乳酸扩链剂熔融共混水解降解

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高等商科院校创业型人才培养与创业文化建设

职业技术教育 2012年第17期33卷 82-85页

作者：初明利潘望远天津商业大学天津300134 天津职业技术师范大学天津300222

商科人才培养对经济社会的发展具有十分重要的意义,高等商科院校应当把培养"懂经济、能创业、善经营、会管理",从事现代微观经济活动的复合型、应用型高素质人才作为高等商科院校人才培养目标,发挥高等商科院校商科专业教育资源优势,承... 详细信息

商科人才培养对经济社会的发展具有十分重要的意义,高等商科院校应当把培养"懂经济、能创业、善经营、会管理",从事现代微观经济活动的复合型、应用型高素质人才作为高等商科院校人才培养目标,发挥高等商科院校商科专业教育资源优势,承续我国源远流长的商业文化,弘扬艰苦创业、诚信经营等商业精神,不断提升大学生的创业资源禀赋。

关键词：高等商科院校创业教育创业型人才创业文化

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang chu Zhicheng lin Tianyuan Fang Yuyu Zhou chuxia Zhang Jianghui Shan Shiyu Chen liping li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu Xiang li Shen Du ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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高校心理健康工作的几个问题

天津大学学报（社会科学版） 2001年第3期3卷 274-276页

作者：初明利天津理工学院学生处天津300191

从高校心理健康工作持续发展的角度对学生心理健康教育工作机制进行了探讨 ,并且论述了思想政治工作与心理咨询工作的区别与联系 ,以及如何把握好心理咨询工作中的角色和角色阻抗问题。

关键词：思想政治工作心理咨询大学生心理健康教育工作机制

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min li Jiazhi Chen Zhuyong Wang Huantao Wen ming Zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex