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Synergistic Action of fMLP-boanmycin Combination on the Growth of Mouse Colon Carcinoma and Its Action Mechanisms

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Chinese Journal of Cancer Research 2010年第2期22卷 135-140页

作者： zhong-dong Li Yan gao Department of Pharmacology General Hospital of PLA Air Force Beijing 100142 China

Objective： The inhibitory action of fMLP-boanmycin （BAM） combination on the growth of mouse colon carcinoma and its action mechanisms were observed in order to provide experimental proof for probing novel regimen of chemotactic modulation in combination with chemotherapy in the treatment of cancer. Methods： Cytotoxicity of BAM-fMLP combination to tumor cells was determined by MTT assay in vitro. Antitumor activity of BAM-fMLP combination was assessed in mice subcutaneously transplanted colon carcinoma 26. The amount of superoxide anion （O2 ·^-）released from fMLP stimulated macrophages was determined by NBT assay. The amount of nitric oxide （NO） was indirectly determined by Griess method. Results： BAM-fMLP combination had no synergistic effect on tumor cells（CDI〉0.85）, but BAM at the doses of 10μg/ml, 30μg/ml and 100μg/ml in combination with fMLP at the concentration 20μg / ml exhibited synergistic effect on tumor cells in the presence of macrophages（CDI〈0.75）, fMLP inhibited the growth of colon carcinoma 26 by 50.0% when it at dose of 1 mg/mouse was administered peritumorally. BAM （1 mg/kg, intraperitoneally, three times） alone and BAM - fMLP combination inhibited the growth of colon carcinoma 26 by 38.6% and 78.4%, respectively （CDI=0.71） on day 12. The amount of O2 ·^- released from fMLP 4.6×10^-7 mol/L （0.2μg/ml） stimulated macrophages which were treated by BAM in vitro increased significantly（P〈0.01）, fMLP 2.3×10^-6 mol/L （1μg/ml） could not stimulate macrophages to release NO, but may stimulate macrophages treated with BAM 10μg/ml and 100μg/ml to release NO significantly（P〈0.01）. Conclusion： The inhibitory action of fMLP-boanmycin combination on the growth of mouse colon carcinoma have synergism, which may associate with the increase of O2 ·^- and NO released by macrophages. Chemotactic modulation in combination with chemotherapy may be a novel regimen in the treatment of cancer.

关键词： Chemotactic peptide fMLP Boanmycin Colon carcinoma

High-precision high-voltage detuning system for HIAF-SRing electron target

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Nuclear Science and Techniques 2023年第5期34卷 125-138页

作者： Kai-ming Yan ming-Rui Li Yun-Bin Zhou Xiao-ming Ma Jin-Bin Shangguan zhong-Kui Huang Xiao-Jun Wang Mei-Tang Tang Jie gao Hou-Ke Huang Da-Qin gao Li-Jun Mao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

The development of a detuning system for the precision control of electron energy is a major challenge when electron targets are used in ion-storage ***,a high-precision,high-voltage,detuning system was developed for the electron target of a high-intensity heavy-ion accelerator facility-spectrometer ring(HIAF-SRing)to produce accurate electron-ion relative energies during *** system consists of auxiliary,and high-voltage detuning power *** front stage of the auxiliary power supply adopts an LCC resonant converter operating in the soft-switching state and an LC filter for a sinusoidal waveform output in the *** detuning power supply is a high-voltage pulse amplifier(HVPA)connected with a high-voltage DC(HVDC)module in *** this paper,the design and development of the detuning system are described in detail,and the test bench is *** test results demonstrated that the detuning system conforms to the technical specifications of the dielectronic recombination(DR)***,a Fe15+DR spectrum was measured using the detuning *** experimental data demonstrated a good experimental resolution and verified the reliability and feasibility of the design.

关键词： Detuning system Storage ring Dielectronic recombination

Recent Progress in Space Science and Applications on Chinese Space Station in 2022–2024

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空间科学学报 2024年第4期44卷 607-621页

作者： GU Yidong gao ming ZHAO Guangheng WANG Qiang LYU Congmin zhong Hongen LIU Guoning Key Laboratory of Space Utilization Technology and Engineering Center for Space UtilizationChinese Academy of SciencesBeijing 100094

Chinese Space Station(CSS)has been fully deployed by the end of 2022,and the facility has entered into the application and development *** has conducted scientific research projects in various fields,such as space life science and biotechnology,space materials science,microgravity fundamental physics,fluid physics,combustion science,space new technologies,and *** this review,we introduce the progress of CSS development and provide an overview of the research conducted in Chinese Space Station and the recent scientific findings in several typical research *** compelling findings mainly concern the rapid solidification of ultra-high temperature alloy melts,dynamics of fluid transport in space,gravity scaling law of boiling heat transfer,vibration fluidization phenomenon of particulate matter,cold atom interferometer technology under high microgravity and related equivalence principle testing,the full life cycle of rice under microgravity and so ***,the planned scientific research and corresponding prospects of Chinese space station in the next few years are presented.

关键词： Chinese Space Station(CSS) Space material science Micro-gravity fluid physics Fundamental physics Space life sciences and biotechnology

Basement faults and volcanic rock distributions in the Ordos Basin

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Science China Earth Sciences 2010年第11期53卷 1625-1633页

作者： Li ming gao JianRong PetroChina Res Inst Petr Explorat & Dev Beijing 100083 Peoples R China

Volcanic rocks in the Ordos Basin are of mainly two types: one in the basin and the other along the margin of the basin. Besides those along the margin, the marginal volcanic rocks also include the volcanic rocks in the Yinshanian orogenic belt north of the basin. Based on the latest collection of gravitational and aeromagnetic data, here we interpret basement faults in the Ordos Basin and its peripheral region, compare the faults derived from aeromagnetic data with those from seismic data, and identify the geological ages of the fault development. Two aeromagnetic anomaly zones exist in the NE-trending faults of the southern basin, and they are in the volcanic basement formed in pre-Paleozoic. These NE-trending faults are the channel of volcanic material upwelling in the early age (Archean-Neoproterozoic), where igneous rocks and sedimentary rocks stack successively on both sides of the continental nucleus. In the Cambrian, the basin interior is relatively stable, but in the Late Paleozoic and Mesozoic, the basin margin underwent a number of volcanic activities, accompanied by the formation of nearly north-south and east-west basement faults in the basin periphery and resulting in accumulation of great amount of volcanic materials. Volcanic tuff from the basin periphery is discovered in the central basin and volcanic materials are exposed in the margins of the basin. According to the source-reservoir-cap rock configuration, the basin peripheral igneous traps formed in the Indosinian-Early Yanshanian and Late Hercynian are favorable exploration objectives, and the volcanic rocks in the central basin are the future target of exploration.

关键词： Ordos Basin volcanic rocks basement fault aeromagnetic anomaly hydrocarbon potential

Estimates of three classical summations on the spaces F_p^(α,q)(R^n)(0 < p ≤ 1)

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Applied Mathematics(A Journal of Chinese Universities) 2014年第3期29卷 329-338页

作者： gao Gui-lian zhong Yong School of Science Hangzhou Dianzi University Postdoctoral Programme of Economics and Management School of Wuhan University Postdoctoral Programme of China Great Wall Asset Management Corporation

We obtain the boundedness on Fp^α,q（R^n）for the Poisson summation and Gauss summation. Their maximal operators are proved to be bounded from Fp^α,q（R^n）to L∞（R^n）For the maximal operator of the Bochner-Riesz ... 详细信息

关键词： Poisson summation Gauss summation Bochner-Riesz summation Triebel-Lizorkin space.

A Healable and Mechanically Enhanced Composite with Segregated Conductive Network Structure for High‑Efficient Electromagnetic Interference Shielding

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Nano-Micro Letters 2021年第11期13卷 18-31页

作者： Ting Wang Wei‑Wei Kong Wan‑Cheng Yu Jie‑Feng gao Kun Dai Ding‑Xiang Yan zhong‑ming Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China The College of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009People’s Republic of China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001People’s Republic of China School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065People’s Republic of China

It is still challenging for conductive polymer composite-based electromagnetic interference(EMI)shielding materials to achieve long-term stability while maintaining high EMI shielding effectiveness(EMI SE),especially undergoing external mechanical stimuli,such as scratches or large ***,an electrostatic assembly strategy is adopted to design a healable and segregated carbon nanotube(CNT)/graphene oxide(GO)/polyurethane(PU)composite with excellent and reliable EMI SE,even bearing complex mechanical *** negatively charged CNT/GO hybrid is facilely adsorbed on the surface of positively charged PU microsphere to motivate formation of segregated conductive networks in CNT/GO/PU composite,establishing a high EMI SE of 52.7 dB at only 10 wt%CNT/GO *** Diels–Alder bonds in PU microsphere endow the CNT/GO/PU composite suffering three cutting/healing cycles with EMI SE retention up to 90%.Additionally,the electrostatic attraction between CNT/GO hybrid and PU microsphere helps to strong interfacial bonding in the composite,resulting in high tensile strength of 43.1 MPa and elongation at break of 626%.The healing efficiency of elongation at break achieves 95%when the composite endured three cutting/healing *** work demonstrates a novel strategy for developing segregated EMI shielding composite with healable features and excellent mechanical performance and shows great potential in the durable and high precision electrical instruments.

关键词： Electrostatic attraction Healable EMI shielding Diels–Alder reaction

Tightly coupled INS/CNS/spectral redshift integrated navigation system with the aid of redshift error measurement

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Science China(Technological Sciences) 2023年第9期66卷 2597-2610页

作者： gao GuangLe gao SheSheng HU gaoGe zhong YongMin PENG Xu School of Automation Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China School of Engineering RMIT University in MelbourneVIC 3000Australia

The integration of an inertial navigation system(INS) and a celestial navigation system(CNS) has the superiority of high autonomy. However, its reliability and accuracy are permanently impaired under poor observation conditions. To address this issue, the present paper proposes a tightly coupled INS/CNS/spectral redshift(SRS) integration framework based on the spectral redshift error measurement. In the proposed method, a spectral redshift error measurement equation is investigated and embedded in the traditional tightly coupled INS/CNS integrated navigation system to achieve better anti-interference under complicated circumstances. Subsequently, the inaccurate redshift estimation from the low signal-to-noise ratio spectrum is considered in the integrated system, and an improved chi-square test-based covariance estimation method is incorporated in the federated Kalman filter, allowing to deal with measurement outliers caused by the inaccurate redshift estimation but not influencing the effect of other correct redshift measurements in suppressing the error of the navigation parameter on the filtering solution. Simulations and comprehensive analyses demonstrate that the proposed tightly coupled INS/CNS/SRS integrated navigation system can effectively handle outliers and outages under hostile observation conditions, resulting in improved performance.

关键词： INS/CNS integrated navigation spectral redshift navigation spectral redshift error measurement equation inaccurate spectral redshift fault-tolerance

Macrophage based drug delivery:Key challenges and strategies

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Bioactive Materials 2024年第8期38卷 55-72页

作者： Qian Guo zhong-ming Qian Laboratory of Drug Delivery School of MedicineShanghai University99 Shangda RoadShanghai200444China Institute of Translational and Precision Medicine Nantong University19 Qi Xiu RoadNantongJiangsu226019China National Clinical Research Center for Aging and Medicine of Huashan Hospital Fudan UniversityShanghai201203China

As a natural immune cell and antigen presenting cell,macrophages have been studied and engineered to treat human *** are well-suited for use as drug carriers because of their biological characteristics,such as excellent biocompatibility,long circulation,intrinsic inflammatory homing and ***,macrophages’uniquely high plasticity and easy re-education polarization facilitates their use as part of efficacious therapeutics for the treatment of inflammatory diseases or *** recent studies have demonstrated promising advances in macrophage-based drug delivery,several challenges currently hinder further improvement of therapeutic effect and clinical *** article focuses on the main challenges of utilizing macrophage-based drug delivery,from the selection of macrophage sources,drug loading,and maintenance of macrophage phenotypes,to drug migration and release at target *** addition,corresponding strategies and insights related to these challenges are ***,we also provide perspective on shortcomings on the road to clinical translation and production.

关键词： Macrophages Cell therapy Drug delivery Nano-or micro-particles Cell polarization

Properties of the Collision Efficiency of Nanoparticles in Brownian Coagulation

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Chinese Physics Letters 2011年第1期28卷 130-133页

作者： WANG Yu-ming LIN Jian-zhong CHEN zhong-Li Institute of Fluid Mechanics China Jiliang University Hangzhou 310018 Department of Mechanics Zhejiang University Hangzhou 310027

The collision efficiency of nanoparticles with diameters from 100nm to 750nm in the Brownian coagulation is studied by building and solving＂ numerically the equations of particle collision in the presence of the van der Waals force, the elastic deformation force, the Stokes resistance, the lubrication force and the electrostatic force. The results show that the collision efficiency decreases overall with the increasing- particle diameter. It is found that there exists an abrupt increase in the collision efficiency when the particle diameter is equals to 550nm. Finally a new expression for the collision efficiency is presented.

关键词： Condensed matter: structural, mechanical & thermal Nanoscale science and low-D systems