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Chinese Chemical Letters 2011年第6期22卷 749-752页

作者： Wei Huang ming Lv zhong gao gao Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China

Copolymers mPEG-PCL were prepared and grafted onto polyethylenimine（PEI） to synthesize copolymers mPEG-PCL-g-PEI with low *** mPEG-PCL-g-PEI could condense siRNA to form nanoparticles with positive zeta *** nanoparticles could delivery siRNA into cells to effectively inhibit the expression of target gene,which suggested that mPEG-PCL-g -PEI could serve as a highly efficient vector for siRNA delivery.

关键词： Copolymers Nanoparticles Vector Synthesis

Research on thermal insulation materials properties under HTHP conditions for deep oil and gas reservoir rock ITP-Coring

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Petroleum Science 2024年第4期21卷 2625-2637页

作者： Zhi-Qiang He He-Ping Xie Ling Chen Jian-Ping Yang Bo Yu Zi-Jie Wei ming-zhong gao State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065SichuanChina Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060GuangdongChina School of Mechanical Engineering Sichuan UniversityChengdu610065SichuanChina College of Polymer Science and Engineering Sichuan UniversityChengdu610065SichuanChina

Deep oil and gas reservoirs are under high-temperature conditions,but traditional coring methods do not consider temperature-preserved measures and ignore the influence of temperature on rock porosity and permeability,resulting in distorted resource *** development of in situ temperaturepreserved coring(ITP-Coring)technology for deep reservoir rock is urgent,and thermal insulation materials are ***,hollow glass microsphere/epoxy resin thermal insulation materials(HGM/EP materials)were proposed as thermal insulation *** materials properties under coupled hightemperature and high-pressure(HTHP)conditions were *** results indicated that high pressures led to HGM destruction and that the materials water absorption significantly increased;additionally,increasing temperature accelerated the *** temperatures directly caused the thermal conductivity of the materials to increase;additionally,the thermal conduction and convection of water caused by high pressures led to an exponential increase in the thermal *** temperatures weakened the matrix,and high pressures destroyed the HGM,which resulted in a decrease in the tensile mechanical properties of the *** materials entered the high elastic state at 150℃,and the mechanical properties were weakened more obviously,while the pressure led to a significant effect when the water absorption was above 10%.Meanwhile,the tensile strength/strain were 13.62 MPa/1.3%and 6.09 MPa/0.86%at 100℃ and 100 MPa,respectively,which meet the application requirements of the self-designed coring ***,K46-f40 and K46-f50 HGM/EP materials were proven to be suitable for ITP-Coring under coupled conditions below 100℃ and 100 *** further improve the materials properties,the interface layer and EP matrix should be *** results can provide references for the optimization and engineering application of materials and thus technical support for deep oil and gas resourc

关键词： Deep oil and gas reservoir rock In situ temperature-preserved coring(ITPCoring) Hollow glass microsphere/epoxy resin thermal insulation materials(HGM/EP materials) High-temperature and high-pressure(HTHP) Physical and mechanical properties

In-situ pressure-preserved coring for deep exploration:Insight into the rotation behavior of the valve cover of a pressure controller

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Petroleum Science 2023年第4期20卷 2386-2398页

作者： Da Guo He-Ping Xie Ling Chen zhong-Ya Zhou He-Ping Lu Lin Dai Ding-ming Wang Tian-Yu Wang Ju Li Zhi-Qiang He Yun-Qi Hu ming-zhong gao School of Mechanical Engineering Sichuan UniversityChengduSichuan610065China MOE Key Laboratory of Deep Underground Science and Engineering College of Water Resource and HydropowerSichuan UniversityChengduSichuan610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhenGuangdong518060China Petroleum Engineering Technology Research Institute of Sinopec Jianghan Oilfield Company WuhanHubei430035China

In-situ pressure-preserved coring(IPP-Coring)is considered to be the most reliable and efficient method for the identification of the scale of oil and gas *** IPP-Coring,because the rotation behavior of the pressure controller valve cover in different medium environments is unclear,interference between the valve cover and inner pipe may occur and negatively affect the IPP-Coring success *** address this issue,we conducted a series of indoor experiments employing a high-speed camera to gain greater insights into the valve cover rotation behavior in different medium environments,e.g.,air,water,and simulated drilling *** results indicated that the variation in the valve cover rotation angle in the air and fluid environments can be described by a one-phase exponential decay function with a constant time parameter and by biphasic dose response function,*** rotation behavior in the fluid environments exhibited distinct elastic and gravitational acceleration *** the fluid environments,the density clearly impacted the valve cover closing time and rotation behavior,whereas the effect of viscosity was very *** can be attributed to the negligible influence of the fluid viscosity on the drag coefficient found in this study;meanwhile,the density can increase the buoyancy and the time period during which the valve cover experienced a high drag *** these results,control schemes for the valve cover rotation behavior during IPP-Coring were proposed for different layers and geological conditions in which the different drilling fluids should be used,e.g.,the use of a high-density valve cover in high-pore pressure layers.

关键词： In-situ coring Pressure coring Pressure controller Rotation behavior Drilling fluid

Magnetically controlled self-sealing pressure-preserved coring technology

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Petroleum Science 2024年第5期21卷 3464-3481页

作者： Gui-Kang Liu He-Ping Xie Cong Li Zhen-Xi You Xiao-Jun Shi Jian-Jun Hu ming-zhong gao State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065SichuanChina Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060GuangdongChina School of Mechanical Engineering Sichuan UniversityChengdu610065SichuanChina

Pressure-preserved coring is an effective means to develop deep resources. However, due to the complexity of existing pressure-preserved technology, the average success rate of pressure-preserved coring is low. In response, a novel in situ magnetically controlled self-sealing pressure-preserved coring technology for deep reserves has been proposed and validated. This innovative technology distinguishes itself from conventional methods by employing noncontact forces to replace traditional pretensioning mechanisms, thereby enhancing the mechanical design of pressure-preserved coring equipment and significantly boosting the fault tolerance of the technology. Here, we report on the design,theoretical calculations, experimental validation, and industrial testing of this technology. Through theoretical and simulation calculations, the self-sealing composite magnetic field of the pressure controller was optimized. The initial pre-tensioning force of the optimal magnetic field was 13.05 N. The reliability of the magnetically controlled self-sealing pressure-preserved coring technology was verified using a self-developed self-sealing pressure performance testing platform, confirming the accuracy of the composite magnetic field calculation theory. Subsequently, a magnetically controlled self-triggering pressure-preserved coring device was designed. Field pressure-preserved coring was then conducted,preliminarily verifying the technology's effective self-sealing performance in industrial ***, the technology was analyzed and verified to be adaptable to complex reservoir environments with pressures up to 30 MPa, temperatures up to 80℃, and p H values ranging from 1 to 14. These research results provide technical support for multidirectional pressure-preserved coring, thus paving a new technical route for deep energy exploration through coring.

关键词： In situ pressure-preserved coring Magnetically controlled Self-sealing Magnetic design Deep earth exploration

Pressure control method and device innovative design for deep oil in-situ exploration and coring

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Petroleum Science 2023年第2期20卷 1169-1182页

作者： Nian-Han Wu ming-zhong gao Liang-Yu Zhu Jia-Nan Li Dong Fan Bin You Wei Luo Guo-Dong Zhu School of Mechanical Engineering Sichuan UniversityChengdu610065China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengduSichuan 610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhenGuangdong 518061China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengduSichuan 610500China Xi'an Research Institute China Coal Technology&Engineering Group CorpXi'anShaanxi 710077China Haiwang Mechanical Electronic Engineering Technology Co. LTDWuhanHubei 430064China Zaoshenzhuang Village Hancheng TowuLubei DistrictTangshanHebei 064002China

Deep oil exploration coring technology cannot accurately maintain the in-situ pressure and temperature of samples, which leads to a distortion of deep oil and gas resource reserve evaluations based on conventional cores and cannot guide the development of deep oil and gas resources on Earth. The fundamental reason is the lack of temperature and pressure control in in-situ coring environments. In this paper, a pressure control method of a coring device is studied. The theory and method of deep intelligent temperature-pressure coupling control are innovatively proposed, and a multifield coupling dynamic sealing model is established. The optimal cardinality three term PID (Proportional-Integral-Differential) intelligent control algorithm of pressure system is developed. The temperature-pressure characteristic of the gas-liquid two-phase cavity is analyzed, and the pressure intelligent control is carried out based on three term PID control algorithms. An in-situ condition-preserved coring (ICP-Coring) device is developed, and an intelligent control system for the temperature and pressure of the coring device is designed and verified by experiments. The results show that the temperature-pressure coupling control system can effectively realize stable sealing under temperature-pressure fields of 140 MPa and 150 °C. The temperature-pressure coupling control method can accurately realize a constant pressure inside the coring device. The maximum working pressure is 140 MPa, and the effective pressure compensation range is 20 MPa. The numerical simulation experiment of pressure system control algorithm is carried out, and the optimal cardinality and three term coefficients are obtained. The pressure steady-state error is less than 0.01%. The method of temperature-pressure coupling control has guiding significance for coring device research, and is also the basis for temperature-pressure decoupling control in ICP-Coring.

关键词： Deep oil exploration Fidelity coring device Temperature-pressure coupling control theory Pressure control algorithm Temperature-pressure field alternating model

Optimal depth of in-situ pressure-preserved coring in coal seams considering roadway excavation and drilling disturbance

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Petroleum Science 2024年第5期21卷 3517-3534页

作者： Peng-Fei Cui De-Lei Shang Peng Chu Ju Li Da-Li Sun Tian-Yu Wang ming-zhong gao He-Ping Xie State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Institute of Deep Earth Sciences and Green EnergyShenzhen UniversityShenzhen518060GuangdongChina Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Shenzhen Key Laboratory of Deep Underground Engineering Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060GuangdongChina State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065SichuanChina School of Mechanical Engineering Sichuan UniversityChengdu610065SichuanChina Jinshi Drilltech Co. Ltd.Tangshan063004HebeiChina

Using pressure-preserved coring technique to determine in-situ gas content provides a more precise assessment of gas resource reserves and safeguard of mining safety in coal seams. How coring technique and depth affect the determination of gas content is unclear due to borehole zoning rupture caused by roadway excavation and drilling disturbance. To this end, a proposed coupling model of stress distribution and gas migration was simulated and validated by FLAC^(3D) and COMSOL Multiphysics considering superposition effects of roadway excavation and drilling disturbance. The findings indicate that the roadway surrounding rock displays distinct zoning features including stress relief zone, stress concentration zone that is composed of plastic zone, elastic zone, and original stress zone;and the broken situations depending on the borehole peeping are consistent with the corresponding simulation *** this basis, this study proposes a set of drilling coring depth calculation and prediction model for the gas desorption affected area under engineering disturbance. Optimal depth of coring drilling is not only approach to the in-situ coal bulk, but also can get the balance of the drilling workload and cost controlling. According to the typical mine site geological conditions and the numerical simulation results in this study, if the roadway excavation time is ~1 year, it is recommended that the pressure-preserved coring depth should be greater than 17 m.

关键词： In-situ fidelity coring In-situ pressure preserved coring Gas content Drilling disturbance Coring depth Excavation damage zone

The mechanism of microwave rock breaking and its potential application to rock-breaking technology in drilling

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Petroleum Science 2022年第3期19卷 1110-1124页

作者： ming-zhong gao Ben-gao Yang Jing Xie Si-Qi Ye Jun-Jun Liu Yi-Ting Liu Rui-Feng Tang Hai-Chun Hao Xuan Wang Xiang-Yue Wen Xue-Min Zhou Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization College of Civil and Transportation EngineeringShenzhen UniversityShenzhenGuangdong518060China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource&HydropowerSichuan UniversityChengduSichuan610065China

The exploration and development of oil and gas resources have shifted from shallow to deep and *** difficulty of rock breaking has also increased,introducing new challenges to traditional rock-breaking ***,there is an urgent need to develop new rock-breaking technologies to improve the development efficiency of deep oil and gas ***,this study focused on the new microwave rock-breaking technology and conducted experimental and numerical simulation research on typical deep,hard rock *** research results showed that granite in the microwave field exhibited high-temperature melting and fracture,and the highest temperature could reach 550°*** the irradiation of circulating microwaves,a minimum irradiation time threshold of 3 min was needed to cause irreversible damage to the *** numerical simulation results showed that the interaction of thermal stress and in situ stress would cause the inside of the rock stratum to separate into a disturbed deterioration area,disturbed unloading area and initial stress *** results are expected to provide the necessary technical guidance and theoretical support for the research and development of high-efficiency rock-breaking drilling for deep hard rock.

关键词： Microwave Well drilling High efficiency Granite

Research on in-situ condition preserved coring and testing systems

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Petroleum Science 2021年第6期18卷 1840-1859页

作者： He-Ping Xie Tao Liu ming-zhong gao Ling Chen Hong-Wei Zhou Yang Ju Feng gao Xiao-Bo Peng Xiong-Jun Li Rui-Dong Peng Ya-Nan gao Cong Li Zhi-Qiang He ming-Qing Yang Zhi-Yu Zhao Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060GuangdongChina Shenzhen Key Laboratory of Deep Underground Engineering Sciences and Green Energy Shenzhen UniversityShenzhen518060GuangdongChina MOE Key Laboratory of Deep Earth Science and Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065SichuanChina School of Mechanical Engineering Sichuan UniversityChengdu610065SichuanChina Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu610065SichuanChina State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology(Beijing)Beijing100083China Frontier Science Research Center for Fluidized Mining of Deep Underground Resources China University of Mining and TechnologyXuzhou221116JiangsuChina

As shallow resources are increasingly depleted,the mechanics'theory and testing technology of deep insitu rock has become *** coring technologies obtain rock samples without retaining the in-situ environmental conditions,leading to distortion of the measured ***,a coring and testing systems retaining in-situ geological conditions is presented:the coring system that obtains in-situ rock samples,and the transfer and testing system that stores and analyzes the rocks under a reconstructed *** ICP-Coring system mainly consists of the pressure controller,active insulated core reactor and insulation layer and sealing *** ultimate bearing strength of 100 MPa for pressurepreservation,temperature control accuracy of 0.97%for temperature-retained are ***_(4)and CO permeability of the optimized sealing film are as low as 3.85 and 0.33 ppm/*** average tensile elongation of the film is 152.4%and the light transmittance is reduced to 0%.Additionally,the pressure and steady-state temperature accuracy for reconstructing the in-situ environment of transfer and storage system up to 1%and±0.2 is *** error recorded of the noncontact sensor ring made of lowdensity polymer is less than 6%than that of the contact *** system can provide technical support for the deep in-situ rock mechanics research,improving deep resource acquisition capabilities and further clarifying deep-earth processes.

关键词： Deep mining In-situ environmental conditions In-situ condition preserved coring and testing In-situ transfer Deep-earth processes ICP-Coring In-situ condition-preserved coring

Differential diagnosis of cervical radiculopathy and superior pulmonary sulcus tumor

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Chinese Medical Journal 2012年第15期125卷 2755-2757页

作者： GU Rui KANG ming-yang gao zhong-li ZHAO Jian-wu WANG Jin-cheng Department of Orthopaedics China-Japan Union Hospital of JilinUniversity Changchun Jilin 130033 China

Background The result would be disastrous if the superior pulmonary sulcus tumor （Pancoast tumor） was misdiagnosed as degenerative cervical spine diseases. The aim of this study was to investigate the differential diagnosis methods of cervical radiculopathy and superior pulmonary sulcus tumor. Methods Clinical manifestations, physical, and radiological findings of 10 patients, whose main complaints were radiating shoulder and arm pain and later were diagnosed with superior pulmonary sulcus tumor, were reviewed and compared with those of cervical radiculopathy. Results Superior pulmonary sulcus tumor patients have shorter mean history and fewer complaints of neck pain or limitation of neck movement. Physical examination showed almost normal cervical spine range of motion. Spurling＇s neck compression test was negative in all patients. Anteroposterior cervical radiographs showed the lack of pulmonary air at the top of the affected lung in all cases and first rib encroachment in one case. The diagnosis of superior pulmonary sulcus tumor can be further confirmed by CT and MRI. Conclusions By the method of combination of history, physical examination, and radiological findings, superior pulmonary sulcus tumor can be efficiently differentiated from cervical radiculopathy. Normal motion range of the cervical spine, negative Spurling＇s neck compression test, and the lack of pulmonary air at the top of the affected lung in anteroposterior cervical radiographs should be considered as indications for further chest radiograph examinations.

关键词： superior pulmonary sulcus tumor, cervical radiculopathy physical examination,anteroposterior cervical radiograph, differential diagnosis

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen Du ming gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity