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Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer

World Journal of Gastrointestinal Oncology 2024年第2期16卷 436-457页

作者： Yao Rong ming-zheng tang Song-Hua Liu Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND A growing number of clinical examples suggest that coronavirus disease 2019(COVID-19)appears to have an impact on the treatment of patients with liver cancer compared to the normal population,and the prevalence of COVID-19 is significantly higher in patients with liver ***,this mechanism of action has not been *** sets for COVID-19(GSE180226)and liver cancer(GSE87630)were obtained from the Gene Expression Omnibus *** identifying the common differentially expressed genes(DEGs)of COVID-19 and liver cancer,functional enrichment analysis,protein-protein interaction network construction and scree-ning and analysis of hub genes were ***,the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was *** Of 518 common DEGs were obtained by screening for functional *** hub genes including aurora kinase B,cyclin B2,cell division cycle 20,cell division cycle associated 8,nucleolar and spindle associated protein 1,etc.,were further identified from DEGs using the“cytoHubba”*** enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation,cell cycle and other functions,and they may serve as potential molecular markers for COVID-19 and liver ***,we selected 10 of the hub genes for in vitro expression validation in liver cancer *** Our study reveals a common pathogenesis of liver cancer and *** common pathways and key genes may provide new ideas for further mechanistic studies.

关键词： COVID-19 Liver cancer Differentially expressed genes Hub genes Pathogenesis

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Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 144-181页

作者： Yao Rong Song-Hua Liu ming-zheng tang Zhi-Hang Wu Guo-Rong Ma Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis Liver cancer

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Investigating the elliptic anisotropy of identified particles in p-Pb collisions with a multi-phase transport model

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Nuclear Science and Techniques 2024年第2期35卷 160-169页

作者： Si-Yu tang Liang zheng Xiao-ming Zhang Ren-Zhuo Wan School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Mathematics and Physics China University of Geosciences(Wuhan)Wuhan 430074China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China Hubei Key Laboratory of Digital Textile Equipment Wuhan Textile UniversityWuhan 430200China School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|<0.8)was investigated in p-Pb collisions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculations of differential v_(2)based on the advanced flow extraction method of light flavor hadrons(pions,kaons,protons,andΛ)in small collision systems were extended to a wider transverse momentum(p_(T))range of up to 8 GeV/c for the first *** string-melting version of the AMPT model provides a good description of the measured p_(T)-differential v_(2)of the mesons but exhibits a slight deviation from the baryon v_(2).In addition,we observed the features of mass ordering at low p_(T)and the approximate number-of-constituentquark(NCQ)scaling at intermediate p_(T).Moreover,we demonstrate that hadronic rescattering does not have a significant impact on v_(2)in p-Pb collisions for different centrality selections,whereas partonic scattering dominates in generating the elliptic anisotropy of the final *** study provides further insight into the origin of collective-like behavior in small collision systems and has referential value for future measurements of azimuthal anisotropy.

关键词： Azimuthal anisotropy Small collision systems Transport model

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Magnetization relaxation of uniaxial anisotropic ferromagnetic particles with linear reaction dynamics driven by DC/AC magnetic field

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Chinese Physics B 2021年第9期30卷 89-93页

作者： Yu-Song Hu Min Jiang Tao Hong zheng-ming tang Ka-Ma Huang School of Electronic Information Engineering China West Normal UniversityNanchong 637000China College of Electronics and Information Engineering Sichuan UniversityChengdu 610065China

The response of uniaxial anisotropic ferromagnetic particles with linear reaction dynamics subjected to alternating current(AC)or direct current(DC)bias magnetic field is evaluated by the reaction-diffusion equation for the probability distribution function of the molecular concentration in the spherical coordinate *** magnetization function and the probability distribution function of the magnetic particles in the reaction system are derived by using the Legendre polynomials and Laplace *** discuss the characteristics of magnetization and probability distribution of the magnetic particles with different anisotropic parameters driven by a DC and AC magnetic fields,*** is shown that both the magnetization and the probability distribution decrease with time increasing due to the reaction *** uniformity of the probability distribution and the amplitude of the magnetization are both affected by the anisotropic ***,the difference between the case with linear reaction dynamics and the non-reaction case is discussed.

关键词： linear reaction probability distribution magnetization anisotropic

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On-demand engineerable visible spectrum by fine control of electrochemical reactions

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National Science Review 2024年第3期11卷 239-249页

作者： Qirong Liu Lei Liu Yongping zheng Min Li Baofu Ding Xungang Diao Hui-ming Cheng Yongbing tang Advanced Energy Storage Technology Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced Technology Chinese Academy of Sciences School of Energy and Power Engineering North University of China School of Resource Environment and Safety EngineeringHunan University of Science and Technology School of Energy and Power Engineering Beihang University Shenzhen Key Laboratory of Energy Materials for Carbon Neutrality Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences

Tunability of optical performance is one of the key technologies for adaptive optoelectronic applications,such as camouflage clothing, displays, and infrared shielding. High-precision spectral tunability is of great importance for some special applications with on-demand adaptability but remains challenging. Here we demonstrate a galvanostatic control strategy to achieve this goal, relying on the finding of the quantitative correlation between optical properties and electrochemical reactions within materials. An electrochromic electro-optical efficiency index is established to optically fingerprint and precisely identify electrochemical redox reactions in the electrochromic device. Consequently, the charge-transfer process during galvanostatic electrochemical reaction can be quantitatively regulated, permitting precise control over the final optical performance and on-demand adaptability of electrochromic devices as evidenced by an ultralow deviation of <3.0%. These findings not only provide opportunities for future adaptive optoelectronic applications with strict demand on precise spectral tunability but also will promote in situ quantitative research in a wide range of spectroelectrochemistry, electrochemical energy storage, electrocatalysis, and material chemistry.

关键词： electrochromics fine control spectral tunability high precision galvanostatic control

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Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands

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Research 2024年第1期2023卷 199-208页

作者： Yuchen tang Xingxing zheng Tingjuan Gao China Key Laboratory of Pesticide and Chemical Biology of Ministry of Education College of ChemistryCentral China Normal UniversityWuhan 430079China

High-throughput assays play an important role in the fields of drug discovery,genetic analysis,and clinical *** super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay,practically,the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction *** challenge results in either inaccurate or insufficient decoding ***,we identified chemical-resistant Raman compounds to build a combinatorial coding system for the high-throughput screening of cell-targeting ligands from a focused 8-mer cyclic peptide *** accurate in situ decoding results proved the signal,synthetic,and functional orthogonality for this Raman coding *** orthogonal Raman codes allowed for a rapid identification of 63 positive hits at one time,evidencing a high-throughput-out capability in the screening *** anticipate this orthogonal Raman coding strategy being generalized to enable efficient high-throughput-out screening of more useful ligands for cell targeting and drug discovery.

关键词： enable throughput allowed

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Investigation on UV-curing Reprocessable Thermosets Bearing Hindered Urea Bonds and Their Composites with Modified Zinc Oxide Nanoparticles

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Chinese Journal of Polymer Science 2024年第6期42卷 751-765页

作者： Jun-Hao Zhou Li-ming tang Key Laboratory of Advanced Materials of Ministry of Education of China Department of Chemical EngineeringTsinghua UniversityBeijing100084China

In this study,a series of hindered urea bond(HUB)containing polyurethane-urea methacrylate prepolymers and a none HUB containing polyurethane methacrylate prepolymer were prepared using isobornyl methacrylate as the reactive diluent via one-pot *** prepolymers were characterized fully by various ***,their thermosets were fabricated via UV curing in presence of a photo initiator,and their mechanical property and thermal behavior were investigated and *** from the none HUB containing thermoset,the HUB containing thermosets(defined as PUT)could be recycled and reprocessed by hot press under relatively mild conditions with high recovery ratio of mechanical ***,zinc oxide(ZnO)nanoparticles were modified with 3-(trimethoxysilyl)propyl methacrylate and the modified ZnO(defined as ZnO-TPM)was dispersed and polymerized into PUT matrix to prepare their *** influence of ZnO-TPM on the mechanical performance of the composites was evaluated,which indicated that the Young’s modulus and tensile strength increased gradually to the maximum values at ZnO-TPM content of 1 wt%and then *** composites also displayed good reprocessability with improved recovery ratio compared to the pure PUT *** addition,the composite materials exhibited strong UV absorption capacity,implying their potential application in the circumstance where UV-shielding was required.

关键词： Polyurethane-urea methacrylate Hindered urea bond ZnO nanoparticles Reprocessing UV curing

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Design and optimization of fluid lubricated bearings operated with extreme working performances——a comprehensive review

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International Journal of Extreme Manufacturing 2024年第2期6卷 325-376页

作者： Guohua Zhang ming Huang Gangli Chen Jiasheng Li Yang Liu Jianguo He Yueqing zheng Siwei tang Hailong Cui Institute of Machinery Manufacturing Technology China Academy of Engineering PhysicsMianyangSichuan 621999People’s Republic of China

Fluid lubricated bearings have been widely adopted as support components for high-end equipment in metrology,semiconductor devices,aviation,strategic defense,ultraprecision manufacturing,medical treatment,and power *** all these applications,the equipment must deliver extreme working performances such as ultraprecise movement,ultrahigh rotation speed,ultraheavy bearing loads,ultrahigh environmental temperatures,strong radiation resistance,and high vacuum operation,which have challenged the design and optimization of reliable fluid lubricated *** of any related bottlenecks will promote the development course of high-end *** promote the advancement of high-end equipment,this paper reviews the design and optimization of fluid lubricated bearings operated at typical extreme working performances,targeting the realization of extreme working performances,current challenges and solutions,underlying deficiencies,and promising developmental *** paper can guide the selection of suitable fluid lubricated bearings and optimize their structures to meet their required working performances.

关键词： fluid lubricated bearings structural design performance optimization extreme working performances

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Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting

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Frontiers in Energy 2024年第3期18卷 378-389页

作者： Zhao-ting SHANG tang-ming LI Bing-qian HU Min LIU Wang-ting LU Fan YU Yun zheng Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education College of Optoelectronic Materials and TechnologyJianghan UniversityWuhan 430056China Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1Canada

The use of two-dimensional(2D)layered metal-organic frameworks(MOFs)as self-sacrificial templates has been proven to be a successful method to create high-efficiency Selenium(Se)-containing electrocatalysts for overall water ***,two strategies are then utilized to introduce Se element into the Co–Fe MOF,one being the etching of as-prepared MOF by SeO_(2) solution,and the other,the replacing of SCN−with SeCN−as the construction *** electrochemical activity of the pristine 2D MOF and their calcinated derivatives for catalyzing the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is evaluated and further *** is found that the effect of introducing Se on improving electrochemical catalytic activity is significant for the HER ***,the calcinated derivative in the replacing method exhibits an overpotential of 235 mV for HER and 270 mV for OER at a current density of 10 mA/*** comparing the two methods of introducing Se element into MOF,similar electrocatalytic activity can be achieved on the their calcinated *** high electrochemical performance of 2D CoFe-MOF derivatives may be resulted from the unique 2D hierarchical porous structure and strong synergistic effect between different components in the material.

关键词： 2D MOF selenium(Se)-containing materials hydrogen evolution reaction(HER) oxygen evolution reaction(OER)

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Experimental Study of Local Scour Around Four Piles Under Different Attack Angles and Gap Ratios

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China Ocean Engineering 2024年第4期38卷 612-624页

作者： LIU ming-ming tang Guo-qiang JIN Xin GENG Shao-yang School of Architecture and Engineering Liaocheng UniversityLiaocheng 252000China Water-Sediment Regulation and Sand Effective Utilization Special Laboratory of Shandong Provincial Education Department Liaocheng UniversityLiaocheng 252000China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China College of Electronic Engineering Chengdu University of Information TechnologyChengdu 610225China College of Energy Chengdu University of TechnologyChengdu 610059China

In an effort to investigate and quantify the patterns of local scour,researchers embarked on an in-depth study using a systematic experimental *** research focused on the effects of local scour around a set of four piles,each subjected to different hydromechanical *** particular,this study aimed to determine how different attack angles—the angles at which the water flow impinges on the piles,and gap ratios—the ratios of the spacing between the piles to their diameters,influence the extent and nature of scour.A comprehensive series of 35 carefully designed experiments were orchestrated,each designed to dissect the nuances in how the gap ratio and attack angle might contribute to changes in the local scour observed at the base of pile *** these experimental trials,a wealth of local scour data were collected to support the *** data included precise topographic profiles of the sediment bed around the pile groups,as well as detailed scour time histories showing the evolution of scour at strategic feature points throughout the test *** analysis of the experimental data provided interesting *** study revealed that the interplay between the gap ratio and the attack angle had a pronounced influence on the scouring dynamics of the pile *** of the key observations was that the initial phases of scour,particularly within the first hour of water flow exposure,were characterized by a sharp increase in the scour depth occurring immediately in front of the *** this initial rapid development,the scour depth transitioned to a more gradual change *** contrast,the scour topography around the piles continuously *** suggests that sediment displacement and the associated sculpting of the seabed around pile foundations are sustained and progressive processes,altering the underwater landscape over *** results of this empirical investigation have significant implications for the design and constructio

关键词： local scour piles gap ratio attack angle

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