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Plasma Homocysteine and Gene Polymorphisms Associated with the Risk of Hyperlipidemia in Northern Chinese Subjects

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Biomedical and Environmental Sciences 2008年第6期21卷 514-520页

作者： LEI HUANG XIAO-ming SONG wen-LI zhu YONG LI Department of Nutrition and Food Hygiene School of Public Health Peking University Beijing 100083 China

Objective To examine the relationship between occurrence of hyperlipidemia, plasma homocysteine and polymorphisms of methylenetetra hydrofolate reductase （MTHFR） gene and methionine synthase （MS） gene. Methods A total of 192 hyperlipidemia patients were selected and divided into hypercholesterolemia group, hypertriglyceridemia group, and combined hyperlipidemia group. Another 208 normal individuals were selected as control. Total plasma homocysteine （tHcy） concentration was measured by high-performance liquid chromatography （HPLC）. Lipid profiles were measured for all subjects The polymorphisms of MTHFR gene C677T and MS gene A2756G were analyzed by PCR-RFLP. Results The tHcy concentration in the combined hyperlipidemia patients was significantly higher than that in the control （15.95μmol/L vs 13.43 μmol/L, P〈0.05）. The prevalence of hyperhomocysteinemia （HHcy） in the combined hyperlipidemia group was significantly higher than that in the control （42.2% vs 23.0%, P=0.015）, with the odds ratio （OR） of 3.339 （95%CI： 1.260-8.849）. The hyperlipidemia patients with HHcy had a higher concentration of total cholesterol （TC） than that in the normal tHcy patients （5.67±0.95 mmol/L vs 5.47±0.92 retool/L, P=0.034）. There was no significant difference in genotype or allele frequencies of MTHFR C677T between the hyperlipidemic and control groups. The hyperlipidemia patients with MTHFR CT/TT genotype had a higher concentration of triglyceride （TG） than those with CC genotype （2.24±1.75 mmol/L vs 1.87±0.95 mmol/L, P〈0.05）. Individuals with CT/TT genotype had a higher concentration of tHcy than those with 677CC genotype both in the hyperlipidemia group （12.61±1.24μmol/L vs 11.20±1.37 μmol/L, P〈0.05） and in the control group （14.04±1.48 μmol/L vs 12.61±1.24 μmol/L, P〈0.05）. The percentage of MS 2756 GG/AG genotype in the combined hyperlipidemia group was significantly higher than that in the control （26.7% vs 13.0%, P=0.012）, with the OR of 3.121 （95%C1： 1.288-7.65/）. The hyperlipid

关键词： Methylenetetra hydrofolate reductase Methionine synthase Gene polymorphism Homocysteine Hyperlipidemia

The diurnal flight activity and influential factors of Frankliniella occidentalis in the greenhouse

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Insect Science 2010年第6期17卷 535-541页

作者： Xing-Hui Liang Zhong-Ren Lei Jin-Zeng wen ming-Liang zhu State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing China

The daily flight activity of westem flower thrips, Frankliniella occidentalis （Pergande）（Thysanoptera： Thripidae） was examined using color, yellow-light and chemical attractant traps in a cucumber greenhouse and under controlled laboratory conditions. In the greenhouse, flying thrips were most abundant between hours 08：00-10：00, declined at mid-day, and then slightly increased during hours 14：00-16：00; however they decreased to a very low level at 18：00. The use of light traps showed no thrip flight activity during the night. The total number of thrips that flew onto cards on rainy or cloudy days was higher than that on sunny days. We reconfirmed that traps treated with attractant attracted 4.0-9.4 times more thrip than the untreated traps. Under laboratory controlled conditions, thrip flight activity was highest under light intensity between 4 000 and 6 000 lux, air temperature of 28℃, and RH of 70%. In addition, starved thrips flew more readily than non-starved thrips.

关键词： attractant daily flight activity Frankliniella occidentalis factors traps

Therapeutic experience of 289 elderly patients with biliary diseases

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World Journal of Gastroenterology 2017年第13期23卷 2424-2434页

作者： Zong-ming Zhang zhuo Liu Li-Min Liu Chong Zhang Hong-Wei Yu Bai-Jiang Wan Hai Deng ming-wen zhu Zi-Xu Liu wen-Ping Wei Meng-Meng Song Yue Zhao Department of General Surgery Beijing Electric Power Hospital State Grid Corporation of China Capital Medical University

AIM To present clinical characteristics, diagnosis and treatment strategies in elderly patients with biliary diseases. METHODS A total of 289 elderly patients with biliary diseases were enrolled in this study. The clinical data relating to these patients were collected in our hospital from June 2013 to May 2016. Patient age, disease type, coexisting diseases, laboratory examinations, surgical methods, postoperative complications and therapeutic outcomes were analyzed. RESULTS The average age of the 289 patients with biliary diseases was 73.9 +/- 8.5 years (range, 60-102 years). One hundred and thirty-one patients (45.3%) had one of 10 different biliary diseases, such as gallbladder stones, common bile duct stones, and cholangiocarcinoma. The remaining patients (54.7%) had two types of biliary diseases. One hundred and seventy-nine patients underwent 9 different surgical treatments, including pancreaticoduodenectomy, radical resection of hilar cholangiocarcinoma and laparoscopic cholecystectomy. Ten postoperative complications occurred with an incidence of 39.3% (68/173), and hypopotassemia showed the highest incidence (33.8%, 23/68). One hundred and sixteen patients underwent non-surgical treatments, including anti-infection, symptomatic and supportive treatments. The cure rate was 97.1% (168/173) in the surgical group and 87.1% (101/116) in the non-surgical group. The difference between these two groups was statistically significant (chi(2) = 17.227, P < 0.05). CONCLUSION Active treatment of coexisting diseases, management of indications and surgical opportunities, appropriate selection of surgical procedures, improvements in perioperative therapy, and timely management of postoperative complications are key factors in enhancing therapeutic efficacy in elderly patients with biliary diseases.

关键词： Biliary diseases Elderly patients Surgical treatment Non-operative treatment

Critical values of monitoring indexes for perioperative major adverse cardiac events in elderly patients with biliary diseases

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World Journal of Clinical Cases 2022年第20期10卷 6865-6875页

作者： Zong-ming Zhang Xi-Yuan Xie Yue Zhao Chong Zhang zhuo Liu Li-Min Liu ming-wen zhu Bai-Jiang Wan Hai Deng Kun Tian Zhen-Tian Guo Xi-Zhe Zhao Department of General Surgery Beijing Electric Power HospitalState Grid Corporation of ChinaCapital Medical UniversityBeijing 100073China Department of Cardiology Beijing Electric Power HospitalState Grid Corporation of ChinaCapital Medical UniversityBeijing 100073China

BACKGROUND Major adverse cardiac events(MACE) in elderly patients with biliary diseases are the main cause of perioperative accidental death, but no widely recognized quantitative monitoring index of perioperative cardiac function so *** To investigate the critical values of monitoring indexes for perioperative MACE in elderly patients with biliary *** The clinical data of 208 elderly patients with biliary diseases in our hospital from May 2016 to April 2021 were retrospectively analysed. According to whether MACE occurred during the perioperative period, they were divided into the MACE group and the non-MACE *** In the MACE compared with the non-MACE group, postoperative complications, mortality, hospital stay, high sensitivity troponin-Ⅰ(Hs-TnI), creatine kinase isoenzyme(CK-MB), myoglobin(MYO), B-type natriuretic peptide(BNP), and Ddimer(D-D) levels were significantly increased(P < 0.05). Multivariate logistic regression showed that postoperative BNP and D-D were independent risk factors for perioperative MACE, and their cut-off values in the receiver operating characteristic(ROC) curve were 382.65 pg/mL and 0.965 mg/L, *** The postoperative BNP and D-D were independent risk factors for perioperative MACE, with the critical values of 382.65 pg/mL and 0.965 mg/L respectively. Consequently, timely monitoring and effective maintenance of perioperative cardiac function stability are of great clinical significance to further improve the perioperative safety of elderly patients with biliary diseases.

关键词： Biliary diseases in elderly patients Major adverse cardiac events Perioperative safety Logistic regression Receiver operating characteristic curve

Therapeutic experience of an 89-year-old high-risk patient with incarcerated cholecystolithiasis:A case report and literature review

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World Journal of Clinical Cases 2020年第20期8卷 4908-4916页

作者： Zong-ming Zhang Chong Zhang zhuo Liu Li-Min Liu ming-wen zhu Yue Zhao Bai-Jiang Wan Hai Deng Hai-Yan Yang Jia-Hong Liao Hong-Yan zhu Xue wen Li-Li Liu Man Wang Xiao-Ting Ma Miao-MiaoZhang Jiao-Jiao Liu Tian-Tian Liu Niu-Niu Huang Pei-Ying Yuan Yu-Jiao Gao Jing Zhao Xi-Ai Guo FangLiao Feng-Yuan Li Xue-Ting Wang Rui-Jiao Yuan Fang Wu Department of General Surgery Beijing Electric Power HospitalState Grid Corporation of ChinaCapital Medical UniversityBeijing 100073China Department of Pathology Beijing Electric Power HospitalState Grid Corporation of ChinaCapital Medical UniversityBeijing 100073China

BACKGROUND The global pandemic of coronavirus disease 2019 pneumonia poses a particular challenge to the emergency surgical treatment of elderly patients with high-risk acute abdominal *** patients are a high-risk group for surgical *** the incarceration of gallstones cannot be relieved,emergency surgery is *** SUMMARY We report an 89-year-old male patient with acute gangrenous cholecystitis and septic shock induced by incarcerated *** had several coexisting,high-risk underlying diseases,had a history of radical gastrectomy for gastric cancer,and was taking aspirin before the ***,he underwent emergency laparoscopic cholecystectomy,with maintenance of postoperative heart and lung function,successfully recovered,and was discharged on day 8 after the *** Emergency surgery for elderly patients with acute abdominal disease is safe and feasible during the coronavirus disease 2019 pandemic,the key is to abide strictly by the hospital's epidemic prevention regulations,fully implement the epidemic prevention procedure for emergency surgery,fully prepare before the operation,accurately perform the operation,and carefully manage the patient postoperatively.

关键词： Extremely elderly patient Cholecystolithiasis incarceration Acute gangrenous cholecystitis Acute abdominal diseases COVID-19 Case report

Identification and Gene Mapping of Completely Dominant Earliness in Rice

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Agricultural Sciences in China 2002年第1期1卷 11-18页

作者： DENG Xiao-jian, ZHOU Kai-da, LI Ren-duan, CHUN Ze LI Ping, WANG wen-ming, ZHAI wen-xue and zhu Li-huang( Rice Research Institute, Sichuan Agricultural University, wenjiang 611130 Institute of Genetics, Chinese Academy of Sciences, Beijing 100101) Rice Research Institute Sichuan Agricultural University Wenjiang 611130 Institute of Genetics Chinese Academy of Sciences Beijing 100101 Rice Research Institute Sichuan Agricultural University Wenjiang 611130 Institute of Genetics Chinese Academy of Sciences Beijing 100101

The completely dominant earliness was identified in a genie male-sterile and early maturing indica line 6442S-7. F1 progenies from 6442S-7 crossed with thirteen various types of medium- or late-maturing varieties, shared the same heading date as 6442S-7. The segregation of heading date in the F2 and B1F1 populations showed that the earliness of 6442S-7 is mainly controlled by two dominant major genes. The local linkage map of one dominant earliness gene harbored in 6442S-7 was constructed with F2 population and four kinds of molecular marker techniques. The results showed that the gene was located between a RFLP marker C515 and a RAPD marker OPI 11.557 on the terminal region of short arm of rice chromosome 3, 10.9cM and 1.5cM from C515 and OPI11.557, respectively. The genetic distances from the target gene to two SSR markers, RM22 and RM231, and one AFLP marker, PT671, were 3.0, 6.7 and 12.4 cM, respectively. This gene, being identified and mapped first, is designated tentatively as Ef-cd(t). As a new genetic resource of completely dominant earliness, 6442S-7 has splendid future in rice improvement.

关键词： Oryza saliva L. Growth duration Earliness Dominant earliness gene Gene mapping

Ischemic or toxic injury: A challenging diagnosis and treatment of drug-induced stenosis of the sigmoid colon

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World Journal of Gastroenterology 2017年第21期23卷 3934-3944页

作者： Zong-ming Zhang Xiang-Chun Lin Li Ma An-Qin Jin Fang-Cai Lin zhuo Liu Li-Min Liu Chong Zhang Na Zhang Li-Juan Huo Xue-Liang Jiang Feng Kang Hong-Jun Qin Qiu-Yang Li Hong-Wei Yu Hai Deng ming-wen zhu Zi-Xu Liu Bai-Jiang Wan Hai-Yan Yang Jia-Hong Liao Xu Luo You-Wei Li wen-Ping Wei Meng-Meng Song Yue Zhao Xue-Ying Shi Zhao-Hui Lu Department of General Surgery Beijing Electric Power HospitalState Grid Corporation of ChinaCapital Medical University Department of Gastroenterology Peking University International Hospital Asian Liver Center and Department of Surgery School of MedicineStanford University Department of Gastroenterology Beijing Electric Power HospitalState Grid Corporation of ChinaCapital Medical University Department of Gastroenterology First HospitalShanxi Medical University Department of Gastroenterology Jinan Military General Hospital Department of Radiology Beijing Electric Power HospitalState Grid Corporation of ChinaCapital Medical University Department of Pathology Beijing Electric Power HospitalState Grid Corporation of ChinaCapital Medical University Department of Pathology Peking University Third HospitalSchool of Basic Medical SciencesPeking University Health Science Center1 Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences

A 48-year-old woman was admitted with 15-mo history of abdominal pain, diarrhea and hematochezia, and 5-mo history of defecation difficulty. She had been successively admitted to nine hospitals, with an initial diagnosis of inflammatory bowel disease with stenotic sigmoid colon. Findings from computed tomography virtual colonoscopy, radiography with meglumine diatrizoate, endoscopic balloon dilatation, metallic stent implantation and later overall colonoscopy, coupled with the newfound knowledge of compound Qingdai pill-taking, led to a subsequent diagnosis of ischemic or toxic bowel disease with sigmoid colon stenosis. The patient was successfully treated by laparoscopic sigmoid colectomy, and postoperative pathological examination revealed ischemic or toxic injury of the sigmoid colon, providing a final diagnosis of druginduced sigmoid colon stenosis. This case highlights that adequate awareness of drug-induced colon stenosis has a decisive role in avoiding misdiagnosis and mistreatment. The diagnostic and therapeutic experiences learnt from this case suggest that endoscopic balloon expansion and colonic metallic stent implantation as bridge treatments were demonstrated as crucial for the differential diagnosis of benign colonic stenosis. Skillful surgical technique and appropriate perioperative management helped to ensure the safety of our patient in subsequent surgery after long-term use of glucocorticoids.

关键词： Benign colonic stenosis Compound Qingdai pill Self-expandable memory metallic stent

教育信息化背景下校园卡系统数据挖掘的研究与实现

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电脑知识与技术 2016年第2Z期12卷 5-6页

作者：文明珠广东外语外贸大学教育技术中心广东广州510000

近年来,随着互联网、高性能计算机的信息技术的发展,越来越多的信息化项目应用被投入到校园网络信息平台的建设中来,这就为进一步发展和研究数据挖掘技术提供了背景知识的支持。校园卡系统是高校建设智慧型校园的重要信息化载体,是高校... 详细信息

近年来,随着互联网、高性能计算机的信息技术的发展,越来越多的信息化项目应用被投入到校园网络信息平台的建设中来,这就为进一步发展和研究数据挖掘技术提供了背景知识的支持。校园卡系统是高校建设智慧型校园的重要信息化载体,是高校的人、财、物等资源数据的重要整合和共享平台,是衡量高校信息化程度的首要标准。该文以数据挖掘为技术条件,对其在校园卡系统开发过程中的应用进行探讨。

关键词：信息化建设数据挖掘校园卡系统

妊娠期糖尿病孕妇发生巨大儿的影响因素及体质量管理对分娩方式的影响

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医学信息 2020年第24期33卷 130-132页

作者：温明珠江西赣州市立医院妇产科

目的观察妊娠期糖尿病孕妇发生巨大儿的影响因素及体质量管理对分娩方式的影响。方法选取2018年1月～2019年12月我院分娩的孕妇98例。根据是否合并妊娠期糖尿病分为妊娠期糖尿病组35例与健康组63例,妊娠期糖尿病组根据体质量管理情况分... 详细信息

目的观察妊娠期糖尿病孕妇发生巨大儿的影响因素及体质量管理对分娩方式的影响。方法选取2018年1月～2019年12月我院分娩的孕妇98例。根据是否合并妊娠期糖尿病分为妊娠期糖尿病组35例与健康组63例,妊娠期糖尿病组根据体质量管理情况分为体质量控制理想组25例与体质量控制不理想组10例。分析巨大儿的影响因素以及妊娠期糖尿病孕妇体质量管理与巨大儿相关性,比较三组分娩方式、巨大儿发生率。结果不同孕前体质量、是否孕期体重增长过多、是否分娩巨大儿史孕妇发生巨大儿情况比较,差异有统计学意义(P<0.05);多因素回归分析显示,孕前体质量肥胖、孕期体重增长过多是导致妊娠期糖尿病孕妇分娩巨大儿的独立危险因素,且妊娠期糖尿病孕妇体质量与巨大儿发生率呈正相关(P<0.05);体质量控制不理想组剖宫产率高于体质量控制理想组与健康组,差异有统计学意义(P<0.05);体质量控制不理想组巨大儿、产后出血、难产及其他妊娠期并发症发生率高于体质量控制理想组与健康组,差异有统计学意义(P<0.05)。结论孕前体质量肥胖、孕期体重增长过多是妊娠期糖尿病孕妇分娩巨大儿的危险因素,体质量越大与巨大儿发生率越高,有效控制妊娠期糖尿病孕妇体质量,可能有助于降低巨大儿及剖宫产率,预防妊娠期并发症。

关键词：妊娠期糖尿病孕妇体质量巨大儿剖宫产