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Aspirin-induced long-term tumor remission in hepatocellular carcinoma with adenomatous polyposis coli stop-gain mutation:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7189-7195页

作者： Qu Lin ming-Jun Bai Hao-Fan Wang Xiang-Yuan Wu ming-sheng huang Xing Li Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Intervention and Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Targeted therapy based on pathway analysis of hepatitis B-related hepatocellular carcinoma(HCC)may be a promising *** SUMMARY The present case involved an advanced hepatocellular carcinoma(HCC)patient who did not receive local regional therapy and was intolerant to *** RNA extracted from the patient’s tumor tissue was used to obtain the gene mutation *** c.3676A>T and c.4402A>T stop-gain mutations in adenomatous polyposis coli(APC)were the most prevalent(42.2%and 35.1%,respectively).MutationMapper analysis indicated that the functional domain of APC was lost in the two APC mutant *** is a major suppressor of the Wnt signaling ***,the Wnt pathway was exclusively activated due to APC dysfunction,as other elements of this pathway were not found to be *** has been reported to suppress the Wnt pathway by inducingβ-catenin phosphorylation through the activation of glycogen synthase kinase 3 beta via cyclooxygenase-2 pathway ***,aspirin was administered to the patient,which achieved four years of disease *** Exclusive mutations of APC of all the Wnt pathway elements could be a therapeutic target in HCC,with aspirin as an effective treatment option.

关键词： Hepatocellular carcinoma Mutation Wnt pathway Aspirin Adenomatous polyposis coli Case report

A Deep Model for Partial Multi-label Image Classification with Curriculum-based Disambiguation

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Machine Intelligence Research 2024年第4期21卷 801-814页

作者： Feng Sun ming-Kun Xie sheng-Jun huang MIIT Key Laboratory of Pattern Analysis and Machine Intelligence College of Computer Science and TechnologyNanjing University of AeronauticsandAstronauticsNanjing211106China

In this paper,we study the partial multi-label(PML)image classification problem,where each image is annotated with a candidate label set consisting of multiple relevant labels and other noisy *** PML methods typically design a disambiguation strategy to filter out noisy labels by utilizing prior knowledge with extra assumptions,which unfortunately is unavailable in many real ***,because the objective function for disambiguation is usually elaborately designed on the whole training set,it can hardly be optimized in a deep model with stochastic gradient descent(SGD)on *** this paper,for the first time,we propose a deep model for PML to enhance the representation and discrimination *** the one hand,we propose a novel curriculum-based disambiguation strategy to progressively identify ground-truth labels by incorporating the varied difficulties of different *** the other hand,consistency regularization is introduced for model training to balance fitting identified easy labels and exploiting potential relevant *** experimental results on the commonly used benchmark datasets show that the proposed method significantlyoutperforms the SOTA methods.

关键词： Partial multi-label image classification curriculum-based disambiguation consistency regularization label difficulty candidatelabel set.

Organic photovoltaic devices with high open-circuit voltage based on oligothiophene derivatives

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Chinese Chemical Letters 2007年第4期18卷 437-440页

作者： Ping Liu Jia Le huang Wan Zhang Pan ming sheng huang Wen Ji Deng Yu Liang Mai An Bo Luan Research Institute of Materials Science South China University of Technology Guangzhou 510640 China Department of Applied Physics South China University of Technology Guangzhou 510640 China Gungdong Province Petroleum Chemicals Institute Guangzhou 510665 China

For the purpose of developing organic photovoltaic devices with good performance characteristics, we have fabricated two devices using 4T-CHO, 5T-CHO and PTCDA. The ITO/4T-CHO/PTCDA/Al device has a Voc of 2.45 V and photoelectric conversion efficiency of 2.76%. The ITO/ST-CHO/PTCDA/Al device has a Voc of 2.1 3V and photoelectric conversion efficiency of 2.90%. The two devices have higher Voc （2.45 and 2.13 V）. It is possible that intennolecular hydrogen bonding between -CHO group of nT-CHO and carboxylic dianhydride of PTCDA contribute to enhance the efficiency by promoting interracial electron transfer and eliminating the subconducting band trap sites.

关键词： Oligothiophene Organic photovoltaic property Device

Flexible organic photovoltaic devices based on oligothiophene derivatives

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Chinese Chemical Letters 2008年第2期19卷 207-210页

作者： Ping Liu Tu Hua Chen Wan Zhang Pan ming sheng huang Wen Ji Deng Yu Liang Mai An Bo Luan Research Institute of Materials Science South China University of Technology Guangzhou 510640 China Department of Applied Physics South China University of Technology Guangzhou 510640 China Guangdong Province Petroleum Chemicals Institute Guangzhou 510665 China

For the purpose of developing flexible organic photovoltaic devices, we have fabricated two flexible devices using 5-formyl- 2,2′：5′,2″：5″,2′″-quaterthiophene （4T-CHO）, 5-formyl-2,2′：5′, 2″：5″,2′″：5′″,2″″-quinquethiophene （5T-CHO） and 3,4,9,10-perylenetertracarboxylic dianhydride （PTCDA）. The PET-ITO/4T-CHO/PTCDA/A1 device has an open circuit voltage （Voc） of 1.56 V, photoelectric conversion efficiency of 0.77%. The PET-ITO/5T-CHO/PTCDA/A1 device has a Voc of 1.70 V, photoelectric conversion efficiency of 0.84%. The two flexible devices have high Voc （1.56 and 1.70 V）. It is possible that intermolecular hydrogen bonding between -CHO group of nT-CHO and carboxylic dianhydride of PTCDA contributes to enhancing the efficiency by promoting interfacial electron transfer and eliminating the subconducting band trap sites.

关键词： Flexible organic photovoltaic device Oligothiophene derivative

Role of interventional therapy in hepatic artery stenosis and non-anastomosis bile duct stricture after orthotopic liver transplantation

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World Journal of Gastroenterology 2007年第22期13卷 3128-3132页

作者： Da-Bing Zhao Hong Shan Zai-Bo Jiang ming-sheng huang Kang-Shun Zhu Gui-Hua Chen Xiao-Chun Meng Shou-Hai Guan Zheng-Ran Li Jie-sheng Qian The Third-Affiliated Hospital Sun Yat-sen University Guangzhou 510630 Guangdong Province China The Xiangfan First Hospital Jiefang road 75 Faneheng District Xiangfan 441000 Hubei Province China

AIM： To analyze the clinical manifestations and the effectiveness of therapy in patients with orthotopic liver bansplantation （OLT）-associated hepatic artery stenosis （HAS） and non-anastomosis bile duct stricture.METHODS： Nine cases were diagnosed as HAS and non-anastomosis bile duct stricture. Percutaneous transluminal angioplasty （PTA） was performed in four HAS cases, and expectant treatment in other five HAS cases, percutaneous transhepatic bile drainage, balloon dilation, stent placement were performed in all nine cases.RESULTS： Diffuse intra- and extra-bile duct stricture was observed in nine cases, which was associated with bile mud siltation and biliary infection. Obstruction of the bile duct was improved obviously or removed. Life span/ follow-up period was 13-30 mo after PTA of four HAS cases, 6-23 mo without PTA of other five cases.CONCLUSION： Progressive, non-anastomosis, and diffuse bile duct stricture are the characteristic manifestations of HAS and non-anastomosis bile duct stricture after OLT. These are often associated with bile mud siltation, biliary infection, and ultimate liver failure. Interventional therapy is significantly beneficial.

关键词： Liver transplantation Bile duct Postoperative complication Stricture Interventional therapy

Universal and efficient hybrid modeling and direct slicing method for additive manufacturing processes

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Advances in Manufacturing 2024年第2期12卷 300-316页

作者： Sen-Lin Wang Li-Chao Zhang Chao Cai ming-Kai Tang Si Chen Jiang huang Yu-sheng Shi State Key Laboratory of Materials Processing and Die and Mould Technology Huazhong University of Science and TechnologyWuhan430074People’s Republic of China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan430081People’s Republic of China

Model design and slicing contour generation in additive manufacturing(AM)data processing face challenges in terms of efficiency and scalability when stereolithography files generated by complex functionally graded structures have millions of *** paper proposes a hybrid modeling and direct slicing method for AM to efficiently construct and handle complex three-dimensional(3D)*** 3D solids,including conformal multigradient structures,were uniformly described using a small amount of data via signed distance *** hybrid representations were quickly discretized into numerous disordered directed lines using an improved marching squares *** establishing a directional HashMap to construct the topological relationship between lines,a connecting algorithm with linear time complexity is proposed to generate slicing contours for *** method replaces the mesh reconstruction and Boolean operation stages and can efficiently construct complex conformal gradient models of arbitrary topologies through hybrid ***,the time and memory consumption of direct slicing are much lower than those of previous methods when handling hybrid models with hundreds of millions of faces after mesh reconstruction.

关键词： Additive manufacturing(AM) Hybrid modeling Direct slicing Signed distance field

Intra-thyroid esophageal duplication cyst:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2231-2236页

作者： Hong-Guo Lin ming Liu Xue-Yang huang Da-sheng Liu Department of Vascular Thyroid Surgery The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Esophageal cysts are relatively rare in clinical practice,with most of the literature comprising case *** cysts protruding into the thyroid gland are easily misdiagnosed as thyroid *** such cases have been reported so *** SUMMARY This article reports the case of a 31-year-old adult male diagnosed with thyroid nodules before *** patient underwent left thyroidectomy and *** the surgery,esophageal cysts were identified in the esophageal muscle and thyroid *** pathology results confirmed a nodular goiter combined with esophageal ***,the patient developed a neck infection and underwent another operation and broad-spectrum antibiotic treatment for *** We report the first clinical case of an esophageal cyst located within the thyroid gland that was successfully treated *** cyst located within the thyroid gland cause difficulties in *** the present study,the contents of the esophageal cysts were calcified foci,and a small amount of fluid mixture,which were easily misdiagnosed as thyroid nodules and misled the surgical methods.

关键词： Esophageal cysts Thyroid Diagnosed Surgery Case report

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World Journal of Gastroenterology 2023年第20期29卷 3168-3184页

作者： Jia-Lin Wu Jun-Yang Luo Zai-Bo Jiang Si-Bo huang Ge-Run Chen Hui-Ying Ran Qi-Yue Liang ming-sheng huang Li-Sha Lai Jun-Wei Chen Department of Interventional Radiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina The First Clinical Medical College Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Radiology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510010Guangdong ProvinceChina

BACKGROUND The efficacy of conversion therapy for patients with unresectable hepatocellular carcinoma(HCC)is a common clinical *** To analyse the prognostic factors of overall survival(OS)in patients with unresectable HCC who received conversion *** One hundred and fifty patients who met the inclusion criteria were enrolled and divided into a training cohort(n=120)and a validation cohort(n=30).Using the independent risk factors in the training cohort,a nomogram model was constructed to predict OS for patients treated with transarterial chemoembolization following hepatic *** nomogram was internally validated with the bootstrapping *** predictive performance of nomogram was assessed by Harrell’s concordance index(C-index),calibration plot and timedependent receiver operating characteristic curves and compared with six other conventional HCC staging *** Multivariate Cox analysis identified that albumin,blood urea nitrogen,gamma-glutamyl transpeptidase to platelet ratio,platelet to lymphocyte ratio,macrovascular invasion and tumour number were the six independent prognostic factors correlated with OS in nomogram *** C-index in the training cohort and validation cohort were 0.752 and 0.807 for predicting OS,which were higher than those of the six conventional HCC staging systems(0.563 to 0.715 for the training cohort and 0.458 to 0.571 for the validation cohort).The calibration plots showed good consistency between the nomogram prediction of OS and the actual observations of *** curve analyses indicated satisfactory clinical *** a total nomogram score of 196,patients were accurately classified into low-risk and high-risk ***,we have deployed the model into online calculators that can be accessed for free at https://***/DynNomapp/.CONCLUSION The nomogram achieved optimal individualized prognostication of OS in HCC patients who received conversion ther

关键词： Hepatocellular carcinoma Conversion therapy Nomogram Inflammation Transarterial chemoembolization

Influences of shale microstructure on mechanical properties and bedding fractures distribution

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Petroleum Science 2024年第3期21卷 1944-1954页

作者： ming-Zhe Gu Mao sheng Shi-Zhong Cheng Fan-Hao Gong Gen-sheng Li State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing2249China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Shenyang Center of China Geological Survey ShenyangLiaoning110034China

The difference in microstructure leads to the diversity of shale mechanical properties and bedding fractures distribution *** this paper,the microstructure and mechanical properties of Longmaxi marine shale and Qingshankou continental shale were studied by X-ray diffractometer(XRD),field emission scanning electron microscope(FE-SEM)with mineral analysis system,and ***,the typical bedding layers area was properly stratified using Focused Ion Beam(FIB),and the effects of microstructure and mechanical properties on the distribution patterns of bedding fractures were *** results show that the Longmaxi marine shale sample contains more clay mineral grains,while the Qingshankou continental shale sample contains more hard brittle mineral grains such as *** Longmaxi marine shale sample,hard brittle minerals with grain sizes larger than 20μm is18.24%and those with grain sizes smaller than 20μm is 16.22%.For Qingshankou continental shale sample,hard brittle minerals with grain sizes larger than 20μm is 40.7%and those with grain sizes smaller than 20μm is 11.82%.In comparison to the Qingshankou continental shale sample,the Longmaxi marine shale sample has a lower modulus,hardness,and *** shales are formed by alternating coarse-grained and fine-grained layers during *** average single-layer thickness of Longmaxi marine shale sample is greater than Qingshankou continental shale *** two types of shale have similar bedding fractures distribution patterns and fractures tend to occur in the transition zone from coarse-grained to fine-grained *** orientation of the fracture is usually parallel to the bedding plane and detour occurs in the presence of hard brittle *** fracture distribution density of the Longmaxi marine shale sample is lower than that of the Qingshankou continental shale sample due to the strong heterogeneity of the Qingshankou continental *** current resea

关键词： Shale Nanoindentation Microstructure Mechanical property Fracture