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A Chinese patient with relapsed and refractory Hodgkin lymphoma treated with brentuximab vedotin

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Chinese Journal of Cancer 2013年第9期32卷 520-523页

作者： Zhi-Gang Cao Hong-Wei Zhou Chao-Jin Peng Mo Liu Yu Du qing-ming yang Department of Hematology and Oncology the First Affiliated Hospital of the People's Liberation Army General Hospital

At present,approximately 20%of Hodgkin lymphomas(HL)are relapsed and refractory,and therapeutic methods including chemotherapy,radiotherapy,and even stem cell transplantation are *** vedotin,composed of CD30 antibody and a chemotherapeutic agent,is a new targeted drug that eradicates tumor cells by binding to the CD30 antigen on their *** clinical trials,the response rate and complete remission rate of this drug were 73%and 40%,respectively,for relapsed and refractory *** we report a case of CD30-positive relapsed and refractory HL that was treated with *** the treatment with brentuximab,the patient underwent chemotherapy,radiotherapy,and autologous stem cell ***,the disease continued to progress,affecting multiple organs and prompting symptoms such as persistent *** the treatment with brentuximab,the patient′s condition *** temperature returned to normal after 4 *** nodules were reduced in size and number after a single course of treatment,and PET/CT showed partial remission and complete remission after 3 and 6 courses of treatment,*** entire treatment process progressed smoothly,though the patient experienced some symptoms due to chemotherapy,including peripheral neuritis of the limbs,irritating dry cough,and mild increase in *** serious adverse effects were *** current general condition of the patient is good;the continuous complete remission has amounted to 6 months.

关键词：淋巴瘤治疗复发患者造血干细胞移植中国金靶向药物

Long-term safety and efficacy of CART-20 cells in patients with refractory or relapsed B-cell non-Hodgkin lymphoma:5-years follow-up results of the phase I and IIa trials

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Signal Transduction and Targeted Therapy 2017年第1期2卷 85-88页

作者： Wen-ying Zhang yang Liu Yao Wang Chun-meng Wang qing-ming yang Hong-li Zhu Wei-dong Han Biotherapeutic Department Chinese PLA General HospitalBeijingChina Department of Geriatric Hematology Chinese PLA General HospitalBeijingChina Department of Immunology Institute of Basic MedicineSchool of Life SciencesChinese PLA General HospitalBeijingChina

For refractory or relapsed(r/r)B-cell non-Hodgkin lymphoma(NHL),the response rates to conventional salvage chemotherapy are 27–44%.1 Chimeric antigen receptors(CARs)efficiently redirect T-cell specificity and cytotoxicity to cells expressing the targeted Ag in an HLA-independent manner.2 The early phase clinical trials of CART cells for(r/r)B-cell NHL have demonstrated promising results..

关键词： lymphoma specificity chemotherapy

Research on in-situ condition preserved coring and testing systems

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Petroleum Science 2021年第6期18卷 1840-1859页

作者： He-Ping Xie Tao Liu ming-Zhong Gao Ling Chen Hong-Wei Zhou yang Ju Feng Gao Xiao-Bo Peng Xiong-Jun Li Rui-Dong Peng Ya-Nan Gao Cong Li Zhi-Qiang He ming-qing yang Zhi-Yu Zhao Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060GuangdongChina Shenzhen Key Laboratory of Deep Underground Engineering Sciences and Green Energy Shenzhen UniversityShenzhen518060GuangdongChina MOE Key Laboratory of Deep Earth Science and Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065SichuanChina School of Mechanical Engineering Sichuan UniversityChengdu610065SichuanChina Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu610065SichuanChina State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology(Beijing)Beijing100083China Frontier Science Research Center for Fluidized Mining of Deep Underground Resources China University of Mining and TechnologyXuzhou221116JiangsuChina

As shallow resources are increasingly depleted,the mechanics'theory and testing technology of deep insitu rock has become *** coring technologies obtain rock samples without retaining the in-situ environmental conditions,leading to distortion of the measured ***,a coring and testing systems retaining in-situ geological conditions is presented:the coring system that obtains in-situ rock samples,and the transfer and testing system that stores and analyzes the rocks under a reconstructed *** ICP-Coring system mainly consists of the pressure controller,active insulated core reactor and insulation layer and sealing *** ultimate bearing strength of 100 MPa for pressurepreservation,temperature control accuracy of 0.97%for temperature-retained are ***_(4)and CO permeability of the optimized sealing film are as low as 3.85 and 0.33 ppm/*** average tensile elongation of the film is 152.4%and the light transmittance is reduced to 0%.Additionally,the pressure and steady-state temperature accuracy for reconstructing the in-situ environment of transfer and storage system up to 1%and±0.2 is *** error recorded of the noncontact sensor ring made of lowdensity polymer is less than 6%than that of the contact *** system can provide technical support for the deep in-situ rock mechanics research,improving deep resource acquisition capabilities and further clarifying deep-earth processes.

关键词： Deep mining In-situ environmental conditions In-situ condition preserved coring and testing In-situ transfer Deep-earth processes ICP-Coring In-situ condition-preserved coring

Alternatives to albumin administration in hepatocellular carcinoma patients undergoing hepatectomy： an open, randomized clinical trial of efficacy and safety

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Chinese Medical Journal 2011年第10期124卷 1458-1464页

作者： yang Jian WANG Wen-tao YAN Lü-nan XU ming-qing yang Jia-yin Division of Liver-Transplantation West China Hospital West China Medical School of Sichuan University Chengdu Sichuan 610041 China

Background The value of artificial colloids in treating patients with liver disease is controversial. The effects of intravascular volume replacement regimens on liver function secondary to alteration of the postoperative inflammatory response are not known. In this study, we evaluated the effects of different volume replacement regimens in hepatocellular carcinoma patients undergoing hepatectomy to clarify whether albumin administration can be replaced by other volume replacement *** Ninety consecutive hepatocellular carcinoma patients scheduled for hepatectomy were prospectively randomized to receive 20% human albumin （HA）, 6% hydroxyethyl starch （HES） or lactated Ringer＇s solution （LR） for postoperative volume replacement. Hemodynamic, liver function and inflammatory response parameters were recorded on postoperative days one, three, and five throughout the investigation *** Significantly less volume was required in the HA and the HES groups. Although patients in all groups had similar baseline values, the plasma osmolality was significantly higher in the HA and HES groups. Total bilirubin （TB）, alanine aminotransferase （ALT）, and aspartate aminotransferase （AST） increased from baseline in all groups, and did not differ significantly between groups. C-reactive protein （CRP） was significantly lower in the HES group compared with the other *** In hepatocellular carcinoma patients undergoing hepatectomy, HA can be replaced by HES or LR in well selected patients. Hemodynamic stability, liver function, and postoperative clinical outcomes could be equivalently achieved in the HES group; also, HES may exert more favorable effects on the acute phase response. （Registered in the Chinese Clinical Trial Registry, ChiCTR-TRC-10000790）

关键词： artificial colloids hepatectomy hepatocellular carcinoma inflammatory response volume replacement

Novel Efficient De-blocking Method for Highly Compressed Images

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Semiconductor Photonics and Technology 2007年第2期13卷 122-125,145页

作者： SHI Min YI qing-ming yang Liang Department of Electronic Engineering Jinan University Guangzhou 510632 CHN

Due to coarse quantization, block-based discrete cosine transform(BDCT) compression methods usually suffer from visible blocking artifacts at the block boundaries. A novel efficient de-blocking method in DCT domain is proposed. A specific criterion for edge detection is given, one-dimensional DCT is applied on each row of the adjacent blocks and the shifted block in smooth region, and the transform coefficients of the shifted block are modified by weighting the average of three coefficients of the block. Mean square difference of slope criterion is used to judge the efficiency of the proposed algorithm. Simulation results show that the new method not only obtains satisfactory image quality, but also maintains high frequency information.

关键词： block-based discrete cosine transform(BDCT) blocking artifacts image compression

Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma:an early phase IIa trial report

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Signal Transduction and Targeted Therapy 2016年第1期1卷 131-139页

作者： Wen-ying Zhang Yao Wang Ye-lei Guo Han-ren Dai qing-ming yang Ya-jing Zhang Yan Zhang Mei-xia Chen Chun-meng Wang Kai-chao Feng Su-xia Li yang Liu Feng-xia Shi Can Luo Wei-dong Han Biotherapeutic Department Chinese PLA General HospitalBeijingChina Department of Immunology Institute of Basic MedicineSchool of Life SciencesChinese PLA General HospitalBeijingChina Department of Geriatric Hematology Chinese PLA General HospitalBeijingChina

Patients with relapsed or refractory non-Hodgkin lymphoma have a dismal *** Antigen Receptor(CAR)-modified T cells(CART cells)that targeted CD20 were effective in a phase I clinical trial for patients with advanced B-cell *** performed a phase IIa trial to further assess the safety and efficacy of administering autologous anti-CD20 CART(CART-20)cells to patients with refractory or relapsed CD20^(+)B-cell *** patients were enrolled,and seven patients underwent cytoreductive chemotherapy to debulk the tumors and deplete the lymphocytes before receiving T-cell *** overall objective response rate was 9 of 11(81.8%),with 6 complete remissions(CRs)and 3 partial remissions;no severe toxicity was *** median progression-free survival lasted for 46 months,and 1 patient had a 27-month continuous CR.A significant inverse correlation between the levels of the CAR gene and disease recurrence or progression was ***,the lesions in special sites,specifically the spleen and testicle,were refractory to CART-20 ***,these results together with our data from phase I strongly demonstrated the feasibility and efficacy of CART-20 treatment in lymphomas and suggest large-scale patient recruitment in a future *** study was registered at *** as NCT01735604.

关键词： patients lymphoma Antigen

An Interoperable System in the Loosely Coupled DL Environment

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An Interoperable System in the Loosely Coupled DL Environmen...

具有功能反应的食物链时滞系统的持久性和稳定性

第二十届全国数据库学术会议

作者： Shu-An Wang ming Zhang Dong-qing yang (Institute of Network and Information System,School of EE&CS,Peking University,Beijing 100871)

The interoperability problem of digital libraries(DL)mainly lies in metadata and *** this paper, we present the design and implementation of our interoperable system prototype in the loosely coupled environment. This prototype is based on the framework of the OAI-PMH and Web *** our work,we adopt both the mature ORDBMS products-Oracle & SQL Server,and the promising techniques,such as XML,SOAP and Java. All of our work puts forward the attempt for similar future work.

关键词： Digital library Interoperability OAI-PMH Web services

来源： cnki会议评论

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四川大学学报（自然科学版） 2002年第4期39卷 639-643页

作者：苟清明杨季冬涪陵师范学院数学系重庆涪陵408003

研究了具有HollingⅡ类功能反应的食物链时滞系统。

关键词：功能反应食物链时滞系统 Holling Ⅱ类功能反应持久性全局稳定性生态数学模型

Outcomes of adult-to-adult living donor liver transplantation： a single center experience

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Chinese Medical Journal 2009年第7期122卷 781-786页

作者： FENG Xi YUAN Ding WEI Yong-gang LI Fu-qiang WEN Tian-fu ZENG Yong ZHAO Ji-chun WANG Wen-tao XU ming-qing yang Jia-yin MA Yu-kui CHEN Zhe-yu YE Hui YAN Lti-nan LI Bo Center of Liver Transplantation West China Hospital SichuanUniversity Chengdu Sichuan 610041 China

Background Since January 2002, adult-to-adult living donor liver transplantation （AALDLT） has gained increasing popularity in China in response to the shortage of cadaveric donor livers. This study presents a detailed analysis of the outcomes of AALDLT in a single center. Methods A total of 70 patients underwent AALDLT at our center between January 2002 and January 2007. Among these, 67 patients received a right lobe graft without the middle hepatic vein and 3 patients received dual grafts. Three-dimensional volumetric computed tomography, magnetic resonance imaging with angiography and cholangiography were performed preoperatively. Recipient operation time, intraoperative transfusion requirement, length of intensive care unit stay, length of hospital stay, liver function tests, coagulation tests and surgical outcomes were routinely investigated throughout this study. Results All donors survived the procedure with an overall complication rate of 15.3%. Overall recipient 1-year survival and complication rates were 87.1% and 34.2%, respectively. Among the 70 cases, average graft recipient weight ratio was 0.94% （0.72%-1.43%） and average graft volume/standard liver volume ratio was 46.42% （31.74%-71.68%）. All residual liver volumes exceeded 35%. Liver function and coagulation recovered rapidly within the first 7 days after transplantation. Conclusions AALDLT is a safe procedure for the donors and an effective therapy for patients with end-stage liver disease. Patient selection and timely decision-making for transplantation are essential in achieving good outcomes. With accumulation of experience in surgery and clinical management, timely feedback and proper modification, we foresee better outcomes in the future.

关键词： adult living donors liver transplantation survival rate postoperative complications