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Clinical benefit of COX-2 inhibitors in the adjuvant chemotherapy of advanced non-small cell lung cancer: A systematic review and metaanalysis

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World Journal of Clinical Cases 2021年第3期9卷 581-601页

作者： Yu-Qiong Xu Xiang Long ming Han ming-qiang huang Jia-Fa Lu Xue-Dong Sun Wei Han Department of Emergency Medicine Shenzhen University General HospitalShenzhen University Clinical Medical AcademyShenzhen 518000Guangdong ProvinceChina Department of Respiratory and Critical Care Medicine Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND Lung cancer is a major cause of death among patients,and non-small cell lung cancer(NSCLC)accounts for more than 80%of all lung cancers in many *** To evaluate the clinical benefit(CB)of COX-2 inhibitors in patients with advanced NSCLC using systematic *** We searched the six electronic databases up until December 9,2019 for studies that examined the efficacy and safety of the addition of COX-2 inhibitors to chemotherapy for *** survival(OS),progression free survival(PFS),1-year survival rate(SR),overall response rate(ORR),CB,complete response(CR),partial response(PR),stable disease(SD),and toxicities were measured with more than one outcome as their *** and random effects models were used to calculate risk estimates in a *** publication bias was calculated using Egger’s linear regression *** analysis was performed using R *** The COX-2 inhibitors combined with chemotherapy were not found to be more effective than chemotherapy alone in OS,progression free survival,1-year SR,CB,CR,and ***,there was a difference in overall response rate for patients with advanced *** a subgroup analysis,significantly increased ORR results were found for celecoxib,rofecoxib,first-line treatment,and *** adverse events,the increase in COX-2 inhibitor was positively correlated with the increase in grade 3 and 4 toxicity of leukopenia,thrombocytopenia,and cardiovascular *** COX-2 inhibitor combined with chemotherapy increased the total effective rate of advanced NSCLC with the possible increased risk of blood toxicity and cardiovascular events and had no effect on survival index.

关键词： Non-small cell lung cancer COX-2 Survival Progression free survival Systematic review Randomized controlled trials

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Theoretical Studies on the Kinetics and Mechanisms of Reactions for Methyl Vinyl Ether and Ozone

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Chinese Journal of Chemical Physics 2008年第4期21卷 324-332页

作者： Bo Long ming-qiang huang Zhen-ya Wang Wei-jun Zhang Laboratory of Environment Spectroscopy Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences. Hefei 230031 China School of Physics and Information Science Guizhou University for Nationalities Guiyang 550025 China

The interconversion between the two distinct isomers of methyl vinyl ether （MVE）, the formation of the primary ozonides from O3-initated reactions of MVE, the transformation between the primary ozonides, and the subsequent fragmentation were studied using quantum chemical methods at the BHandHLYP/6311＋＋G（d,p） level of theory for optimized geometries and frequency calculations and at the QCISD/631G（d,p） level for the single point energy calculations. The rate coefficients were calculated for the temperature range 280-440 K by using the canonical transition state theory （TST）. For ozone addition to MVE, there are two different possibilities discussed on the basis of two different possible orientations for ozone attack. The results of the theoretical study indicate that although the synperiplanar-MVE is 7.11 kJ/mol more stable than the antiperiplanar-MVE, the antiperiplanar-MVE plays a more important role in formation of the primary ozonides because the primary ozonides formed from the ozone addition antiperiplanar-MVE are more stable and the energy barriers corresponding to transition states are lower. The intereonversion between the primary ozonides formed from the ozone addition to antiperiplanar-MVE is the most accessible compared with the transformations between other primary ozonides. The cleavage of the primary ozonides mainly leads to the formation of the CH2OO, which is in agreement with the experimental estimates. The calculated overall rate constant for the ozone-initiated reactions is 4.8× 10^-17 cm^3/（molecule.s） at 298.15 K, which agrees with the experimental value for ethyl vinyl ether.

关键词： Methyl vinyl ether Ozone Reaction pathway Primary ozonide Interconversion Rate constant Transition state theory

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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： qiang Liu Xiang Li Shen Du ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian NIE Wei huang Jin ZHU Ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

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Efficient photocatalytic H2 evolution over tubular mesoporous carbon nitride with N-vacancy by microwave-assisted synthesis

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Science China Chemistry 2025年

作者： Yuanlong Pan qiang Zhang Guangzheng huang Yannan Luo Honglin Gao School of Materials and Energy National Center for International Research on Photoelectric and Energy MaterialsYunnan University

Modifying the microstructure of photocatalysts while simultaneously introducing vacancies has shown significant potential in enhancing their performance for hydrogen production. Herein, a novel tubular mesoporous carbon nitride（TMCN） with nitrogen vacancies was fabricated using a microwave-assisted synthesis strategy, employing melamine-cyanuric acid supramolecular（MC-S） as the precursor. The optimized TMCN exhibited an outstanding H2production rate, approximately 29 times higher than that of pristine g-C3N4. The N-vacancies serve as sites for reactant adsorption and activation, leading to enhanced delocalization of HOMO-LUMO. Furthermore, the porous structures of TMCN facilitate the reactant diffusion, while its tubular architectures promote the oriented transfer of charge carriers. Crucially, the markedly improved photocatalytic performance of TMCN can be predominantly attributed to the synergistic effects arising from its superior structure and N-vacancy defects. This work opens new possibilities for the simultaneous formation of surface defect states as photocatalytic reaction sites and distinctive structures conducive to charge carrier transport.

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Apoptosis of rat hepatic stellate cells induced by anti-focal adhesion kinase antibody

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World Journal of Gastroenterology 2002年第4期8卷 734-738页

作者： Xiao-Jing Liu Ou qiang ming-Hui huang Laboratory of Department of Internal Medicine,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Li Yang Yi-Ping Wang Department of Gastroenterology of West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Hong-Bin Wu Laboratory of Department of Surgery,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Laboratory of Department of Internal Medicine West China Hospital Sichuan University 37 Wainan Guoxueshang Chengdu 610041 Sichuan Province China. xiaojingliu67@***

AIM: To explore the role of focal adhesion kinase (FAI)in the apoptosis in culture-activated rat hepatic stellatecells (HSCs) using a specific anti-FAK ***: Rat HSCs were prepared from Wistar rats byin situ perfusion of collagenase and pronase and single-step density Nycodenze gradient. Culture-activatedHSCs were serum-starved and treated with the anti-FAK antibodies for 24, 48 or 72 h. The apoptosis of HSCwas detected by DNA-fragment assay, flow cytometryand caspase-3 activity determination. The expressionof tissue inhibitor of metalloproteinase-1 (TIMP-1)mRNA was assessed by reverse transcriptionpolymerase chain reaction (RT-PCR).RESULTS: The experiment showed that anti-FAKantibodies induced apoptosis of culture-activated ratHSCs. This phenomenon displayed the classical featuresof apoptotic cell death (DNA fragmentation, cell cycleanalysis) after treated with 30 mg@L-1 FAK antibody for72 h, and accompanied by a significant increase ofcespase-3 activity(1208±76) vs (309±28) nmol@min-1@ g-1, t=-208.5, P＜0.05. Meanwhile, treatment with theFAK antibody in HSCs could markedly decrease theTIMP-1 mRNA expression (0.07±0.01 vs 0.38±0.03, t=2.72, P＜0.05).CONCLUSION: FAK plays an important role in the survivalof HSCs and the specific anti-FAK antibody could inducethe apoptosis in rat HSCs.

关键词：粘着斑激酶抗体肝脏星形细胞动物实验细胞凋亡

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-qiang Jiao ming Li Xi Chen Mei-Ze Xu Tian Ding Xiao-Ping Gong Zhuo-Mei Li Xue-Yuan Liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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Structural and functional units in p-type transparent conducting compounds

Structural and functional units in p-type transparent conduc...

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中国化学会第五届全国结构化学学术会议

作者： Min-Ling Liu Yao-ming Wang Fu-qiang huang~* Li-Dong Chen State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,P.R.China,

＜正＞The structure-property relationship of p-type transparent conductin8 compounds has been systematically *** have found that all the p-type transparent conducting materials contain the p-type conducting structural...

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食叶草蛋白的提取工艺及其性质研究

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食品与发酵工业 2025年第1期51卷 189-198页

作者：高思聪黄文选黄志超缪铭江南大学食品学院江苏无锡214122 秦皇岛森源投资集团有限公司河北秦皇岛066199

食叶草是一种潜在的优质植物蛋白质来源,该研究旨在优化食叶草蛋白的提取工艺,实现食叶草的高值化利用。本研究采用乙醇预处理结合碱溶酸沉法提取食叶草蛋白,并采用响应面试验对提取工艺进行优化。优化后的最佳工艺条件为:碱溶温度81.12... 详细信息

食叶草是一种潜在的优质植物蛋白质来源,该研究旨在优化食叶草蛋白的提取工艺,实现食叶草的高值化利用。本研究采用乙醇预处理结合碱溶酸沉法提取食叶草蛋白,并采用响应面试验对提取工艺进行优化。优化后的最佳工艺条件为:碱溶温度81.12℃,加碱量10.57 g/L,料液比1∶34.04(g∶mL),pH 3.5。在此条件下,食叶草蛋白得率为(63.26±1.01)%,纯度为(81.63±2.35)%。对食叶草蛋白结构特征进行分析,圆二色谱结果显示食叶草蛋白的α-螺旋和无规卷曲含量较高,分别为36.1%和52.5%,这可能表明其表面疏水性较高;荧光光谱显示食叶草蛋白在345 nm出现最大荧光吸收峰,表明其色氨酸残基微环境非极性较强;扫描电镜结果显示食叶草蛋白较为聚集,呈堆积状。通过考察食叶草蛋白的功能性质,发现其在碱性条件下具有良好的溶解性和乳化性,但起泡性较差。该研究将为食叶草蛋白在后续食品工业生产中的应用提供数据支撑。

关键词：食叶草叶蛋白提取工艺结构特征功能性质

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