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Lipid-lowering effects of gefarnate in statin-treated patients with residual hypertriglyceridemia:a randomized controlled study

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Journal of Geriatric Cardiology 2024年第8期21卷 791-798页

作者： Jing SHI ming-lu xu Mei-Jiao HE Wan-Lan BO Hai-Yu ZHANG Dang-Hui SUN Ding-Yu WANG Xiao-Yu WANG Qun SHAO Yu-Jiao PAN Yu ZHANG Chen-Guang DAI Jing-Ying WANG Lin-Wei ZHANG Guang-Zhong LIU Yue LI for the GPROT Study Group Department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbinChina Department of Gastroenterology the Fourth Affiliated HospitalHarbin Medical UniversityHarbinChina Department of Cardiology Harbin Medical University Cancer HospitalHarbinChina Department of Cardiology Shenzhen People’s HospitalShenzhenChina National Key Laboratory of Frigid Zone Cardiovascular Diseases Harbin Medical UniversityHarbinChina NHC Key Laboratory of Cell Transplantation Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang ProvinceHeilongjiang Province Clinical Medical Research Center for Hypertensionthe First Affiliated HospitalHarbin Medical UniversityHarbinChina Institute of Metabolic Disease Heilongjiang Academy of Medical ScienceHarbinChina 不详

BACKGROUND The prevention of coronary artery disease(CAD)faces dual challenges:the aspirin-induced gastrointestinal injury,and the residual cardiovascular risk after statin *** acetate(Gefarnate)is an anti-ulcer *** was reported that geraniol might participate in lipid metabolism through a variety of *** aim of this study was to assess the lipid-lowering effects of gefarnate in statin-treated CAD patients with residual *** In this prospective,open-label,randomized,controlled trial,69 statin-treated CAD patients with residual hypertriglyceridemia were randomly assigned to gefarnate group and control group,received gefarnate(100 mg/3 times a day)combined with statin and statin alone,*** baseline and after one-month treatment,the levels of plasma triglyceride,high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and total cholesterol were *** After one-month gefarnate treatment,triglyceride level was significantly lowered from 2.64 mmol/L to 2.12 mmol/L(P=0.0018),LDL-C level lowered from 2.7 mmol/L to 2.37 mmol/L(P=0.0004),HDL-C level increased from 0.97 mmol/L to 1.17mmol/L(P=0.0228).Based on statin therapy,gefarnate could significantly reduce the plasma triglyceride level(P=0.0148)and increase the plasma HDL-C level(P=0.0307).Although the LDL-C and total cholesterol levels tended to decrease,there was no statistically significant *** The addition of gefarnate to statin reduced triglyceride level and increased HDL-C level to a significant extent compared to statin alone in CAD patients with residual *** suggested that gefarnate might provide the dual benefits of preventing gastrointestinal injury and lipid lowering in CAD patients.

关键词： nat alone Lipid

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Facile synthesis of 9-(N-amino-4-fluoromethyl-3-pyrrolidinyl)-2-fluoro-6-aminopurine from trans-4-hydroxy-L-proline

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Chinese Chemical Letters 2007年第11期18卷 1313-1315页

作者： Ye Qing Li ming lu Chun xu lu Sai Jian Zhu Qi Fa Liu Chemical Engineering College Nanjing University of Science and Technology Nanjing 210094 PR China

A novel and simple procedure for synthesis of azanucleoside by Mitsunobu reaction between N-（p-nitrobenzyloxycarbonyl）- trans-4-hydroxy-D-proline methyl ester obtained from trans-4-hydroxy-L-proline after six-step reaction and 2-fluoro-6-azidopurine is described, and azanucleoside is fluorinated by new fluridizer 2,2-difluoro-1,3-dimethylimidazolidine （DFI）. All reactions could be carried out under mild condition.

关键词： trans-4-Hydroxy-D-proline 2-Fluoro-6-azidopurine Fluoride azanucleosides Mitsunobu reaction DFI

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Zinc finger protein A20 protects rats against chronic liver allograft dysfunction

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World Journal of Gastroenterology 2012年第27期18卷 3537-3550页

作者： Jie Yang ming-Qing xu lu-Nan Yan Xiao-Bo Chen Jiao Liu Department of Liver and Vascular Surgery Liver Transplanta-tion Center West China Hospital Sichuan University Chengdu610041 Sichuan Province China

AIM： To investigate the effect of zinc finger protein A20 on chronic liver allograft dysfunction in rats. METHODS： AIIogeneic liver transplantation from DA rats to Lewis rats was performed. Chronic liver allograft dysfunction was induced in the rats by administering low-dose tacrolimus at postoperative day （POD） 5. Hepatic overexpression of A20 was achieved by recom- binant adenovirus （rAd.）-mediated gene transfer ad- ministered intravenously every 10 d starting from POD 10. The recipient rats were injected with physiologi- cal saline, rAdEasy-A20 （1 × 109 pfu/30 g weight） or rAdEasy （1 × 109 pfu/30 g weight） every 10 d through the tail vein for 3 mo starting from POD 10. Liver tissue samples were harvested on POD 30 and POD 60. RESULTS： Liver-transplanted rats treated with only tacrolimus showed chronic allograft dysfunction with severe hepatic fibrosis. A20 overexpression ameliorated the effects on liver function, attenuated liver allograft fibrosis and prolonged the survival of the recipient rats. Treatment with A20 suppressed hepatic protein pro- duction of tumor growth factor （TGF）-β1, interleukin- 113, caspase-8, CD40, CD40L, intercellular adhesion molecule-i, vascular cell adhesion molecule-1 and E-selectin. A20 treatment suppressed liver cell apopto- sis and inhibited nuclear factor-KB activation of Kupffer cells （KCs）, liver sinusoidal endothelial cells （LSECs） and hepatic stellate cells （HSCs）, and it subsequently decreased cytokine mRNA expression in KCs and LSECs and reduced the production of TGF-β1 in HSCs. CONCluSION： A20 might prevent chronic liver allogra- ft dysfunction by re-establishing functional homeostasis of KCs, LSECs and HSCs.

关键词： Chronic allograft dysfunction Liver trans-plantation Zinc finger protein A20 Rat

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Experimental realization of deterministic joint remote preparation of an arbitrary two-qubit pure state via GHZ states

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Science China(Information Sciences) 2024年第3期67卷 317-318页

作者： Nachuan LI lu xu Jin-ming LIU State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal University Hefei Origin Quantum Computing Technology Co. Ltd.

Quantum teleportation(QT) [1] enables secure transfer of an unknown quantum state between remote locations without physically transmitting the initial state. Unlike QT,with the sender possessing complete knowledge of the initial state, remote state preparation(RSP) [2] exhibits a tradeoff between the amount of the entanglement resource used and the classical communication cost.

关键词： Quantum communication

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Synthesis,Style Editing,and Animation of 3D Cartoon Face

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Tsinghua Science and Technology 2024年第2期29卷 506-516页

作者： ming Guo Feng xu Shunfei Wang Zhibo Wang ming lu Xiufen Cui Xiao Ling School of Software and BNRist Tsinghua UniversityBeijing 100084China Department of Multimedia and Smart Guangdong OPPO Mobile Telecommunications Corp.Ltd.Dongguan 523860China Intel Labs IntelBeijing 100089China

As a popular kind of stylized face,cartoon faces have rich application *** is challenging to create personalized 3D cartoon faces directly from 2D real ***,in order to adapt to more application scenarios,automatic style editing,and animation of cartoon faces is also a crucial problem that is urgently needed to be solved in the industry,but has not yet had a perfect *** solve this problem,we first propose“3D face cartoonizer”,which can generate high-quality 3D cartoon faces with texture when fed into 2D facial *** contribute the first 3D cartoon face hybrid dataset and a new training strategy which first pretrains our network with low-quality triplets in a reconstruction-then-generation manner,and then finetunes it with high-quality triplets in an adversarial manner to fully leverage the hybrid ***,we implement style editing for 3D cartoon faces based on k-means,which can be easily achieved without retrain the neural *** addition,we propose a new cartoon faces'blendshape generation method,and based on this,realize the expression animation of 3D cartoon faces,enabling more practical *** dataset and code will be released for future research.

关键词： cartoon 3D face animation computer graphics

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Structure regulating of metal clusters in carbonized metallic organic frameworks for high-efficient microwave absorption via tuning interaction strength between metals and ligands

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Nano Research 2024年第3期17卷 1699-1709页

作者： Chang Sun Kun-Yan Zhao ming-lu Huang Cheng-Long luo xu-Dong Chen ming Wang School of Chemistry and Chemical Engineering Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function ManufacturingSouthwest UniversityChongqing 400715China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Carbonized metallic organic frameworks(CMOF)have been attracting attention in microwave absorption(MA)research area because of their diverse structures,tunable compositions,and rich ***,structure regulation on metal clusters in CMOF is achieved by tuning the interaction strength between metals and ligands to enhance microwave absorption *** to relatively weak interaction among copper cations and ligands,copper nanoclusters(CuNC)can be uniformly formed and embedded within the cobalt/zinc(Co/Zn)***,copper cations are added to the Co/Zn bimetallic zeolitic imidazolate frameworks(ZIFs).Secondly,the CMOF composite particles with CuNCs(CuNCs/CoZn-CMOF)were developed by a pyrolysis *** CuNCs/CoZn-CMOF with an appropriate amount of CuNCs can harmonize both dielectric and magnetic *** a result,the minimum reflection loss(RLmin)reaches–45.1 dB at a matching thickness of 2.30 mm and the effective absorption bandwidth(EAB)is 8.80 GHz at a thickness of 3.10 *** broadband response to electromagnetic waves is attributed to interfacial polarization at CuNCs surface and heterogeneous interfaces,impedance matching and multiple scattering of electromagnetic *** study provides a feasible method to develop CMOF microwave absorption materials with high EAB values.

关键词： heterogeneous interface carbonized metallic organic frameworks microwave absorption interfacial polarization

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Strategic regulation of nitrogen-containing intermediates for enhanced nitrate reduction over Co_(3)O_(4)/SiC catalyst having multiple active centers

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Journal of Energy Chemistry 2024年第9期96卷 291-299页

作者： ming-Hao Guan Hao-Nan xu Jin Liu Tao Wu An-Hui lu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina

Regulating the intermediates involved in the electrocatalytic nitrate reduction reaction(NO_(3)RR)is crucial for the enhancement of reaction ***,it remains a great challenge to regulate the reaction intermediates through active site manipulation on the surface of the ***,a family of n%-Co_(3)O_(4)/SiC(n=5,8,12,20)catalysts with a delicate percentage of Co^(2+)and Co^(3+)were prepared for NO_(3)*** found that Co^(3+)primarily acts as the active site for NO_(3)^(−)reduction to NO_(2)^(−),while Co^(2+)is responsible for the conversion of NO_(2)^(−)to NH_(3).Moreover,the conversion of these intermediates over the active sites is autonomous and separately *** processes synergistically accomplish the reduction of nitrate ions to synthesize *** the experimental studies and density functional theory(DFT)calculations,it is discovered the pathway(^(*)NHO→^(*)NHOH→^(*)NH_(2)OH→^(*)NH_(2)→^(*)NH_(3))is more favorable due to the lowerΔG value(0.25 eV)for the rate-limiting step(^(*)NO→^(*)NHO).The NH_(3)yield rate of 8%-Co_(3)O_(4)/SiC reached 1.08 mmol/(cm^(2)h)with a Faradaic efficiency of 96.4%at−0.89 V versus the reversible hydrogen electrode(RHE),surpassing those of most reported non-noble NO_(3)RR *** strategy not only provides an efficient catalyst for NO_(3)RR but also serves as an illustrative model for the regulation of multi-step reaction intermediates through the design of distinct active sites,thereby presenting a new approach to enhance the efficiency of intricate reactions.

关键词： Electrocatalysis Nitratereduction Co_(3)O_(4)/SiC catalysts Intermediates control

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A review of ultra-high temperature heat-resistant energetic materials

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Defence Technology（防务技术） 2024年第8期38卷 33-57页

作者： Rongzheng Zhang Yuangang xu Feng Yang Pengcheng Wang Qiuhan Lin Hui Huang ming lu School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China

Heat-resistant energetic materials refer to a type of energetic materials that possess a high melting point,high stability and operational safety. By studying the structures of these energetic materials has showed that the thermal stability can be enhanced by introducing amino groups to form intra/inter-molecular hydrogen bonds, constructing conjugate systems and designing symmetrical structures. This article aims to review the physical and chemical properties of ultra-high temperature heat-resistant energetic compounds and provide valuable theoretical insights for the preparation of ultra-high temperature heatresistant energetic materials. We also analyze the selected 20 heat-resistant energetic materials with decomposition temperatures higher than 350℃, serving as templates for the synthesis of various highperformance heat-resistant energetic materials.

关键词： Heat-resistant energetic materials Organic synthesis Conjugated Hydrogen bond Symmetrical structure Stabilization

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Influence of erosion voids and traffic loads on buried large-diameter reinforced concrete pipes

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Underground Space 2024年第4期17卷 120-131页

作者： ming xu Dawei Shen Department of Civil Engineering Tsinghua UniversityBeijing 100084China Beijing Institute of Technology Beijing 100081China

Geotechnical centrifuge tests were conducted to examine the influence of invert voids and surface traffic loads on 1400 mm diameter reinforced concrete pipes buried with a shallow soil cover depth of 700 *** formation beneath the pipe was simulated during centrifuge *** test results revealed that before void formation,the surface load directly above the middle of the pipe caused a significant increase in not only the circumferential bending moments but also the longitudinal bending moments,the latter of which was considerable and could not be *** formation beneath the middle of the pipe led to a reduction in both the circumferential bending moments and longitudinal bending moments at all measuring positions,i.e.,crown,springline,and *** most significant reduction occurred at the invert,and there was even a reversal in the sign of the invert longitudinal bending moment.A comparison was made between centrifuge tests with erosion voids and surface loads at different horizontal positions,which had a marked influence even when the positions differed by half a pipe *** rotation played an important role in relieving large bending moments of pipe barrels in a jointed pipeline when the void and surface load were located at the joint.

关键词： Centrifuge test Erosion void Reinforced concrete pipe Traffic loading Longitudinal bending moment Joint rotation

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Management of venous stenosis in living donor liver transplant recipients

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World Journal of Gastroenterology 2009年第39期15卷 4969-4973页

作者： Jie Yang ming-Qing xu lu-Nan Yan Wu-Sheng lu Xiao Li Zheng-Rong Shi Bo Li Tian-Fu Wen Wen-Tao Wang Jia-Ying Yang Department of Liver and Vascular Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM:To retrospectively evaluate the management and outcome of venous obstruction after living donor liver transplantation(LDLT).METHODS:From February 1999 to May 2009,1 intraoperative hepatic vein(HV) tension induced HV obstruction and 5 postoperative HV anastomotic stenosis occurred in 6 adult male LDLT *** portal vein(PV) anastomotic stenosis occurred in 1 pediatric left lobe *** ranged in age from 9 to 56 years(median,44 years).An air balloon was used to correct the intraoperative HV *** surgical reoperation,transjugular HV balloon dilatation with stent placement and transfemoral venous HV balloon dilatation was performed for HV stenosis on days 3,15,50,55,and 270 after LDLT,*** dilatation followed with stent placement via superior mesenteric vein was performed for the pediatric PV stenosis 168 d after ***:The intraoperative HV tension was corrected with an air *** recipient who underwent emergent reoperation for hepatic stenosis died of hemorrhagic shock and renal failure 2 d *** balloon dilatation via the transjugular and transfemoral venous approach was technically successful in all *** patient with early-onset HV stenosis receiving transjugular balloon dilatation and stent placement on the 15th postoperative day left hospital 1 wk later and disappeared,while the patient receiving the same interventional procedures on the 50th postoperative day died of graft failure and renal failure 2 wk *** patients with late-onset HV stenosis receiving balloon dilatation have survived for 8 and 4 mo without recurrent stenosis and ascites,*** dilatation and stent placement via the superior mesenteric venous approach was technically successful in the pediatric left lobe LDLT,and this patient has survived for 9 mo without recurrent PV stenosis and ***:Intraoperative balloon placement,emergent reoperation,proper interventional balloon dilatation and

关键词： Living donor liver transplantation Venous obstruction Anastomotic stenosis Venoplasty Stent

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