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Primary myelofibrosis with thrombophilia as first symptom combined with thalassemia and Gilbert syndrome:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4161-4170页

作者： Guzailinuer Wufuer Kaisaer Wufuer Tu Ba Tao Cui Ling Tao Ling Fu ming Mao ming-hui duan Department of Hematology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Thoracic Surgery The Eighth Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Pathology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Radiology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Hematology Peking Union Medical College HospitalBeijing 100730China

BACKGROUND A 46-year-old Han man first had sigmoid sinus and transverse sinus venous thrombosis at the age of *** the age of 44,he once again developed *** testing showed heterozygous SERPINC1 mutation,bone marrow biopsy showed fibrosis grade 1(MF-1),and JAK2 V617F mutation was positive,accompanied by UGT1A1 mutation andβ-thalassemia gene *** SUMMARY A 46-year-old Han man was first found to have sigmoid sinus and transverse sinus venous thrombosis at the age of 42 but had no individual or family thrombosis history,and he had been regularly taking warfarin anticoagulant therapy for a long period of *** the age of 44,venous thrombosis reappeared in parts of the intrahepatic vein,main portal vein,splenic vein,and superior mesenteric vein,and his spleen was obviously *** had a history of jaundice for many years,and genetic testing revealed that he carried a heterozygous SERPINC1 *** marrow biopsy showed multifocal fibrous tissue hyperplasia among trabeculae and focal *** was positive for the JAK2 V617F *** the same time,UGT1A1 andβ-thalassemia gene mutations existed,and a SERPINC1 mutation and UGT1A1 mutation were both found in his *** The patient in this case had thrombophilia as the primary symptom,JAK2V617-positive myeloproliferative neoplasm(MPN)was the main potential cause,and hereditary AT-III deficiency may have been one of multiple secondary *** remains to be determined whether UGT1A1 andβ-thalassemia gene mutations are related to ***,the clinical features of MPN in this patient were hidden,and the relevant clinical features of coexisting thalassemia and hereditary Gilbert syndrome,reported here for the first time domestically and abroad,were complicating factors,causing great difficulties for a clear ***,when thrombophilia has been determined,it is necessary to screen the relevant latent problems *** the clinical features cannot be perfect

关键词： Thrombophilia Prefibrotic myelofibrosis Negative family thrombosis history Case report

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Well-differentiated systemic mastocytosis with KIT K509I mutation and uterus infiltration in an Asian woman with good response to imatinib

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Chinese Medical Journal 2019年第16期132卷 2002-2003页

作者： Duo-Duo Zhao Lu Zhang Wen-Qin Li ming-hui duan Jun-Ling Zhuang Dao-Bin Zhou Department of Hematology Peki叩 Union Medical College HospitalPeking Union Medical College & Chinese Academy of Medicine SciencesBeijing 100730China Department of Pathology Peking Union Medical College HospitalPeking Union Medical College & Chinese Academy of Medicine SciencesBeijing 100730China Department of Pathology Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830000China

To the Editor: We report a 27-year-old woman with a 2-month history of irregular uterine bleeding between periods. Blistering on the head was noted in the patient at the age of 2 months, and she gradually developed red maculopapular lesions over her neck and back during puberty, which were itchy after exposure to physical friction. On admission, physical examination had revealed diffuse faint maculopapular rash mainly on the neck and back [Figure 1]. Pelvic examination showed a smooth red lump (5 cm) on the cervix. No abnormality was detected in the complete blood count. Afterwards, the cervical lump was resected and confirmed to be the infiltration of mature mast cells (MCs) after careful pathological investigation. Additionally, a skin nodule biopsy also indicated mass aggregation of MCs, and a bone marrow (BM) biopsy showed a mass of round MCs with abundant cytoplasmic granules. The MCs accounted for about 22.5% of all cells in the aspirate smears. Flow cytometry immunophenotypic analysis on BM suggested that an aberrant MC population had represented 10% of the total analyzed cells, which was positive for CD117, CD33, and CD9, partially positive for CD2 and CD68, and negative for CD25. Genetic test through exome-wide sequencing for the receptor tyrosine kinase (KIT) gene had revealed K509I mutation.

关键词： systemic mastocytosis KIT K509I mutation Asian woman

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Crystalline-amorphous M@MN_x(M=Co,Fe,Ni)encapsulated in nitrogen-doped carbon for enhanced efficient and durable hydrogen evolution reaction

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Rare Metals 2024年第4期43卷 1547-1556页

作者： Yang Yang Xiao-Chuan duan Shao-hui Guo Xian-ming Zhang College of Materials Science and Engineering College of ChemistryKey Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyYuci030600China

Developing earth-abundant electrocatalysts for hydrogen evolution reaction(HER)is important for the sustainable energy ***,efficient and stable heterocatalysts consisting of crystalline-amorphous M@MN_(x)(M=Co,Fe,Ni)encapsulated in N-doped carbon layers supported with N-doped graphene sheets(denoted as M@MN_(x)@NC-NG)are synthesized by facile hydrothermal reaction and nitridation *** the nitriding process,metal ions in M(tzbc)_2(H_(2)O)_4(tzbc=4-(1H-1,2,4-triazol-1-yl)benzoic acid)complexes are reduced to crystalline M cores,accompanied by the formation of amorphous MN_(x)shells;the tzbc ligands are insitu carbonized to form outermost N-doped carbon(NC)layers that connect with inner MN_(x)via M-N-C motifs inherited from the complex precursors and inhibit the transition of MN_(x)from amorphous to crystalline *** Co@CoN_(x)@NC-NG catalyst exhibits excellent HER activity with small overpotentials of 45 and 64 mV at a cathode current density of 10 mA·cm^(-2)and low Tafel slopes of 40 and 85 mV·dec^(-1)in 0.5 mol·L^(-1)H_(2)SO_4 and1.0 mol·L^(-1)KOH electrolytes,*** Co@CoN_(x)@NC-NG retains 97%of the initial overpotential after 100,000 s in both acidic and alkaline *** outstanding HER performance originates from the crystalline-amorphous Co@CoN_(x)that redistributes electrons around the heterointerfaces,facilitating the conversion process of H^(+)/H_(2)O to hydrogen and thereby promoting HER *** outermost NC layers serve as the armor of Co@CoN_(x),and graphene nanosheets act as carriers of egg-like Co@CoN_(x)@NC and conduction paths for electron shuttles,ensuring stable and continuous electrocatalytic hydrogen production.

关键词： Hydrogen evolution reaction Electrocatalysts Iron group metals Heterojunction Crystalline-amorphous structure

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Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan Fang Li-hui Li ming-Qian He Yue Ji Dong-Yan Lu Li-Bing Zhang Jin-Lan Yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,P<0.001),social isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,P<0.001);health literacy was identified effect on psychological distress among pre-frail older persons(β=-0.307,P<0.001).Health literacy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

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一种双网实时串口通信的设计与实现

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计算机系统应用 2017年第3期26卷 234-238页

作者：王华刘冰刘焕敏段慧芬马东艳中国卫星海上测控部江阴214431

设计了一种跨网传输的串口通信软件,该软件采用数据收发双线程机制和数据队列线程间数据共享机制,设计了数据通信的数据帧类型校验、数据帧CRC校验和数据帧帧长校验等方法,保证数据高效性、安全性和完整性,通过速率测试和误码测试,证明... 详细信息

设计了一种跨网传输的串口通信软件,该软件采用数据收发双线程机制和数据队列线程间数据共享机制,设计了数据通信的数据帧类型校验、数据帧CRC校验和数据帧帧长校验等方法,保证数据高效性、安全性和完整性,通过速率测试和误码测试,证明该模型实现了可靠、安全和高效的串口通信,满足了在试验网和信息网之间实时数据通信的需要.

关键词：串口通信帧长校验实时数据通信 CRC校验

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Non-hyperbolic Closed Characteristics on Non-degenerate Star-shaped Hypersurfaces in R2n

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Acta Mathematica Sinica,English Series 2018年第1期34卷 1-18页

作者： Hua Gui duan hui LIU Yi ming LONG Wei WANG School of Mathematical Sciences and LPMC Nankai University School of Mathematics and Statistics Wuhan University Chern Institute of Mathematics and LPMC Nankai University School of Mathematical Sciences and LMAM Peking University

In this paper, we prove that for every index perfect non-degenerate compact star-shaped hypersurface E C R2n, there exist at least n non-hyperbolic closed characteristics with even Maslov- type indices on E when n is even. When n is odd, there exist at least n closed characteristics with odd Maslov-type indices on E and at least （n - 1） of them are non-hyperbolic. Here we call a compact star-shaped hypersurfaee E ∈R2 index perfect if it carries only finitely many geometrically distinct prime closed characteristics, and every prime closed characteristic （T, y） on E possesses positive mean index and whose Maslov-type index i（y, m） of its m-th iterate satisfies i（y, m） ≠-1 when n is even, and i（y, rn） ≠2{-1,0} when n is odd for all rn E N.

关键词： Closed characteristic star-shaped hypersurface non-hyperbolic Maslov-type index

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Rigid elliptical cross-section ogive-nose projectiles penetration into concrete targets

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Defence Technology（防务技术） 2021年第3期17卷 800-811页

作者： Xiang-hui Dai Ke-hui Wang ming-rui Li Jian duan Bing-wen Qian Gang Zhou Laboratory of Intense Dynamic Loading and Effect Northwest Institute of Nuclear TechnologyXi’anShaanxi710024PR China

The elliptical cross-section ogive-nose projectile(ECOP) has recently attracted attention because it is well suited to the flattened shape of earth-penetrating weapons. However, the penetration performance of ECOPs has not been completely understood. The objective of this study was to investigate the penetration performance of ECOPs into concrete targets using a theoretical method. A general geometric model of ECOPs was introduced, and closed-form penetration equations were derived according to the dynamic cavity-expansion theory. The model was validated by comparing the predicted penetration depths with test data, and the maximum deviation was 15.8%. The increment in the penetration depth of the ECOP was evaluated using the proposed model, and the effect of the majoreminor axis ratio on the increment was examined. Additionally, the mechanism of the penetration-depth increment was investigated with respect to the caliber radius head, axial stress, and resistance.

关键词： Elliptical cross-section Projectile Penetration Concrete target Dynamic cavity-expansion

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我国优秀蹦床运动员脊柱腰段损伤致伤机制研究

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福建体育科技 2016年第6期35卷 32-34页

作者：张宏俊王莹胡鑫韩尚洁高明段卉山西医科大学山西太原030001

运用问卷调查、专家访谈、数理统计等方法,综合生物学和训练学两大学科视角,对我国优秀蹦床运动员运脊柱腰段损伤的总体情况和致伤机制进行了细致分析与探讨。研究表明,我国优秀蹦床运动员脊柱腰段损伤率高达83.3%,前三大损伤类型为腰... 详细信息

运用问卷调查、专家访谈、数理统计等方法,综合生物学和训练学两大学科视角,对我国优秀蹦床运动员运脊柱腰段损伤的总体情况和致伤机制进行了细致分析与探讨。研究表明,我国优秀蹦床运动员脊柱腰段损伤率高达83.3%,前三大损伤类型为腰肌劳损、腰扭伤、腰椎间盘突出,其生物学致因在于生理解剖结构弱点、过劳加速生理性退变以及违背生物力学原理的运动;训练学角度主观因素主要在于不合理的技术动作、注意力不稳定、局部负荷过重和力量素质欠佳,客观因素主要为高危的项目特征和技术动作的复杂性。最终从损伤防护、力量训练、技术训练和心智训练方面给出指导性建议。

关键词：蹦床脊柱腰段运动损伤致伤因素损伤机制

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Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin Ying-Yi Chen Yuan-ming Tsai Ti-hui Wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

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Reliability-based selective maintenance for redundant systems with dependent performance characteristics of components

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Journal of Systems Engineering and Electronics 2023年第3期34卷 804-814页

作者： CAO hui duan Fuhai duan Yu’nan School of Mechanical Engineering Dalian University of TechnologyDalian 116024China

The reliability-based selective maintenance(RSM)decision problem of systems with components that have multiple dependent performance characteristics(PCs)reflecting degradation states is addressed in this paper.A vine-Copulabased reliability evaluation method is proposed to estimate the reliability of system components with multiple ***,the marginal degradation reliability of each PC is built by using the Wiener stochastic process based on the PC’s degradation *** joint degradation reliability of the component with multiple PCs is established by connecting the marginal reliability of PCs using *** addition,two RSM decision models are developed to ensure the system accomplishes the next *** genetic algorithm(GA)is used to solve the constraint optimization problem of the models.A numerical example illustrates the application of the proposed RSM method.

关键词： D-vine genetic algorithm(GA) reliability-based selective maintenance(RSM) redundant system Wiener stochastic process

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