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Tetrandrine stimulates the apoptosis of hepatic stellate cells and ameliorates development of fibrosis in a thioacetamide rat model

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World Journal of Gastroenterology 2007年第8期13卷 1214-1220页

作者： ming-fu yin Li-Hua Lian Dong-ming Piao Ji-Xing Nan Key Laboratory of Organism functional Factors of the Changbai Mountain (Yanbian University) Ministry of Education and College of Pharmacy Yanbian University Yanji 133002 Jilin Province China College of Pharmacy Yanbian University Yanji 133002 Jilin Province China Department of Pathology the Affiliated Hospital Medical College Yanbian University Yanji 133002 Jilin Province China

AIM： To investigate the therapeutic effect of tetrandrine on liver fibrosis induced by thioacetamide in rats in vivo and in vitro. METHODS： In vitro study： we investigated the effect of tetrandrine on the apoptosis of rat hepatic stellate cells transformed by simian virus 40 （T-HSC/CI-6）, which retains the features of activated cells. In vivo study： hepatic fibrosis was induced in rats by thioacetamide. Tetrandrine was given orally to rats at doses of 5, 10 or 20 mg/kg for 4 wk compared with intraperitoneal injection of interferon-r. RESULTS： In vitro study： 5, 10 or 25 μg/mL of tetrandrine-induced activation of caspase-3 in t-HSC/CI-6 cells occurred dose-dependently. In vivo study： tetrandrine treatment as well as interferon-r significantly ameliorated the development of fibrosis as determined by lowered serum levels of aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, total bilirubin （T-Bil） and the levels of liver hydroxyproline （Hyp）, hyaluronic acid （HA）, laminin （LN） and also improved histological findings. The effects of tetrandrine at the concentration of 20 mg/kg were better than the other concentration groups. CONCLUSION： Tetrandrine promotes the apoptosis of activated HSCs in vitro. Tetrandrine administration can prevent liver fibrosis and liver damage induced by thioacetamide in rats in vivo, indicating that it might exert a direct effect on rat HSCs.

关键词： Tetrandrine Apoptosis Caspase-3 Liver fibrosis Thioacetamide

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党的民族政策与边疆多民族地区和谐民族关系的构建——以云南为例

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学术探索 2014年第1期 33-38页

作者：付明银付杰云南大学公共管理学院云南昆明650091

民族政策的价值取向决定着民族关系的状态,发展和谐的民族关系一直是党的民族政策的核心理念。作为一个多民族的边疆省份,云南在运用党的民族政策构建和谐民族关系中取得了良好成效,其做法对边疆多民族地区和谐民族关系的构建具有重要... 详细信息

民族政策的价值取向决定着民族关系的状态,发展和谐的民族关系一直是党的民族政策的核心理念。作为一个多民族的边疆省份,云南在运用党的民族政策构建和谐民族关系中取得了良好成效,其做法对边疆多民族地区和谐民族关系的构建具有重要的借鉴意义。但在当前深刻变化的国际、国内背景下,还有必要进一步强化"多元一体"的民族政策价值取向,构建权利义务对等的民族政策输出机制,构建必要的民族意识调控机制,建立边疆多民族地区公共危机应急处理机制,建立以法律手段为主的民族政策实施方式,以实现党的民族政策持续促进边疆多民族地区民族关系的和谐。

关键词：边疆多民族地区民族政策和谐民族关系

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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen Du ming Gao Yanbin yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai fu Geping yin Liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi yin ming Yang Xuxu Chen Xinhua yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑Yuan Yu Jing Wu Guang yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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西加拿大盆地M区块层序地层与油砂资源评价

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科学技术与工程 2017年第10期17卷 13-21页

作者：刘亚明谢寅符张志伟阳孝法王丹丹中国石油勘探开发研究院北京100083

正确认识油层平面分布是油砂资源评价的基础,无井区油层厚度的预测需要以地质认识为指导。以钻井资料为基础,对M区块的层序地层与沉积特征进行了研究,分析层序格架和储层展布;并在此基础上开展油层分布预测与油砂资源评价,取得了以下新... 详细信息

正确认识油层平面分布是油砂资源评价的基础,无井区油层厚度的预测需要以地质认识为指导。以钻井资料为基础,对M区块的层序地层与沉积特征进行了研究,分析层序格架和储层展布;并在此基础上开展油层分布预测与油砂资源评价,取得了以下新认识:(1)首次对区块进行了层序地层划分。区块可划分为2个长期旋回和6个中期旋回和10个短期旋回。(2)首次系统厘定了区块的沉积相类型及发育特征。区块发育河流、三角洲、滨岸、河口湾和浅海5类沉积相,11类沉积亚相和15类沉积微相。(3)评价结果改变了前人认识,大幅度增加了区块的资源潜力。评价认为区块油砂资源量为2.2×10~8t,比前人评价结果增加22.5%;钻探结果证实了评价结果的正确性,发现区块东部为资源最富集区,改变了前人认为区块西部为主力区的认识。

关键词：层序地层沉积相油砂资源评价 M区块西加拿大盆地

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不同生鲜水牛乳滴定酸度的分析

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食品与机械 2016年第10期32卷 53-56页

作者：李清张瑞云李文毛华明张安富尹以昌云南农业大学动物科学技术学院云南昆明650201 云南省动物营养与饲料重点实验室云南昆明650201 湖南工业大学生命科学与化学学院湖南株洲412007 云南省德宏州陇川农业局云南德宏678600 云南省德宏州畜牧站云南德宏678600

按GB4789．18-2010《乳与乳制品检验》标准对云南省主要奶水牛养殖小区、合作社同一季节26户养殖户的228个水牛生乳及相同来源不同月份的655个水牛生乳的酸度进行滴定，同时进行酒精检测和掺碱试验，并对日粮组成、饲喂模式及胎次和泌... 详细信息

按GB4789．18-2010《乳与乳制品检验》标准对云南省主要奶水牛养殖小区、合作社同一季节26户养殖户的228个水牛生乳及相同来源不同月份的655个水牛生乳的酸度进行滴定，同时进行酒精检测和掺碱试验，并对日粮组成、饲喂模式及胎次和泌乳天数进行普查。同一季节不同来源的228个水牛生乳滴定酸度在10-13°T的占83．8％；相同来源不同月份的655个水牛生乳样品的滴定酸度在10-13°T的占86．4％；总的883个生鲜水牛乳滴定酸度为10-13°T的占85．7％，大于14°T占10．6％，小于10°T仅占3．6％。

关键词：生鲜水牛乳滴定酸度分析

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云南弥渡苴力地区多金属矿找矿远景

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云南地质 2010年第3期29卷 303-306页

作者：李国取王绍明郭光华付明银涂国府武警黄金第十支队云南昆明650111

研究区有:与火山岩有关的铜矿、与断裂活动有关的热液脉状铜矿、与基性-超基性侵入岩有关的铂钯(铜、镍)矿等矿产。成矿条件分析表明,弥渡苴力地区具有较好的多金属矿找矿远景。

关键词：多金属矿构造岩浆控矿成矿条件分析远景靶区云南弥渡苴力

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Pyraclostrobin-loaded poly(lactic-co-glycolic acid) nanospheres: Preparation and characteristics

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Journal of Integrative Agriculture 2018年第8期17卷 1822-1832页

作者： yin ming-ming ZHENG Yu CHEN fu-liang Institute of Plant Protection Chinese Academy of Agricultural SciencesBeijing 100193P.R.China

We used poly(lactic-co-glycolic acid)(PLGA) as a carrier polymer for pyraclostrobin-loaded nanospheres. Using the ultrasound emulsification-solvent evaporation method, the physicochemical characteristics and release properties of the pyraclostrobin-loaded nanospheres were studied by dialysis. The optimal nanospheres prepared had a diameter of 0.6 μm, an active ingredient loading of 17.2%, and a loading rate of 89.7%. Infrared spectroscopy data and differential scanning calorimetry revealed that pyraclostrobin was successfully embedded in the carrier PLGA, and photostability tests indicated enhanced ultraviolet resistance of pyraclostrobin-loaded PLGA nanospheres nanospheres. Release property testing indicated that smaller particles had a faster release rate. Nanospheres also had a faster release rate in slightly acidic and slightly basic environments than in a neutral condition. Agitated nanospheres had a faster release rate than immobile nanospheres. The cumulative release kinetics of pyraclostrobin-loaded nanospheres was consistent with the first order kinetic equation and the Weibull equation.

关键词： nanospheres pyraclostrobin PLGA physical and chemical properties slow release

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