检索结果-南通市图书馆

System control-mediated drug delivery towards complex systems via nanodiamond carriers

International Journal of Smart and Nano Materials 2010年第1期1卷 69-81页

作者： Dean ho chih-ming ho Department of Biomedical Engineering Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Robert H.Lurie Comprehensive Cancer Center Northwestern UniversityChicagoIL 60611USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLACA 90095USA Center for Cell Control A NIH Nanomedicine Development CenterLos AngelesCA 90095USA

Cells represent the basic units of life and contain an intertwined network of signaling and regulatory circuitries that drive the processes of *** processes include the mediation of mechano-sensation,onset of and protection against disease,inflammation,and *** the network of bio-complex systems,each pathway interacts nonlinearly with others through different molecular *** a result,specific functionalities can not be simply linked to the cellular molecules in isolation.A complex system generally possesses very rich information content that can be characterized by the following features:(i)they contain a large number of building blocks;(ii)their interactions among building blocks and with their environment;(iii)they display organization without an external organizing principle being applied;and(iv)they exhibit adaptability and *** properties account for the innate intelligence of biology and its ability to regulate its homeostatic ***,this same complexity underlies,in cancer for example,challenges towards disease management,as the addressing of singular pathways with therapeutic compounds is not ***,combinatorial therapy often serves as a key strategy towards tumor *** iterative searching for optimized therapeutic combinations is indeed a daunting,if not preclusive task,we introduce the feedback system control(FSC)scheme,which may serve as a clinically relevant approach,provided a translational approach towards drug delivery is *** to their innate biocompatibility,which has been comprehensively observed,as well as their ability to delivery virtually any type of therapeutic in a sustained fashion due to their unique surface properties,nanodiamonds may serve as a foundation for nanoenabled combinatorial therapy.

关键词： bio-complex system feedback system control drug delivery,nanodiamond combinatorial medicine signaling network nanomedicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Management of early hepatic artery occlusion after liver transplantation with failed rescue

引用

World Journal of Gastroenterology 2015年第44期21卷 12729-12734页

作者： chih-Yang Hsiao Cheng-Maw ho Yao-ming Wu ming-chih ho Rey-Heng Hu Po-Huang Lee Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine

Hepatic artery thrombosis is a serious complication after liver transplantation which often results in biliary complications, early graft loss, and patient death. It is generally thought that early hepatic artery thrombosis without urgent re-vascularization or retransplantation almost always leads to mortality, especially if the hepatic artery thrombosis occurs within a few days after transplantation. This series presents 3 cases of early hepatic artery thrombosis after living donor liver transplantation, in which surgical or endovascular attempts at arterial re-vascularization failed. Unexpectedly, these 3 patients survived with acceptable graft function after 32 mo, 11 mo, and 4 mo follow-up, respectively. The literatures on factors affecting this devastating complication were reviewed from an anatomical perspective. The collective evidence from survivors indicated that modified nonsurgical management after liver transplantation with failed revascularization may be sufficient to prevent mortality from early hepatic artery occlusion. Re-transplantation may be reserved for selected patients with unrecovered graft function.

关键词： Complication Hepatic artery Thrombosis Liver trans

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prophylactic liver transplantation for high-risk recurrent hepatocellular carcinoma

引用

World Journal of Hepatology 2016年第31期8卷 1309-1317页

作者： Po-chih Yang Cheng-Maw ho Rey-Heng Hu ming-chih ho Yao-ming Wu Po-Huang Lee Department of Surgery National Taiwan University Hospital Hsinchu Branch Department of Surgery National Taiwan University Hospital Department of Surgery National Taiwan University Hospital

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. Radical treatment of HCC in early stages results in a long disease-free period and improved overall survival. The choice of optimal management strategy for HCC mainly depends on the severity of the underlying liver disease. For patients with decompensated liver cirrhosis and HCC within Milan criteria (MC), liver transplant (LT) is the choice of treatment. however, for patients with good residual liver reserve and HCC within MC, selection of other curative treatments such as liver resection (LR) or radiofrequency ablation may be a reasonable alternative. For patients without cirrhosis, LR can result in an overall survival similar to that provided by LT. Therefore, it is an accepted alternative to LT especially in areas with organ shortage. however, the cumulative 5-year recurrence rate of HCC post LR might be as high as 70%. For initial transplant-eligible (within MC) patients with recurrent HCC post LR, salvage liver transplant (SLT) was first proposed in 2000. however, most patients with recurrent HCC considered for SLT are untransplantable cases due to HCC recurrence beyond MC or comorbidity. Thus, the strategy of opting for SLT results in the loss of the opportunity of LT for these patients. Some authors proposed the concept of “de principe liver transplant” (i.e., prophylactic LT before HCC recurrence) to prevent losing the chance of LT for these potential candidates. Factors associated with the failure of SLT will be dissected and discussed in three parts: Patient, tumor, and underlying liver disease. Regarding patient-related factors, the rate of transplantability depends on patient compliance. Patients without regular follow-up tend to develop HCC recurrence beyond MC at the time of tumor detection. Advancing age is another factor related to severe comorbidities when LT is considered for HCC recurrence, and these elderly candidates become ineligibl

关键词： Liver transplant Hepatocellular carcinoma Salvage Risk factor Resection Microvascular invasion Recurrence Prophylactic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The impact of molecular diagnosis in current management of gynecologic cancer

The impact of molecular diagnosis in current management of g...

引用

2018年浙江省妇科肿瘤学学术年会暨温台妇产科年会

作者： chih-ming ho Taiwan Association of Gynecologic Oncologists Department of Medical Research Gynecologic Cancer Center in Cathay General hospital Fu-Jen Catholic University Taipei Medical University

＜正＞～～

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Subvoxel light-sheet microscopy for high-resolution high-throughput volumetric imaging of large biomedical specimens

引用

Advanced Photonics 2019年第1期1卷 45-57页

作者： Peng Fei Jun Nie Juhyun Lee Yichen Ding Shuoran Li Hao Zhang Masaya Hagiwara Tingting Yu Tatiana Segura chih-ming ho Dan Zhu Tzung KHsiaic Huazhong University of Science and Technology School of Optical and Electronic InformationWuhanChina Huazhong University of Science and Technology Britton Chance Center for Biomedical PhotonicsWuhan National Laboratory for OptoelectronicsWuhanChina University of California Los AngelesDepartment of BioengineeringLos AngelesCaliforniaUnited States University of Texas at Arlington Joint Department of Bioengineering of UT Arlington/UT SouthwesternArlingtonTexasUnited States University of California Los AngelesSchool of MedicineLos AngelesCaliforniaUnited States University of California Los AngelesChemical and Biomolecular Engineering DepartmentLos AngelesCaliforniaUnited States Osaka Prefecture University Nanoscience and Nanotechnology Research CenterResearch Organization for the 21st CenturyOsakaJapan University of California Los AngelesMechanical and Aerospace Engineering DepartmentLos AngelesCaliforniaUnited States

A key challenge when imaging whole biomedical specimens is how to quickly obtain massive cellular information over a large field of view(FOV).We report a subvoxel light-sheet microscopy(SLSM)method enabling high-throughput volumetric imaging of mesoscale specimens at cellular resolution.A nonaxial,continuous scanning strategy is developed to rapidly acquire a stack of large-FOV images with three-dimensional(3-D)nanoscale shifts ***,by adopting a subvoxel-resolving procedure,the SLSM method models these low-resolution,cross-correlated images in the spatial domain and can iteratively recover a 3-D image with improved resolution throughout the *** technique can surpass the optical limit of a conventional light-sheet microscope by more than three times,with high acquisition speeds of gigavoxels per *** fast reconstruction of 3-D cultured cells,intact organs,and live embryos,SLSM method presents a convenient way to circumvent the trade-off between mapping large-scale tissue(>100 mm3)and observing single cell(∼1-μm resolution).It also eliminates the need of complicated mechanical stitching or modulated illumination,using a simple light-sheet setup and fast graphics processing unit-based computation to achieve high-throughput,high-resolution 3-D microscopy,which could be tailored for a wide range of biomedical applications in pathology,histology,neuroscience,etc.

关键词： light-sheet microscopy subvoxel-resolving reconstruction large tissue imaging high-throughput volumetric imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence

引用

World Journal of Gastroenterology 2014年第32期20卷 11384-11393页

作者： Chun-Jen Liu Juliana Chang Po-Huang Lee Deng-Yn Lin Cheng-Chung Wu Long-Bin Jeng Yih-Jyh Lin King-Tong Mok Wei-Chen Lee hong-Zen Yeh ming-chih ho Sheng-Shun Yang Mei-Due Yang ming-Chin Yu Rey-Heng Hu Cheng-Yuan Peng Kuan-Lang Lai Stanley Shi-Chung Chang Pei-Jer Chen Graduate Institute of Clinical Medicine Hepatitis Research Center and Department of Internal Medicine National Taiwan University College of Medicine and National Taiwan University Hospital Chang Gung Memorial hospital-Linkou Medical Center and Chang Gung University Taichung Veterans General hospital China Medical University hospital National Cheng Kung University hospital Kaohsiung Veterans General hospital Medigen Biotechnology Corporation

AIM: To demonstrate that administering heparanase inhibitor PI-88 at 160 mg/d is safe and promising in reducing hepatocellular carcinoma (HCC) recurrence for up to 3 year following curative resection.

关键词： Antiangiogenesis Antimetastasis Adjuvant therapy Disease-free survival Heparanase inhibitor Hepatocellular carcinoma PI-88 Tumor recurrence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

微电子机械系统和流体流动

引用

力学进展 1998年第2期 106-128页

作者： chihming hoMechanical and Aerospace Engineering Department, University of California, Los Angles Los Angeles, California 90095 YuChong Tai Electrical Engineering Department, California Institute of Technology, Pasadena, California 91125

出现于８０年代后期的微机械工艺技术可提供微米尺度的传感器和致动器．这些微型转换器与信号调节和处理电路集成后，组成了可执行分布式实时控制的微电子机械系统（ＭＥＭＳ）．这种性能为流动控制研究开辟了一个崭新的领域．另一方面... 详细信息

出现于８０年代后期的微机械工艺技术可提供微米尺度的传感器和致动器．这些微型转换器与信号调节和处理电路集成后，组成了可执行分布式实时控制的微电子机械系统（ＭＥＭＳ）．这种性能为流动控制研究开辟了一个崭新的领域．另一方面，由于微米尺度结构中表面积与体积之比很大，在流体流经这些微小机械器件时，表面效应占据了主导地位．为此需要重新审视动量方程中的各类表面力项．由于它们非常小，气体流动具有很大的Ｋｎｕｄｓｅｎ数，所以边界条件也应加以修正．总之，微电子机械系统（ＭＥＭＳ）不但是一项实用技术，也为流动机理的基础研究提出了许多挑战．

关键词：流动控制微电子机械系统(MEMS) 微转换器尺寸效应表面力

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A NEMS approach to specific and sensitive DNA/protein biomarker sensors for early detection of oral cancer in raw saliva

A NEMS approach to specific and sensitive DNA/protein biomar...

引用

第2届世界华人生物医学工程研讨会

作者： Winny Tan Na Li Yang Li Xiaofeng Zhou David T. Wong chih-ming ho Henry Samueli School of Engineering and Applied Science School of Dentistry University of California Los Angeles 420 Westwood Plaza Los Angeles CA 90025

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

宁夏渔业调查

引用

兰州大学学报 1964年第2期 116-128页

作者：王香亭宋志明贺汝良秦王石宁夏回族自治区农业厅水产实验场

笔者等自1960—1963年7月对本区渔业进行了调查,调查地区包括西南起自青铜峡,东北至于石咀山的全程黄河本流及其附属水本,内容涉及鱼奖区系的组成,渔具及主要经济鱼类的生物学。 (一)境内黄河水质总硬度为11.2—29.6;透明度为0.75—3厘... 详细信息

笔者等自1960—1963年7月对本区渔业进行了调查,调查地区包括西南起自青铜峡,东北至于石咀山的全程黄河本流及其附属水本,内容涉及鱼奖区系的组成,渔具及主要经济鱼类的生物学。 (一)境内黄河水质总硬度为11.2—29.6;透明度为0.75—3厘米:pH7.4—3.4;溶解氧4.5—57毫克/升;磷酸盐0.666—0.612毫克/升。境内黄河中的浮游生物种类不多,计有波纹矽藻(Cymatopleura)新月矽藻(Cymbella)等15种浮游植物;浮游动物比较贫乏,习见的为桡足类幼虫及中剑(Mesocyclops),底悽动物有跳虾(Gummarus),蜻蛉科(Libellulidae),扁蜉科(Ecdyuridae),浮蜉科(Ephemeridae)及摇蚊科(Chironomidae)幼虫,软体动物有田螺(Bellamya)及蚬(Corbicula)。黄河主要附属水体为一些大的由下陷地区所形成的不定型的洼地浅水湖泊,面织约20万市亩。由于引黄灌溉,这些湖泊一方面接受稻田所排之水,同时又以排沟泻入黄河,起蓄洪作用。湖泊的特点是水生植物从生,敞水区较小,硫化氢含量高,冬季覆冰期长,因覆冰而引起的冬季窒息现象年有发生,虽利于鱼类繁殖、肥育,但不利于鱼类越冬。 (二)本区土著鱼类有17种,分隶于14属、4科,2目。种类不多,区系成份简单,没有中亚高原复合体中的特有种,亦乏中国平原复合体的种类,产生这一情况的原因可能由于本区处于黄土高原的边缘,距中亚高原甚远,使这些鱼类达不到此地,而其下流则因为流经山陕高原,水势猛,流速犬,使平原地区的鱼类不能逆流而上达于此地。本区雅罗鱼及鲫无疑是属于北方平原复合体的种类;而鲤、泥鳅则属于古代上第三纪动物区系复合体的成份,显然在本区占有优势,永宁黑泉湖的鲫鱼因大(7市斤)而闻名。 (三)宁夏捕鱼工具有10多种,渔法有很多缺点,如炸鱼及叉鱼应当禁止,采用干湖捕鱼亦应当注意保护幼鱼。 (四)本区发展渔业与农田盐渍化亦须正确处理,目前有些人认为:为了避免农田盐渍化就必须排除湖泊,重点发展水稻栽培业,但从同一单位面积产值及营养价值来说,两者并重是一个理想的措施。但对于哪些浇水沼泽不适于鱼类越冬的湖泊应当排除,而用来作为发展渔业的湖泊需要筑堤设闸,控制水位,以防湖水溢出影响农田。 (五)结合本区水域特点,可以考虑散放麝鼠同时发展芦苇生产,这是因为芦苇本身不仅可以作为许多日常生活用具,还能起脱盐洗碱的作用,对改良本匹盐渍土壤有很重要意义。

关键词：体长鱼类越冬怀卵量侧扁宁夏

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Interrogating a cell signalling network sensitively monitors cell fate transition during early differentiation of mouse embryonic stem cells

引用

Science China(Life Sciences) 2010年第1期53卷 78-86页

作者： YUE ZhiCao ZHUANG FengFeng LIU Yi-Hsin ho chih-ming Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesCA 90095USaA Center for Cell Control University of CaliforniaLos AngelesCA 90095USA Institute of Life Sciences Fuzhou UniversityFuzhou 350108China Department of Ophthalmology and Doheny Eye Institute University of Southern CaliforniaLos AngelesCA 90033USA

The different cell types in an animal are often considered to be specified by combinations of transcription factors,and defined by marker gene *** paradigm is challenged,however,in stem cell research and *** a mouse embryonic stem cell(mESC) culture system,here we show that the expression level of many key stem cell marker genes/transcription factors such as Oct4,Sox2 and Nanog failed to monitor cell status transition during mESC *** the other hand,the response patterns of cell signalling network to external stimuli,as monitored by the dynamics of protein phosphorylation,changed *** results also suggest that an irreversible alternation in the cell signalling network precedes the adjustment of transcription factor *** is consistent with the notion that signal transduction events regulate cell fate *** propose that interrogating a cell signalling network can assess the cell property more precisely,and provide a sensitive measurement for the early events in cell fate *** wish to bring attention to the potential problem of cell identification using a few marker genes,and suggest a novel methodology to address this issue.

关键词： signalling network cell identification differentiation mouse embryonic stem cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：