检索结果-南通市图书馆

Fundamental Research 2024年第3期4卷 708-709页

作者： ming fan Department of Neurobiology Beijing Institute of Basic Medical SciencesBeijing 100850China Chinese Institute for Brain Research Beijing 102206China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Lanzhou University School of Information Science&Engineering Lanzhou 730000China

The widespread adoption of artificial light sources,particularly LED lights,catalyzed by industrial modernization,has revolutionized human living and working environments.This transformation,while enhancing life's convenience,harbors potential health implications.Public health studies have identified an association between nighttime light pollution and an increased risk of metabolic diseases such as diabetes and obesity.However,the biological mechanisms through which light regulates glucose metabolism remain unclear.

关键词： catalyzed metabolism harbor

Multidisciplinary comprehensive treatment of massive hepatocellular carcinoma with hemorrhage:A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2225-2232页

作者： Xian-Shuai Kou fan-fan Li Yun Meng Jian-ming Zhao Sheng-Fen Liu Lan Zhang The First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Thoracic Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Department of Orthopedics Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC),a major contributor to cancer-related deaths,is particularly prevalent in Asia,largely due to hepatitis B virus infection.Its prognosis is generally poor.This case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration,particularly in patients with massive HCC complicated by ruptured bleeding,a scenario not extensively documented previously.CASE SUMMARY The patient presented with large HCC complicated by intratumoral bleeding.Treatment involved a multidisciplinary approach,providing individualized care.The strategy included drug-eluting bead transarterial chemoembolization,sorafenib-targeted therapy,laparoscopic partial hepatectomy,and standardized sintilimab monoclonal antibody therapy.Six months after treatment,the patient achieved complete radiological remission,with significant symptom relief.Imaging studies showed no lesions or recurrence,and clinical assessments confirmed complete remission.This report is notable as possibly the first docu-mented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts,offering new insights and a reference for future similar cases.CONCLUSION This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding,providing insights for future similar cases.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Sorafenib Translational therapy Multidisciplinary team Case report

Review of Fiber-Optic Localized Surface Plasmon Resonance Sensors:Geometries,Fabrication Technologies,and Bio-Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonic Sensors 2024年第2期14卷 31-56页

作者： Mengdi LU Chen WANG Ruizhi fan ming LIN Jianye GUANG Wei PENG Affiliated Cancer Hospital Dalian University of TechnologyShenyang 110042China School of Physics Dalian University of TechnologyDalian 116024China

Localized surface plasmon resonance(LSPR)biosensors,which enable nanoscale confinement and manipulation of light,offer the enhanced sensitivity and electromagnetic energy localization.The integration of LSPR with the fiber-optic technology has led to the development of compact and versatile sensors for miniaturization and remote sensing.This comprehensive review explores various sensor configurations,fiber types,and geometric shapes,highlighting their benefits in terms of sensitivity,integration,and performance improvement.Fabrication techniques such as focused non-chemical bonding strategies and self-assembly of nanoparticles are discussed,providing control over nanostructure morphology and enhancing sensor performance.Bio-applications of fiber-optic LSPR(FOLSPR)sensors are detailed,specifically in biomolecular interactions and analysis of proteins,pathogens and cells,nucleic acids(DNA and RNA),and other small molecules(organic compounds and heavy metal ions).Surface modification and detection schemes are emphasized for their potential for label-free and real-time biosensing.The challenges and prospects of FOLSPR sensors are addressed,including the developments in sensitivity,fabrication techniques,and measurement reliability.Integration with emerging technologies such as nanomaterials is highlighted as a promising direction for future research.Overall,this review provides insights into the advancements and potential applications of FOLSPR sensors,paving the way for sensitive and versatile optical biosensing platforms in various fields.

关键词： Fiber-optic localized surface plasmon resonance biosensor nanoparticles geometric configuration fabrication technology

Investigation of Maxima Assumptions in Modelling Tropical Cyclone- Induced Hazards in the South China Sea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第3期38卷 491-504页

作者： WEN Ze-guo WANG Fu-ming WAN Jing YANG fan School of Civil Engineering Sun Yat-sen University&Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Guangdong Academy of Safety Science and Technology Guangzhou 510060China Guangdong Key Laboratory of Oceanic Civil Engineering Guangzhou 510275China Advanced Energy Science and Technology Guangdong Laboratory(Yangjiang Offshore Wind Energy Laboratory) Yangjiang 529500China

The present study aims to examine the suitability of two commonly used assumptions that simplify modelling metoceanconditions for designing offshore wind turbines in the South China Sea (SCS). The first assumption assumes thatjoint N-year extreme wind and wave events can be independently estimated and subsequently combined. The secondone assumes peak wind and waves can be modelled as occurring simultaneously during a tropical cyclone (TC) event.To better understand the potential TC activity, a set of 10000 years synthetic TC events are generated. The wind fieldmodel and the Mike 21 spectral wave model are employed to model the TC-induced hazards. Subsequently, theeffect of the assumptions is evaluated by analyzing the peak structural response of both monopile and semisubmersibleoffshore wind turbines during TC events. The results demonstrate that the examined assumptions are generally accurate.By assessing the implications of these assumptions, valuable insights are obtained, which can inform andimprove the modelling of TC-induced hazards in the SCS region.

关键词： tropical cyclone numerical wave modelling hazards offshore wind turbines structural response

Indium-based electrocatalysts for CO_(2) reduction to C1 products

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 134-145页

作者： Qin Cheng ming Huang Qingqing Ye Bangwei Deng fan Dong Research Center for Carbon-Neutral Environmental&Energy Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou)&Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaHuzhou 313000China Suzhou Industrial Technology Research Institute of Zhejiang University Suzhou 215163China

Electrocatalytic CO_(2) reduction at mild conditions is a promising strategy to transform greenhouse gases into fuels or value-added chemicals to solve the increasingly serious environmental and energy problems.The most crucial factor in determining the CO_(2) reduction performance is to develop efficient electrocatalysts with high selectivity and stability.Among the various electrocatalysts,indium-based catalysts have attracted extensive attention due to their non-toxicity,low cost,and high formic acid/formate selectivity.In this work,we comprehensively review the recent development and research progress of indium-based electrocatalysts for CO_(2)RR.The reaction mechanism,reaction pathways,structure-activity relationship,and strategies to enhance the activity of CO_(2)RR on indium-based catalysts have also been briefly presented and discussed.Finally,the existing challenges and future developments for indium-based highperformance catalysts for CO_(2)RR are proposed.

关键词： Electrocatalytic CO_(2)reduction In-based catalysts Formate Reaction mechanism Structure-activity relationship

A survey on model-based reinforcement learning

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第2期67卷 59-84页

作者： fan-ming LUO Tian XU Hang LAI Xiong-Hui CHEN Weinan ZHANG Yang YU National Key Laboratory for Novel Software Technology Nanjing University Polixir. ai Department of Computer Science and Engineering Shanghai Jiao Tong University

Reinforcement learning(RL) interacts with the environment to solve sequential decision-making problems via a trial-and-error approach. Errors are always undesirable in real-world applications, even though RL excels at playing complex video games that permit several trial-and-error attempts. To improve sample efficiency and thus reduce errors, model-based reinforcement learning(MBRL) is believed to be a promising direction, as it constructs environment models in which trial-and-errors can occur without incurring actual costs. In this survey, we investigate MBRL with a particular focus on the recent advancements in deep RL. There is a generalization error between the learned model of a non-tabular environment and the actual environment. Consequently, it is crucial to analyze the disparity between policy training in the environment model and that in the actual environment, guiding algorithm design for improved model learning, model utilization, and policy training. In addition, we discuss the recent developments of model-based techniques in other forms of RL, such as offline RL, goal-conditioned RL, multi-agent RL, and meta-RL. Furthermore,we discuss the applicability and benefits of MBRL for real-world tasks. Finally, this survey concludes with a discussion of the promising future development prospects for MBRL. We believe that MBRL has great unrealized potential and benefits in real-world applications, and we hope this survey will encourage additional research on MBRL.

关键词： reinforcement learning model-based reinforcement learning planning model learning model learning with reduced error model usage

Supramolecular polymer network constructed by a functionalized polyimidazolium salt derived from metal-carbene template approach

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第4期67卷 1224-1228页

作者： ming-ming Gan Zi-En Zhang Yi-fan Zhang Heng Zhang Li-Ying Sun Ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China

In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane moieties.This strategy involves the formation of metal-carbene templates,photochemical cycloaddition,and subsequent demetallation of metal ions.Driven by the host-guest chemistry between crown ether units and ammonium salts,we successfully fabricated a supramolecular polymer SPN1,which features imidazolium receptors and cyclobutane units.The obtained SPN1 demonstrates outstanding reversible stimulus-response,antibacterial behavior and conductivity.

关键词： metal-carbene template crown ether polyimidazolium salt host-guest chemistry

Heparin is an effective treatment for preventing liver failure after hepatectomy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第22期30卷 2881-2892页

作者： Zhi-Ying Xu Min Peng ming-ming fan Qi-Fei Zou Yi-Ran Li Dong Jiang Hepatic Surgery IV Shanghai Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND Posthepatectomy liver failure(PHLF)is one of the most important causes of death following liver resection.Heparin,an established anticoagulant,can protect liver function through a number of mechanisms,and thus,prevent liver failure.AIM To look at the safety and efficacy of heparin in preventing hepatic dysfunction after hepatectomy.METHODS The data was extracted from Multiparameter Intelligent Monitoring in Intensive Care III(MIMIC-III)v1.4 pinpointed patients who had undergone hepatectomy for liver cancer,subdividing them into two cohorts:Those who were injected with heparin and those who were not.The statistical evaluations used were unpaired ttests,Mann-Whitney U tests,chi-square tests,and Fisher’s exact tests to assess the effect of heparin administration on PHLF,duration of intensive care unit(ICU)stay,need for mechanical ventilation,use of continuous renal replacement therapy(CRRT),incidence of hypoxemia,development of acute kidney injury,and ICU mortality.Logistic regression was utilized to analyze the factors related to PHLF,with propensity score matching(PSM)aiming to balance the preoperative disparities between the two groups.RESULTS In this study,1388 patients who underwent liver cancer hepatectomy were analyzed.PSM yielded 213 matched pairs from the heparin-treated and control groups.Initial univariate analyses indicated that heparin potentially reduces the risk of PHLF in both matched and unmatched samples.Further analysis in the matched cohorts confirmed a significant association,with heparin reducing the risk of PHLF(odds ratio:0.518;95%confidence interval:0.295-0.910;P=0.022).Additionally,heparin treatment correlated with improved short-term postoperative outcomes such as reduced ICU stay durations,diminished requirements for respiratory support and CRRT,and lower incidences of hypoxemia and ICU mortality.CONCLUSION Liver failure is an important hazard following hepatic surgery.During ICU care heparin administration has been proved to decrease the occurrence of hepatectomy induced liver

关键词： Liver resection Posthepatectomy liver failure Prophylactic treatment Heparin Prognosis of hepatectomy

Tourmaline guiding the electric field and dechlorination pathway of 2,3-dichlorophenol by Desulfitobacterium hafniense

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第1期135卷 262-273页

作者： Yue Lu fangyi Liang fanzhi Qin Linrui Zhong Jianhong Jiang Qi Liu Shoujuan Zhang ming Yan Changzheng fan Haoran Dong College of Environmental Science and Engineering Hunan UniversityChangsha 410082China Shenzhen Research Institute Hunan UniverisyShenzhen 510082China Key Laboratory of Environment Biology and Pollution Control Hunan UniversityMinistry of EducationChangsha 410082China China Machinery International Engineering Design&Research Institute Co. Ltd.Changsha 410007China Hunan Engineering Research Center for Water Treatment Process&Equipment Changsha 410007China

The dehalogenation of organohalides has been a research hotspot in bioremediation field;however,the influence of tourmaline,a natural ore that can generate spontaneous electric field,on organohalide-respiring bacteria(OHRB)and their dechlorination process is not well known.In this study,the effect and mechanism of tourmaline on the reductive dechlorination of 2,3-dichlorophenol(2,3-DCP)by Desulfitobacterium hafniense DCB-2Twere explored.The characterization results confirmed that tourmaline had good stability and the optimal dosage of tourmaline was 2.5 g/L,which shortened the total time required for dechlorination reaction to 72 hr.Besides,tourmaline amendment also increased the proportion of 2-chlorophenol(2-CP)from 18%to 30%of end products,while that of 3-CP decreased correspondingly.The theoretical calculations showed that the bond charge of the orthosubstituted chlorine declined from-0.179 to-0.067,and that of meta-substituted chlorine increased from-0.111 to-0.129,which indicated that the spontaneous electric field of tourmaline affected the charge distribution of 2,3-DCP and was more conducive to the generation of 2-CP.Overall,tourmaline with the spontaneous electric field affected the reductive dechlorination pathway of Desulfitobacterium,and the tourmaline-OHRB combining system might serve as a novel strategy for the bioremediation of environments polluted with chlorinated phenols.

关键词： Reductive dechlorination Desulfitobacterium hafniense Tourmaline Electric field 2 3-dichlorophenol

Bilateral iridocorneal endothelial syndrome-Chandler’s syndrome:a case report and literature review

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第4期17卷 773-776页

作者： Xiao-Hua Pan Yu-Fei Tao ming-Min Yang Xiao-Li Shen Jiao Si ming Li Ning fan Shenzhen Eye Hospital Jinan UniversityShenzhen 518040Guangdong ProvinceChina

Dear Editor,I ridocorneal endothelial syndrome(ICE)is a rare ocular disease first proposed by Eagle et al[1]in 1979.It is mainly characterized by corneal endothelial abnormalities,accompanied by iris atrophy,iris pigmented nodules and peripheral anterior synechiae.ICE syndrome is typically unilateral,and classified into three clinical variants based on the changes of the cornea and iris,including progressive iris atrophy,Chandler’s syndrome,and Cogan-Reese syndrome.

关键词： corneal atrophy clinical